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1. 发明授权

US5978498A Apparatus for automated identification of cell groupings on a biological specimen 失效
标题翻译：用于自动识别生物样本上的细胞分组的装置
公开(公告)号：US5978498A
公开(公告)日：1999-11-02
申请号：US927379
申请日：1997-09-12
申请人： Paul S. Wilhelm , Shih-Jong J. Lee
发明人： Paul S. Wilhelm , Shih-Jong J. Lee
IPC分类号： G06K9/00 , G06K9/34 , G06K9/40
CPC分类号： G06K9/00127 , G06K9/346 , G06K2209/01
摘要： The detection of cellular aggregates within cytologic samples. An image analysis system with an image gathering system includes a camera, a motion controller, an illumination system and an interface obtains images of cell groupings. The image gathering system is constructed for gathering image data of a specimen mounted on a slide and is coupled to a data processing system. Image data is transferred from the image gathering system to the data processing system. The data processing system obtains objects of interest. A four step process finds cellular aggregates. The first step is acquisition of an image for analysis. The second step is extraction of image features. The third step is classification of the image to determine if any potential cellular aggregates may exist in the image. The fourth step is segmentation of objects which includes the substeps of detecting and locating potential cellular aggregates.
摘要翻译：细胞学样品中细胞聚集体的检测。具有图像采集系统的图像分析系统包括摄像机，运动控制器，照明系统和接口获得单元分组的图像。图像采集系统被构造用于收集安装在载玻片上的样本的图像数据，并耦合到数据处理系统。图像数据从图像采集系统传送到数据处理系统。数据处理系统获得感兴趣的对象。四步法发现细胞聚集。第一步是获取图像进行分析。第二步是提取图像特征。第三步是图像的分类，以确定图像中是否存在潜在的细胞聚集。第四步是对包括检测和定位潜在细胞聚集体子步骤的物体进行分割。

2. 发明授权

US5619428A Method and apparatus for integrating an automated system to a laboratory 失效
标题翻译：将自动化系统整合到实验室的方法和装置
公开(公告)号：US5619428A
公开(公告)日：1997-04-08
申请号：US455388
申请日：1995-05-31
申请人： Shih-Jong J. Lee , Dayle G. Ellison , Chih-Chau L. Kuan , Seho Oh , Paul S. Wilhelm
发明人： Shih-Jong J. Lee , Dayle G. Ellison , Chih-Chau L. Kuan , Seho Oh , Paul S. Wilhelm
IPC分类号： G01B9/04 , G01N1/31 , G02B21/36
CPC分类号： G01N1/312
摘要： An automated biological screening system obtains biological and procedural data from a slide set of a selected clinical laboratory. The integration system tests the data on standardized criteria and passes and fails the data in selected categories. The results of the assessment are used to make process adjustment recommendations based on the results of a laboratory process adjustment procedure. Assessment and adjustment may continue until data from a slide set from the selected clinical laboratory passes in each category. The integration system then sets up, calibrates and installs the automated biological screening system. During operation, the integration system continuously monitors biological data generated by the automated biological screening system. The biological data may also be stored in a central product/service database for additional monitoring. The integration system also serves as an objective standard for reviewing and improving laboratory practices.
摘要翻译：自动生物筛选系统从选定的临床实验室的幻灯片中获得生物学和程序性数据。集成系统对标准化标准的数据进行测试，并对所选类别的数据进行传递和失败。评估结果用于根据实验室过程调整程序的结果制定过程调整建议。评估和调整可以继续，直到来自所选临床实验室的幻灯片的数据在每个类别中通过。整合系统建立，校准和安装自动化生物筛选系统。在运行过程中，集成系统会持续监控自动化生物筛选系统产生的生物数据。生物数据也可以存储在中央产品/服务数据库中以用于附加监控。整合系统也是检查和改进实验室实践的客观标准。

3. 发明授权

US6134354A Apparatus for the identification of free-lying cells 失效
公开(公告)号：US6134354A
公开(公告)日：2000-10-17
申请号：US121012
申请日：1998-07-22
申请人： Shih-Jong J. Lee , Paul S. Wilhelm , Wendy R. Bannister , Chih-Chau L. Kuan , Seho Oh , Michael G. Meyer
发明人： Shih-Jong J. Lee , Paul S. Wilhelm , Wendy R. Bannister , Chih-Chau L. Kuan , Seho Oh , Michael G. Meyer
IPC分类号： G01N15/14 , G06K9/00 , G06K9/38
CPC分类号： G06K9/00127 , G01N15/1475 , G01N2015/1497
摘要： A free-lying cell classifier. An automated microscope system comprising a computer and high speed processing field of view processors identifies free-lying cells. An image of a biological specimen is obtained and the image is segmented to create a set of binary masks. The binary masks are used by a feature calculator to compute the features that characterize objects of interest including free-lying cells, artifacts and other biological objects. The objects are classified to identify their type, their normality or abnormality or their identification as an artifact. The results are summarized and reported. A stain evaluation of the slide is performed as well as a typicality evaluation. The robustness of the measurement is also quantified as a classification confidence value. The free-lying cell evaluation is used by an automated cytology system to classify a biological specimen slide.

4. 发明授权

US5828776A Apparatus for identification and integration of multiple cell patterns 失效
标题翻译：用于识别和整合多个细胞图案的装置
公开(公告)号：US5828776A
公开(公告)日：1998-10-27
申请号：US678124
申请日：1996-07-11
申请人： Shih-Jong J. Lee , Chih-Chau L. Kuan , Wendy R. Bannister , Paul S. Wilhelm , Michael G. Meyer
发明人： Shih-Jong J. Lee , Chih-Chau L. Kuan , Wendy R. Bannister , Paul S. Wilhelm , Michael G. Meyer
IPC分类号： G06K9/00 , G06K9/68
CPC分类号： G06K9/00127 , G06K9/685
摘要： A biological specimen classification strategy employs identification and integration of multiple cell patterns. An automated microscope acquires an image of a biological specimen such as a Pap smear and provides an image output to biological classifiers. The classifiers independently detect and classify a number of specimen types and provide classifications to an output field of view integrator. The integrator integrates the classifications. The integrated output then determines whether the classifiers should be reapplied to the image.
摘要翻译：生物样本分类策略采用多重细胞模式的识别和整合。自动显微镜获取诸如巴氏涂片的生物样本的图像，并向生物分类器提供图像输出。分类器独立地检测和分类多个样本类型，并为输出视场积分器提供分类。集成商整合分类。然后，集成输出确定分类器是否应重新应用于映像。

5. 发明授权

US5715327A Method and apparatus for detection of unsuitable conditions for automated cytology scoring 失效
标题翻译：用于检测不适合自动细胞学评分条件的方法和装置
公开(公告)号：US5715327A
公开(公告)日：1998-02-03
申请号：US309117
申请日：1994-09-20
申请人： Paul S. Wilhelm , Shih-Jong J. Lee
发明人： Paul S. Wilhelm , Shih-Jong J. Lee
IPC分类号： G01N33/48 , G01M11/00 , G01N1/28 , G01N15/00 , G01N15/14 , G01N21/27 , G01N21/95 , G01N33/483 , G06K9/00 , G06T1/00
CPC分类号： G06K9/00127 , G01N15/1475 , G01N21/95
摘要： A method and apparatus for determining whether a slide is suitable for processing. A suite of suitability tests are performed by an automated microscope system. The tests include magnification error flags, staining flags, main optical density flags, including detected intermediate cell nuclei, rings around detected intermediate cell nuclei, average texture measure of detected intermediate cell nuclei, average contrast to detected intermediate cell nuclei to cytoplasm, standard deviation of detected intermediate cell nuclei optical densities, detected intermediate cell ratios, average stripe area, measure of a saturated magnification of the image, measure of a grossly saturated magnification, and the percentage of images focused properly on a first try, including images never focused properly. The automated microscope quantifies the measurements in a reliable and repeatable way.
摘要翻译：一种用于确定滑块是否适于处理的方法和装置。一套适合性测试由自动显微镜系统进行。测试包括放大误差标志，染色标记，主要光密度标记，包括检测到的中间细胞核，检测到的中间细胞核周围的环，检测到的中间细胞核的平均质地测量，与检测到的中间细胞核到细胞质的平均对比度，标准偏差检测到的中间细胞核光密度，检测到的中间细胞比例，平均条纹面积，图像的饱和放大倍数的测量，大体积饱和放大倍率的测量以及首次尝试聚焦的图像的百分比，包括从未聚焦的图像。自动显微镜以可靠和可重复的方式量化测量。

6. 发明授权

US5642433A Method and apparatus for image contrast quality evaluation 失效
标题翻译：用于图像对比度质量评估的方法和装置
公开(公告)号：US5642433A
公开(公告)日：1997-06-24
申请号：US509185
申请日：1995-07-31
申请人： Shih-Jong J. Lee , Paul S. Wilhelm
发明人： Shih-Jong J. Lee , Paul S. Wilhelm
IPC分类号： G01N15/14 , G06T7/00 , G06K9/36
CPC分类号： G06T7/0085 , G06K9/00134 , G06K9/036 , G06T7/0002 , G01N15/1475 , G06T2207/10056 , G06T2207/20036 , G06T2207/30024 , G06T2207/30168
摘要： A method for single image based image contrast quality evaluation is used in a computer controlled image system including an automated microscope for acquiring images. An image is acquired. An image contrast score is computed for the image. An image reliability score is computed for the image. The image contrast score and image reliability score are accumulated and combined to produce a contrast quality score. The contrast quality score is compared to a predetermined limit so as to produce a quality of processing result.
摘要翻译：一种用于基于单个图像的图像对比度质量评估的方法用于包括用于获取图像的自动显微镜的计算机控制图像系统中。获取图像为图像计算图像对比分数。为图像计算图像可靠性分数。图像对比度分数和图像可靠性分数被积累并组合以产生对比度质量得分。将对比质量分数与预定限度进行比较，以产生处理结果的质量。

7. 发明授权

US5745601A Robustness of classification measurement apparatus and method 失效
标题翻译：分类测量仪器和方法的鲁棒性
公开(公告)号：US5745601A
公开(公告)日：1998-04-28
申请号：US509181
申请日：1995-07-31
申请人： Shih-Jong J. Lee , Michael G. Meyer , Chih-Chau L. Kuan , Paul S. Wilhelm
发明人： Shih-Jong J. Lee , Michael G. Meyer , Chih-Chau L. Kuan , Paul S. Wilhelm
IPC分类号： G06T7/00 , G06K9/00 , G06K9/62 , G06T1/00
CPC分类号： G06K9/6282 , G06K9/00127
摘要： A classifier measures robustness responsive to object presentation effects and decision boundary effects. A cytological image analysis computer obtains objects of interest and classifies them responsive to a decision tree classifier. The robustness of classification is calculated dynamically as objects are classified responsive to a segmentation robustness and a classification decisiveness measure. The results of the decisiveness measure and the segmentation robustness data are combined to provide enhanced overall classification reliability.
摘要翻译：分类器测量响应于对象呈现效果和决策边界效应的鲁棒性。细胞学图像分析计算机获得感兴趣的对象，并对它们进行分类以响应于决策树分类器。根据分割鲁棒性和分类决定性度量对象进行分类，动态计算分类的鲁棒性。结合果蔬措施和分割鲁棒性数据的结果，提高整体分类的可靠性。

8. 发明授权

US6137899A Apparatus for the identification of free-lying cells 失效
标题翻译：用于鉴定自由躺卧细胞的装置
公开(公告)号：US6137899A
公开(公告)日：2000-10-24
申请号：US120860
申请日：1998-07-22
申请人： Shih-Jong J. Lee , Paul S. Wilhelm , Wendy R. Bannister , Chih-Chau L. Kuan , Seho Oh , Michael G. Meyer
发明人： Shih-Jong J. Lee , Paul S. Wilhelm , Wendy R. Bannister , Chih-Chau L. Kuan , Seho Oh , Michael G. Meyer
IPC分类号： G01N15/14 , G06K9/00
CPC分类号： G06K9/00127 , G01N15/1475 , G01N2015/1497
摘要： A free-lying cell classifier. An automated microscope system comprising a computer and high speed processing field of view processors identifies free-lying cells. An image of a biological specimen is obtained and the image is segmented to create a set of binary masks. The binary masks are used by a feature calculator to compute the features that characterize objects of interest including free-lying cells, artifacts and other biological objects. The objects are classified to identify their type, their normality or abnormality or their identification as an artifact. The results are summarized and reported. A stain evaluation of the slide is performed as well as a typicality evaluation. The robustness of the measurement is also quantified as a classification confidence value. The free-lying cell evaluation is used by an automated cytology system to classify a biological specimen slide.
摘要翻译：一个自由的细胞分类器。包括计算机和高速处理视野处理视野处理器的自动显微镜系统识别自由放置的单元。获得生物样本的图像，并将图像分割以产生一组二进制掩模。特征计算器使用二进制掩码来计算表征感兴趣对象的特征，包括自由放置的细胞，伪影和其他生物物体。这些物体被分类以识别它们的类型，它们的正常性或异常或它们作为人造物的识别。总结和报告结果。执行幻灯片的染色评估以及典型评估。测量的鲁棒性也被量化为分类置信度值。自由细胞学评估系统用于分离生物样本载玻片。

9. 发明授权

US5625706A Method and apparatus for continously monitoring and forecasting slide and specimen preparation for a biological specimen population 失效
标题翻译：用于连续监测和预测生物样本群体的载玻片和标本制备的方法和装置
公开(公告)号：US5625706A
公开(公告)日：1997-04-29
申请号：US455296
申请日：1995-05-31
申请人： Shih-Jong J. Lee , Dayle G. Ellison , Paul S. Wilhelm
发明人： Shih-Jong J. Lee , Dayle G. Ellison , Paul S. Wilhelm
IPC分类号： G01N33/48 , G01N1/28 , G01N1/30 , G01N33/483 , G02B21/34 , G06T1/00 , G06K9/00
CPC分类号： G01N1/312 , G01N35/00594
摘要： An automated laboratory process monitoring method for a computer controlled automated cytology system initializes lab process assessment slide data so as to produce an initial batch of qualified slides. Monitor parameters are extracted from the initial batch of qualified slides so as to determine control limits. Field data is monitored by comparing the field data to the control limits.
摘要翻译：用于计算机控制的自动细胞学系统的自动化实验室过程监测方法初始化实验室过程评估幻灯片数据，以便产生初始合格幻灯片。从初始批次的幻灯片中提取监视器参数，以确定控制限制。通过将现场数据与控制限制进行比较来监控现场数据。

10. 发明授权

US5987158A Apparatus for automated identification of thick cell groupings on a biological specimen 失效
标题翻译：用于在生物样本上自动识别厚细胞分组的装置
公开(公告)号：US5987158A
公开(公告)日：1999-11-16
申请号：US969970
申请日：1997-11-13
申请人： Michael G. Meyer , Shih-Jong J. Lee , Paul S. Wilhelm
发明人： Michael G. Meyer , Shih-Jong J. Lee , Paul S. Wilhelm
IPC分类号： G06K9/00 , G06K9/68 , G06T7/00
CPC分类号： G06T7/0012 , G06K9/00127 , G06T2207/10056 , G06T2207/30024
摘要： A thick group of cells classifier. Image data acquired from an automated microscope from a cytological specimen is processed by a computer system. The computer applies filters at different stages. Obvious artifacts are eliminated from analysis early in the processing. The first stage of processing is image segmentation where objects of interest are identified. The next stage of processing is feature calculation where properties of each segmented thick group object are calculated. The final step is object classification where every segmented thick group object is classified as being abnormal or as belonging to a cellular or non-cellular artifact.
摘要翻译：一组细胞分类器。从细胞学标本的自动显微镜获取的图像数据由计算机系统处理。计算机在不同阶段应用过滤器。在处理初期，从分析中消除了明显的文物。第一阶段的处理是识别感兴趣对象的图像分割。处理的下一个阶段是计算每个分段厚组对象的属性的特征计算。最后一步是对象分类，其中每个分段的粗组对象被分类为异常或属于细胞或非细胞假象。

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