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91. 发明授权

US6122397A Method and apparatus for maskless semiconductor and liquid crystal display inspection 失效
标题翻译：无掩模半导体和液晶显示器检查的方法和装置
公开(公告)号：US6122397A
公开(公告)日：2000-09-19
申请号：US888115
申请日：1997-07-03
申请人： Shih-Jong J. Lee , Alan C. Nelson
发明人： Shih-Jong J. Lee , Alan C. Nelson
IPC分类号： G01B11/30 , G01M11/00 , G01N21/956 , G01N21/958 , G06T1/00 , G06T7/00 , H01L21/66 , G06K9/00
CPC分类号： G06T7/001 , G06T2207/30121 , G06T2207/30148
摘要： Image primitive based maskless semiconductor wafer and liquid crystal display panel inspection by the characterization of wafer patterns. Potential defects are detected as exceptions to the rules of general semiconductor surface pattern structure. The wafer or liquid crystal display, lcd, structure is encoded into multiple profiles of a set of primitive characterization modules. Primitive profiles are correlated with potential defects along with aligned pattern images for surface component to surface component, lcd active matrix element to lcd active matrix element, comparison and further refines the results using data from multiple surface components or lcd active matrix elements. Multiple stage defect classification is applied to the potential defects to reject false defects. Multiple layer correlation and automatic learning enhance and tailor detection rules during a ramp-up stage. There is a dramatic reduction of false and nuisance defects and a high sensitivity to critical defects. The highly robust method is not sensitive to factors such as metal grain structure and imperfect alignment. Automatic learning tailors the inspection system for a specific semiconductor surface design and manufacturing process.
摘要翻译：基于图像原始的无掩模半导体晶片和液晶显示面板通过晶圆图案的表征进行检查。潜在的缺陷被检测为一般半导体表面图案结构规则的例外。晶片或液晶显示器，lcd，结构被编码成一组原始表征模块的多个轮廓。原始曲线与潜在的缺陷以及表面成分到表面分量，lcd有源矩阵元素到lcd有源矩阵元素的对齐图案图像相关，并且使用来自多个表面分量或lcd有源矩阵元素的数据进一步优化结果。多级缺陷分类应用于潜在的缺陷以排除假缺陷。多层相关和自动学习在加速阶段提高和定制检测规则。虚假和滋扰缺陷大大减少，对关键缺陷有很高的敏感性。高度鲁棒的方法对金属晶粒结构和不完全对准等因素不敏感。自动学习为特定的半导体表面设计和制造过程定制了检测系统。

92. 发明授权

US5987158A Apparatus for automated identification of thick cell groupings on a biological specimen 失效
标题翻译：用于在生物样本上自动识别厚细胞分组的装置
公开(公告)号：US5987158A
公开(公告)日：1999-11-16
申请号：US969970
申请日：1997-11-13
申请人： Michael G. Meyer , Shih-Jong J. Lee , Paul S. Wilhelm
发明人： Michael G. Meyer , Shih-Jong J. Lee , Paul S. Wilhelm
IPC分类号： G06K9/00 , G06K9/68 , G06T7/00
CPC分类号： G06T7/0012 , G06K9/00127 , G06T2207/10056 , G06T2207/30024
摘要： A thick group of cells classifier. Image data acquired from an automated microscope from a cytological specimen is processed by a computer system. The computer applies filters at different stages. Obvious artifacts are eliminated from analysis early in the processing. The first stage of processing is image segmentation where objects of interest are identified. The next stage of processing is feature calculation where properties of each segmented thick group object are calculated. The final step is object classification where every segmented thick group object is classified as being abnormal or as belonging to a cellular or non-cellular artifact.
摘要翻译：一组细胞分类器。从细胞学标本的自动显微镜获取的图像数据由计算机系统处理。计算机在不同阶段应用过滤器。在处理初期，从分析中消除了明显的文物。第一阶段的处理是识别感兴趣对象的图像分割。处理的下一个阶段是计算每个分段厚组对象的属性的特征计算。最后一步是对象分类，其中每个分段的粗组对象被分类为异常或属于细胞或非细胞假象。

93. 发明授权

US5933519A Cytological slide scoring apparatus 失效
标题翻译：细胞学评分仪
公开(公告)号：US5933519A
公开(公告)日：1999-08-03
申请号：US867017
申请日：1997-06-03
申请人： Shih-Jong J. Lee , Paul S. Wilhelm , Michael G. Meyer , Wendy R. Bannister , Chih-Chau L. Kuan , William E. Ortyn , Larry A. Nelson , Keith L. Frost , Jon W. Hayenga
发明人： Shih-Jong J. Lee , Paul S. Wilhelm , Michael G. Meyer , Wendy R. Bannister , Chih-Chau L. Kuan , William E. Ortyn , Larry A. Nelson , Keith L. Frost , Jon W. Hayenga
IPC分类号： G06K9/00 , G06K9/62 , G06K9/68 , G06K9/70
CPC分类号： G06K9/00127 , G06K9/6253 , G06K9/685
摘要： The invention detects areas of interest at low magnification, locating possible abnormal cells or other cells of interest using image processing and statistical pattern recognition techniques. Next, at high magnification, the areas identified at low magnification are re-examined. The information from the low magnification and high magnification scans is collated and a determination is made about the slide--whether it is normal, abnormal, contains endocervical component, and so forth. The invention also provides a method and apparatus to train object feature and slide feature classifiers. The invention provides an automated cytology system that can process training slides for use in a feed back classifier development environment. The invention also can classify endocervical groups of cells.
摘要翻译：本发明使用图像处理和统计模式识别技术来检测低放大倍数的感兴趣区域，定位可能的异常细胞或感兴趣的其它细胞。接下来，在高放大倍数下，重新检查在低倍率下识别的区域。对来自低放大倍数和高倍率扫描的信息进行整理，并确定载玻片是否正常，异常，包含宫颈内部成分等。本发明还提供了一种训练对象特征和幻灯片特征分类器的方法和装置。本发明提供了一种自动细胞学系统，其可以处理用于反馈分类器开发环境中的训练幻灯片。本发明还可以分类宫颈癌细胞群。

94. 发明授权

US5671288A Method and apparatus for assessing slide and specimen preparation quality 失效
标题翻译：评估载玻片和标本制备质量的方法和装置
公开(公告)号：US5671288A
公开(公告)日：1997-09-23
申请号：US455182
申请日：1995-05-31
申请人： Paul S. Wilhelm , Shih-Jong J. Lee
发明人： Paul S. Wilhelm , Shih-Jong J. Lee
IPC分类号： G01N33/48 , G01N1/28 , G01N1/30 , G02B21/34 , G06K9/00 , G06T1/00
CPC分类号： G06T1/0007 , G06K9/00127
摘要： An automated biological specimen screener reports an assessment of slide and specimen preparation and quality. The automated biological specimen screener measures, parameters which reflect slide physical characteristics, specimen collection quality, and specimen preparation quality. The automated system reports an objective measure and uses a consistent standard of evaluation. The automated system evaluates characteristics of a slide set from a clinic. The automated system makes a determination of whether these characteristics are within a training capability of a given automated biological screener. Additionally, rather than periodic reviews, slides successfully scanned by the automated system may be used as part of a specimen preparation assessment.
摘要翻译：自动生物样本筛选器报告了载玻片和样品制备和质量的评估。自动化生物样本筛选器测量，反映滑动物理特性，样本采集质量和样品制备质量的参数。自动化系统报告客观测量，并使用一致的评估标准。自动化系统评估来自诊所的幻灯片集的特征。自动化系统确定这些特征是否在给定的自动生物筛选器的训练能力内。另外，而不是定期审查，由自动化系统成功扫描的幻灯片可以用作样品制备评估的一部分。

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