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91. 发明授权

US06384032B1 Inhibitors of IL-12 production 有权
标题翻译： IL-12抑制剂的生产
公开(公告)号：US06384032B1
公开(公告)日：2002-05-07
申请号：US09594362
申请日：2000-06-15
申请人： Mitsunori Ono , Yumiko Wada , Beatrice Brunkhorst , Tadeusz Warchol , Wojciech Wrona , Dan Zhou , Nha Huu Vo , Stephen Gillies
发明人： Mitsunori Ono , Yumiko Wada , Beatrice Brunkhorst , Tadeusz Warchol , Wojciech Wrona , Dan Zhou , Nha Huu Vo , Stephen Gillies
IPC分类号： C07D25146
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12
摘要： The invention relates to a compound of formula (I) which can inhibit the production of IL-12. Also disclosed is a method of inhibiting IL-12 production by administering to a patient in need thereof an effective amount of a compound of formula (I).
摘要翻译：本发明涉及可抑制IL-12产生的式（I）化合物。还公开了通过向有需要的患者施用有效量的式（I）化合物来抑制IL-12产生的方法。

92. 发明授权

US06303157B1 Extracts of kava-kava 失效
标题翻译：卡瓦卡拉的提取物
公开(公告)号：US06303157B1
公开(公告)日：2001-10-16
申请号：US09584220
申请日：2000-05-31
申请人： Mitsunori Ono , Lan Bo Chen
发明人： Mitsunori Ono , Lan Bo Chen
IPC分类号： A01N6500
CPC分类号： A61K31/366 , A61K31/365 , A61K47/40
摘要： This invention relates to a kava-kava lactone-containing product. Also disclosed is a method of preparing such a kava-kava lactone-containing product by extracting kava-kava lactones from crude kava-kava extracts with a solubilizing agent.
摘要翻译：本发明涉及含有卡拉卡瓦内酯的产品。还公开了一种通过用增溶剂从粗卡瓦卡瓦提取物中提取卡瓦卡诺内酯来制备这种含有卡拉卡含内酯的产品的方法。

93. 发明授权

US5300421A Method for quantitative measurement of trace enzyme and substrate used therein 失效
标题翻译：其中使用的痕量酶和底物的定量测定方法
公开(公告)号：US5300421A
公开(公告)日：1994-04-05
申请号：US727347
申请日：1991-07-08
申请人： Nobuhito Masuda , Nobuo Suzuki , Shoji Ishiguro , Mitsunori Ono
发明人： Nobuhito Masuda , Nobuo Suzuki , Shoji Ishiguro , Mitsunori Ono
IPC分类号： C12Q1/00 , G01N33/535 , G01N33/58 , G01N33/53
CPC分类号： C12Q1/00 , G01N33/535 , G01N33/581
摘要： A synthetic substrate used for quantitative analysis of a trace enzyme. The substrate has a molecular structure (B)-(A)-(C) comprising at least one structure (A) catalytically affected by the enzyme to be analysed, at least one photographically active labelling structure (B) linked to the structure (A) and at least one specific adsorbing structure (C) linked to the structure (A). The substrate is used in a quantitative analysis of a trace enzyme, in which the structure (A) or the linkage between the structure (A) and the structure (C), or the linkage between the structure (B) and the structure (A) is cleaved by the action of the analyte enzyme. The reaction product of the enzymatic reaction is separated by allowing the same to contact with an adsorbent for the structure (C). The separated reaction product is developed photographically and then the optical density of the resultant developed silver and/or colored dye is measured.
摘要翻译：用于痕量酶定量分析的合成底物。底物具有分子结构（B） - （A） - （C） - 包含至少一种被待分析酶催化影响的结构（A），至少一种与结构连接的照相活性标记结构（B））和至少一种与结构（A）连接的特定吸附结构（C）。该基质用于微量酶的定量分析，其中结构（A）或结构（A）和结构（C）之间的连接或结构（B）和结构（A）之间的连接）被分析物酶的作用切割。通过使酶反应的反应产物与用于结构（C）的吸附剂接触来分离。分离出的反应产物用照相机显影，然后测量所得显影的银和/或着色染料的光密度。

94. 发明授权

US5204217A Photosensitive composition 失效
标题翻译：感光组合物
公开(公告)号：US5204217A
公开(公告)日：1993-04-20
申请号：US641834
申请日：1991-01-16
申请人： Toshiaki Aoai , Mitsunori Ono
发明人： Toshiaki Aoai , Mitsunori Ono
IPC分类号： G03F7/039 , C08F20/22 , C08F20/26 , C08F26/00 , C08F28/00 , C08F28/02 , C08F34/00 , C08F212/00 , C08F212/08 , G03F7/004 , H01L21/027
CPC分类号： G03F7/0045
摘要： A photosensitive composition containing a compound having a group represented by formula (I) or (II), said group, when irradiated with actinic radiation, forming a carboxylic acid or a sulfonic acid: ##STR1## where R.sub.1 represents hydrogen, an alkyl group, or an aryl group; andR.sub.2 to R.sub.6 may be the same or different and each represents hydrogen, a halogen, an alkoxyl group, an aryloxyl group, cyano group, or an alkyl group, provided that at least one of R.sub.2 to R.sub.6 represents an alkoxyl or aryloxyl group and two of R.sub.2 to R.sub.6 may link to form a ring.
摘要翻译：（I）或（II）表示的具有式（I）或（II）表示的基团的化合物的光敏组合物，所述基团用光化辐射照射时，形成羧酸或磺酸。其中R1表示氢，烷基或芳基; 并且R 2至R 6可以相同或不同，各自表示氢，卤素，烷氧基，芳氧基，氰基或烷基，条件是R 2至R 6中的至少一个表示烷氧基或芳氧基， R2到R6中的两个可以链接形成环。

95. 发明授权

US5117034A Phosphatidylserine derivatives 失效
标题翻译：磷脂酰丝氨酸衍生物
公开(公告)号：US5117034A
公开(公告)日：1992-05-26
申请号：US602557
申请日：1990-10-24
申请人： Mitsunori Ono , Hideto Mori
发明人： Mitsunori Ono , Hideto Mori
IPC分类号： C07F9/09 , C07F9/12
CPC分类号： C07F9/12 , C07F9/091 , Y02P20/55
摘要： A phosphatidylserine derivative represented by formulae (I), (II), and (III): ##STR1## wherein R represents a protective group which can be removed by an acid; and R' represents a straight chain or branched alkyl group having from 8 to 24 carbon atoms and may contain a substituent group, or may be unsaturated, provided that if an asymmetric carbon is present, the phosphatidylserine derivative is a racemic mixture or an optically active isomer thereof. Preferably, R represents a tertiary butoxycarbonyl group; R' represents a straight chain or branched alkyl group having 14, 16, or 18 carbon atoms; and the substituent is an alkylcarbonyl group, an alkoxycarbonyl group, a halogen atom, or an aryl group.
摘要翻译：（I），（II）和（III）表示的磷脂酰丝氨酸衍生物：其中R表示可被酸除去的保护基， ; 并且R'表示具有8至24个碳原子并且可以含有取代基的直链或支链烷基，或可以是不饱和的，条件是如果存在不对称碳，则磷脂酰丝氨酸衍生物是外消旋混合物或光学活性异构体。优选地，R表示叔丁氧基羰基; R'表示具有14,16或18个碳原子的直链或支链烷基; 取代基是烷基羰基，烷氧基羰基，卤素原子或芳基。

96. 依法登记的发明

USH782H Silver halide color photographic material 失效
公开(公告)号：USH782H
公开(公告)日：1990-05-01
申请号：US95714
申请日：1987-09-14
申请人： Mitsunori Ono , Koji Tamoto , Yoshisada Nakamura , Shingo Sato
发明人： Mitsunori Ono , Koji Tamoto , Yoshisada Nakamura , Shingo Sato
IPC分类号： G03C7/26 , G03C7/32 , G03C7/38
CPC分类号： G03C7/3225
摘要： A silver halide color photographic material in disclosed which comprises a support having thereon at least one silver halide emulsion layer, wherein the photographic material contains at least one compound represented by general formula (I) and at least one compound represented by general formula (II) in combination:Cp--(TIME).sub.n --X--Dye (I)wherein Cp represents a coupler residue capable of releasing --(TIME).sub.n --X--Dye upon coupling with an oxidation product of an aromatic primary amine developing agent; TIME represents a timing group; n represents 0 or a positive integer; Dye represents a dye residue, and X represents an auxochromic group of said dye; ##STR1## wherein R represents a hydrogen atom or a substituent; Y represents a hydrogen atom or a coupling-off group; Za, Zb and Zc each represents a methine group, a substituted methine group, .dbd.N-- or --NH--; either the Za--Zb bond or the Zb-Zc bond represents a double bond and the other represents a single bond, provided that when Za, Zb or Zc represents a substituted methine group, one of the substituted methine group or R may be a divalent group capable of linking to form a dimer or higher polymer, and provided that Y does not represent --(TIME).sub.n --X--Dye as defined in general formula (I). The photographic material has improved sharpness and color reproducibility.

97. 发明授权

US4743595A Process for preparing 2-amino-5-nitrophenol derivatives 失效
标题翻译： 2-氨基-5-硝基苯酚衍生物的制备方法
公开(公告)号：US4743595A
公开(公告)日：1988-05-10
申请号：US743956
申请日：1985-06-12
申请人： Isamu Itoh , Mitsunori Ono , Hidetoshi Kobayashi , Kazuyoshi Yamakawa
发明人： Isamu Itoh , Mitsunori Ono , Hidetoshi Kobayashi , Kazuyoshi Yamakawa
IPC分类号： C07C213/00 , C07C215/76 , C07C233/75 , C07D233/60 , C07D263/56 , C07D263/57 , C07D295/08 , C07D307/68 , C07D413/04 , C07D413/12 , C09B29/00 , C07C149/42 , C07C87/60 , C07C91/40 , C07C103/87
CPC分类号： C07D263/56 , C07D263/57 , C07D307/68 , C07D413/04
摘要： A process for efficiently preparing 2-amino-5-nitrophenol derivatives in which benzoxazole derivatives are subjected to nucleophilic substitution reaction at the 5 position thereof to obtain corresponding benzoxazole derivatives, and the oxazole ring of the benzoxazole derivatives is then subjected to ring-opening to obtain 2-amino-5-nitrophenol derivatives. The 2-amino-5-nitrophenol derivatives are useful as industrial starting materials, reducing agents or antioxidants and intermediates for cyan-image-forming couplers.
摘要翻译：一种有效制备其中苯并恶唑衍生物在其5位进行亲核取代反应以获得相应的苯并恶唑衍生物的2-氨基-5-硝基苯酚衍生物的方法，然后将苯并恶唑衍生物的恶唑环进行开环得到2-氨基-5-硝基苯酚衍生物。 2-氨基-5-硝基苯酚衍生物可用作工业起始材料，还原剂或抗氧化剂以及用于青色成像成色剂的中间体。

98. 发明授权

US4734353A Methods using oximes for processing a silver halide photographic light-sensitive material 失效
标题翻译：使用肟处理卤化银照相感光材料的方法
公开(公告)号：US4734353A
公开(公告)日：1988-03-29
申请号：US857505
申请日：1986-04-21
申请人： Mitsunori Ono , Isamu Itoh , Keiji Mihayashi
发明人： Mitsunori Ono , Isamu Itoh , Keiji Mihayashi
IPC分类号： G03C7/26 , G03C1/10 , G03C1/43 , G03C5/305 , G03C7/305 , G03C5/54 , G03C5/26
CPC分类号： G03C7/305 , G03C1/10 , G03C1/43 , Y10S430/156 , Y10S430/158 , Y10S430/16
摘要： A method for processing a silver halide photographic light-sensitive material comprising a support having thereon a light-sensitive silver halide emulsion layer having associated therewith a blocked photographic agent capable of releasing a photographically useful agent, which method comprises processing the photographic light-sensitive material in the presence of an oxime.According to this method for processing a silver halide photographic light-sensitive material, both stability of the photographic light-sensitive material during storage and release of a photographically useful agent during processing are achieved without undersirable side-reactions, and a high sensitivity/fog ratio is obtained.
摘要翻译：一种用于处理卤化银照相感光材料的方法，其包括其上具有感光卤化银乳剂层的载体，其具有能够释放照相用的试剂的封闭的照相剂，该方法包括处理照相感光材料在肟的存在下。根据这种用于处理卤化银照相感光材料的方法，在加工过程中摄影感光材料在照相感光材料的储存和释放期间的稳定性都达不到不需要的副反应，并且高灵敏度/雾度比获得。

99. 发明授权

US4500636A Silver halide photographic light-sensitive material 失效
标题翻译：卤化银照相感光材料
公开(公告)号：US4500636A
公开(公告)日：1985-02-19
申请号：US574432
申请日：1984-01-27
申请人： Mitsunori Ono , Isamu Itoh , Keiji Mihayashi , Yukio Karino
发明人： Mitsunori Ono , Isamu Itoh , Keiji Mihayashi , Yukio Karino
IPC分类号： G03C7/26 , C07D405/12 , G03C1/06 , G03C1/42 , G03C7/305 , G03C1/02
CPC分类号： C07D405/12 , G03C1/06 , G03C7/30511 , Y10S430/156 , Y10S430/158 , Y10S430/159 , Y10S430/16 , Y10S430/161
摘要： A silver halide photographic light-sensitive material which comprises a light-sensitive silver halide emulsion layer having associated therewith a blocked photographic agent, said blocked photographic agent being represented by the following general formula (I): ##STR1## wherein A represents a photographic agent moiety which is attached to a blocking moiety through a hetero atom; Z represents a divalent linkage group; p represents 0 or 1; X and Y each represents a substituent: m represents an integer of 0 to 4: and n represents an integer of 0 to 5.
摘要翻译：一种卤化银照相感光材料，其包含与其相关联的感光卤化银乳剂层，其中封闭的照相剂，所述封闭的照相剂由以下通式（I）表示：其中A表示通过杂原子连接到阻挡部分的照相剂部分; Z表示二价连接基团; p表示0或1; X和Y各自表示取代基：m表示0〜4的整数，n表示0〜5的整数。

100. 发明授权

US08318224B2 Composition for enhancing physical performance 有权
标题翻译：用于增强身体表现的组合
公开(公告)号：US08318224B2
公开(公告)日：2012-11-27
申请号：US11675576
申请日：2007-02-15
申请人： Thomas Christian Lines , Mitsunori Ono
发明人： Thomas Christian Lines , Mitsunori Ono
IPC分类号： A23L1/302
CPC分类号： A61K31/352 , A23L2/02 , A23L33/105 , A23L33/15 , A23V2002/00 , A61K31/185 , A61K31/353 , A61K31/355 , A61K31/375 , A61K31/4415 , A61K31/445 , A61K31/455 , A61K31/51 , A61K31/522 , A61K31/525 , A61K31/675 , A61K31/7048 , A61K31/714 , A61K36/16 , A61K36/185 , A61K36/48 , A61K45/06 , A61K2300/00 , A23V2250/214 , A23V2250/2116 , A23V2250/2108 , A23V2250/7042 , A23V2250/7044 , A23V2250/7046 , A23V2250/704 , A23V2250/7052 , A23V2250/706 , A23V2250/712 , A23V2250/70 , A23V2200/322 , A23V2250/21168 , A23V2200/33 , A23V2200/30
摘要： This invention relates to a composition that contains quercetin, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, caffeine, epigallocatechin gallate, epicatechin, epicatechin gallate, and epigallocatechin.
摘要翻译：本发明涉及含有槲皮素，维生素B1，维生素B2，维生素B3，维生素B6，维生素B12，维生素C，咖啡因，表没食子儿茶素没食子酸酯，表儿茶素，表儿茶素没食子酸酯和表没食子儿茶素的组合物。

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