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91. 发明授权

US07256561B2 Method for operating a rotating electrical machine 有权
标题翻译：旋转电机操作方法
公开(公告)号：US07256561B2
公开(公告)日：2007-08-14
申请号：US11295546
申请日：2005-12-07
申请人： Tobias Geyer , Georgios Papafotiou , Manfred Morari
发明人： Tobias Geyer , Georgios Papafotiou , Manfred Morari
IPC分类号： H02K21/00
CPC分类号： H02P23/30
摘要： A method is specified for operating a rotating electrical machine, in which the rotating electrical machine is connected in terms of phase to a converter circuit, having a DC voltage circuit, for connecting at least two voltage levels, and the phases of the converter circuit are connected to the DC voltage circuit in accordance with a selected switching state combination of switching states for power semiconductor switches in the converter circuit. In order to reduce the switching frequency of the power semiconductor switches, a prediction is made of the further behavior of the overall system and according to this prediction, the optimum switching state combination is selected starting from the preceding selected switching state combination and with respect to the number of transitions from the preceding selected switching state combination to the selected switching state combination and with respect to the respective predetermined value range for the torque of the rotating electrical machine, for the magnetic stator flux of the rotating electrical machine and for the potential at the subconnection.
摘要翻译：一种用于操作旋转电机的方法，其中旋转电机以相位方式连接到具有DC电压电路的转换器电路，用于连接至少两个电压电平，并且转换器电路的相位为根据所述转换器电路中功率半导体开关的切换状态的选择开关状态组合，连接到所述直流电压电路。为了降低功率半导体开关的开关频率，对整个系统的进一步的行为进行预测，根据该预测，从先前选择的开关状态组合开始选择最佳开关状态组合，相对于对于旋转电机的磁定子磁通和对于旋转电机的转矩的电位的转换，从前一选择的开关状态组合到所选择的开关状态组合的转换次数以及旋转电机的转矩的相应预定值范围子连接。

92. 发明授权

US07247609B2 Growth factor modified protein matrices for tissue engineering 有权
标题翻译：用于组织工程的生长因子修饰蛋白质基质
公开(公告)号：US07247609B2
公开(公告)日：2007-07-24
申请号：US10325021
申请日：2002-12-18
申请人： Matthias Lütolf , Jason Schense , Jeffrey A. Hubbell , Anna Jen
发明人： Matthias Lütolf , Jason Schense , Jeffrey A. Hubbell , Anna Jen
IPC分类号： A01N37/18
CPC分类号： A61L27/225 , A61K38/00 , A61L27/227 , C07K14/635 , C07K2319/00
摘要： Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, by enzymatic action and/or diffusion. As demonstrated by the examples, one method is to bind heparin to the matrix by either covalent or non-covalent methods, to form a heparin-matrix. The heparin then non-covalently binds heparin-binding growth factors to the protein matrix. Alternatively, a fusion protein can be constructed which contains a crosslinking region such as a factor XIIIa substrate and the native protein sequence. Incorporation of degradable linkages between the matrix and the bioactive factors can be particularly useful when long-term drug delivery is desired, for example in the case of nerve regeneration, where it is desirable to vary the rate of drug release spatially as a function of regeneration, e.g. rapidly near the living tissue interface and more slowly farther into the injury zone. Additional benefits include the lower total drug dose within the delivery system, and spatial regulation of release which permits a greater percentage of the drug to be released at the time of greatest cellular activity.
摘要翻译：将蛋白质掺入用于组织修复，再生和/或重塑和/或药物递送的蛋白质或多糖基质中。可以掺入蛋白质，使其通过降解基质，通过酶作用和/或扩散来释放。如实施例所示，一种方法是通过共价或非共价方法将肝素与基质结合，形成肝素基质。然后肝素将肝素结合生长因子非共价结合到蛋白质基质上。或者，可以构建融合蛋白，其包含交联区域，例如因子XIIIa底物和天然蛋白质序列。当需要长期药物递送时，例如在神经再生的情况下，在基质和生物活性因子之间引入可降解的键可能是特别有用的，其中期望在空间上改变作为再生的功能的药物释放速率，例如快速靠近生物组织界面，并进一步向进入损伤区更慢。额外的益处包括递送系统内的总药物剂量越少，释放的空间调节，允许在最大的细胞活动时释放更多百分比的药物。

93. 发明授权

US07077391B2 Holding device for a ceramic blank 失效
标题翻译：用于陶瓷坯料的保持装置
公开(公告)号：US07077391B2
公开(公告)日：2006-07-18
申请号：US10433722
申请日：2001-12-03
申请人： Frank Filser , Ludwig Gauckler , Peter Kocher , Heinz Luethy , Peter Schaerer , Heiner Hoerhold , Peter Kreuder , Stefan Fecher
发明人： Frank Filser , Ludwig Gauckler , Peter Kocher , Heinz Luethy , Peter Schaerer , Heiner Hoerhold , Peter Kreuder , Stefan Fecher
IPC分类号： B23Q3/00
CPC分类号： B23Q3/084 , A61C13/0003 , A61C13/0022
摘要： A holding device comprises a cylindrical or prismatic, porous ceramic blank and elements for clamping in a machine tool for processing the blank by removing material, in order to produce a ceramic workpiece. A narrow frame is fixed by an adhesive connection over at least part of the periphery of the blank, which is held without stresses, in the area of a plane encompassing the longitudinal middle axis (A) of the blank. The frame only covers a small part of the surface of the blank and can be detached and held in a stable holder with a clamping adapter, in such a way that it cannot slide. The entire combination is fixed in the machine tool in such a way as to be resistant to twisting and sliding. The ceramic workpiece emerges continuously form the ceramic blank without predetermination of the advance direction, until holding segments which can then only be freely selected according to number and location have been formed. The holding segments end on the residual material of the blank in the area of the frame or on the frame itself. The holding device is used especially as a workpiece for producing fully ceramic dental prostheses, particularly crowns or bridges.
摘要翻译：保持装置包括圆柱形或棱柱形多孔陶瓷坯料和用于夹紧在机床中的元件，用于通过去除材料来处理坯料，以便产生陶瓷工件。在包围坯料的纵向中间轴线（A）的平面的区域中，窄框架通过粘合剂连接固定在坯料周边的至少一部分上，该坯料的周边保持无应力。该框架仅覆盖坯件表面的一小部分，并且可以用夹紧适配器分离并保持在稳定的保持器中，使得其不能滑动。整个组合固定在机床上，以防止扭转和滑动。陶瓷工件在不预先确定前进方向的情况下连续地形成陶瓷坯料，直到形成仅能够根据数量和位置自由选择的保持段。保持段在框架的区域中或框架本身上结束在坯料的残余材料上。保持装置特别用作用于生产完全陶瓷牙科假体的工件，特别是冠或桥。

94. 发明授权

US07075130B2 Photosensitive device with low power consumption 失效
标题翻译：具有低功耗的感光装置
公开(公告)号：US07075130B2
公开(公告)日：2006-07-11
申请号：US10251208
申请日：2002-09-19
申请人： Tobias Delbrück , Shih-Chii Liu , Samual Zahnd , Patrick Lichtsteiner
发明人： Tobias Delbrück , Shih-Chii Liu , Samual Zahnd , Patrick Lichtsteiner
IPC分类号： H01L27/148
CPC分类号： H03F3/082
摘要： A photosensitive device with a photodiode and an amplifier is disclosed. The diode is in series with a feedback transistor which forces the voltage derived from the photocurrent to be a logarithmic function of the light intensity. A current mirror is provided which controls the bias current to the amplifier to be proportional to the photocurrent. This arrangement ensures that the amplifier, just as the voltage derived from the photocurrent, becomes faster with increasing light intensity and therefore prevents an unnecessarily high power consumption at low light intensities.
摘要翻译：公开了具有光电二极管和放大器的光敏器件。二极管与反馈晶体管串联，其将从光电流导出的电压强制为光强度的对数函数。提供电流镜，其控制到放大器的偏置电流与光电流成比例。这种布置确保放大器，正如从光电流导出的电压一样，随着光强的增加而变得更快，因此防止在低光强度下不必要的高功率消耗。

95. 发明授权

US06960452B2 Enzyme-mediated modification of fibrin for tissue engineering: incorporation of proteins 有权
标题翻译：酶介导的纤维蛋白修饰组织工程：掺入蛋白质
公开(公告)号：US06960452B2
公开(公告)日：2005-11-01
申请号：US09798338
申请日：2001-03-02
申请人： Jeffrey A. Hubbell , Jason C. Schense , Shelly E. Sakiyama
发明人： Jeffrey A. Hubbell , Jason C. Schense , Shelly E. Sakiyama
IPC分类号： C07K14/475 , C12P21/00 , A01N1/00 , A61K9/14
CPC分类号： C07K14/475
摘要： Disclosed are materials that may be used in the design of improved devices and wound treatment platforms though covalent and/or non-covalent attachment of bioactive proteins. The proteins comprise any variety of cell growth and/or healing promoting proteins, such as growth factor. The incorporation of these whole proteins may be designed to provide controlled release thereof in a biological system through further use of enzyme degradation sites. Heparin-binding protein or fusion proteins synthesized to contain a heparin-binding domain are two mechanisms that may be used in providing these properties to a matrix, such as a fibrinogen matrix. The proteins will be used to provide enhanced healing in various tissues including vasculature, skin, nerve, and liver. The materials disclosed will be used to enhance would?? Healing and other generative processes by engineering the fibrin gel to contain appropriate proteins with specifically designed release and/or degradation characteristics.
摘要翻译：公开了可以用于设计改进的装置和伤口治疗平台的材料，尽管共价和/或非共价连接生物活性蛋白质。蛋白质包括任何多种细胞生长和/或愈合促进蛋白质，例如生长因子。可以将这些全蛋白的掺入设计成通过进一步使用酶降解位点来提供其在生物系统中的受控释放。合成含有肝素结合结构域的肝素结合蛋白或融合蛋白是可用于向基质例如纤维蛋白原基质提供这些性质的两种机制。蛋白质将用于在各种组织中提供增强的愈合，包括脉管系统，皮肤，神经和肝脏。所披露的材料将被用来增强通过设计纤维蛋白凝胶来包含具有专门设计的释放和/或降解特性的合适蛋白质来治疗和其他生成过程。

96. 发明授权

US06894022B1 Growth factor modified protein matrices for tissue engineering 有权
标题翻译：用于组织工程的生长因子修饰蛋白质基质
公开(公告)号：US06894022B1
公开(公告)日：2005-05-17
申请号：US09563760
申请日：2000-05-01
申请人： Jeffrey A. Hubbell , Jason C. Schense , Shelly E. Sakiyama-Elbert
发明人： Jeffrey A. Hubbell , Jason C. Schense , Shelly E. Sakiyama-Elbert
IPC分类号： C07K14/475 , A61K31/727
CPC分类号： C07K14/475
摘要： Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling, and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, enzymatic action, and/or diffusion. In one embodiment, a fusion protein, which contains a crosslinking region, such as a factor XIIIa substrate, and a native protein sequence, such as a bioactive factor, is constructed. Degradable linkages may be included between the crosslinking region and the bioactive factor.
摘要翻译：将蛋白质掺入用于组织修复，再生和/或重塑和/或药物递送的蛋白质或多糖基质中。可以掺入蛋白质，使其通过降解基质，酶作用和/或扩散而释放。在一个实施方案中，构建了含有交联区域（例如因子XIIIa底物）和天然蛋白质序列（例如生物活性因子）的融合蛋白质。交联区域和生物活性因子之间可以包括可降解的连接。

97. 发明申请

US20020061288A1 Gels and multilayer surface structures from boronic acid containing polymers 有权
标题翻译：含有硼酸的聚合物的凝胶和多层表面结构
公开(公告)号：US20020061288A1
公开(公告)日：2002-05-23
申请号：US10035625
申请日：2001-12-28
申请人： Eidgenossische Technische Hochschule Zurich
发明人： Jeffrey A. Hubbell , Donald L. Elbert , Natalie D. Winblade
IPC分类号： A61K031/74 , A61L002/00 , A61K047/48 , B05D003/00
CPC分类号： A61L31/10 , A61L27/34 , A61L29/085 , C08L71/02
摘要： Boronic acid containing polymers are used to form bioinert gels and multilayer surface structures. These polymers form crosslinked hydrogels, which are highly swollen in water. The crosslinking can either be chemical or physical. Water soluble polymers containing boronic acid groups, such as phenylboronic acid (PBA), can be physically crosslinked by mixing the polymers in water with other polymers containing hydroxyls or carboxylic acids. Alternatively, surfaces can be treated by stepwise incubation with a solution of the boronic acid containing polymer, followed by incubation with a solution of a diol or carboxylic acid containing polymer. Many successive layers can be generated, increasing the thickness of the formed structure at each step. The bioinert gel or surface coating can be used for passivating the surfaces of medical implants (especially those based on transplanted tissue), or for passivating the surfaces of tissues in situ, decreasing the incidence or severity of such pathologic conditions as the formation of post-surgical adhesions, and thrombosis following angioplasty.
摘要翻译：含硼酸的聚合物用于形成生物凝胶和多层表面结构。这些聚合物形成在水中高度溶胀的交联水凝胶。交联可以是化学或物理的。含有硼酸基团的水溶性聚合物如苯基硼酸（PBA）可通过将水中的聚合物与含有羟基或羧酸的其它聚合物混合而物理交联。或者，可以通过与含硼酸的聚合物的溶液逐步温育，然后与含二醇或含羧酸的聚合物的溶液温育来处理表面。可以产生许多连续的层，从而在每个步骤增加形成的结构的厚度。生物测定凝胶或表面涂层可用于钝化医疗植入物（特别是基于移植组织的植入物）的表面，或用于钝化组织表面的原位，降低这种病理状况的发生率或严重程度，手术粘连和血管成形术后的血栓形成。

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