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91. 发明申请

US20120321639A1 METHODS AND COMPOSITIONS FOR THE INHIBITION OF STAT5 IN PROSTATE CANCER CELLS 有权
标题翻译：抑制STAT5在前列腺癌细胞中的方法和组合物
公开(公告)号：US20120321639A1
公开(公告)日：2012-12-20
申请号：US13477923
申请日：2012-05-22
申请人： MARJA T. NEVALAINEN
发明人： MARJA T. NEVALAINEN
IPC分类号： C12N9/99 , A61P35/00 , G01N33/535 , A61K31/7052 , A61K39/395
CPC分类号： C12N15/86 , A61K38/1709 , A61K48/00 , C07K14/4705 , C07K16/3069 , C07K16/40 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2710/10343
摘要： The present invention relates to compositions and methods for the treatment of prostate cancer. In certain embodiments, the invention relates to compositions and methods for the inhibition of prostate cancer cell growth, comprising inhibiting the activity of Stat5 in prostate cancer cells.
摘要翻译：本发明涉及用于治疗前列腺癌的组合物和方法。在某些实施方案中，本发明涉及抑制前列腺癌细胞生长的组合物和方法，包括抑制Stat5在前列腺癌细胞中的活性。

92. 发明授权

US08273568B2 Replication-competent herpes simplex virus mediates destruction of neoplastic cells 有权
标题翻译：复制能力的单纯疱疹病毒介导肿瘤细胞的破坏
公开(公告)号：US08273568B2
公开(公告)日：2012-09-25
申请号：US10788410
申请日：2004-03-01
申请人： Robert L. Martuza , Samuel D. Rabkin , Toshihiro Mineta
发明人： Robert L. Martuza , Samuel D. Rabkin , Toshihiro Mineta
IPC分类号： C12N15/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/86 , A01K67/0271 , A01K2217/05 , A01K2267/0331 , A61K35/763 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2121/00 , C07K14/005 , C12N7/00 , C12N15/8509 , C12N2710/16622 , C12N2710/16632 , C12N2710/16643 , C12N2830/00
摘要： A method for killing malignant brain tumor cells in vivo entails providing replication competent herpes simplex virus vectors to tumor cells. A replication competent herpes simplex virus vector, with defective expression of the γ34.5 gene and the ribonucleotide reductase gene, specifically destroys tumor cells, is hypersensitive to anti-viral agents, and yet is not neurovirulent.
摘要翻译：在体内杀死恶性脑肿瘤细胞的方法需要向肿瘤细胞提供可复制的单纯疱疹病毒载体。具有γ34.5基因和核糖核苷酸还原酶基因缺陷表达的复制能力的单纯疱疹病毒载体，特异性地破坏肿瘤细胞，对抗病毒剂是过敏反应，而不是神经毒性。

93. 发明授权

US08263349B2 Antibody specific for a mammalian sphingosine kinase type 2 isoform protein and methods of use thereof 失效
公开(公告)号：US08263349B2
公开(公告)日：2012-09-11
申请号：US12804664
申请日：2010-07-27
申请人： Sarah Spiegel , Takafumi Kohama
发明人： Sarah Spiegel , Takafumi Kohama
IPC分类号： G01N33/53 , C07K16/00
CPC分类号： C12N9/1205 , A61K38/00 , G01N2333/9121 , G01N2500/10
摘要： Polyclonal or monoclonal antibodies which are specific for a mammalian sphingosine kinase type 2 isoform protein and methods for detecting the presence of sphingosine kinase type 2 isoform using the antibodies.

94. 发明申请

US20120153262A1 Systems and process for forming carbon nanotube sensors 有权
标题翻译：用于形成碳纳米管传感器的系统和工艺
公开(公告)号：US20120153262A1
公开(公告)日：2012-06-21
申请号：US12970997
申请日：2010-12-17
申请人： Makarand Paranjape , Jianyun Zhou
发明人： Makarand Paranjape , Jianyun Zhou
IPC分类号： H01L29/775 , H01L21/335 , B82Y15/00 , B82Y40/00 , B82Y99/00
CPC分类号： H01L51/0048 , B82Y10/00 , B82Y15/00 , B82Y40/00 , G01N27/4145 , H01L51/055 , H01L51/0558
摘要： A process for forming a functionalized sensor for sensing a molecule of interest includes providing at least one single or multi-wall carbon nanotube having a first and a second electrode in contact therewith on a substrate; providing a third electrode including a decorating material on the substrate a predetermined distance from the at least one single or multi-wall carbon nanotube having a first and a second electrode in contact therewith, wherein the decorating material has a bonding affinity for a bioreceptors that react with the molecule of interest; and applying a voltage to the third electrode, causing the decorating material to form nanoparticles of the decorating material on the at least one single or multi-wall carbon nanotube.
摘要翻译：用于形成用于感测感兴趣分子的功能化传感器的方法包括提供至少一个单壁或多壁碳纳米管，其具有与衬底接触的第一和第二电极; 在与所述至少一个具有与其接触的第一和第二电极的所述至少一个单壁或多壁碳纳米管的预定距离的基底上提供包括装饰材料的第三电极，其中所述装饰材料对生物感受器具有结合亲和力，与感兴趣的分子; 以及向所述第三电极施加电压，使所述装饰材料在所述至少一个单壁或多壁碳纳米管上形成所述装饰材料的纳米颗粒。

95. 发明授权

US08097472B2 System and method for the separation of analytes 有权
标题翻译：用于分离分离物的系统和方法
公开(公告)号：US08097472B2
公开(公告)日：2012-01-17
申请号：US12644341
申请日：2009-12-22
申请人： Thomas Wayne Schneider , James N. Baraniuk
发明人： Thomas Wayne Schneider , James N. Baraniuk
IPC分类号： G01N33/558
CPC分类号： G01N27/44795 , G01N27/44721 , G01N27/44791 , G01N33/558
摘要： A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel. The fractions are stacked to form plugs, the number of which is determined by a number of parallel second microchannels integrally connected to the first microchannel, into which the fractions are directed according to the buffer characteristics found in each of the individual microchannels. Within the microchannels the plugs are separated into proteins according to a different chemical property, i.e., “m/z,” utilizing capillary electrophoresis (“CE”).
摘要翻译：分离模块用于利用毛细管等电聚焦（“CIEF”）在第一微通道内，根据pI，即pI带分离或分离分析物。级分被堆叠以形成塞子，其数量由多个与第一微通道整体连接的平行的第二微通道确定，根据在每个单个微通道中发现的缓冲特性，分段被引导到该第一微通道中。在微通道内，使用毛细管电泳（“CE”），将栓塞根据不同的化学性质即“m / z”分离成蛋白质。

96. 发明申请

US20110301208A1 VIRAL AND FUNGAL INHIBITORS 有权
标题翻译：病毒和真菌抑制剂
公开(公告)号：US20110301208A1
公开(公告)日：2011-12-08
申请号：US13120610
申请日：2009-09-23
申请人： Radhakrishnan Padmanabhan , William C. Groutas , Brent E. Korba
发明人： Radhakrishnan Padmanabhan , William C. Groutas , Brent E. Korba
IPC分类号： A61K31/4245 , C07D275/04 , C07D417/06 , C07D413/06 , C07D239/95 , C07D401/12 , C07D405/12 , C07D417/12 , C07D403/12 , A61K31/4035 , A61K31/428 , A61P31/12 , A61P31/10 , A61P31/14 , C07D209/46
CPC分类号： C07D217/24 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus, and fungal infections such as, for example, candidiasis.
摘要翻译：公开了新型的病毒和真菌抑制剂。这些化合物可用于治疗，预防和/或改善病毒感染，例如丙型肝炎病毒，西尼罗河病毒，登革热病毒和日本脑炎病毒，以及真菌感染例如念珠菌病。

97. 发明申请

US20110269733A1 Silent Desensitizers of Neuronal nAChR and Methods of Use Thereof 有权
标题翻译：神经元nAChR的沉默脱敏剂及其使用方法
公开(公告)号：US20110269733A1
公开(公告)日：2011-11-03
申请号：US12994376
申请日：2009-05-26
申请人： Milton I. Brown , Mikell A. Paige , Yingxian Xiao , Kenneth J. Kellar
发明人： Milton I. Brown , Mikell A. Paige , Yingxian Xiao , Kenneth J. Kellar
IPC分类号： A61K31/4439 , C07D401/12 , A61K31/4427 , C07D405/14 , A61K31/443 , A61K31/444 , C07D409/14 , A61K31/4436 , A61P29/00 , A61P3/04 , A61P25/18 , A61P25/00 , A61P17/00 , A61P25/16 , A61P25/14 , A61P25/28 , A61P9/12 , A61P11/14 , A61P25/30 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine receptor.
摘要翻译：本发明的一个方面涉及作为烟碱乙酰胆碱受体配体的杂环化合物。本发明的第二方面涉及本发明化合物用于调节哺乳动物烟碱乙酰胆碱受体的用途。

98. 发明申请

US20110256469A1 Platinum Adlayered Ruthenium Nanoparticles, Method for Preparing, and Uses Thereof 有权
标题翻译：铂金钌纳米粒子，其制备方法及用途
公开(公告)号：US20110256469A1
公开(公告)日：2011-10-20
申请号：US13081809
申请日：2011-04-07
申请人： YuYe Tong , Bingchen Du
发明人： YuYe Tong , Bingchen Du
IPC分类号： H01M4/92 , B01J23/46 , B01J37/16 , B01J37/02 , B01J37/08 , H01M8/22 , B01J37/34 , B82Y30/00
CPC分类号： H01M8/1011 , B82Y30/00 , H01M4/8657 , H01M4/92 , H01M4/921 , H01M4/926 , Y02E60/523 , Y02P70/56
摘要： A superior, industrially scalable one-pot ethylene glycol-based wet chemistry method to prepare platinum-adlayered ruthenium nanoparticles has been developed that offers an exquisite control of the platinum packing density of the adlayers and effectively prevents sintering of the nanoparticles during the deposition process. The wet chemistry based method for the controlled deposition of submonolayer platinum is advantageous in terms of processing and maximizing the use of platinum and can, in principle, be scaled up straightforwardly to an industrial level. The reactivity of the Pt(31)-Ru sample was about 150% higher than that of the industrial benchmark PtRu (1:1) alloy sample but with 3.5 times less platinum loading. Using the Pt(31)-Ru nanoparticles would lower the electrode material cost compared to using the industrial benchmark alloy nanoparticles for direct methanol fuel cell applications.
摘要翻译：已经开发了一种优异的工业可升级的一锅乙二醇基湿法化学方法来制备铂 - 钌钌纳米颗粒，其提供了对该层的铂填充密度的精细控制，并有效地防止了沉积过程中纳米颗粒的烧结。用于亚单层铂的受控沉积的基于湿化学的方法在加工和使铂的使用方面是有利的，并且原则上可以直接扩大到工业级。 Pt（31）-Ru样品的反应性比工业基准PtRu（1：1）合金样品的反应性高约150％，但是铂负载的3.5倍。与使用工业基准合金纳米颗粒直接甲醇燃料电池应用相比，使用Pt（31）-Ru纳米颗粒将降低电极材料成本。

99. 发明申请

US20110230442A1 NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS 有权
标题翻译： NA通道，疾病和相关测定和组合物
公开(公告)号：US20110230442A1
公开(公告)日：2011-09-22
申请号：US13059182
申请日：2009-08-17
申请人： Milton L. Brown , Scott Grindrod , Thomas H. Walls , Todd Hansen , Simeng Suy , Mikell A. Paige
发明人： Milton L. Brown , Scott Grindrod , Thomas H. Walls , Todd Hansen , Simeng Suy , Mikell A. Paige
IPC分类号： A61K31/69 , C07D233/76 , C07F5/02 , A61K31/4166 , C12Q1/02 , C07C231/10 , C07D209/14 , C07C231/02 , G01N33/574 , C12N5/07 , G01N21/00 , C12Q1/68 , A61P25/08 , A61P35/00
CPC分类号： A61K31/4164 , C07D209/14 , C07D233/72 , C07D317/26
摘要： Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have superior blocking efficacy, for instance in displacing the radioligand [3H]-Batrachotoxin-B ([3H]-BTX-B) that binds to site 2 of a VGSC. The molecules of the invention comprise a moiety which increases the binding affinity of molecules for the protein binding site in prostate cancer cells (PCs), and which is also fluorescent. In one embodiment the invention molecules are an inhibition system that can be used to target over-abundant or hyperactive VGSCs selectively in pain, epilepsy or prostate cancer, inhibiting the proliferation of PCs. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo.
摘要翻译：公开了分子及其合成，用于阻断门控离子通道如电压门控钠通道（VGSC）和前列腺电压钠通道（PVSC）。这些抑制剂具有优异的阻断效能，例如置换与VGSC的位点2结合的放射性配体[3 H] -Batrachotoxin-B（[3 H] -BTX-B）。本发明的分子包含增加前列腺癌细胞（PC）中蛋白质结合位点的分子的结合亲和力的部分，其也是荧光的。在一个实施方案中，本发明分子是可用于在疼痛，癫痫或前列腺癌中选择性地靶向过量或过度活跃的VGSC的抑制系统，从而抑制PC的增殖。荧光部分还有助于药物在体外和体内生物系统中的筛选，跟踪和药效学研究。

100. 发明申请

US20110213146A1 Transition Metal-Catalyzed C-H Amination Using Unactivated Amines 有权
标题翻译：使用未活化胺过渡金属催化的C-H胺化
公开(公告)号：US20110213146A1
公开(公告)日：2011-09-01
申请号：US13061021
申请日：2009-09-03
申请人： Timothy H. Warren
发明人： Timothy H. Warren
IPC分类号： C07D295/03 , C07C209/02 , C07C231/08 , C07D207/267 , C07D405/04
CPC分类号： C07D263/52 , C07D263/14 , C07D521/00
摘要： One aspect of the invention relates to a method of animation or amidation, comprising the step of combining a substrate, comprising a reactive C—H bond, and an amine or amide, comprising a reactive N—H bond, in the presence of an oxidizing agent and a metal-containing catalyst, thereby forming a product with a covalent bond between the carbon of the reactive C—H bond and the nitrogen of the reactive N—H bond.
摘要翻译：本发明的一个方面涉及一种动画或酰胺化方法，其包括以下步骤：将包含反应性C-H键的底物与包含反应性N-H键的胺或酰胺在氧化试剂和含金属的催化剂，从而在反应性C-H键的碳和反应性N-H键的氮之间形成具有共价键的产物。

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