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91. 外观设计

USD753140S1 Display screen with graphical user interface 有权
公开(公告)号：USD753140S1
公开(公告)日：2016-04-05
申请号：US29488811
申请日：2014-04-23
申请人： ARES TRADING S.A.
设计人： Georgios Kouvas , Andrew Paterson , Colin Lake , Simon Exell

92. 外观设计

USD752616S1 Display screen with graphical user interface 有权
公开(公告)号：USD752616S1
公开(公告)日：2016-03-29
申请号：US29488815
申请日：2014-04-23
申请人： ARES TRADING S.A.
设计人： Georgios Kouvas , Andrew Paterson , Colin Lake , Simon Exell

93. 发明授权

US09233982B2 Spiro tetrahydro—benzothiophen derivatives useful for the treatment neurodegenerative diseases 有权
标题翻译：用于治疗神经变性疾病的螺四氢 - 苯并噻吩衍生物
公开(公告)号：US09233982B2
公开(公告)日：2016-01-12
申请号：US14401959
申请日：2013-05-10
申请人： Ares Trading S.A.
发明人： Anna Quattropani , Dominique Swinnen
IPC分类号： C07D513/10 , C07D495/10 , C07D498/10 , A61K31/547 , A61K31/4188 , A61K31/4439 , A61K31/4245
CPC分类号： C07D513/10 , A61K31/4188 , A61K31/4245 , A61K31/4439 , A61K31/547 , C07D495/10 , C07D498/10
摘要： The present invention provide compounds of Formula (I) used as BACE inhibitors for the treatment of neurodegenerative diseases.
摘要翻译：本发明提供用作治疗神经变性疾病的BACE抑制剂的式（I）化合物。

94. 发明申请

US20150150847A1 USE OF N-ACETYL-5-METHOXYTRYPTAMINE OR ANALOGUES THEREOF, FOR PROMOTING THE MECHANISM OF IMPLANTATION OF THE EMBRYO AND RELATED COMPOSITIONS AND CULTURE MEDIA 审中-公开
标题翻译：使用N-乙酰基-5-甲氧基甲基胺或其类似物，用于促进植物的植入及相关组合物和培养基的机理
公开(公告)号：US20150150847A1
公开(公告)日：2015-06-04
申请号：US14403920
申请日：2013-05-27
申请人： Ares Trading S.A.
发明人： Nicoletta Maxia
IPC分类号： A61K31/4045 , C12N5/071 , A61B17/435 , A61K9/00
CPC分类号： A61K31/4045 , A61B17/435 , A61B2017/4216 , A61K9/0034 , A61K9/0039 , A61K31/165 , C12N5/0682 , C12N2501/825
摘要： The present invention refers to the use of N-acetyl-5-methoxytryptamine (melatonin) and/or an analogue thereof, for use in the medical or veterinary field in the assisted reproduction for promoting the mechanism of implantation of the embryo, and in particular for the prevention of implantation failure into the uterus, by topical administration of an effective amount in a mammalian subject female in need of such treatment, and related compositions, culture media and medical devices.
摘要翻译：本发明涉及N-乙酰基-5-甲氧基色胺（褪黑激素）和/或其类似物在辅助生殖中用于医疗领域或兽医领域中用于促进胚胎移植机制的用途，特别是用于通过在需要这种治疗的哺乳动物受试者女性中有效量的局部给药以及相关组合物，培养基和医疗装置来防止植入失败进入子宫。

95. 发明授权

US08309069B2 Human serum albumin-free stabilized interferon liquid formulations 有权
标题翻译：人血清白蛋白无稳定型干扰素液体制剂
公开(公告)号：US08309069B2
公开(公告)日：2012-11-13
申请号：US10554602
申请日：2004-04-29
申请人： Fabrizio Samaritani , Alessandra Del Rio
发明人： Fabrizio Samaritani , Alessandra Del Rio
IPC分类号： A61K38/21 , A61K38/00 , C07K14/565
CPC分类号： A61K38/21 , A61K9/0019 , A61K9/08 , A61K38/215 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26
摘要： A stabilized HSA-free liquid pharmaceutical composition is described, which comprises an interferon (IFN), wherein said formulation is a solution that comprises a buffer, a surfactant, an isotonicity agent and an antioxidant. Preferably the interferon is human recombinant IFN-beta.
摘要翻译：描述了稳定的不含HSA的液体药物组合物，其包含干扰素（IFN），其中所述制剂是包含缓冲液，表面活性剂，等渗剂和抗氧化剂的溶液。优选地，干扰素是人重组IFN-β。

96. 发明授权

US08222371B2 vWFA and/or ANT—IG domain containing proteins 失效
标题翻译： vWFA和/或含有ANT-IG结构域的蛋白质
公开(公告)号：US08222371B2
公开(公告)日：2012-07-17
申请号：US11718183
申请日：2005-10-28
申请人： Mark Douglas Davies , David Michalovich , Melanie Yorke , Christine Power
发明人： Mark Douglas Davies , David Michalovich , Melanie Yorke , Christine Power
IPC分类号： A61K38/16 , A61K35/00 , C07K14/00
CPC分类号： C07K14/70503 , A61K38/00 , Y02A50/469
摘要： Proteins (INSP141, INSP142, INSP143, and INSP144) identified as anthrax receptor-like proteins containing von Willebrand factor A (vWFA) and Anthrax receptor extracellular (ANT_IG) domains and the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease are described.
摘要翻译：鉴定为蛋白质（INSP141，INSP142，INSP143和INSP144），其被鉴定为含有血管性血友病因子A（vWFA）和炭疽芽孢杆菌受体胞外（ANT_IG）结构域的炭疽受体样蛋白，并且使用来自编码基因的这些蛋白质和核酸序列描述了疾病的诊断，预防和治疗。

97. 发明授权

US08124748B2 Cell surface glycoprotein 失效
标题翻译：细胞表面糖蛋白
公开(公告)号：US08124748B2
公开(公告)日：2012-02-28
申请号：US11660014
申请日：2005-08-11
申请人： Stephen Fitzgerald , Richard Fagan , Jadwiga Bienkowska , Christine Power , Melanie Yorke-Smith
发明人： Stephen Fitzgerald , Richard Fagan , Jadwiga Bienkowska , Christine Power , Melanie Yorke-Smith
IPC分类号： C07H21/02 , C07H21/04 , C12N15/00 , C12N5/00 , C12N5/02 , C12N1/00 , C12P21/06
CPC分类号： C07K14/705
摘要： This invention relates to a novel protein, termed INSP201, herein identified as a cell surface glycoprotein, and to the use of this protein and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease.
摘要翻译：本发明涉及一种称为INSP201的新型蛋白质，在本文中被鉴定为细胞表面糖蛋白，以及该蛋白质和编码基因的核酸序列在诊断，预防和治疗疾病中的用途。

98. 发明申请

US20110305669A1 PROCESS FOR THE PREPARATION OF GLYCOSYLATED INTERFERON BETA 有权
标题翻译：制备糖苷化干扰素的方法
公开(公告)号：US20110305669A1
公开(公告)日：2011-12-15
申请号：US13159864
申请日：2011-06-14
申请人： DINA FISCHER , Alain Bernard , Paul Ducommun , Mara Rossi
发明人： DINA FISCHER , Alain Bernard , Paul Ducommun , Mara Rossi
IPC分类号： A61K38/21 , C07K14/565 , C07K1/36 , C12P21/00
CPC分类号： C12N5/0031 , A61K38/215 , C07K14/565 , C12N5/0037 , C12N5/06 , C12N15/00 , C12N2500/12 , C12N2500/32 , C12N2500/90 , C12N2500/92 , C12N2500/99 , C12N2510/02
摘要： The present invention relates to a process for the production of interferon beta, and to an interferon beta composition having a unique glycosylation pattern.
摘要翻译：本发明涉及生产干扰素β的方法以及具有独特糖基化模式的干扰素β组合物。

99. 发明授权

US08008333B2 Single dose aromatase inhibitor for treating infertility 失效
标题翻译：单剂量芳香酶抑制剂治疗不育症
公开(公告)号：US08008333B2
公开(公告)日：2011-08-30
申请号：US10475101
申请日：2002-04-17
申请人： Robert F. Casper , Mohamed F. M. Mitwally
发明人： Robert F. Casper , Mohamed F. M. Mitwally
IPC分类号： A61K31/41
CPC分类号： A61K31/5685 , A61K31/00 , A61K31/4196 , A61K31/56 , A61K38/24 , A61K2300/00
摘要： The use of an aromatase inhibitor (AI) in the preparation of a medicament for use in inducing ovulation in a female suffering from anovulatory infertility which comprises administering to said female a single dose of the at least one aromatase inhibitor. The use of an aromatase inhibitor (AI) for the preparation of a medicament comprising a single dose of at least one aromatase inhibitor (AI) for administration to an ovulating female suffering from unexplained infertility or other types of ovulatory infertility early in one or more menstrual cycles. Such a medicament may also be administered to an anovulatory female in combination with a plurality of daily doses of follicle stimulating hormone (FSH) whereby the dosage levels of FSH may be reduced. The use of AI in the preparation of a medicament for administration to a female who is a poor responder to FSH, which comprises a combination of a single dose of AI with a plurality of daily doses of FSH is also disclosed. The related pharmaceutical preparations and packages are also described.
摘要翻译：芳香酶抑制剂（AI）用于制备用于在患有排卵不育症的女性中诱导排卵的药物的用途，其包括向所述女性施用单剂量的所述至少一种芳香酶抑制剂。芳香酶抑制剂（AI）用于制备药物的方法，该药物包含单剂量的至少一种芳香酶抑制剂（AI），用于在一个或多个月经初期向排卵女性施用不明原因不孕或其他类型的排卵不育症周期。这种药物还可以与多个日剂量的促卵泡激素（FSH）结合施用于排卵女性，从而可以减少FSH的剂量水平。还公开了在制备用于给予FSH的不良反应者的女性的药物中的用途，其包含单剂量的AI与多个日剂量的FSH的组合。还描述了相关的药物制剂和包装。

100. 发明授权

US07967784B2 Hand-held electronically controlled injection device for injecting liquid medications 有权
标题翻译：用于注射液体药物的手持式电子注射装置
公开(公告)号：US07967784B2
公开(公告)日：2011-06-28
申请号：US12717344
申请日：2010-03-04
申请人： Vincent Pongpairochana , Timothy John MacLean , Robert Prasser , Gerhard Lauchard , Werner Wurmbauer , Gerhard Kogler
发明人： Vincent Pongpairochana , Timothy John MacLean , Robert Prasser , Gerhard Lauchard , Werner Wurmbauer , Gerhard Kogler
IPC分类号： A61M5/20
CPC分类号： A61M5/20 , A61M5/24 , A61M5/326 , A61M5/34 , A61M5/48 , A61M2005/2013 , A61M2005/208 , A61M2005/2407 , A61M2005/2496 , A61M2005/31518 , A61M2005/31588 , A61M2205/13 , A61M2205/14 , A61M2205/3561 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/502 , A61M2205/6027 , A61M2205/6072 , A61M2205/8206 , G06F19/00
摘要： A medication delivery device includes a housing, a door coupled to the housing and moveable between a closed position and an open position. The door permits insertion of a medication container, containing liquid medication, into the housing in the open position. A door opening mechanism is coupled to the door. A push member is axially moveable between a retracted position and a non-retracted position and located external to the medication container. The push member enters the medication container and pushes the liquid medication out of the medication container. A lock mechanism is coupled to the door opening mechanism and prevents opening of the door when the push member is in the non-retracted position inside the medication container, wherein the lock mechanism automatically unlocks the door opening mechanism when the push member is in the retracted position.
摘要翻译：药物输送装置包括壳体，联接到壳体并可在关闭位置和打开位置之间移动的门。门允许将含有液体药物的药物容器插入外壳中的打开位置。门打开机构联接到门。推动构件在缩回位置和非缩回位置之间轴向移动并且位于药物容器的外部。推动构件进入药物容器并将液体药物推出药物容器。锁定机构联接到门打开机构，并且当推动构件处于药物容器内部的非缩回位置时防止门的打开，其中当推动构件处于缩回状态时，锁定机构自动解锁门打开机构位置。

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