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91. 发明申请

US20090293590A1 Ionic liquid thin layer sensor for electrochemical and/or piezoelectric measurements 有权
标题翻译：用于电化学和/或压电测量的离子液体薄层传感器
公开(公告)号：US20090293590A1
公开(公告)日：2009-12-03
申请号：US12387600
申请日：2009-05-05
申请人： Xiangqun Zeng , Lei Yu , Yue Huang , Andrew J. Mason
发明人： Xiangqun Zeng , Lei Yu , Yue Huang , Andrew J. Mason
IPC分类号： G01N29/02
CPC分类号： G01N29/036 , G01N27/026 , G01N27/4162 , G01N29/022 , G01N2291/0256 , G01N2291/0426
摘要： An electrochemical piezoelectric sensor is disclosed. The sensor includes a piezoelectric substrate, three (or more) electrodes over a first surface of the substrate, and another electrode over a second (opposing) surface of the substrate. An ionic liquid in the form of a film is adhered, bound, immobilized, or otherwise positioned over the substrate and electrodes of the first surface. The ionic liquid film permits the absorption and detection of analytes from a gaseous sample, for environmental gases, example explosive vapors and/or explosive vapor species in the gaseous sample. Detection (optionally including analyte quantitation and qualitative identification) can be performed by both electrochemical and piezoelectric techniques using a single sensor. Systems incorporating and methods of using the electrochemical piezoelectric sensor also are disclosed.
摘要翻译：公开了一种电化学压电传感器。传感器包括压电衬底，在衬底的第一表面上方的三个（或更多个）电极，以及位于衬底的第二（相对））表面上的另一个电极。膜形式的离子液体被粘附，结合，固定或以其它方式定位在第一表面的基底和电极上。离子液体膜允许从气态样品中吸收和检测分析物，用于气态样品中的环境气体，例如爆炸性蒸气和/或爆炸性气体物质。可以通过使用单个传感器的电化学和压电技术来执行检测（可选地包括分析物定量和定性鉴定）。还公开了使用电化学压电传感器的系统和方法。

92. 发明授权

US07521415B2 Methods of intracellular peptide delivery 有权
标题翻译：细胞内肽递送方法
公开(公告)号：US07521415B2
公开(公告)日：2009-04-21
申请号：US11251956
申请日：2005-10-17
申请人： Kenjiro Minomi , Lei Yu
发明人： Kenjiro Minomi , Lei Yu
IPC分类号： A61K38/04 , A61K38/02 , A61K38/00
CPC分类号： A61K38/47 , A61K47/183 , A61K47/59 , A61K47/645 , A61K47/6901 , C07K14/005 , C07K2319/10 , C12N15/87 , C12N2740/16322
摘要： Methods and kits for transporting heterologous compounds into cells, particularly mammalian cells, are disclosed. The method involves the pretreatment of the cell with a polycation, cationic polymer and/or cationic peptide before transportation of the heterologous compound into the cell. The methods are particularly applicable to the transport of peptides and proteins.
摘要翻译：公开了将异源化合物转运到细胞，特别是哺乳动物细胞中的方法和试剂盒。该方法包括在将异源化合物运送到细胞内之前用聚阳离子阳离子聚合物和/或阳离子肽预处理细胞。该方法特别适用于肽和蛋白质的转运。

93. 发明授权

US07264969B1 Carrier system for specific artery wall gene delivery 有权
标题翻译：特异性动脉壁基因递送载体系统
公开(公告)号：US07264969B1
公开(公告)日：2007-09-04
申请号：US10416381
申请日：2001-11-09
申请人： Lei Yu , Sung Wan Kim , Jae-Woon Nah
发明人： Lei Yu , Sung Wan Kim , Jae-Woon Nah
IPC分类号： C12N15/88 , C12N15/00 , C12N15/87
CPC分类号： A61K48/0075
摘要： An artery wall binding peptide (AWBP) based on the artery wall cell-binding domain of apolipoprotein B-100 was conjugated to a cationic backbone configured for forming a complex with a nucleic acid to produce a composition that enhances gene transfer to artery wall cells. An illustrative cationic backbone is poly(ethylene glycol)-grafted-poly(L-lysine) (PEG-g-PLL). Methods of making and using the composition for gene transfer are also described.
摘要翻译：基于载脂蛋白B-100的动脉壁细胞结合结构域的动脉壁结合肽（AWBP）缀合到阳离子骨架上，其配置用于与核酸形成复合物，以产生增强基因转移到动脉壁细胞的组合物。一个说明性的阳离子骨架是聚（乙二醇）移植的聚（L-赖氨酸）（PEG-g-PLL）。还描述了制备和使用用于基因转移的组合物的方法。

94. 发明申请

US20060147376A1 Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier 审中-公开
公开(公告)号：US20060147376A1
公开(公告)日：2006-07-06
申请号：US11364596
申请日：2006-02-27
申请人： Lei Yu , Fusheng Du , Shouping Ji , Kenji Matsumoto
发明人： Lei Yu , Fusheng Du , Shouping Ji , Kenji Matsumoto
IPC分类号： C40B40/02 , G01N33/53 , A61K49/00
CPC分类号： C08G73/02 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/645 , A61K48/0041
摘要： The present invention provides a controllably degradable cationic polymer for delivery of biomolecules (nucleic acids, peptides, etc.), drugs, molecules used in medical imaging applications, sensitizing agents used in cancer treatments, and molecules used in tissue engineering. The present invention also provides a method for synthesizing the polymer according to the present invention.

95. 发明申请

US20060037356A1 Refrigerator 审中-公开
标题翻译：冰箱
公开(公告)号：US20060037356A1
公开(公告)日：2006-02-23
申请号：US11205051
申请日：2005-08-17
申请人： Ji-hun Ahn , Lei Yu
发明人： Ji-hun Ahn , Lei Yu
IPC分类号： F25B39/04
CPC分类号： F28F9/26 , F25B6/00 , F25B39/04 , F25D23/003
摘要： A refrigerator having a refrigerator body and a component chamber provided in the refrigerator body to accommodate components includes a condenser provided in the component chamber, and has a plurality of condensing parts positioned separately from each other. The refrigerator also includes at least one fan provided in the component chamber, to cool the condenser. Thus, the refrigerator has a condenser with an improved heat radiating efficiency.
摘要翻译：具有设置在冰箱主体中以容纳部件的冰箱主体和部件室的冰箱包括设置在部件室中的冷凝器，并且具有彼此分开定位的多个冷凝部。冰箱还包括设置在组件室中的至少一个风扇以冷却冷凝器。因此，冰箱具有提高散热效率的冷凝器。

96. 发明授权

US5866346A Methods of using dynorphins as ligands for XOR1 receptor 失效
标题翻译：使用强啡多作为XOR1受体配体的方法
公开(公告)号：US5866346A
公开(公告)日：1999-02-02
申请号：US881686
申请日：1997-06-24
申请人： Lei Yu
发明人： Lei Yu
IPC分类号： C07K14/665 , C07K14/705 , C12N15/12 , C12Q1/00
CPC分类号： C07K14/705 , C07K14/665
摘要： Orphan receptor expressed in Xenopus oocytes. The coupling of the receptor to a G protein-activated K.sup.+ channel was used as a functional essay in oocytcs. Endogenous opioid peptides dynorphins were found to activate the K.sup.+ channel by stimulating the orphan receptor.
摘要翻译：非洲爪蟾卵母细胞中表达的孤儿受体。受体与G蛋白激活的K +通道的偶联被用作卵母细胞中的功能论文。发现内源性阿片类肽的强啡肽通过刺激孤儿受体激活K +通道。

97. 发明授权

US5649065A Optimal filtering by neural networks with range extenders and/or reducers 失效
标题翻译：通过范围扩展器和/或减速器的神经网络进行最优滤波
公开(公告)号：US5649065A
公开(公告)日：1997-07-15
申请号：US104488
申请日：1993-08-09
申请人： James Ting-Ho Lo , Lei Yu
发明人： James Ting-Ho Lo , Lei Yu
IPC分类号： H03H17/02 , H03H21/00 , G06F15/18
CPC分类号： H03H17/0255 , H03H21/0012 , H03H17/0223 , H03H2222/04
摘要： A method and apparatus is provided for processing a measurement process to estimate a signal process, even if the signal and/or measurement processes have large and/or expanding ranges. The method synthesizes training data comprising realizations of the signal and measurement processes into a primary filter for estimating the signal process and, if required, an ancillary filter for providing the primary filter's estimation error statistics. The primary and ancillary filters each comprise an artificial recurrent neural network (RNN) and at least one range extender or reducer. Their implementation results in the filtering apparatus. Many types of range extender and reducer are disclosed, which have different degrees of effectiveness and computational cost. For a neural filter under design, range extenders and/or reducers are selected from those types jointly with the architecture of the RNN in consideration of the filtering accuracy, the RNN size and the computational cost of each selected range extender and reducer so as to maximize the cost effectiveness of the neural filter. The aforementioned synthesis is performed through training RNNs together with range extenders and/or reducers.
摘要翻译：提供了一种用于处理测量过程以估计信号处理的方法和装置，即使信号和/或测量过程具有大的和/或扩展的范围。该方法将包括信号和测量过程的实现的训练数据合成到用于估计信号处理的主滤波器中，并且如果需要，将辅助滤波器合成以提供初级滤波器的估计误差统计。主要和辅助过滤器各自包括人造复发神经网络（RNN）和至少一个范围扩展器或减速器。它们的实现导致了过滤装置。公开了许多类型的扩展器和减速器，其具有不同程度的有效性和计算成本。对于设计中的神经滤波器，考虑到滤波精度，RNN尺寸和每个选定范围扩展器和减速器的计算成本，从这些类型中选择范围扩展器和/或减速器，从而使RNN的架构最大化神经滤波器的成本效益。上述合成通过与范围扩展器和/或减速器一起训练RNN来执行。

98. 发明申请

US20230122682A1 Valve piston pump body device 有权
公开(公告)号：US20230122682A1
公开(公告)日：2023-04-20
申请号：US18066993
申请日：2022-12-15
申请人： Lei Yu
发明人： Lei Yu
IPC分类号： F04B19/04 , F04B17/00 , F04B53/14 , F04B49/12
摘要： A valve piston pump body device of water flosser includes a front bracket shell equipped with a back bracket shell. A pump body is installed at the middle-upper end of the cavity between the front bracket shell and the back bracket shell. A motor is installed at the middle-lower end of the cavity between the front bracket shell and the back bracket shell. The rotating shaft at the upper end of the motor is equipped with motor teeth. A first metal shaft is arranged in the hole of the cavity between the front bracket shell and the back bracket shell. A driving gear is installed on the first metal shaft and the driving gear and the motor teeth are mutually engaged. A one-way valve piston device is used.

99. 发明授权

US11324575B2 Pump body of oral irrigator 有权
公开(公告)号：US11324575B2
公开(公告)日：2022-05-10
申请号：US17095776
申请日：2020-11-12
申请人： Lei Yu
发明人： Lei Yu
IPC分类号： A61C17/02
摘要： A pump body of an oral irrigator includes a mount, a motor disposed at a rear end away from the mount, a pinion disposed on a shaft of the motor, an annular gear disposed on a shaft member to mesh with the pinion, a cam disposed in the annular gear and adjacent to one side, a linkage secured to the cam, front and rear plungers disposed on a front end of the linkage, and a cylindrical tube disposed on the plungers in the mount. The rotation of the cam only allows the linkage to repetitively move in a back-and-forth linear motion. Wear between the plungers and the cylindrical tube is decreased to a minimum and leakage is prevented.

100. 发明申请

US20210059801A1 Portable oral irrigator 有权
公开(公告)号：US20210059801A1
公开(公告)日：2021-03-04
申请号：US17095778
申请日：2020-11-12
申请人： Lei Yu
发明人： Lei Yu
IPC分类号： A61C17/02
摘要： A portable oral irrigator includes a nozzle, a handle, an outer water container and an inner water container. The nozzle is at an upper end of the portable oral irrigator. The handle is below the nozzle. The outer water container is below the handle. The inner water container is below the outer water container. A sealing ring is at a bottom of the inner water container for sealing the inner water container. An annular silicone sealing member is at a joining portion of the outer water container and the inner water container. A gasket is between the outer water container and the handle. An air passable silicone seal is on the gasket. With provision of the air passable silicone seal, a raised bottom of the air passable silicone seal contracts to close its cross-shaped opening due to water pressure in the outer water container, thereby preventing leakage.

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