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91. 发明申请

US20100216387A1 DUCT ARCHITECTURE FOR REGULATING CLIMATE ZONE IN A VEHICLE 审中-公开
标题翻译：用于调节车辆中的气候区的导管结构
公开(公告)号：US20100216387A1
公开(公告)日：2010-08-26
申请号：US12389400
申请日：2009-02-20
申请人： Mukesh Kumar , Paul Bryan Hoke
发明人： Mukesh Kumar , Paul Bryan Hoke
IPC分类号： B60H1/34 , F24F13/10
CPC分类号： B60H1/26 , B60H1/00564 , F24F13/10
摘要： A climate control duct architecture having articulated and controlled interior surfaces to deliver variable and controllable airflow to target zones in the vehicle upon demand. By creating zone climates within the vehicle and providing conditioned airflow to only desired vehicle seating positions, the volume of necessary airflow is minimized, the need for cooling is reduced, and flexibility of the system is created. The interior surface may be mechanically or electrically controlled and may be situated in the common central “octopus” duct.
摘要翻译：一种气候控制管道结构，具有铰接和受控的内表面，以根据需要将可变且可控的气流输送到车辆中的目标区域。通过在车辆内部产生区域气候并将调节气流提供给仅仅期望的车辆座位位置，所需的气流量被最小化，减少了冷却的需要，并且产生了系统的灵活性。内表面可以是机械或电气控制的并且可以位于公共中央“章鱼”管道中。

92. 发明申请

US20100047318A1 CERAMIC IMPLANTS AFFORDING CONTROLLED RELEASE OF ACTIVE MATERIALS 有权
标题翻译：陶瓷植入物处理活性材料的控制释放
公开(公告)号：US20100047318A1
公开(公告)日：2010-02-25
申请号：US12195789
申请日：2008-08-21
申请人： Mukesh Kumar
发明人： Mukesh Kumar
IPC分类号： A61K9/00 , A61P43/00
CPC分类号： A61K9/0024 , A61K9/5031
摘要： Implantable compositions capable of providing release of bioactive agents according to a predetermined release profile and methods for their use. Such compositions include at least one ceramic substrate; a bioactive substance loaded on a surface of a said ceramic substrate forming a loaded surface zone operable to release said bioactive substance according to a release profile under physiological conditions; and a biodegradable polymer having an in vivo degradation period, forming a continuous or discontinuous coating on an area of a said ceramic substrate. The composition comprises at least two said loaded surface zones having different release profiles, or at least two said coatings having different in vivo degradation periods.
摘要翻译：能够根据预定释放特征提供生物活性剂释放的植入物组合物及其使用方法。这样的组合物包括至少一个陶瓷衬底; 负载在所述陶瓷基材的表面上的生物活性物质，其形成负载表面区域，其可操作以在生理条件下根据释放曲线释放所述生物活性物质; 以及具有体内降解期的可生物降解聚合物，在所述陶瓷基材的区域上形成连续或不连续的涂层。所述组合物包含至少两个所述负载的表面区域具有不同的释放曲线，或至少两个所述涂层具有不同的体内降解期。

93. 发明申请

US20060226076A1 Stabilized formulation 失效
标题翻译：稳定配方
公开(公告)号：US20060226076A1
公开(公告)日：2006-10-12
申请号：US11449476
申请日：2006-06-08
申请人： Anand Burman , Rama Mukherjee , Dinesh Kumar , Dhiraj Khattar , Mukesh Kumar , Praveen Khullar , Perundurai Srinivasan , Rajesh Srivastava
发明人： Anand Burman , Rama Mukherjee , Dinesh Kumar , Dhiraj Khattar , Mukesh Kumar , Praveen Khullar , Perundurai Srinivasan , Rajesh Srivastava
IPC分类号： B01D15/08
CPC分类号： C07D305/14 , A61K47/44 , B01D15/325 , B01J20/287
摘要： A stabilized pharmaceutical composition of anticancer drug and a solvent like Polyethoxylated castor oil (cremophor) also containing any other suitable solubilizer suitable for human administration like dehydrated alcohol, is disclosed. Compositions prepared using this purified polyethoxylated castor oil enhance the stability of paclitaxel in such compositions.
摘要翻译：公开了一种稳定的抗癌药物和溶剂，如聚乙氧基化蓖麻油（cremophor）的药物组合物，其也含有适于人类给药的任何其它合适的增溶剂如脱水醇。使用该纯化的聚乙氧基化蓖麻油制备的组合物增强紫杉醇在这些组合物中的稳定性。

94. 发明授权

US07118888B2 Gene expression vaccine 有权
公开(公告)号：US07118888B2
公开(公告)日：2006-10-10
申请号：US10073065
申请日：2002-02-12
申请人： Shyam S. Mohapatra , Mukesh Kumar , Shua-ku Huang , Kam Leong
发明人： Shyam S. Mohapatra , Mukesh Kumar , Shua-ku Huang , Kam Leong
IPC分类号： C12P21/06
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K2039/53 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/544 , A61K2039/55583 , C12N2760/18522 , C12N2760/18534
摘要： An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to formulate nanospheres. In a murine model of RSV infection, intranasal administration with GXV results in significant induction of RSV-specific antibodies, nasal IgA antibodies, cytotoxic T lymphocytes, and IFN-γ production in the lung and splenocytes. A single dose of GXV induces a drastic reduction of viral titers.

95. 发明申请

US20060198943A1 Acetabular shell system and method for making 有权
标题翻译： ular壳系统及制作方法
公开(公告)号：US20060198943A1
公开(公告)日：2006-09-07
申请号：US11366727
申请日：2006-03-02
申请人： Mukesh Kumar
发明人： Mukesh Kumar
IPC分类号： A61L27/32 , B05D1/02 , B05D1/08
CPC分类号： A61L27/306
摘要： A method for forming an acetabular shell includes providing a working surface such as a mandrel, and spraying the working surface with a first layer of material having a first composition such as aluminum oxide. After a suitable thickness is generated, the spray composition is gradually changed to other compositions having desired particle sizes and distribution. In one example, the composition is changed to a mixture of aluminum oxide and titanium oxide and/or titanium. As thickness builds up, the relative amount of aluminum oxide is decreased such that the composition is all titanium and titanium oxide. After a desired thickness is generated, the acetabular shell is extracted off the mandrel.
摘要翻译：一种用于形成髋臼壳的方法包括提供诸如心轴的工作表面，并且用具有第一组成的第一层材料如氧化铝喷涂工作表面。在产生合适的厚度之后，将喷雾组合物逐渐变为具有所需粒度和分布的其它组合物。在一个实例中，将组合物改变为氧化铝和氧化钛和/或钛的混合物。随着厚度的增加，氧化铝的相对量降低，使得组合物全部为钛和氧化钛。在产生期望的厚度之后，将髋臼壳从芯轴上取出。

96. 发明申请

US20060159783A1 Method for treating cancer using betulinic acid rich herbal extract 审中-公开
标题翻译：使用富含桦木酸的草药提取物治疗癌症的方法
公开(公告)号：US20060159783A1
公开(公告)日：2006-07-20
申请号：US11219482
申请日：2005-09-02
申请人： Rama Mukherjee , Dhiraj Khattar , Manu Jaggi , Anu Singh , Mukesh Kumar , Honey Bala
发明人： Rama Mukherjee , Dhiraj Khattar , Manu Jaggi , Anu Singh , Mukesh Kumar , Honey Bala
IPC分类号： A61K36/906
CPC分类号： A61K31/56 , A61K36/725
摘要： This invention relates to an orally effective herbal extract-based composition having broad-spectrum anticancer activity, more specifically a method of treating, inhibiting and/or preventing malignant tumors of the colon, intestine, stomach, breast, melanoma, glioblastoma, lung, cervix, ovary, prostate, oral cavity, larynx, liver, pancreas, kidney, bladder, endothelial cells, leukemia and myeloma using a herbal extract of Zizyphus, rich in betulinic acid. An advantage of the extract is that the betulinic acid has low systemic toxicity. The extract inhibits Protein Kinase C activity of cancer cells and induces apoptosis.
摘要翻译：本发明涉及具有广谱抗癌活性的口服有效的草药提取物组合物，更具体地，涉及治疗，抑制和/或预防结肠，肠，胃，乳腺，黑素瘤，成胶质细胞瘤，肺，子宫颈恶性肿瘤的方法，卵巢，前列腺，口腔，喉，肝，胰腺，肾，膀胱，内皮细胞，白血病和骨髓瘤，使用梓属的草药提取物，富含桦木酸。提取物的优点是桦木酸具有低的全身毒性。提取物抑制癌细胞的蛋白激酶C活性并诱导细胞凋亡。

97. 发明申请

US20050077252A1 Readying cooling circuits for use in fuel cells 审中-公开
标题翻译：准备用于燃料电池的冷却回路
公开(公告)号：US20050077252A1
公开(公告)日：2005-04-14
申请号：US10684718
申请日：2003-10-14
申请人： George Shih , William Schwartz , Chendong Huang , Mukesh Kumar , Byung Kim , Sherry Mueller , Vijay Garg
发明人： George Shih , William Schwartz , Chendong Huang , Mukesh Kumar , Byung Kim , Sherry Mueller , Vijay Garg
IPC分类号： B01D36/00 , H01M8/04
CPC分类号： H01M8/04029 , H01M8/04044
摘要： A flush and fill process is used to ready a fuel cell cooling circuit for initial use. An external flushing system relasably connected to the cooling circuit circulates flushing coolant through the cooling circuit to remove contaminants from the wetted surfaces of the cooling circuit before the fuel cell is put into use. The flushing system includes a pump for circulating the flushing coolant through the cooling circuit, filters for removing contaminants from the coolant and a heater for elevating the temperature of the coolant. Following the flushing process to remove contaminants, the flushing system is disconnected from the cooling circuit and the cooling circuit is filled with fresh coolant.
摘要翻译：使用冲洗和填充过程来准备燃料电池冷却回路以便初始使用。可靠地连接到冷却回路的外部冲洗系统使冲洗冷却剂循环通过冷却回路，以在燃料电池投入使用之前从冷却回路的润湿表面去除污染物。冲洗系统包括用于使冲洗冷却剂循环通过冷却回路的泵，用于从冷却剂中除去污染物的过滤器和用于升高冷却剂温度的加热器。在冲洗过程中除去污染物后，冲洗系统与冷却回路断开连接，冷却回路充满新鲜的冷却液。

98. 发明申请

US20050037030A1 Stable topical formulation of clarithromycin 审中-公开
标题翻译：稳定的局部配方克拉霉素
公开(公告)号：US20050037030A1
公开(公告)日：2005-02-17
申请号：US10498407
申请日：2002-12-12
申请人： Mukesh Kumar , Ajay Singla , Vinod Arora , Rajiv Malik
发明人： Mukesh Kumar , Ajay Singla , Vinod Arora , Rajiv Malik
IPC分类号： A61K9/00 , A61K9/06 , A61K9/107 , A61K31/7048
CPC分类号： A61K31/7048 , A61K9/0014 , A61K9/06 , A61K9/107
摘要： This invention relates to a stable topical formulation of clarithromycin and its use in the treatment of acne.
摘要翻译：本发明涉及克拉霉素的稳定局部制剂及其在治疗痤疮中的用途。

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