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91. 发明授权

US4587737A Hand punch 失效
标题翻译：手打
公开(公告)号：US4587737A
公开(公告)日：1986-05-13
申请号：US637067
申请日：1984-08-02
申请人： James M. Wilson
发明人： James M. Wilson
IPC分类号： B21D28/34 , B26F1/32
CPC分类号： B21D28/34 , B26F1/32 , Y10T83/8847
摘要： There is disclosed a hand punch comprising a C-shaped member having a punch and die mounted in the extremities thereof. A rotary head having a threaded member axially disposed therein is mounted for rotation in one extremity of the C and the punch or cutting head is mounted on that member so that, when the rotary head is rotated, the cutting head is advanced into the die. The cutting head has cutting edges adapted to bite into the material to be punched and to hold it against rotation. It is threaded onto the threaded member by a reverse thread so that, once it bites into the material to be punched, the threaded member is held against rotation, whereby rotation of the rotary head drives the punch into the die.
摘要翻译：公开了一种手动冲头，其包括C形构件，其具有安装在其四肢中的冲头和模具。安装有轴向设置在其中的螺纹构件的旋转头安装成用于在C的一个末端旋转，并且冲头或切割头安装在该构件上，使得当旋转头旋转时，切割头前进到模具中。切割头具有适于咬入要冲压的材料并保持其抵抗旋转的切割边缘。它通过反向螺纹螺纹连接到螺纹构件上，使得一旦咬入被冲击的材料中，螺纹构件被保持抵抗旋转，由此旋转头的旋转将冲头驱动到模具中。

92. 发明授权

US08999678B2 Method of increasing the function of an AAV vector 有权
标题翻译：增加AAV载体功能的方法
公开(公告)号：US08999678B2
公开(公告)日：2015-04-07
申请号：US11887679
申请日：2006-04-07
申请人： Luk Vandenberghe , Guangping Gao , James M. Wilson
发明人： Luk Vandenberghe , Guangping Gao , James M. Wilson
IPC分类号： C12N15/86 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61K48/0091 , C07K14/005 , C12N7/00 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14152
摘要： A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
摘要翻译：提供了一种校正所选AAV序列中的单体以提高所选AAV的包装产率，转导效率和/或基因转移效率的方法。该方法涉及改变亲本AAV衣壳中的一个或多个单体以使单体与对准的功能性AAV衣壳序列的相应位置中的氨基酸一致。

93. 发明授权

US08834863B2 Subfamily E simian adenoviruses A1321, A1325, A1295, A1309, A1316 and A1322 and uses thereof 有权
标题翻译：亚家族猿猴腺病毒A1321，A1325，A1295，A1309，A1316和A1322及其用途
公开(公告)号：US08834863B2
公开(公告)日：2014-09-16
申请号：US13475535
申请日：2012-05-18
申请人： Soumitra Roy , James M. Wilson
发明人： Soumitra Roy , James M. Wilson
IPC分类号： C12N15/861 , C12N7/01 , C07K14/075 , C12N15/33
CPC分类号： A61K35/761 , A61K48/00 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10021 , C12N2710/10022 , C12N2710/10041 , C12N2710/10043 , C12N2710/10321 , C12N2710/10322 , C12N2710/10334 , C12N2710/10343
摘要： Recombinant vectors comprise simian adenovirus A1321 (SAdV-A1321), SAdV-A1325, SAdV-A1295, SAdV-A1309, SAdV-A1316, and/or SAdV-A1322 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1321, SAdV-A1325, SAdV-A1295, SAdV-A1309, SAdV-A1316, and/or SAdV-A1322 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
摘要翻译：重组载体包含猿猴腺病毒A1321（SAdV-A1321），SAdV-A1325，SAdV-A1295，SAdV-A1309，SAdV-A1316和/或SAdV-A1322序列和在调节序列控制下的异源基因。还公开了表达猿腺病毒SAdV-A1321，SAdV-A1325，SAdV-A1295，SAdV-A1309，SAdV-A1316和/或SAdV-A1322基因的细胞系。提供了使用载体和细胞系的方法。

94. 发明申请

US20140031418A1 Regimens and Compositions for AAV-Mediated Passive Immunization of Airborne Pathogens 审中-公开
标题翻译： AAV介导的机载病原体被动免疫的方案和组成
公开(公告)号：US20140031418A1
公开(公告)日：2014-01-30
申请号：US14112802
申请日：2012-04-20
申请人： James M. Wilson , Maria P. Limberis
发明人： James M. Wilson , Maria P. Limberis
IPC分类号： A61K31/713
CPC分类号： A61K31/713 , A61K39/07 , A61K2039/505 , A61K2039/5256 , A61K2039/53 , A61K2039/543 , C07K16/1018 , C12N2750/14132
摘要： A prophylactic regimen for passively preventing infection with a pathogen which has a typical route of infection through the nasopharynx region of a subject, e.g., an airborne virus typically transmitted through coughing or sneezing. The method involves specifically targeting a subject's nasopharynx with a viral vector comprising an AAV capsid and carrying a nucleic acid sequence encoding an anti-viral neutralizing antibody construct operably linked to expression control sequences, in order to provide for high levels of expression of the anti-viral neutralizing antibody construct in the nasal airway cells. Optionally, the neutralizing antibody construct is expressed under a promoter which is regulated or induced by a small molecule which is delivered separately from the viral vector. In one embodiment, the method permits transfection of a subject's nasopharynx even where the subject has circulating neutralizing antibodies against the AAV capsid.
摘要翻译：用于被动地预防感染病原体的预防方案，所述病原体具有典型的通过受试者的鼻咽部感染途径，例如通常通过咳嗽或打喷嚏传播的空气传播的病毒。该方法包括用包含AAV衣壳的病毒载体特异性靶向受试者的鼻咽，并携带编码与表达控制序列可操作地连接的抗病毒中和抗体构建体的核酸序列，以便提供高水平的抗 - 鼻气管细胞中的病毒中和抗体构建体。任选地，中和抗体构建体在由与病毒载体分开递送的小分子调节或诱导的启动子表达。在一个实施方案中，即使受试者具有针对AAV衣壳的循环中和抗体，该方法也允许转染受试者的鼻咽。

95. 发明申请

US20130209037A1 CABLE LEG AND CONNECTOR MANAGEMENT SYSTEM 有权
标题翻译：电缆连接器管理系统
公开(公告)号：US20130209037A1
公开(公告)日：2013-08-15
申请号：US13420079
申请日：2012-03-14
申请人： Terry L. Cooke , Christopher S. Houser , Ronald A. Leonard , James M. Wilson
发明人： Terry L. Cooke , Christopher S. Houser , Ronald A. Leonard , James M. Wilson
IPC分类号： G02B6/38
CPC分类号： G02B6/4465 , G02B6/3849
摘要： An interconnect assembly includes an optical fiber cable, legs, connectors, and covers. The optical fiber cable includes a jacket and sub-units. The jacket has an interior defining a passage and the sub-units extend through the passage and include optical fibers extending lengthwise through the sub-units. The legs of the interconnect assembly extend from the passage on an end of the jacket, where the legs are continuations of or extensions from the sub-units such that the optical fibers further extend through the legs. The connectors are attached to the optical fibers on distal ends of the legs and the covers are attached to the connectors. The covers each include an end having a track for wrapping one or more of the legs over in order to package the legs and connectors, such as for placement of the legs and connectors within a pulling grip for installation of the interconnect assembly through a duct.
摘要翻译：互连组件包括光纤电缆，支腿，连接器和盖。光缆包括夹套和子单元。护套具有限定通道的内部，并且子单元延伸穿过通道并且包括纵向延伸穿过子单元的光纤。互连组件的腿部从夹套的端部上的通道延伸，其中腿部是子单元的延伸或延伸，使得光纤进一步延伸穿过腿部。连接器附接到腿的远端处的光纤，并且盖连接到连接器。盖子包括具有用于将一个或多个腿部包裹以覆盖腿部和连接器的轨道的端部，例如用于将腿部和连接器放置在牵引夹具内，以通过导管安装互连组件。

96. 发明申请

US20120197896A1 SYSTEM AND METHOD FOR DETECTING, COLLECTING, ANALYZING, AND COMMUNICATING EVENT-RELATED INFORMATION 有权
标题翻译：用于检测，收集，分析和传播事件相关信息的系统和方法
公开(公告)号：US20120197896A1
公开(公告)日：2012-08-02
申请号：US13192160
申请日：2011-07-27
申请人： Peter C. LI , Jeffrey R. Collmann , Jane W. Blake , Mark G. Polyak , James M. Wilson , Jae In Yoon , Manabu Torii , Carla S. Thomas
发明人： Peter C. LI , Jeffrey R. Collmann , Jane W. Blake , Mark G. Polyak , James M. Wilson , Jae In Yoon , Manabu Torii , Carla S. Thomas
IPC分类号： G06F17/30
CPC分类号： G06F19/3493 , G06F17/30616 , G06F19/00 , G06Q10/04 , G06Q50/22 , G06Q50/26 , G16H50/80 , H04L29/08072 , Y02A90/22 , Y02A90/24
摘要： A system and method involves detecting operational social disruptive events on a global scale, assigning event staging and warnings to express data in more simplistic terms, modeling data in conjunction with linguistics analysis to establish responsive actions, generating visualization and modeling capabilities for communicating information, and modeling propagation of events for containment and forecasting purposes.
摘要翻译：一种系统和方法涉及在全球范围内检测运营的社会破坏性事件，分配事件分段和警告以更简单的术语表达数据，结合语言学分析建模数据以建立响应动作，生成用于传达信息的可视化和建模能力，以及用于遏制和预测目的的事件建模传播。

97. 发明申请

US20120128305A1 FIBER OPTIC CABLE ASSEMBLY 有权
标题翻译：光纤电缆总成
公开(公告)号：US20120128305A1
公开(公告)日：2012-05-24
申请号：US12953207
申请日：2010-11-23
申请人： Terry L. Cooke , David L. Dean, JR. , Christopher S. Houser , James M. Wilson
发明人： Terry L. Cooke , David L. Dean, JR. , Christopher S. Houser , James M. Wilson
IPC分类号： G02B6/44 , B29C65/02 , G02B6/36
CPC分类号： G02B6/3887
摘要： A fiber optic cable assembly includes a fiber optic connector and a fiber optic cable having at least one strength element, the connector and cable held together by a crimp band. The crimp band may include at least one lateral aperture on at least one end for inspecting the disposition of the strength element prior to crimping to ensure a uniform distribution of the strength element.
摘要翻译：光纤电缆组件包括光纤连接器和具有至少一个强度元件的光纤电缆，该连接器和电缆通过压接带保持在一起。压接带可以包括至少一个端部上的至少一个侧向孔口，用于在压接之前检查强度元件的布置，以确保强度元件的均匀分布。

98. 发明申请

US20110263027A1 Adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby 有权
标题翻译：腺相关病毒（AAV）序列并分离鉴定的新序列
公开(公告)号：US20110263027A1
公开(公告)日：2011-10-27
申请号：US11985096
申请日：2007-11-14
申请人： Guangping Gao , James M. Wilson , Mauricio R. Alvira
发明人： Guangping Gao , James M. Wilson , Mauricio R. Alvira
IPC分类号： C12N7/01 , C12N5/10 , C12N1/21 , C12N15/34 , C07K14/075 , C07K7/06 , C07K7/08 , C12N15/11 , C12N15/86 , C12N1/19
CPC分类号： C12N15/86 , A61K38/177 , A61K38/4846 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152 , C12N2750/14162 , C12N2750/14171 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12Q1/701 , C12Q2600/158 , C12Y304/21022
摘要： Adeno-associated virus 7 sequences, vectors containing same, and methods of use are provided.
摘要翻译：提供了腺相关病毒7序列，含有其的载体和使用方法。

99. 发明申请

US20090227030A1 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor 有权
标题翻译：腺相关病毒（AAV）血清型8序列，含有其的载体及其用途
公开(公告)号：US20090227030A1
公开(公告)日：2009-09-10
申请号：US11981022
申请日：2007-10-31
申请人： Guangping Gao , James M. Wilson , Mauricio R. Alvira
发明人： Guangping Gao , James M. Wilson , Mauricio R. Alvira
IPC分类号： C12N15/87 , C12N15/63 , C12N15/86 , C12N5/10
CPC分类号： C12N15/86 , A61K9/0019 , A61K35/761 , A61K38/177 , A61K38/45 , A61K38/4846 , A61K48/00 , C07K14/005 , C07K14/705 , C07K14/755 , C12N7/00 , C12N9/1018 , C12N9/644 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y201/03003 , C12Y304/21021 , C12Y304/21022
摘要： Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles.
摘要翻译：提供血清型8腺相关病毒和含有这些序列的载体和宿主细胞的序列。还描述了在生产rAAV颗粒中使用这种宿主细胞和载体的方法。

100. 发明申请

US20080270130A1 SYSTEMS AND METHODS FOR REDUCING ANNOTATION TIME 有权
标题翻译：减少安息时间的系统和方法
公开(公告)号：US20080270130A1
公开(公告)日：2008-10-30
申请号：US12165755
申请日：2008-07-01
申请人： Tirso M. Alonso , Ilana Bromberg , Dilek Z. Hakkani-Tur , Barbara B. Hollister , Mazin G. Rahim , Giuseppe Riccardi , Lawrence Lyon Rose , Daniel Leon Stern , Gokhan Tur , James M. Wilson
发明人： Tirso M. Alonso , Ilana Bromberg , Dilek Z. Hakkani-Tur , Barbara B. Hollister , Mazin G. Rahim , Giuseppe Riccardi , Lawrence Lyon Rose , Daniel Leon Stern , Gokhan Tur , James M. Wilson
IPC分类号： G10L15/00
CPC分类号： G10L15/19 , G10L15/063 , G10L15/183 , H04M3/4936
摘要： Systems and methods for annotating speech data. The present invention reduces the time required to annotate speech data by selecting utterances for annotation that will be of greatest benefit. A selection module uses speech models, including speech recognition models and spoken language understanding models, to identify utterances that should be annotated based on criteria such as confidence scores generated by the models. These utterances are placed in an annotation list along with a type of annotation to be performed for the utterances and an order in which the annotation should proceed. The utterances in the annotation list can be annotated for speech recognition purposes, spoken language understanding purposes, labeling purposes, etc. The selection module can also select utterances for annotation based on previously annotated speech data and deficiencies in the various models.
摘要翻译：用于注释语音数据的系统和方法。本发明通过选择最有益的用于注释的话语来减少注释语音数据所需的时间。选择模块使用包括语音识别模型和语言理解模型在内的语音模型来基于诸如由模型产生的置信度得分的标准来识别应当注释的话语。这些话语被放置在注释列表中，以及要为语句执行的注释类型以及注释应该继续执行的顺序。注释列表中的话语可以被注释用于语音识别目的，语言理解目的，标签目的等。选择模块还可以基于先前注释的语音数据和各种模型中的缺陷来选择用于注释的话语。

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