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91. 发明授权

US08236009B2 Needle assembly for tissue manipulation 有权
标题翻译：用于组织操作的针组件
公开(公告)号：US08236009B2
公开(公告)日：2012-08-07
申请号：US12579295
申请日：2009-10-14
申请人： Vahid Saadat , Chris Rothe , Richard C. Ewers
发明人： Vahid Saadat , Chris Rothe , Richard C. Ewers
IPC分类号： A61B17/03
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/29 , A61B2017/00349 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Needle assemblies for tissue manipulation are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. A needle deployment assembly is deployable through the tissue manipulation assembly via a handle assembly, through the tubular member, and into or through tissue. An elongate pusher is translationally disposed within a sheath of the needle deployment assembly and can be urged distally for deploying an anchor assembly from the sheath distal end. The anchor assembly is positioned distally of the pusher within the sheath.
摘要翻译：用于组织操作的针组件在本文中描述。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，位于所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。针部署组件可经由手柄组件穿过组织操纵组件展开，穿过管状构件，并且进入或穿过组织。细长的推动器平移地设置在针展开组件的护套内，并且可以向远侧推动以从护套远端展开锚固组件。锚固组件位于鞘内的推动器的远侧。

92. 发明授权

US08235985B2 Visualization and ablation system variations 有权
标题翻译：可视化和消融系统的变化
公开(公告)号：US08235985B2
公开(公告)日：2012-08-07
申请号：US12209057
申请日：2008-09-11
申请人： Vahid Saadat , Ruey-Feng Peh , Zachary J. Malchano , Chris A. Rothe
发明人： Vahid Saadat , Ruey-Feng Peh , Zachary J. Malchano , Chris A. Rothe
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B1/00165 , A61B18/1477 , A61B90/37 , A61B2018/00214 , A61B2018/00285 , A61B2018/00351 , A61B2018/00577 , A61B2018/00898 , A61B2018/1425 , A61B2218/002
摘要： Visualization and ablation system variations are described which utilize various tissue ablation arrangements. Such assemblies are configured to facilitate the application of bipolar energy delivery, such as RF ablation, to an underlying target tissue for treatment in a controlled manner while directly visualizing the tissue during the bipolar ablation process.
摘要翻译：描述了利用各种组织消融装置的可视化和消融系统变化。这种组件被配置为便于将双极能量输送（例如RF消融）应用于潜在的靶组织，以受控的方式进行治疗，同时在双极烧蚀过程期间直接使组织可视化。

93. 发明授权

US08066719B2 Apparatus and methods for forming gastrointestinal tissue approximations 有权
标题翻译：用于形成胃肠组织近似的装置和方法
公开(公告)号：US08066719B2
公开(公告)日：2011-11-29
申请号：US10992912
申请日：2004-11-18
申请人： Richard C. Ewers , Boris Reydel , Cang C. Lam , Eugene Chen , Brent D. Seybold , Rodney Brenneman , Vahid Saadat
发明人： Richard C. Ewers , Boris Reydel , Cang C. Lam , Eugene Chen , Brent D. Seybold , Rodney Brenneman , Vahid Saadat
IPC分类号： A61B17/10 , A61B17/32
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/0487 , A61B17/0644 , A61B17/29 , A61B17/3421 , A61B17/3468 , A61B17/3478 , A61B2017/0404 , A61B2017/0417 , A61B2017/0419 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61B2017/061 , A61B2017/3445 , A61B2017/3488
摘要： Apparatus and methods are provided for forming a gastrointestinal tissue fold by engaging tissue at a first tissue contact point, moving the first tissue contact point from a position initially distal to a second tissue contact point to a position proximal of the second contact point to form a tissue fold, and extending an anchor assembly through the tissue fold near the second tissue contact point.
摘要翻译：提供了设备和方法，用于通过在第一组织接触点处接合组织来形成胃肠组织折叠，将第一组织接触点从最初远端到第二组织接触点的位置移动到第二接触点的近侧的位置，以形成组织折叠，并且使锚固组件穿过第二组织接触点附近的组织褶皱延伸。

94. 发明授权

US07938830B2 Powered tissue modification devices and methods 有权
标题翻译：动力组织修饰装置及方法
公开(公告)号：US07938830B2
公开(公告)日：2011-05-10
申请号：US11406486
申请日：2006-04-17
申请人： Vahid Saadat , Jeffery L. Bleich , Kenneth Michlitsch , John E. Ashley
发明人： Vahid Saadat , Jeffery L. Bleich , Kenneth Michlitsch , John E. Ashley
IPC分类号： A61B17/00
CPC分类号： A61B17/1659 , A61B17/00234 , A61B17/02 , A61B17/1671 , A61B17/1757 , A61B17/320016 , A61B17/32002 , A61B17/3421 , A61B2017/00261 , A61B2017/00867 , A61B2017/32006 , A61B2017/3488 , A61B2090/08021
摘要： A device for modifying tissue in a spine may include: a shaft having a proximal portion and a distal portion, the distal portion having dimensions which allow it to be passed into an epidural space of the spine and between target and non-target tissues; at least one distal force application member extending from the distal portion of the shaft and configured to facilitate application of at least one of anchoring force and tensioning force to the shaft; at least one movable tissue modifying member coupled with the shaft at or near its distal portion; at least one drive member coupled with the at least one tissue modifying member to activate the at least one tissue modifying member; and at least one power transmission member coupled with the at least one drive member to deliver power to the at least one drive member.
摘要翻译：用于修改脊柱中的组织的装置可以包括：具有近端部分和远侧部分的轴，所述远端部分具有允许其进入脊柱的硬膜外腔中以及靶和非靶组织之间的尺寸; 至少一个远端力施加构件，其从所述轴的远侧部分延伸并且构造成便于将锚固力和张紧力中的至少一个施加到所述轴; 至少一个可动组织修改构件，其在远端部分处或其附近与所述轴联接; 至少一个驱动构件与所述至少一个组织修改构件联接以激活所述至少一个组织修改构件; 以及与所述至少一个驱动构件联接的至少一个动力传递构件，以向所述至少一个驱动构件输送动力。

95. 发明授权

US07837615B2 Shape lockable apparatus and method for advancing an instrument through unsupported anatomy 有权
标题翻译：形状可锁定装置和方法，用于通过不支持的解剖结构推进器械
公开(公告)号：US07837615B2
公开(公告)日：2010-11-23
申请号：US11115947
申请日：2005-04-26
申请人： Tung Thanh Le , Vahid Saadat , Elvia Muro
发明人： Tung Thanh Le , Vahid Saadat , Elvia Muro
IPC分类号： A61B1/00 , A61B1/04
CPC分类号： A61B1/0058 , A61B1/00135 , A61B1/0055 , A61B1/31
摘要： Apparatus and methods are provided for placing and advancing a diagnostic or therapeutic instrument in a hollow body organ of a tortuous or unsupported anatomy, comprising a handle, an overtube disposed within a hydrophilic sheath or liner, and a distal region having an atraumatic tip. The sheath/liner may be disposable to permit reuse of the overtube. Loading devices may be provided for disposing the sheath/liner about the overtube. Tensioning mechanisms may be provided to selectively stiffen the overtube to reduce distension of the organ caused by advancement of the diagnostic or therapeutic instrument. The distal region permits passive steering of the overtube caused by deflection of the diagnostic or therapeutic instrument, while the atraumatic tip prevents the wall of the organ from becoming caught or pinched during manipulation of the diagnostic or therapeutic instrument.
摘要翻译：提供了设备和方法，用于将诊断或治疗仪器放置在曲折或无支撑解剖结构的中空身体器官中，包括手柄，设置在亲水护套或衬垫内的外套管以及具有无创尖端的远侧区域。护套/衬垫可以是一次性的，以允许外套管的再次使用。可以提供装载装置用于围绕外套管布置护套/衬垫。可以提供张紧机构以选择性地加固外套管，以减少由诊断或治疗仪器的前进引起的器官膨胀。远侧区域允许由诊断或治疗仪器的偏转引起的外套管的被动转向，而无创伤尖端防止器官的壁在操纵诊断或治疗仪器期间被卡住或夹住。

96. 发明授权

US07736374B2 Tissue manipulation and securement system 有权
标题翻译：组织操纵和固定系统
公开(公告)号：US07736374B2
公开(公告)日：2010-06-15
申请号：US11070846
申请日：2005-03-01
申请人： Robert A. Vaughan , Cang C. Lam , Richard C. Ewers , Vahid Saadat
发明人： Robert A. Vaughan , Cang C. Lam , Richard C. Ewers , Vahid Saadat
IPC分类号： A61B17/08 , A61B17/12 , A61B17/00
CPC分类号： A61B17/10 , A61B1/0051 , A61B17/0401 , A61B17/0487 , A61B17/06066 , A61B17/29 , A61B2017/00349 , A61B2017/00827 , A61B2017/00867 , A61B2017/00876 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0496 , A61B2017/06052 , A61B2017/06076 , A61B2017/3488 , A61B2090/037
摘要： Tissue manipulation and securement systems are described herein. A tissue manipulation assembly is pivotably coupled to the distal end of a tubular member and has a lower jaw member and an upper jaw member pivotably coupled to the lower jaw member. A reconfigurable launch tube is also pivotably coupled to the upper jaw member and is used to urge the jaw members from a low-profile configuration to an open configuration for receiving tissue. The tissue manipulation assembly may be advanced through a shape-lockable endoscopic device, a conventional endoscope, or directly by itself into a patient. A second tool can be used in combination with the tissue manipulation assembly to engage tissue and manipulate the tissue in conjunction with the tissue manipulation assembly.
摘要翻译：本文描述了组织操纵和固定系统。组织操作组件可枢转地联接到管状构件的远端，并且具有下颚构件和可枢转地联接到下颚构件的上颚构件。可重构的发射管也可枢转地联接到上钳口构件，并且用于将钳口构件从小轮廓构造推动到用于接收组织的打开构型。组织操作组件可以通过形状可锁定内窥镜装置，常规内窥镜，或者直接自身进入患者。第二工具可以与组织操作组件组合使用以接合组织并且与组织操作组件一起操作组织。

97. 发明授权

US07703459B2 Apparatus and methods for mapping out endoluminal gastrointestinal surgery 有权
标题翻译：用于绘制腔内胃肠手术的装置和方法
公开(公告)号：US07703459B2
公开(公告)日：2010-04-27
申请号：US10954658
申请日：2004-09-29
申请人： Vahid Saadat , Chris Rothe , Ruey-Feng Peh , Richard C. Ewers
发明人： Vahid Saadat , Chris Rothe , Ruey-Feng Peh , Richard C. Ewers
IPC分类号： A61B17/00
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/12013 , A61B17/320016 , A61B17/32053 , A61B17/32075 , A61B17/3211 , A61B17/3478 , A61B18/14 , A61B18/1482 , A61B18/1492 , A61B90/39 , A61B2017/00269 , A61B2017/00349 , A61B2017/00818 , A61B2017/00986 , A61B2017/0411 , A61B2017/0419 , A61B2017/06052 , A61B2017/306 , A61B2017/308 , A61B2017/320044 , A61B2018/00029 , A61B2018/00244 , A61B2018/00291 , A61B2018/00494 , A61B2018/00577 , A61B2018/00595 , A61B2018/00982 , A61B2018/124 , A61B2018/1415 , A61B2018/144 , A61B2018/1467 , A61B2090/036 , A61B2090/3908 , A61B2090/3912 , A61B2090/3937 , A61B2090/395 , A61B2090/3987 , A61B2090/3991 , A61B2218/002 , A61B2218/007 , A61F5/0013
摘要： Apparatus and methods are provided for mapping out endoluminal gastrointestinal surgery, including endoluminal gastric reduction. Mapping is achieved by locally marking the interior of the gastrointestinal lumen at specified locations. In some variations, mucosectomy and/or mucosal ablation are performed to map out endoluminal GI surgery, to facilitate direct endoluminal engagement of underlying muscularis tissue and/or to initiate a wound healing response. Specialized apparatus may be provided to achieve desired spacing and/or positioning of tissue markings, as well as to actually form the markings. Methods of using apparatus of the present invention are provided.
摘要翻译：提供装置和方法用于映射腔内胃肠手术，包括腔内胃减少。通过在指定位置局部标记胃肠腔的内部来实现测绘。在一些变型中，进行粘膜切除术和/或粘膜消融以绘出腔内GI手术，以促进下面的肌层组织的直接腔内接合和/或引发伤口愈合反应。可以提供专用设备以实现组织标记的期望的间隔和/或定位，以及实际形成标记。提供了使用本发明装置的方法。

98. 发明申请

US20080183036A1 SYSTEMS AND METHODS FOR UNOBSTRUCTED VISUALIZATION AND ABLATION 审中-公开
标题翻译：用于无障碍可视化和消除的系统和方法
公开(公告)号：US20080183036A1
公开(公告)日：2008-07-31
申请号：US11959158
申请日：2007-12-18
申请人： Vahid Saadat , Chris A. Rothe , Ruey-Feng Peh , Edmund Tam
发明人： Vahid Saadat , Chris A. Rothe , Ruey-Feng Peh , Edmund Tam
IPC分类号： A61B1/005 , A61B18/14
CPC分类号： A61B1/00089 , A61B1/00085 , A61B1/005 , A61B1/018 , A61B1/3137 , A61B17/12022 , A61B17/12036 , A61B17/1204 , A61B17/12136 , A61B17/12172 , A61B18/1492 , A61B2018/00357 , A61B2018/00577 , A61B2018/00982
摘要： Systems and methods for unobstructed, visualization and ablation, particularly of the pulmonary veins, are described herein. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration as well as one or more expandable anchors which are temporarily securable within a respective pulmonary vein while allowing blood flow to pass through the anchor unimpeded. With the one or more non-impeding anchors secured within a respective pulmonary vein, ablation of the tissue surrounding the ostium or several ostia may be effected with the catheter while the tissue is under direct visualization.
摘要翻译：本文描述了用于无障碍，可视化和消融，特别是肺静脉的系统和方法。这样的系统可以包括部署导管和可展开到扩展构型中的附接成像罩，以及一个或多个可扩展锚固件，其可临时固定在相应的肺静脉内，同时允许血液流动通过锚固体而不受阻碍。利用固定在相应的肺静脉内的一个或多个无阻塞的锚固件，可以在组织处于直接可视化的状态下用导管实现围绕口或组织的几个口的组织的消融。

99. 发明申请

US20080033241A1 LEFT ATRIAL APPENDAGE CLOSURE 审中-公开
标题翻译：左侧附件关闭
公开(公告)号：US20080033241A1
公开(公告)日：2008-02-07
申请号：US11828281
申请日：2007-07-25
申请人： Ruey-Feng Peh , Vahid Saadat
发明人： Ruey-Feng Peh , Vahid Saadat
IPC分类号： A61B1/00 , A61B17/128
CPC分类号： A61B1/3137 , A61B1/0008 , A61B1/00082 , A61B1/00089 , A61B1/00179 , A61B5/6882 , A61B17/0057 , A61B17/0469 , A61B17/0644 , A61B17/12122 , A61B2017/00345 , A61B2017/00575 , A61B2017/0409 , A61B2017/0443 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0649 , A61B2017/306
摘要： Methods and apparatus for intraluminally or transluminally closing a left atrial appendage while under direct visualization are described herein. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Additionally, any number of therapeutic tools can also be passed through the deployment catheter and into the imaging hood for performing any number of procedures on the tissue for accessing and closing the left atrial appendage.
摘要翻译：本文描述了在直接可视化期间内壁或平滑闭合左心耳的方法和装置。这样的系统可以包括部署导管和可展开成扩展配置的附接成像罩。在使用中，成像罩被放置在通常填充有不透明体液如血液的体腔中的待成像组织区域附近或邻近。半透明或透明的液体（例如盐水）可被泵送到成像罩中，直到流体移动任何血液，从而留下通过展开导管中的成像元件成像的组织的清晰区域。此外，任何数量的治疗工具也可以通过展开导管并进入成像罩，用于在组织上执行用于访问和关闭左心耳的任何数量的程序。

100. 发明申请

US20080009747A1 TRANSMURAL SUBSURFACE INTERROGATION AND ABLATION 审中-公开
标题翻译：传递式的表面介入和排除
公开(公告)号：US20080009747A1
公开(公告)日：2008-01-10
申请号：US11775837
申请日：2007-07-10
申请人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , David Miller , Chris Rothe
发明人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , David Miller , Chris Rothe
IPC分类号： A61B8/14 , A61B1/04 , A61M31/00 , A61B18/04
CPC分类号： A61B1/005 , A61B1/0008 , A61B1/00082 , A61B1/00085 , A61B1/00089 , A61B1/015 , A61B1/018 , A61B1/04 , A61B5/02007 , A61B8/12 , A61B8/4472 , A61B18/1477 , A61B18/1492 , A61B2018/00214 , A61B2018/00702 , A61B2018/00791 , A61B2018/00809 , A61B2018/00875 , A61B2018/1425 , A61B2090/3614
摘要： Transmural subsurface interrogation and ablation apparatus and methods are described where tissue to be ablated is monitored while under direct visualization for tissue parameters (e.g., temperature and impedance) prior to, during, or after ablation. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to the tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid can be pumped into the imaging hood until the fluid displaces any blood leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. An ablation probe and one or more interrogation needles having sensors are advanced into the tissue to be ablated and monitored. Alternatively, a combined ablation and interrogation probe may be used.
摘要翻译：描述了跨壁地下询问和消融设备和方法，其中在消融之前，期间或之后的组织参数（例如，温度和阻抗）直接可视化的同时监测要消融的组织。这样的系统可以包括部署导管和可展开成扩展配置的附接成像罩。在使用中，将成像罩放置在通常填充有不透明体液（例如血液）的体腔中的待成像组织上或邻近待成像的组织。半透明或透明流体可被泵送到成像罩中，直到流体移动通过部署导管中的成像元件离开要成像的组织的清晰区域的任何血液。消融探针和具有传感器的一个或多个询问针被推进到待烧蚀和监测的组织中。或者，可以使用组合消融和询问探针。

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