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91. 发明授权

US07846433B2 Methods of treating pre-eclampsia and eclampsia 有权
标题翻译：治疗先兆子痫和子痫的方法
公开(公告)号：US07846433B2
公开(公告)日：2010-12-07
申请号：US12069757
申请日：2008-02-12
申请人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
IPC分类号： A61K38/00 , A61K39/00 , G01N33/53 , C07K17/00
CPC分类号： A61K39/3955 , A61K31/522 , A61K38/1866 , A61K38/1891 , A61K45/06 , A61K2039/505 , C07K16/1217 , C07K16/18 , C07K16/2863 , C07K16/40 , C07K2317/76 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12Q1/485 , G01N33/689 , G01N33/6893 , G01N33/74 , G01N2500/00 , G01N2800/368
摘要： Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the binding of VEGF or PlGF to sFlt1—are also disclosed herein for the treatment of pre-eclampsia or eclampsia.
摘要翻译：本文公开了诊断先兆子痫和子痫的方法。本文还公开了使用增加VEGF或PlGF水平的化合物或降低sFlt-1水平的化合物治疗先兆子痫和子痫的方法。本文还公开了抑制VEGF或PlGF与sFlt-1结合的化合物用于治疗先兆子痫或子痫。

92. 发明申请

US20100239559A1 Novel nutritional food products for improved digestion and intestinal absorption 审中-公开
标题翻译：新型营养食品，用于改善消化和肠道吸收
公开(公告)号：US20100239559A1
公开(公告)日：2010-09-23
申请号：US12587579
申请日：2009-10-09
申请人： Steven Freedman , Deborah A. DaSilva
发明人： Steven Freedman , Deborah A. DaSilva
IPC分类号： A61K38/46 , A61K38/47 , A61K38/48 , C12N9/20 , C12N9/26 , C12N9/48 , A61P1/14
CPC分类号： C12Y301/01003 , A23L33/135 , A23L33/17 , A23L33/195 , A23L33/40
摘要： The present invention is directed to novel food products, e.g., nutritional food products and infant formula, which contain one ore more enzymes selected from lipase, protease, and amylase that have been formulated/stabilized to have sustained stability in an aqueous medium. Such formulations are intended to provide a greater degree of compliance based on their ability to be incorporated into aqueous media while avoiding unstable breakdown of the enzyme and large overdosing due to expected breakdown when exposed to an aqueous environment, including saliva. Further described in the invention are additives packaged with instructions for combination with an aqueous medium, and instructions for the administration of the resulting mixture to a subject. In certain embodiments, enzyme insufficient patients, e.g., infants and elderly persons, would find particular benefit from the food products described herein.
摘要翻译：本发明涉及新的食品，例如营养食品和婴儿配方食品，其含有一种或多种选自脂肪酶，蛋白酶和淀粉酶的酶，其已被配制/稳定以在水性介质中具有持续的稳定性。这样的制剂旨在基于它们掺入水性介质中的能力而提供更大程度的依从性，同时避免酶的不稳定分解，并且当暴露于包括唾液在内的水性环境时，由于预期的分解导致的大量过量。在本发明中进一步描述的是包含与水性介质组合的说明书的添加剂以及将所得混合物施用于受试者的说明书。在某些实施方案中，酶不足的患者，例如婴儿和老年人，将从本文所述的食品中获益。

93. 发明申请

US20100221243A1 METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF DISEASES CHARACTERIZED BY VASCULAR LEAK, HYPOTENSION, OR A PROCOAGULANT STATE 审中-公开
标题翻译：通过血管渗漏，血压异常或程序性疾病治疗和诊断疾病的方法和组合
公开(公告)号：US20100221243A1
公开(公告)日：2010-09-02
申请号：US12359954
申请日：2009-01-26
申请人： Vikas P. Sukhatme , S. Ananth Karumanchi , Samir M. Parikh
发明人： Vikas P. Sukhatme , S. Ananth Karumanchi , Samir M. Parikh
IPC分类号： A61K39/395 , A61P9/00 , A61P7/02
CPC分类号： C07K16/22 , A61K31/4409 , A61K31/551 , A61K38/1891 , A61K49/0008 , C07K14/515 , C07K2317/76 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/6893 , G01N2333/485 , G01N2333/515 , G01N2333/525 , G01N2333/5412 , G01N2333/545 , G01N2333/9129 , G01N2800/32
摘要： Disclosed herein are methods for treating a vascular leak disorder, hypotension, or a procoagulant state using angiopoietin-2 (Ang-2) antagonist compounds. Also disclosed are methods for treating a vascular leak disorder associated with high dose IL-2 therapy using angiopoietin-2 antagonist compounds. Methods for diagnosing and monitoring vascular leak disorders, hypotension, or a procoagulant state that include the measurement of Ang-2 polypeptide or nucleic acid levels are also disclosed. Methods for inducing a vascular leak using an Ang-2 agonist are also disclosed.
摘要翻译：本文公开了使用血管生成素-2（Ang-2）拮抗剂化合物治疗血管渗漏障碍，低血压或促凝血状态的方法。还公开了使用血管生成素-2拮抗剂化合物治疗与高剂量IL-2治疗相关的血管渗漏障碍的方法。还公开了用于诊断和监测包括Ang-2多肽或核酸水平测量的血管渗漏障碍，低血压或促凝血状态的方法。还公开了使用Ang-2激动剂诱导血管渗漏的方法。

94. 发明申请

US20100210894A1 Transcranial magnetic stimulation (TMS) methods and apparatus 审中-公开
标题翻译：经颅磁刺激（TMS）方法和装置
公开(公告)号：US20100210894A1
公开(公告)日：2010-08-19
申请号：US12312931
申请日：2007-12-01
申请人： Alvaro Pascual-Leone , Alexander Rotenberg , Iain Glass , Frances E. Jensen
发明人： Alvaro Pascual-Leone , Alexander Rotenberg , Iain Glass , Frances E. Jensen
IPC分类号： A61N2/04
CPC分类号： A61N2/006 , A61B5/0006 , A61B5/04001 , A61B5/0476 , A61B5/0482 , A61B5/4094 , A61B90/14 , A61N2/008 , A61N2/02
摘要： Method and devices are provided for treating subjects with Transcranial Magnetic Stimulation (TMS). According to some approaches, the methods and devices are configured for the treatment of ongoing seizures. Other approaches relate to the use of TMS as an antiepileptogenic or for use in determining preferential placement of intracranial probes.
摘要翻译：提供了用经颅磁刺激（TMS）治疗受试者的方法和装置。根据一些方法，方法和装置被配置用于治疗持续性发作。其他方法涉及使用TMS作为抗癫痫发生或用于确定颅内探针的优先放置。

95. 发明授权

US07649014B2 Genipin derivatives and uses thereof 失效
标题翻译：栀子衍生物及其用途
公开(公告)号：US07649014B2
公开(公告)日：2010-01-19
申请号：US11241768
申请日：2005-09-29
申请人： Chen-Yu Zhang , Bradford B. Lowell , John A Porco, Jr. , Ruichao Shen , Cheng T. Lin , Stefan Krauss
发明人： Chen-Yu Zhang , Bradford B. Lowell , John A Porco, Jr. , Ruichao Shen , Cheng T. Lin , Stefan Krauss
IPC分类号： A61K31/382 , A61K31/336 , C07D493/06 , C07D493/16
CPC分类号： C07D221/04 , A61K31/352 , A61K31/353 , A61K31/365 , A61K31/4741 , A61K31/7048 , C07D211/90 , C07D309/32 , C07D311/94 , C07D491/04 , C07D493/04 , C07D493/06
摘要： Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed.
摘要翻译：公开了抑制哺乳动物中解偶联蛋白-2（UCP2）的活性并且可用于治疗缺乏一期胰岛素分泌，非胰岛素依赖性糖尿病和缺血的京尼平衍生物及其药物组合物。

96. 发明申请

US20090226064A1 FACTOR ANALYSIS IN MEDICAL IMAGING 有权
标题翻译：医学成像中的因素分析
公开(公告)号：US20090226064A1
公开(公告)日：2009-09-10
申请号：US12414153
申请日：2009-03-30
申请人： Georges El Fakhri , Arkadiusz Sitek
发明人： Georges El Fakhri , Arkadiusz Sitek
IPC分类号： G06K9/00 , G06T17/00
CPC分类号： G06T7/0012 , A61B6/037 , A61B6/503 , A61B6/5217 , G06F19/00 , G06T2207/30024 , G06T2207/30101
摘要： A method for estimating kinetic parameters from image data includes using a processor to execute instructions for providing a model of kinetic contributions from first and second physiological regions; grouping voxels of the image data into first and second groups; determining an average value of the factors associated with the first group, the factors corresponding to blood-flow time activity curves; incorporating the average value of the factors associated with the first group into the model of kinetic contributions from the first and second physiological regions; and estimating the kinetic parameters based on the model of kinetic contributions.
摘要翻译：用于从图像数据估计动力学参数的方法包括使用处理器执行用于提供来自第一和第二生理区域的动力学贡献的模型的指令; 将图像数据的体素分组成第一和第二组; 确定与第一组相关因素的平均值，与血流时间活动曲线相对应的因子; 将与第一组相关因素的平均值并入来自第一和第二生理区域的动力学贡献模型; 并基于动力学贡献模型估计动力学参数。

97. 发明授权

US07553631B2 RBP4 in insulin sensitivity/resistance, diabetes, and obesity 失效
标题翻译： RBP4在胰岛素敏感性/耐药性，糖尿病和肥胖中的作用
公开(公告)号：US07553631B2
公开(公告)日：2009-06-30
申请号：US11009409
申请日：2004-12-10
申请人： Barbara B. Kahn , Qin Yang , Tim Graham , Odile Peroni
发明人： Barbara B. Kahn , Qin Yang , Tim Graham , Odile Peroni
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： A61K31/167 , A61K48/00 , A61K49/0008 , C07K14/705 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5088 , G01N33/6893 , G01N2500/00 , G01N2800/042
摘要： Methods for screening molecules that modulate the activity of Retinol Binding Protein 4 (RBP4) and their use in treatment of insulin resistance are described. Also described are methods of diagnosing insulin resistance and related conditions by detecting modulation of RBP4 activity.
摘要翻译：描述了筛选调节视黄醇结合蛋白4（RBP4）活性的分子及其在治疗胰岛素抵抗中的应用的方法。还描述了通过检测RBP4活性的调节来诊断胰岛素抵抗和相关条件的方法。

98. 发明授权

US07479783B2 Echo train preparation for fast spin-echo acquisition 有权
标题翻译：回波训练准备快速自旋回波采集
公开(公告)号：US07479783B2
公开(公告)日：2009-01-20
申请号：US11729815
申请日：2007-03-29
申请人： David Alsop
发明人： David Alsop
IPC分类号： G01V3/00
CPC分类号： G01R33/5615 , G01R33/5617
摘要： In one aspect, a method of inducing nuclear magnetic resonance (NMR) signals from a region of an object to be imaged is provided. The method comprises applying to the region a preparation sequence configured to substantially establish a zero flip-angle pseudo steady state (PSS) for the region, applying to the region a transitioning sequence configured to transition the zero flip-angle PSS to a higher target flip-angle PSS, and applying a radio frequency (RF) pulse sequence configured to cause the region to emit detectable NMR signals.
摘要翻译：在一个方面，提供从待成像对象的区域诱导核磁共振（NMR）信号的方法。该方法包括向该区域施加配置为基本上为该区域建立零翻转伪稳态（PSS）的准备序列，向该区域施加被配置为将零翻转PSS转换到较高目标翻转的转换序列并且施加射频（RF）脉冲序列，其配置成使该区域发射可检测的NMR信号。

99. 发明申请

US20080312146A1 METH1 and METH2 Polynucleotides and Polypeptides 审中-公开
标题翻译： METH1和METH2多核苷酸和多肽
公开(公告)号：US20080312146A1
公开(公告)日：2008-12-18
申请号：US11751261
申请日：2007-05-21
申请人： Luisa Iruela-Arispe , Gregg A. Hastings , Steven M. Ruben , Zdenka L. Jonak , Stephen H. Trulli , James A. Fornwald , Jonathan A. Terrett
发明人： Luisa Iruela-Arispe , Gregg A. Hastings , Steven M. Ruben , Zdenka L. Jonak , Stephen H. Trulli , James A. Fornwald , Jonathan A. Terrett
IPC分类号： A61K38/00 , C12N15/11 , C12N15/00 , C12N5/06 , A61P9/00 , C12N15/87 , C12P21/04 , C07K14/00
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/78 , C07K2319/00 , C12N9/6489 , C12N2799/026
摘要： The present invention relates to novel anti-angiogenic proteins, related to thrombospondin. More specifically, isolated nucleic acid molecules are provided encoding human METH1 and METH2. METH1 and METH2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for the prognosis of cancer and therapeutic methods for treating individuals in need of an increased amount of METH1 or METH2. Also provided are methods for inhibiting angiogenesis using METH1 or METH2.
摘要翻译：本发明涉及与血小板反应蛋白相关的新型抗血管生成蛋白。更具体地，提供编码人METH1和METH2的分离的核酸分子。还提供了METH1和METH2多肽，以及载体，宿主细胞和用于制备它们的重组方法。还提供了用于预测癌症的诊断方法和用于治疗需要增加量的METH1或METH2的个体的治疗方法。还提供了使用METH1或METH2抑制血管生成的方法。

100. 发明授权

US07435419B2 Methods of diagnosing and treating pre-eclampsia or eclampsia 有权
标题翻译：诊断和治疗先兆子痫或子痫的方法
公开(公告)号：US07435419B2
公开(公告)日：2008-10-14
申请号：US11019559
申请日：2004-12-21
申请人： S. Ananth Karumanchi , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Vikas P. Sukhatme
IPC分类号： A61K38/00 , A61K39/00 , G01N33/53 , C07K17/00
CPC分类号： G01N33/689 , A61K31/522 , A61K2039/505 , C07K16/1217 , C07K16/2863 , C12Q1/485 , G01N33/6893 , G01N33/74 , G01N2500/00 , G01N2800/368
摘要： Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia or a propensity to develop pre-eclampsia or eclampsia by detecting the levels of placental growth factor in a subject.
摘要翻译：本文公开了通过检测受试者中胎盘生长因子的水平来诊断先兆子痫和子痫或倾向于发展先兆子痫或子痫的方法。

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