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91. 发明授权

US07687664B2 Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it 失效
标题翻译：羧酸衍生物，其盐或它们的酯，以及包含它们的药物
公开(公告)号：US07687664B2
公开(公告)日：2010-03-30
申请号：US10479427
申请日：2002-06-04
申请人： Fumiyoshi Matsuura , Eita Emori , Masanobu Shinoda , Richard Clark , Shunji Kasai , Hideki Yoshitomi , Kazuto Yamazaki , Takashi Inoue , Sadakazu Miyashita , Taro Hihara
发明人： Fumiyoshi Matsuura , Eita Emori , Masanobu Shinoda , Richard Clark , Shunji Kasai , Hideki Yoshitomi , Kazuto Yamazaki , Takashi Inoue , Sadakazu Miyashita , Taro Hihara
IPC分类号： C07C57/34 , A01N37/44 , A01N43/08 , A01N43/10
CPC分类号： C07D213/40 , C07C59/68 , C07C69/732 , C07C69/734 , C07C233/87 , C07C235/52 , C07C271/22 , C07C271/28 , C07C2601/08 , C07C2601/14 , C07D213/75 , C07D213/79 , C07D213/80 , C07D261/18 , C07D277/56 , C07D307/68 , C07D307/79 , C07D333/38 , C07D417/04 , C07D417/12
摘要： The present invention provides novel carboxylic acid derivatives useful as an insulin sensitizer, a salt thereof or a hydrate of them, and a medicament comprising the derivative as the active ingredient. Specifically, it provides a carboxylic acid derivative represented by the following formula (I): (wherein Y, L, X, T, Z, U, M and W are defined in the specification) and a salt thereof, and ester thereof or a hydrate of them.
摘要翻译：本发明提供可用作胰岛素敏化剂，其盐或其水合物的新型羧酸衍生物和包含该衍生物作为活性成分的药物。具体地说，它提供由下式（I）表示的羧酸衍生物：其中Y，L，X，T，Z，U，M和W在说明书中定义）及其盐及其酯或它们的水合物。

92. 发明申请

US20080015199A1 Triazolone derivatives 有权
标题翻译：三唑酮衍生物
公开(公告)号：US20080015199A1
公开(公告)日：2008-01-17
申请号：US11723893
申请日：2007-03-22
申请人： Richard Clark , Fumiyoshi Matsuura , Kazunobu Kira , Shinsuke Hirota , Hiroshi Azuma , Tadashi Nagakura , Tatsuo Horizoe , Kimiyo Tabata , Kazutomi Kusano , Takao Omae , Atsushi Inoue
发明人： Richard Clark , Fumiyoshi Matsuura , Kazunobu Kira , Shinsuke Hirota , Hiroshi Azuma , Tadashi Nagakura , Tatsuo Horizoe , Kimiyo Tabata , Kazutomi Kusano , Takao Omae , Atsushi Inoue
IPC分类号： A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61P7/02 , A61P9/00 , C07D249/08 , C07D401/04 , C07D403/04 , C07D409/04 , C07D417/04
CPC分类号： C07D249/12 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/04
摘要： A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability. [wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc.; R2 represents optionally substituted phenyl, etc.; R3 represents optionally substituted C6-10 aryl, etc.; and Z1 and Z2 each independently represent hydrogen]
摘要翻译：由以下通式（1）表示的化合物，其盐或其前体的水合物是可用于治疗和/或预防与血栓形成有关的疾病的新型化合物，其具有合适的理化稳定性更安全。 [其中R 1a，R 1b，R 1c和R 1d各自独立地表示氢等。 R 2表示任选取代的苯基等; R 3表示任选取代的C 6-10芳基等; Z 1和Z 2各自独立地表示氢]

93. 发明授权

US07312195B2 Cyclised conotoxin peptides 有权
标题翻译：环化芋螺毒素肽
公开(公告)号：US07312195B2
公开(公告)日：2007-12-25
申请号：US11052168
申请日：2005-02-07
申请人： David James Craik , Norelle Lee Daly , Katherine Justine Nielsen , Christopher John Armishaw , Richard Clark , Paul Francis Alewood
发明人： David James Craik , Norelle Lee Daly , Katherine Justine Nielsen , Christopher John Armishaw , Richard Clark , Paul Francis Alewood
IPC分类号： A61K38/12 , C07K14/00
CPC分类号： C07K14/43504 , A61K38/00
摘要： This invention relates to cyclised conotoxin peptides, processes for their preparation and their pharmaceutical use.
摘要翻译：本发明涉及环化芋螺毒素肽，其制备方法及其药物应用。

94. 发明申请

US20070205137A1 FUEL COMPOSITION 有权
标题翻译：燃料组合物
公开(公告)号：US20070205137A1
公开(公告)日：2007-09-06
申请号：US11614118
申请日：2006-12-21
申请人： Richard Clark , Richard Heins , Robert Wardle
发明人： Richard Clark , Richard Heins , Robert Wardle
IPC分类号： C10L1/04
CPC分类号： C10L1/08
摘要： A composition having a density at 15° C. of between 820 and 845 kg/m3 and a cetane number of equal or greater than 40, which composition has been obtained by blending the following components: (a) a cracked gas oil, (b) a mineral derived gas oil other than (a), and (c) a Fischer-Tropsch derived kerosene fraction; and the use of this composition as an automotive gas oil fuel composition.
摘要翻译：在15℃下的密度在820和845kg / m 3之间的组合物和十六烷值等于或大于40的组合物，该组合物通过混合以下组分获得：（a ）裂化瓦斯油，（b）除（a）以外的矿物油瓦斯油，和（c）费 - 托衍生的煤油馏分; 并将该组合物用作汽车瓦斯油燃料组合物。

95. 发明授权

US07244861B2 Benzene compound and salt thereof 失效
标题翻译：苯化合物及其盐
公开(公告)号：US07244861B2
公开(公告)日：2007-07-17
申请号：US10471254
申请日：2002-03-27
申请人： Fumiyoshi Matsuura , Eita Emori , Masanobu Shinoda , Richard Clark , Shunji Kasai , Hideki Yoshitomi , Kazuto Yamazaki , Takashi Inoue , Sadakazu Miyashita , Taro Hihara
发明人： Fumiyoshi Matsuura , Eita Emori , Masanobu Shinoda , Richard Clark , Shunji Kasai , Hideki Yoshitomi , Kazuto Yamazaki , Takashi Inoue , Sadakazu Miyashita , Taro Hihara
IPC分类号： C07C229/00 , C07C227/00
CPC分类号： C07D307/79 , A61K31/00 , C07C233/87 , C07C235/12 , C07C235/52 , C07C255/60 , C07C2601/08 , C07C2601/14 , C07D261/18 , C07D277/56 , C07D417/12
摘要： The present invention provides a medicament comprising a benzene compound useful as an insulin sensitizer, a salt thereof or a hydrate of them and a derivative of them as the active ingredient. Specifically, it provides a benzene compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, X represents 1) a C6-10 aryl group which may have one or more substituents or 2) a 5- to 10-membered heteroaryl group which may have one or more substituents; Y represents a group represented by the formula: (in the above formulae, Ry1, Ry2 and Ry3 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, or a C3-7 cycloalkyl group) etc.; Z represents a group represented by the formula: (in the formula, m represents an integer of 0 to 2; Rz1, Rz2, Rz3 and Rz4 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-7 cycloalkyl group, a halogenated C1-6 alkyl group, a halogenated C1-6 alkoxy group etc.); and R1, R2, R3 and R4 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-7 cycloalkyl group etc.
摘要翻译：本发明提供一种药物，其包含可用作胰岛素敏化剂的苯化合物，其盐或它们的水合物及其衍生物作为活性成分。具体地说，它提供由下式表示的苯化合物，其盐或它们的水合物。在该式中，X表示1）可具有一个或多个取代基的C 6-14芳基，或2）可具有一个或多个取代基的5至10元杂芳基; Y表示由下式表示的基团：（在上式中，R y1，R y2，R y2，R y3和Y 3都相同或不同）各自表示氢原子，卤素原子，C 1-6烷基，C 1-6烷氧基或C 1 -C 6烷氧基， 3-7环烷基）等; Z表示由下式表示的基团：（式中，m表示0〜2的整数，R 0，Z 1，R z，Z 2，R z， SUP＆gt;和R z4彼此相同或不同，并且各自表示氢原子，卤素原子，C 1-6烷基，C 1〜 C 1-6烷基，C 3-7环烷基，卤代C 1-6烷基，卤代C 1 -6个烷氧基等）; 且R 1，R 2，R 3和R 4彼此相同或不同，并且各自表示氢原子，卤素原子，C 1-6烷基，C 1-6烷氧基，C 3-7烷基， SUB>环烷基等

96. 发明授权

US07244730B2 2-iminopyrrolidine derivatives 有权
标题翻译： 2-亚氨基吡咯烷衍生物
公开(公告)号：US07244730B2
公开(公告)日：2007-07-17
申请号：US10475188
申请日：2002-04-19
申请人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musya , Motoji Kogushi , Tsutomu Kawada , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
发明人： Shuichi Suzuki , Makoto Kotake , Mitsuaki Miyamoto , Tetsuya Kawahara , Akiharu Kajiwara , Ieharu Hishinuma , Kazuo Okano , Syuhei Miyazawa , Richard Clark , Fumihiro Ozaki , Nobuaki Sato , Masanobu Shinoda , Atsushi Kamada , Itaru Tsukada , Fumiyoshi Matsuura , Yoshimitsu Naoe , Taro Terauchi , Yoshiaki Oohashi , Osamu Ito , Hiroshi Tanaka , Takashi Musya , Motoji Kogushi , Tsutomu Kawada , Toshiyuki Matsuoka , Hiroko Kobayashi , Ken-ichi Chiba , Akifumi Kimura , Naoto Ono
IPC分类号： A61K31/535 , A61K31/40 , C07D265/30 , C07D241/04 , C07D209/44
CPC分类号： C07D209/44
摘要： A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101–R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10—R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc.; and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocyclic ring], etc.}, or a salt thereof.
摘要翻译：由下式表示的2-亚氨基吡咯烷衍生物：其中环B表示苯环，吡啶环等; R 101为-O-，卤素，C 1-6烷基等; R 5表示氢，C 1-6烷基，C 1-6烷氧基-C 1-6烷基等等 R 6表示氢，C 1-6烷基，C 1-6烷氧基羰基等; Y 1表示单键，-CH 2 - 等; Y 2表示单键，-CO-等; 和Ar表示氢，由下式表示的基团：其中R 10 -R 14表示氢，C 1-6烷基，羟基 C 1-6烷氧基等; 并且R 11和R 12或R 12和R 13可以键合在一起形成5-8个 - 杂环]等，或其盐。

97. 发明申请

US20070135664A1 PROCESS TO BLEND A MINERAL DERIVED HYDROCARBON PRODUCT AND A FISCHER-TROPSCH DERIVED HYDROCARBON PRODUCT 审中-公开
标题翻译：混合矿物烃类产品和FISCHER-TROPSCH衍生的油品的工艺
公开(公告)号：US20070135664A1
公开(公告)日：2007-06-14
申请号：US11534112
申请日：2006-09-21
申请人： Claire Ansell , Richard Clark , Richard Heins
发明人： Claire Ansell , Richard Clark , Richard Heins
IPC分类号： C10M101/02 , C10L5/00
CPC分类号： C10L1/04 , C10G2/30 , C10L1/02
摘要： A process to blend a mineral derived hydrocarbon product and a Fischer-Tropsch derived hydrocarbon product is disclosed including the step of providing in an Above Ground Storage Tank a quantity of mineral derived hydrocarbon product and Fischer-Tropsch derived hydrocarbon product such that initially the mineral derived hydrocarbon product is located substantially above the Fischer-Tropsch derived hydrocarbon product.
摘要翻译：公开了一种混合矿物衍生的烃产物和费 - 托衍生的烃产物的方法，包括在地上储存罐中提供一定量的矿物衍生的烃产物和费 - 托衍生的烃产物的步骤，使得最初的矿物衍生烃产物基本上位于费 - 托衍生烃产物的上方。

98. 发明申请

US20070055626A1 Method and system for reporting cashflows to clients 有权
标题翻译：向客户报告现金流量的方法和系统
公开(公告)号：US20070055626A1
公开(公告)日：2007-03-08
申请号：US11514206
申请日：2006-09-01
申请人： Serge Rivest , Michael King , Richard Clark
发明人： Serge Rivest , Michael King , Richard Clark
IPC分类号： G06Q40/00
CPC分类号： G06Q40/06 , G06Q20/10 , G06Q20/102 , G06Q30/08 , G06Q40/00 , G06Q40/02 , G06Q40/025
摘要： A system and method of providing a client with cashflow monitoring during a transfer of services (e.g. pre-authorized debits and credits) from a first account to a second account, the method comprising the steps of: (i) determining an effective date for the transfer of each service, said effective dates creating a transfer window; (ii) determining cashflows for said first account and said second account during said transfer window; (iii) adjusting effective dates for transfer of each services to avoid cashflow interruptions in said first and said second accounts; and (iv) providing a cashflow analysis to the client that lists all the effective dates for each service transfer and predicted cashflows for said first and said second account during said transfer window.
摘要翻译：一种在从第一帐户转移到第二帐户的服务转移（例如预授权借记和信用）期间向客户提供现金流监视的系统和方法，所述方法包括以下步骤：（i）确定所述客户端的生效日期传输每个服务，表示生效日期创建一个转移窗口; （ii）在所述传送窗口期间确定所述第一帐户和所述第二帐户的现金流; （iii）调整每个服务的转移的生效日期以避免所述第一和第二帐户中的现金流中断; 以及（iv）向所述客户提供现金流分析，列出在所述转移窗口期间所述第一帐户和所述第二账户的每个服务转移的所有生效日期和所述预测的现金流。

99. 发明申请

US20070055116A1 Mobile clinical workstation 有权
标题翻译：移动临床工作站
公开(公告)号：US20070055116A1
公开(公告)日：2007-03-08
申请号：US11358164
申请日：2006-02-21
申请人： Richard Clark , Michael Jacobs , Steven Flemig , Fouad Abu-Akel , Darin Janoschka , Keith Washington
发明人： Richard Clark , Michael Jacobs , Steven Flemig , Fouad Abu-Akel , Darin Janoschka , Keith Washington
IPC分类号： A61B5/00
CPC分类号： G06F1/1632 , A61B5/0002 , G06F1/1635 , G06F1/1637 , G06F1/166 , G06F1/1662 , G06F1/1686 , G06F1/26 , G06F19/00 , G06F19/3418 , H02J7/0045 , Y10S248/918
摘要： A mobile workstation for use with a computer network. The mobile workstation may include a medical monitoring device, a radio transceiver in communication with the medical monitoring device operable for receiving and sending data to the computer network, a display screen, and a wheeled chassis for mounting the medical monitoring device, the radio transceiver and the display screen.
摘要翻译：用于计算机网络的移动工作站。移动工作站可以包括医疗监视设备，与医疗监视设备通信的无线电收发器，可操作用于向计算机网络接收和发送数据，显示屏幕和用于安装医疗监控设备的轮式底盘，无线电收发器和显示屏幕。

100. 发明申请

US20060262156A1 Constant current mode firing circuit for thermal inkjet-printing nozzle 有权
标题翻译：用于热喷墨打印喷嘴的恒流模式点火电路
公开(公告)号：US20060262156A1
公开(公告)日：2006-11-23
申请号：US11134015
申请日：2005-05-20
申请人： Hang Liao , Bao Yeh , Galen Kawamoto , Dennis Schloeman , Richard Clark
发明人： Hang Liao , Bao Yeh , Galen Kawamoto , Dennis Schloeman , Richard Clark
IPC分类号： B41J29/38
CPC分类号： B41J2/04541 , B41J2/0455 , B41J2/04555 , B41J2/0457 , B41J2/0458
摘要： A firing circuit for a thermal inkjet-printing nozzle includes a heater resistor and a switch. The heater resistor heats ink to cause the ink to be ejected from the nozzle. The heater resistor has a first end and a second end, the second end connected to a ground. The switch controls activation of the heater resistor. The switch has a first end connected to a voltage source and a second end connected to the first end of the heater resistor. The switch operates in a constant current mode, such that an at least substantially constant current flows through the heater resistor upon activation.
摘要翻译：用于热喷墨打印喷嘴的点火电路包括加热电阻器和开关。加热电阻加热墨水使墨水从喷嘴喷出。加热电阻器具有第一端和第二端，第二端连接到地。开关控制加热电阻的激活。开关具有连接到电压源的第一端和连接到加热电阻器的第一端的第二端。开关工作在恒定电流模式，使得至少基本上恒定的电流在激活时流过加热电阻器。

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