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91. 发明授权

US07402596B2 Bicycloheteroaryl compounds as P2X7 modulators and uses thereof 失效
标题翻译：双环杂芳基化合物作为P2X7调节剂及其用途
公开(公告)号：US07402596B2
公开(公告)日：2008-07-22
申请号：US11384199
申请日：2006-03-17
申请人： Michael G. Kelly , John Kincaid
发明人： Michael G. Kelly , John Kincaid
IPC分类号： C07D211/74 , A61K31/47
CPC分类号： C07D217/24 , C07D401/06 , C07D405/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D487/04
摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有下列化学式的双杂环芳基化合物：该化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

92. 发明申请

US20080122068A1 THERMALLY ENHANCED SEMICONDUCTOR PACKAGE 有权
标题翻译：热增强半导体封装
公开(公告)号：US20080122068A1
公开(公告)日：2008-05-29
申请号：US11557884
申请日：2006-11-08
申请人： Michael G. Kelly , Ki Wook Lee , Chang Ho Jang
发明人： Michael G. Kelly , Ki Wook Lee , Chang Ho Jang
IPC分类号： H01L23/36
CPC分类号： H01L23/13 , H01L23/36 , H01L23/3677 , H01L23/4334 , H01L23/49816 , H01L24/48 , H01L2224/48091 , H01L2224/48227 , H01L2924/00014 , H01L2924/01046 , H01L2924/01079 , H01L2924/14 , H01L2924/15153 , H01L2924/1517 , H01L2924/15311 , H01L2924/181 , H01L2924/00 , H01L2924/00012 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： A semiconductor package has a substrate having a first surface, a second surface, and a through hole opening. A heat spreader has a first surface, a second surface, and a plurality of notches formed on the second surface. A semiconductor die is coupled to the first surface of the heat spreader. The semiconductor die is electrically coupled to the substrate. An encapsulant is used to cover portions of the first surface of the substrate, portions of the first surface of the heat spreader, and the semiconductor die. A first set of solder balls is coupled to the second surface of the substrate. A second set of solder balls is coupled to the second surface of the heat spreader wherein the second set of solder balls is located in the notches.
摘要翻译：半导体封装具有具有第一表面，第二表面和通孔开口的基板。散热器具有形成在第二表面上的第一表面，第二表面和多个凹口。半导体管芯耦合到散热器的第一表面。半导体管芯电耦合到衬底。密封剂用于覆盖基板的第一表面的部分，散热器的第一表面的部分和半导体管芯。第一组焊球耦合到衬底的第二表面。第二组焊球联接到散热器的第二表面，其中第二组焊球位于凹口中。

93. 发明授权

US07312330B2 Bicycloheteroarylamine compounds as ion channel ligands and uses thereof 失效
标题翻译：双杂芳基胺化合物作为离子通道配体及其用途
公开(公告)号：US07312330B2
公开(公告)日：2007-12-25
申请号：US11122266
申请日：2005-05-04
申请人： Michael G. Kelly , Satyanarayana Janagani , Guoxian Wu , John Kincaid , David Lonergan , YunFeng Fang , Zhi-Liang Wei
发明人： Michael G. Kelly , Satyanarayana Janagani , Guoxian Wu , John Kincaid , David Lonergan , YunFeng Fang , Zhi-Liang Wei
IPC分类号： C07D471/02 , C07D417/14 , C07D265/30 , A61K31/54 , A61K31/535 , A01N43/40
CPC分类号： C07D471/04
摘要： Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有由下列化学式表示的式的胺化合物：该化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的各种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

94. 发明授权

US07312233B2 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same 失效
标题翻译：酰胺衍生物作为离子通道配体和药物组合物及其使用方法
公开(公告)号：US07312233B2
公开(公告)日：2007-12-25
申请号：US11375692
申请日：2006-03-14
申请人： Michael G. Kelly , John Kincaid , Satyanarayana Janagani , Matthew Duncton
发明人： Michael G. Kelly , John Kincaid , Satyanarayana Janagani , Matthew Duncton
IPC分类号： A01N43/42 , A61K31/47 , C07D211/72 , C07D211/84 , C07D213/00
CPC分类号： C07C233/65 , A61K31/165 , A61K31/428 , A61K31/4412 , A61K31/4706 , C07C233/75 , C07C2601/02 , C07C2602/10 , C07D213/75 , C07D215/38 , C07D277/62 , C07D319/18
摘要： Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有下列化学式的化合物：化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例的疼痛，炎症，创伤性损伤等。

95. 发明授权

US07179813B2 Bicyclic indolyl derivatives and methods for their use as serotonergic agents 失效
标题翻译：双环吲哚基衍生物及其用作5-羟色胺能药剂的方法
公开(公告)号：US07179813B2
公开(公告)日：2007-02-20
申请号：US10864698
申请日：2004-06-09
申请人： Michael G. Kelly , Wayne E. Childers , Boyd L. Harrison , Gan Zhang , Byron A. Bravo , Lee E. Schechter
发明人： Michael G. Kelly , Wayne E. Childers , Boyd L. Harrison , Gan Zhang , Byron A. Bravo , Lee E. Schechter
IPC分类号： A61K31/496 , C07D401/14
CPC分类号： C07D401/12
摘要： Bicyclic indolyl derivatives and compositions containing such compounds are disclosed. Methods of using the bicyclic indolyl derivatives and compositions containing such composition as serotonergic agents, such as in the treatment of depression and anxiety, are also disclosed. In addition, processes for the preparation of bicyclic indolyl derivatives are disclosed.
摘要翻译：公开了双环吲哚基衍生物和含有这些化合物的组合物。还公开了使用双环吲哚基衍生物的方法和含有这样的组合物的组合物作为血清素能剂，例如治疗抑郁症和焦虑症的方法。此外，公开了制备双环吲哚基衍生物的方法。

96. 发明授权

US07067518B2 Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents 失效
标题翻译：吡啶基 - 甲基 - 乙基环己烷甲酰胺作为血清素能药
公开(公告)号：US07067518B2
公开(公告)日：2006-06-27
申请号：US10652420
申请日：2003-08-29
申请人： Lynne P. Greenblatt , Michael G. Kelly , Yvette L. Palmer
发明人： Lynne P. Greenblatt , Michael G. Kelly , Yvette L. Palmer
IPC分类号： A61K31/496 , C07D401/06 , C07D401/14 , C07D405/14
CPC分类号： C07D401/06 , C07D401/12 , C07D405/12 , C07D405/14
摘要： A compound having 5-HT1A receptor activity, represented by the chemical formula wherein: Ar is 2-methoxyphenyl, 1H-indol-4-yl or 2,3-dihydro-1,4-benzodioxin-5-yl; R1 is 2-, 3- or 4-pyridyl; R2 is H or C1-6alkyl; R3 is H or C1-6alkyl; and R4 is H or methyl, or an optical isomer thereof, or a pharmaceutically acceptable salt of such a compound or optical isomer. The invention also includes compositions containing such a compound, as well as methods for using a compound of the invention.
摘要翻译：具有5-HT 1A受体活性的化合物，其化学式为：Ar为2-甲氧基苯基，1H-吲哚-4-基或2,3-二氢-1,4-苯并二恶英 - 嘧啶-5-基; R 1是2-，3-或4-吡啶基; R 2是H或C 1-6烷基; R 3是H或C 1-6烷基; R 4为H或甲基，或其旋光异构体，或该化合物或旋光异构体的药学上可接受的盐。本发明还包括含有这种化合物的组合物，以及使用本发明化合物的方法。

97. 发明授权

US06696450B2 Serotonergic agents with long-acting in vivo effects 失效
标题翻译：血清素能药物具有长效的体内作用
公开(公告)号：US06696450B2
公开(公告)日：2004-02-24
申请号：US10114577
申请日：2002-04-02
申请人： Wayne E. Childers , Michael G. Kelly , Lee E. Schechter , Sharon J. Rosenzweig-Lipson
发明人： Wayne E. Childers , Michael G. Kelly , Lee E. Schechter , Sharon J. Rosenzweig-Lipson
IPC分类号： C07D29514
CPC分类号： C07D295/125 , C07B2200/05 , C07C2601/14
摘要： Compounds of the formula have a long duration of action and are useful for the treatment of chronic diseases resulting from the dysfunction of the serotonergic 5-HT1A system, such as schizophrenia and other psychotic disorders such as paranoia and mano-depressive illness.
摘要翻译：该化合物具有长时间的作用，并且可用于治疗由5-羟色胺能5-HT1A系统的功能障碍引起的慢性疾病，例如精神分裂症和其它精神病如偏执狂和抑郁症。

98. 发明授权

US06432974B1 Pyrrolo-isoquinoline and tetra-hydropyrrolo-isoquinoline derivatives and their use as mediators of the 5-HT7 receptor 失效
标题翻译：吡咯并 - 异喹啉和四氢吡咯并 - 异喹啉衍生物及其作为5-HT7受体介体的用途
公开(公告)号：US06432974B1
公开(公告)日：2002-08-13
申请号：US09771316
申请日：2001-01-26
申请人： Michael G. Kelly , Young H. Kang
发明人： Michael G. Kelly , Young H. Kang
IPC分类号： A61K314745
CPC分类号： C07D471/04
摘要： Compounds of the formula are useful in the treatment of anxiety, depression and related disorders of the central nervous system and other conditions such as schizophrenia, sleep disorders, including instances of circadian rhythm, the treatment of alcohol and drug withdrawal and sexual dysfunction.
摘要翻译：该化合物可用于治疗中枢神经系统的焦虑，抑郁和相关疾病以及诸如精神分裂症，睡眠障碍，包括昼夜节律的事件，治疗酒精和药物戒断以及性功能障碍等其他病症。

99. 发明授权

US06396116B1 Integrated circuit packaging for optical sensor devices 有权
标题翻译：用于光学传感器设备的集成电路封装
公开(公告)号：US06396116B1
公开(公告)日：2002-05-28
申请号：US09513797
申请日：2000-02-25
申请人： Michael G. Kelly , James-Yu Chang , Gary Dean Sasser , Andrew Arthur Hunter , Cheng-Cheng Chang
发明人： Michael G. Kelly , James-Yu Chang , Gary Dean Sasser , Andrew Arthur Hunter , Cheng-Cheng Chang
IPC分类号： H01L27148
CPC分类号： H01L31/0203 , H01L27/14618 , H01L27/14636 , H01L31/02325 , H01L2224/48091 , H01L2924/09701 , H01L2924/16195 , H01L2924/00014
摘要： An optical device packaging technique involves an optical sensor that is formed on a first substrate and flip chip bonded to a second substrate. The second substrate includes a through hole or a transparent section that is aligned with the optical sensor in order to allow light to contact the optical sensor. An embodiment of an optical device structure includes an optical sensor, a first substrate, a second substrate, and a circuit board. The optical sensor is formed on or within the first substrate and the individual sensors or pixels of the optical sensor are electrically connected to contact pads that are exposed on the first substrate. The first substrate is flip chip bonded to the second substrate. The second substrate is flip chip bonded to a circuit board. Another embodiment of an optical device structure includes an optical sensor, a first substrate, and a circuit board as the second substrate. In the embodiment, contact pads of the first substrate are flip chip bonded to contact pads of the circuit board with conductive balls. The connection between the first substrate and the circuit board provides the electrical connection between the optical sensor and the circuit board.
摘要翻译：光学器件封装技术涉及形成在第一衬底上的光学传感器和与第二衬底结合的倒装芯片。第二基板包括与光学传感器对准的通孔或透明部分，以允许光接触光学传感器。光学装置结构的实施例包括光学传感器，第一基板，第二基板和电路板。光学传感器形成在第一基板上或内部，并且光学传感器的各个传感器或像素电连接到暴露在第一基板上的接触焊盘。第一衬底被倒装芯片接合到第二衬底。第二基板被倒装芯片接合到电路板上。光学装置结构的另一实施例包括光学传感器，第一基板和作为第二基板的电路板。在本实施例中，第一基板的接触焊盘与导电球倒装芯片接合到电路板的接触焊盘。第一基板和电路板之间的连接提供光学传感器和电路板之间的电连接。

100. 发明授权

US06376494B1 Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents 失效
标题翻译：环烷基取代的芳基哌嗪，哌啶和四氢吡啶作为血清素能药
公开(公告)号：US06376494B1
公开(公告)日：2002-04-23
申请号：US09723478
申请日：2000-11-28
申请人： Wayne E. Childers , Michael G. Kelly , Yvette L. Palmer , Edward J. Podlesny
发明人： Wayne E. Childers , Michael G. Kelly , Yvette L. Palmer , Edward J. Podlesny
IPC分类号： A61K31496
CPC分类号： C07D239/42 , C07D209/08 , C07D211/22 , C07D213/74 , C07D217/22 , C07D277/82 , C07D295/125 , C07D295/13 , C07D319/20
摘要： This invention relates to compounds which have activity as 5-HT1A agonists and antagonists which may be useful for the treatment of anxiety, depression, cognitive deficits, and prostate cancer, having the formula wherein: X is a moiety selected from the group of: n is selected from the integers 1 through 5; R1 is optionally substituted aryl or mono or bicyclic heteroaryl, with a proviso that heteroaryl is not thiadiazole; R2 is H or alkyl; R3 is H, COR5, COOR5, and CONR5R6; R4 is H, alkyl, alkenyl, alkynyl, aryl, mono or bicyclic heteroaryl, aralkyl, and mono or bicyclic heteroaralkyl, wherein the aryl or heteroaryl groups are optionally substituted; R5 and R6 are H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, adamantyl, and noradamantyl or R5 and R6 taken together may form a 5-7 membered azacyclic ring, optionally containing an additional heteroatom selected from O, S, or NR4; when R5 or R6 are chosen from cycloalkyl or cycloalkenyl, the cyclic group may optionally be substituted at the 1-position with a C1-C3 alkyl group; or an optical isomer; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及具有作为5-HT 1A激动剂和拮抗剂的活性的化合物，其可用于治疗具有下列基团的焦虑，抑郁，认知缺陷和前列腺癌：X是选自以下的部分：n是从整数1到5中选择; R1是任选取代的芳基或单或双环杂芳基，条件是杂芳基不是噻二唑; R2是H或烷基; R3是H，COR5，COOR5和CONR5R6; R 4是H，烷基，烯基，炔基，芳基，单或双环杂芳基，芳烷基和单或双环杂芳烷基，其中芳基或杂芳基任选被取代; R5和R6是H，烷基，烯基，炔基，环烷基，环烯基，金刚烷基和去月桂烷基或R5和R6一起可以形成5-7元的氮杂环，任选地含有选自O，S或NR4的另外的杂原子; 当R5或R6选自环烷基或环烯基时，环状基团可以任选在1-位被C1-C3烷基取代;或光学异构体; 或其药学上可接受的盐。

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