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91. 发明授权

US06753346B2 CETP activity inhibitor 有权
标题翻译： CETP活性抑制剂
公开(公告)号：US06753346B2
公开(公告)日：2004-06-22
申请号：US10151813
申请日：2002-05-22
申请人： Hisashi Shinkai , Kimiya Maeda , Hiroshi Okamoto
发明人： Hisashi Shinkai , Kimiya Maeda , Hiroshi Okamoto
IPC分类号： A61K31255
CPC分类号： C07D307/10 , A61K31/164 , A61K31/18 , A61K31/33 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/435 , A61K31/44 , C07C311/14 , C07C311/15 , C07C311/21 , C07C323/40 , C07C323/41 , C07C323/42 , C07C327/30 , C07C329/10 , C07C329/20 , C07C333/04 , C07C333/08 , C07C333/10 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/22 , C07C2602/28 , C07C2603/74 , C07D211/34 , C07D213/80 , C07D213/81 , C07D307/68 , C07D333/38 , Y02P20/55
摘要： The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): wherein R represents a straight chain or branched alkyl group; a straight chain or branched alkenyl group; a lower haloalkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted cycloalkenyl group; a substituted or unsubstituted cycloalkylalkyl group; a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, X1, X2, X3, and X4 may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group; a lower alkoxy group; a cyano group; a nitro group; an acyl group; or an aryl group, Y represents —CO— or —SO2—, and Z represents a hydrogen atom or a mercapto-protecting group, or a prodrug compound, a pharmaceutically acceptable salt, or hydrate or solvate thereof. The compounds represented by the formula (I) can increase HDL and at the same time decrease LDL through selective inhibition of CETP activity and, therefore, is expected to be useful as a new type of a preventive or therapeutic agent for atherosclerosis or hyperlipidemia.
摘要翻译：本发明提供一种CETP活性抑制剂，其包含由式（I）表示的化合物作为活性成分：其中R表示直链或支链烷基; 直链或支链烯基; 低级卤代烷基; 取代或未取代的环烷基; 取代或未取代的环烯基; 取代或未取代的环烷基烷基; 取代或未取代的芳基或取代或未取代的杂环基，X 1，X 2，X 3和X 4可以相同或不同，各自表示氢原子，卤素原子，低级烷基，低级卤代烷基。低级烷氧基; 氰基; 硝基; 酰基; 或芳基，Y表示-CO-或-SO 2 - ，Z表示氢原子或巯基保护基，或前药化合物，其药学上可接受的盐或水合物或溶剂化物。由式（I）表示的化合物可以增加HDL，同时通过选择性抑制CETP活性降低LDL，因此预期可用作动脉粥样硬化或高脂血症的新型预防或治疗剂。

92. 发明授权

US06731472B2 Suspension for disc drive 有权
标题翻译：悬挂磁盘驱动器
公开(公告)号：US06731472B2
公开(公告)日：2004-05-04
申请号：US09803849
申请日：2001-03-12
申请人： Hiroshi Okamoto , Koji Uozumi , Masao Hanya , Tetsuya Fujiwara , Toshio Shiigi , Kenichi Takikawa , Osamu Iriuchijima
发明人： Hiroshi Okamoto , Koji Uozumi , Masao Hanya , Tetsuya Fujiwara , Toshio Shiigi , Kenichi Takikawa , Osamu Iriuchijima
IPC分类号： G11B558
CPC分类号： G11B21/025 , G11B21/16
摘要： A suspension for disc drive having a micro actuator mechanism comprises a base plate, a connecting plate having a hinge portion thinner than the base plate, a load beam provided with a flexure, a pair of actuator elements such as PZT, etc. The micro actuator mechanism includes a pivot portion formed between a pair of slits and support walls formed on the connecting plate. The actuator elements are provided individually on the opposite sides of the pivot portion. Each support wall is a bent portion that is formed by raising an edge portion of the connecting plate in the thickness direction of the main portion of the connecting plate.
摘要翻译：具有微执行器机构的盘驱动器的悬架包括基板，具有比基板薄的铰链部分的连接板，设置有挠曲件的负载梁，诸如PZT等的一对致动器元件。微致动器机构包括在一对狭缝之间形成的枢轴部分和形成在连接板上的支撑壁。致动器元件分别设置在枢转部分的相对侧上。每个支撑壁是通过在连接板的主要部分的厚度方向上提升连接板的边缘部而形成的弯曲部分。

93. 发明授权

US6140474A Monoclonal antibody reactive with human-origin CETP and method of quantifying human-origin CETP 失效
标题翻译：与人源CETP反应的单克隆抗体和量化人源CETP的方法
公开(公告)号：US6140474A
公开(公告)日：2000-10-31
申请号：US945646
申请日：1997-10-31
申请人： Masafumi Kamada , Hiroshi Okamoto , Takuya Tamatani
发明人： Masafumi Kamada , Hiroshi Okamoto , Takuya Tamatani
IPC分类号： A61K38/00 , A61P3/10 , A61P9/10 , C07K16/18 , C12P21/08 , A61K39/395 , C07K16/40
CPC分类号： C07K16/18 , A61K2039/505 , A61K38/00 , C07K2317/54 , C07K2317/55 , Y10S435/81
摘要： Monoclonal antibodies which have binding specificity to human CETP (CETP inhibition activity) and which are useful as reagents for purification or quantification of human CETP, and as pharmaceuticals to prevent and/or treat hyperlipidemia or arteriosclerosis are provided. Furthermore, purification and quantification methods of human CETP by using the monoclonal antibodies are also provided.
摘要翻译： PCT No.PCT / JP96 / 01191 Sec。 371日期1997年10月31日 102（e）日期1997年10月31日PCT提交1996年5月1日PCT公布。公开号WO96 / 34948 PCT 日期1996年11月7日提供了对人CETP具有结合特异性（CETP抑制活性）并且可用作纯化或定量人CETP的试剂以及用作预防和/或治疗高脂血症或动脉硬化的药物的单克隆抗体。此外，还提供了使用单克隆抗体的人CETP的纯化和定量方法。

94. 发明授权

US5860610A Magnetic tape tension control device 失效
标题翻译：磁带张力控制装置
公开(公告)号：US5860610A
公开(公告)日：1999-01-19
申请号：US607764
申请日：1996-02-27
申请人： Masafumi Nishida , Osamu Yamaguchi , Souichirou Fujioka , Hiroshi Okamoto , Yoshiho Gotoh
发明人： Masafumi Nishida , Osamu Yamaguchi , Souichirou Fujioka , Hiroshi Okamoto , Yoshiho Gotoh
IPC分类号： G11B15/43 , G11B15/46 , G11B15/54 , B65H59/38 , G11B23/42
CPC分类号： G11B15/43 , G11B15/46 , G11B15/54
摘要： A torque command supplied to a tape running unit for drawing out and driving a tape wound on a first reel is modulated by a torque modulator depending on a moment of inertia of the first reel, a winding radius of the tape wound on the first reel, a moment of inertia and a rotating radius of the tape running unit, which are detected by a parameter detector. The first motor is responsive to the modulated torque command for rotating the first reel, thereby keeping the tension of the tape constant.
摘要翻译：提供给用于拉出和驱动卷绕在第一卷轴上的带的带运行单元的扭矩指令由扭矩调制器调制，该转矩调节器根据第一卷轴的惯性矩，缠绕在第一卷轴上的带的卷绕半径，磁带运行单元的惯性矩和旋转半径，由参数检测器检测。第一马达响应于用于旋转第一卷轴的调制转矩指令，从而保持带的张力恒定。

95. 发明授权

US5604512A Still picture reproduction system that allows skip retrieval 失效
标题翻译：允许跳过检索的静态图像再现系统
公开(公告)号：US5604512A
公开(公告)日：1997-02-18
申请号：US361850
申请日：1994-12-21
申请人： Hiroshi Okamoto , Youji Sugiura
发明人： Hiroshi Okamoto , Youji Sugiura
IPC分类号： H04N5/91 , H04N1/00 , H04N1/21 , H04N5/76 , H04N5/781 , H04N5/783 , H04N5/85 , H04N5/93 , H04N5/937
CPC分类号： H04N1/00458 , H04N1/00198 , H04N1/0044 , H04N1/00461 , H04N1/2166 , H04N5/937 , H04N5/781 , H04N5/783 , H04N5/85
摘要： In a still picture reproduction system used for presentation of pictures in museums, a particular still picture can be retrieved rapidly by applying a retroactive reproduction function. When the mode is switched from a normal reproduction mode to a retroactive reproduction mode by a mouse, only the first still picture of a series of still pictures reproduced in the normal reproduction mode is reproduced and displayed on an HDTV. These first still pictures in each of a number of series are selectively and manually switched in sequence.
摘要翻译：在用于在博物馆中呈现图片的静止图像再现系统中，可以通过应用追溯再现功能来快速检索特定静止图像。当通过鼠标将模式从正常再现模式切换到追溯再现模式时，只有在正常再现模式中再现的一系列静止图像的第一静止图像被再现并显示在HDTV上。这些序列中的每一个中的这些第一静止图像依次选择性地和手动地切换。

96. 发明授权

US5540398A Magnetic tape tension control device 失效
标题翻译：磁带张力控制装置
公开(公告)号：US5540398A
公开(公告)日：1996-07-30
申请号：US375223
申请日：1995-01-19
申请人： Masafumi Nishida , Osamu Yamaguchi , Souichirou Fujioka , Hiroshi Okamoto , Yoshiho Gotoh
发明人： Masafumi Nishida , Osamu Yamaguchi , Souichirou Fujioka , Hiroshi Okamoto , Yoshiho Gotoh
IPC分类号： G11B15/43 , G11B15/46 , G11B15/54 , B65H59/38 , G11B23/42
CPC分类号： G11B15/43 , G11B15/46 , G11B15/54
摘要： A torque command is applied to a tape running unit. The tape running unit for draws out and drives a tape wound on a first reel and taken up on a second reel. The torque command is modulated by a torque modulator in accordance with a moment of inertia of the first reel, a winding radius of the tape wound on the first reel, a moment of inertia of the second reel and a rotating radius of the second reel, which are detected by a parameter detector. The first motor is responsive to the modulated torque command for rotating the first reel, thereby keeping the tension of the tape constant.
摘要翻译：扭矩指令被施加到带运行单元。磁带运行单元，用于拉出并驱动卷绕在第一卷轴上的磁带并卷绕在第二卷轴上。根据第一卷轴的转动惯量，缠绕在第一卷轴上的带的卷绕半径，第二卷轴的惯性矩和第二卷轴的转动半径，转矩指令由转矩调制器调制，其由参数检测器检测。第一马达响应于用于旋转第一卷轴的调制转矩指令，从而保持带的张力恒定。

97. 发明授权

US5530468A Apparatus for and of recording an image using a photosensitive drum for exposure and having a built-in web cutting assembly 失效
标题翻译：用于使用用于曝光的感光鼓记录图像并具有内置卷筒纸切割组件的装置
公开(公告)号：US5530468A
公开(公告)日：1996-06-25
申请号：US19072
申请日：1993-02-18
申请人： Yasuhito Yoshimi , Toru Kawada , Hiroyuki Fujisawa , Takashi Kakihara , Makoto Urata , Hiroshi Okamoto
发明人： Yasuhito Yoshimi , Toru Kawada , Hiroyuki Fujisawa , Takashi Kakihara , Makoto Urata , Hiroshi Okamoto
IPC分类号： G03B27/32 , G03B27/58 , G03D13/00 , G03F7/20 , B41J2/435
CPC分类号： G03B27/585 , G03B27/32 , G03D13/003
摘要： An image recording apparatus comprises a temporary storing magazine for temporarily retaining a recorded photosensitive material sheet. The temporary storing magazine stocks the recorded photosensitive sheet received therein from an image recording section while discharging the recorded photosensitive material sheet into an automatic developing machine. Hence, image recording is executed without interruption and parallel to discharge of the recorded photosensitive material sheet into the developing machine, enhancing the capability of the image recording apparatus.
摘要翻译：图像记录装置包括用于临时保存记录的感光材料片的临时储存盒。临时储存库将记录的感光片从图像记录部分存放，同时将记录的感光材料片排出到自动显影机中。因此，不间断地执行图像记录，并且平行于将记录的感光材料片放电到显影机中，增强了图像记录装置的能力。

98. 发明授权

US5510976A Control system 失效
标题翻译：控制系统
公开(公告)号：US5510976A
公开(公告)日：1996-04-23
申请号：US194378
申请日：1994-02-08
申请人： Naoki Tanaka , Hiroshi Okamoto , Masayoshi Naito , Shin-ichiro Umemura , Yasuo Morooka , Masahiro Kayama , Hiroaki Okudaira
发明人： Naoki Tanaka , Hiroshi Okamoto , Masayoshi Naito , Shin-ichiro Umemura , Yasuo Morooka , Masahiro Kayama , Hiroaki Okudaira
IPC分类号： G05B5/01 , C05B13/02 , G06F15/18
CPC分类号： G05B5/01 , Y10S706/903
摘要： A control system is for accelerating stabilization of a chaotic state of a controlled system into a desired periodic state. In the control system, the SOGY algorithm is extended to permit selection of a region on a chaotic attractor as a target, so that the SOGY algorithm can be successfully combined with the OGY algorithm for the purpose of stabilization of the controlled system in the periodic state. Also, the method of nonlinear prediction is introduced so as to secure the effectiveness of the SOGY algorithm. Further, an uncertainty of prediction is taken into consideration so as to eliminate unnecessary control and to improve the effectiveness of the SOGY algorithm.
摘要翻译：控制系统用于加速将受控系统的混沌状态稳定到期望的周期状态。在控制系统中，扩展SOGY算法以允许选择混沌吸引子上的一个区域作为目标，从而SOGY算法可以与OGY算法成功合并，以便在周期状态下稳定受控系统。此外，引入了非线性预测的方法，以确保SOGY算法的有效性。此外，考虑到预测的不确定性，以消除不必要的控制并提高SOGY算法的有效性。

99. 发明授权

US5499202A Residue circuit 失效
标题翻译：残留电路
公开(公告)号：US5499202A
公开(公告)日：1996-03-12
申请号：US253057
申请日：1994-06-02
申请人： Tsugio Takahashi , Hitoshi Fujita , Hiroshi Okamoto
发明人： Tsugio Takahashi , Hitoshi Fujita , Hiroshi Okamoto
IPC分类号： G06F7/496 , G06F7/72 , G06F7/52 , G06F7/50
CPC分类号： G06F7/727
摘要： A residue circuit takes weights of even number bits of a dividend as 1 and weights of odd number bits of the dividend as 2. The circuit includes a plurality of adders for summing bits having weight 1 to output weight 1 at a summing output and weight 2 at a carry output, and a plurality of adders for summing bits having weight 2 to output weight 2 at a summing output and weight 1 at a carry output. With these adders, summing of respective bits of the dividend bits are performed taking the weights into account to repeat summing until the number of bits finally becomes 3 bits. Depending upon the pattern of this 3 bits, a remainder is output by a modulus 3 generation circuit.
摘要翻译：残余电路将除数的偶数位的权重设为1，并且将被除数的奇数位的权重作为2.该电路包括多个加法器，用于将加权1的位相加以在加法输出和权重2处输出权重1 以及多个加法器，用于对具有权重2的位进行求和，以在加法输出处输出权重2，并在进位输出处加权1。利用这些加法器，对于重复求和，考虑权重来执行除数比特的各个比特的相加，直到比特数最终变为3比特。根据该3位的模式，余数由模数3生成电路输出。

100. 发明授权

US5469081A Circuit for interconnecting integrated semiconductor circuits 失效
标题翻译：用于互连集成半导体电路的电路
公开(公告)号：US5469081A
公开(公告)日：1995-11-21
申请号：US292142
申请日：1994-08-08
申请人： Satomi Horita , Yasushi Aoki , Masahiro Wakana , Hiroshi Okamoto , Kiyohiko Chiba , Shizue Daikoku
发明人： Satomi Horita , Yasushi Aoki , Masahiro Wakana , Hiroshi Okamoto , Kiyohiko Chiba , Shizue Daikoku
IPC分类号： H03K19/017 , H03K19/0175 , H03K19/0185
CPC分类号： H03K19/018507
摘要： An interconnection circuit having a circuit portion which is provided in one of two integrated semiconductors to be connected, for limiting the amplitude in voltage of the signal output from said one circuit, and another circuit portion which is provided in the other one of the two circuits, for discriminating the logic level of the signal input thereinto based on a threshold level set at an intermediate level between said amplitude. The amplitude of the logic signal transferred across the two circuits is thus compressed, thereby deereasing delay time for the signal to transfer between the two circuits.
摘要翻译：一种互连电路，具有设置在要连接的两个集成半导体中的一个中的电路部分，用于限制从所述一个电路输出的信号的电压幅度，以及设置在两个电路中的另一个中的另一个电路部分用于基于在所述幅度之间的中间电平设置的阈值电平来区分其中输入的信号的逻辑电平。因此，两个电路之间传输的逻辑信号的幅度被压缩，从而消除了在两个电路之间传输信号的延迟时间。

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