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91. 发明授权

US07155278B2 Neurostimulation to treat effects of sleep apnea 有权
标题翻译：神经刺激治疗睡眠呼吸暂停的效果
公开(公告)号：US07155278B2
公开(公告)日：2006-12-26
申请号：US10419405
申请日：2003-04-21
申请人： Gary W. King , Marcus J. Mianulli , Michael R. S. Hill , Thomas J. Mullen , Roy L. Testerman , John E. Burnes , Xiaohong Zhou
发明人： Gary W. King , Marcus J. Mianulli , Michael R. S. Hill , Thomas J. Mullen , Roy L. Testerman , John E. Burnes , Xiaohong Zhou
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/36017 , A61N1/36114
摘要： Neurostimulation is delivered to one or more predetermined locations on or within a patient in order to treat effects of sleep apnea by modulating autonomic nervous activity. Delivery of neurostimulation at predetermined locations can decrease sympathetic nervous activity and/or increase parasympathetic nervous activity, countering the increased intrinsic sympathetic activity associated with apnea-arousal cycles. In some embodiments, neurostimulation is delivered to the spinal cord of the patient via an implanted electrode. In other embodiments, neurostimulation is delivered transcutaneously to the spinal cord or other locations via electrodes located on the surface of the patient. In some embodiments, delivery of neurostimulation is initiated or modified in response to detection of apneas.
摘要翻译：神经刺激被递送到患者体内或患者内的一个或多个预定位置，以通过调节自主神经活动来治疗睡眠呼吸暂停的影响。在预定位置递送神经刺激可降低交感神经活动和/或增加副交感神经活动，抵抗与呼吸暂停 - 觉醒周期相关的增加的内在交感神经活动。在一些实施方案中，神经刺激经由植入的电极递送至患者的脊髓。在其他实施方案中，神经刺激通过位于患者表面上的电极经皮递送至脊髓或其它位置。在一些实施方案中，响应于呼吸暂停的检测开始或修饰神经刺激的递送。

92. 发明授权

US07076298B2 Method and apparatus for prevention of arrhythmia clusters using overdrive pacing 有权
公开(公告)号：US07076298B2
公开(公告)日：2006-07-11
申请号：US10171231
申请日：2002-06-14
申请人： Vasant Padmanabhan , Walter H. Olson , Rahul Mehra , Xiaohong Zhou , Thomas J. Mullen , William J. George
发明人： Vasant Padmanabhan , Walter H. Olson , Rahul Mehra , Xiaohong Zhou , Thomas J. Mullen , William J. George
IPC分类号： A61N1/36
CPC分类号： A61N1/3622
摘要： An implantable medical device that includes a microprocessor that characterizes cardiac activity of a patient to enable the implantable medical device to deliver therapy in response to an identified arrhythmia event. A monitor/controller monitors the characterized cardiac activity and the delivered therapy, and controls activation of triggered overdrive pacing subsequent to the delivered therapy.

93. 发明申请

US20050177097A1 Delivery of a sympatholytic cardiovascular agent to the central nervous system 有权
标题翻译：交配性心血管药物向中枢神经系统递送
公开(公告)号：US20050177097A1
公开(公告)日：2005-08-11
申请号：US10903599
申请日：2004-07-30
申请人： Keith Hildebrand , Michael Ujhelyi , Xiaohong Zhou , Daniel Sigg , Linda Page
发明人： Keith Hildebrand , Michael Ujhelyi , Xiaohong Zhou , Daniel Sigg , Linda Page
IPC分类号： A61B5/02 , A61M5/142 , A61M5/168 , A61M5/172 , A61N1/39 , A61K31/137 , A61K9/22 , A61K31/24
CPC分类号： A61M5/142 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3523 , A61M2230/00 , A61M2230/04 , A61M2230/63 , A61N1/3962
摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine).
摘要翻译：由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解急性或慢性心脏损伤或心脏功能受损的症状。药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与心脏损伤相关的生理参数或心脏功能受损并触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。交感神经心血管药剂是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂（例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫索尼定，甲基多巴，甲苯噻嗪，胍法西林，美托洛尼，美托咪定和右美托咪定）。

94. 发明授权

US5869965A Correction of artifacts caused by Maxwell terms in MR echo-planar images 失效
标题翻译：修正由MR回波平面图像中的麦克斯韦术引起的伪影
公开(公告)号：US5869965A
公开(公告)日：1999-02-09
申请号：US835669
申请日：1997-04-10
申请人： Yiping Du , Xiaohong Zhou , Matthew A. Bernstein , Joseph K. Maier
发明人： Yiping Du , Xiaohong Zhou , Matthew A. Bernstein , Joseph K. Maier
IPC分类号： G01R33/54 , A61B5/055 , A61B6/00 , G01R33/561 , G01R33/565 , G01V3/00
CPC分类号： G01R33/56581 , G01R33/56554 , A61B5/055 , A61B5/7257 , A61B6/541
摘要： A method for correcting Maxwell field induced distortion, ghosting, and blurring artifacts in non-axially oriented EPI images is disclosed. In one embodiment phase corrections are calculated and used to offset Maxwell term errors during the image reconstruction process, and in another embodiment corrections are made after the image is reconstructed.
摘要翻译：公开了一种用于校正非轴向定向EPI图像中的麦克斯韦场诱发失真，重影和模糊伪影的方法。在一个实施例中，计算相位校正并用于在图像重建处理期间偏移麦克斯韦尔术语误差，并且在另一实施例中，在图像被重构之后进行校正。

95. 发明授权

US09656079B2 Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac conditions 有权
公开(公告)号：US09656079B2
公开(公告)日：2017-05-23
申请号：US12565910
申请日：2009-09-24
申请人： Michael R. S. Hill , Gary W. King , Thomas J. Mullen , Xiaohong Zhou
发明人： Michael R. S. Hill , Gary W. King , Thomas J. Mullen , Xiaohong Zhou
IPC分类号： A61N1/00 , A61N1/36 , A61N1/362
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.

96. 发明授权

US08868182B2 Device based cardiac monitoring and stress test 有权
标题翻译：基于设备的心脏监测和压力测试
公开(公告)号：US08868182B2
公开(公告)日：2014-10-21
申请号：US13549983
申请日：2012-07-16
申请人： Zhendong Song , Xiaohong Zhou
发明人： Zhendong Song , Xiaohong Zhou
IPC分类号： A61N1/365
CPC分类号： A61B5/0452 , A61B5/02028 , A61B5/021 , A61B5/7275
摘要： A medical device and associated method establish an occurrence of a premature atrial contraction. The device senses a ventricular signal. A control unit is configured to determine a metric of the ventricular signal during an interval following the premature atrial contraction and detect a change in cardiac stress tolerance in response to the determined metric.
摘要翻译：医疗器械和相关方法建立了早发性心房收缩的发生。该装置感测到心室信号。控制单元被配置为在过早心房收缩之后的间隔期间确定心室信号的度量，并响应于所确定的度量来检测心脏应力容忍度的变化。

97. 发明授权

US08718763B2 Vagal stimulation 有权
公开(公告)号：US08718763B2
公开(公告)日：2014-05-06
申请号：US13353824
申请日：2012-01-19
申请人： Xiaohong Zhou , Robert Stadler , Richard N. M. Cornelussen , Lilian Kornet , Paul D. Ziegler , Karen J. Kleckner , Alberto Della Scala
发明人： Xiaohong Zhou , Robert Stadler , Richard N. M. Cornelussen , Lilian Kornet , Paul D. Ziegler , Karen J. Kleckner , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36114
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

98. 发明授权

US08634903B2 Measuring T-Wave alternans 有权
标题翻译：测量T波交替
公开(公告)号：US08634903B2
公开(公告)日：2014-01-21
申请号：US12610062
申请日：2009-10-30
申请人： Vinod Sharma , Xiaohong Zhou
发明人： Vinod Sharma , Xiaohong Zhou
IPC分类号： A61B5/0468
CPC分类号： A61B5/0452
摘要： An implantable medical device (IMD), such as an implantable pacemaker, cardioverter, or diagnostic device, generates an EGM signal, e.g., a far field EGM signal, samples the EGM signal to obtain a single T-wave amplitude value for each T-wave over a plurality of beats, and stores the T-wave amplitude values in memory. The IMD creates a time series of the T-wave amplitude values stored in memory, calculates the power spectral density for the times series, and selects a power spectral density of a particular frequency, e.g., 0.5 cycles per beat, as the TWA value. The IMD may periodically determine TWA values for the patient and store the values in memory. The TWA values may be presented to medical personnel, e.g., as a trend. The IMD may deliver or modify therapy, or provide an alert, based on the TWA values.
摘要翻译：诸如可植入心脏起搏器，心律转复器或诊断装置的可植入医疗装置（IMD）生成例如远场EGM信号的EGM信号，对EGM信号进行采样，以获得每个T- 在多个节拍中波动，并将T波幅度值存储在存储器中。 IMD产生存储在存储器中的T波幅度值的时间序列，计算时间序列的功率谱密度，并选择特定频率的功率谱密度，例如每个节拍0.5个周期作为TWA值。 IMD可以周期性地确定患者的TWA值并将值存储在存储器中。 TWA值可以呈现给医务人员，例如作为趋势。 IMD可以根据TWA值提供或修改治疗或提供警报。

99. 发明申请

US20140018688A1 DEVICE BASED CARDIAC MONITORING AND STRESS TEST 有权
标题翻译：基于设备的心脏监测和应力测试
公开(公告)号：US20140018688A1
公开(公告)日：2014-01-16
申请号：US13549983
申请日：2012-07-16
申请人： Zhendong Song , Xiaohong Zhou
发明人： Zhendong Song , Xiaohong Zhou
IPC分类号： A61B5/0205 , A61B5/0452
CPC分类号： A61B5/0452 , A61B5/02028 , A61B5/021 , A61B5/7275
摘要： A medical device and associated method establish an occurrence of a premature atrial contraction. The device senses a ventricular signal. A control unit is configured to determine a metric of the ventricular signal during an interval following the premature atrial contraction and detect a change in cardiac stress tolerance in response to the determined metric.
摘要翻译：医疗器械和相关方法建立了早发性心房收缩的发生。该装置感测到心室信号。控制单元被配置为在过早心房收缩之后的间隔期间确定心室信号的度量，并响应于所确定的度量来检测心脏应力容忍度的变化。

100. 发明授权

US08611996B2 Implantable medical device crosstalk evaluation and mitigation 有权
公开(公告)号：US08611996B2
公开(公告)日：2013-12-17
申请号：US12362842
申请日：2009-01-30
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
IPC分类号： A61N1/00
CPC分类号： A61N1/3706 , A61B5/04288 , A61B5/7217 , A61N1/025 , A61N1/0551 , A61N1/36114 , A61N1/36185 , A61N1/3686 , A61N1/3702 , A61N1/3718 , A61N1/37247 , A61N1/37288 , A61N1/3962
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

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