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91. 发明申请

US20070025912A1 Cytotoxicity mediation of cells evidencing surface expression of CD63 失效
标题翻译：证实CD63表面表达的细胞的细胞毒性调解
公开(公告)号：US20070025912A1
公开(公告)日：2007-02-01
申请号：US11362452
申请日：2006-02-24
申请人： David Young , Helen Findlay , Susan Hahn , Luis da Cruz , Daad Sayegh , Kristian Rogers , Shankar Kumar , Paul Hinton
发明人： David Young , Helen Findlay , Susan Hahn , Luis da Cruz , Daad Sayegh , Kristian Rogers , Shankar Kumar , Paul Hinton
IPC分类号： A61K51/00 , A61K39/395 , C07K16/46 , C07K16/30
CPC分类号： G01N33/57492 , A61K47/6849 , A61K47/6851 , A61K51/1027 , A61K51/1045 , A61K2039/505 , C07K16/2896 , C07K16/30 , C07K2317/24 , C07K2317/732 , C07K2317/92 , G01N33/56966 , G01N33/5743 , G01N2333/70596
摘要： This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMAB of the instant invention.
摘要翻译：本发明涉及癌症的诊断和治疗，特别涉及肿瘤细胞的细胞毒性的介导; 并且最特别地涉及使用任选与一种或多种化学治疗剂组合的癌性疾病修饰抗体（CDMAB）作为起始细胞毒性应答的手段。本发明还涉及利用本发明的CDMAB的结合测定法。

92. 发明申请

US20070023464A1 Metal stamped hook back 失效
标题翻译：金属冲压回钩
公开(公告)号：US20070023464A1
公开(公告)日：2007-02-01
申请号：US11191225
申请日：2005-07-28
申请人： Patrick Barkdoll , David Young
发明人： Patrick Barkdoll , David Young
IPC分类号： A41D27/22
CPC分类号： A47F5/0823
摘要： A back unit for use in a display hanger assembly is provided. The back unit comprises a body, arms, and mounting tabs. The body includes a vertical channel. The vertical channel forms a concave surface on a first side and a convex surface on a second side. The arms are integrally formed with the body and extend outwardly away from the first side. The arms include a slot. The mounting tabs are integrally formed with the body and extend outwardly away from the second side.
摘要翻译：提供了用于显示器衣架组件的后部单元。后部单元包括主体，臂和安装凸片。身体包括一个垂直通道。垂直通道在第一侧上形成凹面，在第二侧形成凸面。臂与主体一体地形成并且从第一侧向外延伸。手臂包括一个插槽。安装突片与主体一体地形成并且从第二侧向外延伸。

93. 发明申请

US20070016650A1 System and methods for collaborative development of content over an electronic network 审中-公开
标题翻译：通过电子网络协同开发内容的系统和方法
公开(公告)号：US20070016650A1
公开(公告)日：2007-01-18
申请号：US11395052
申请日：2006-03-31
申请人： Gary Gilbert , Byron Fuller , David Young , Rodney Hing , Mike Sanders , Sherman Mohler
发明人： Gary Gilbert , Byron Fuller , David Young , Rodney Hing , Mike Sanders , Sherman Mohler
IPC分类号： G06F15/16 , G06F17/00
CPC分类号： G09B7/02 , G09B5/00
摘要： Systems and methods for collaborative authorship of content for a distributed delivery system are provided. The system comprises a server configured to store and regulate access to one or more course materials developed by one or more authors, wherein the one or more course materials comprise information to be taught to a student. The system further comprises one or more client computer systems configured to communicate with said server, each of the one or more client computer systems comprising a display configured to show a hierarchy of course materials, a messaging module configured to send and receive content-related event messages to and from the server, and a user interface module configured to update the display in accordance with content-related events. The server is configured to send event messages to the one or more client computer systems. In some embodiments, the one or more client computer systems are configured to synchronize content with the server.
摘要翻译：提供了用于分布式传送系统的内容的协作作者的系统和方法。该系统包括被配置为存储和调节对由一个或多个作者开发的一个或多个课程材料的访问的服务器，其中所述一个或多个课程材料包括要向学生教授的信息。该系统还包括被配置为与所述服务器通信的一个或多个客户端计算机系统，所述一个或多个客户端计算机系统中的每一个包括被配置为显示课程材料的层次结构的显示器，被配置为发送和接收内容相关事件消息到服务器和从服务器发送的消息，以及被配置为根据内容相关事件来更新显示器的用户界面模块。服务器被配置为向一个或多个客户端计算机系统发送事件消息。在一些实施例中，一个或多个客户端计算机系统被配置为使内容与服务器同步。

94. 发明申请

US20060216234A1 Cancerous disease modifying antibodies 失效
公开(公告)号：US20060216234A1
公开(公告)日：2006-09-28
申请号：US11370203
申请日：2006-03-07
申请人： David Young , Susan Hahn , Helen Findlay
发明人： David Young , Susan Hahn , Helen Findlay
IPC分类号： A61K51/00 , A61K39/395 , C07K16/30 , C07K16/46
CPC分类号： C07K16/3015 , A61K47/6851 , A61K47/6855 , A61K47/6869 , A61K51/1051 , A61K51/1072 , A61K2039/505 , C07K16/30 , C07K16/3069
摘要： The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

95. 发明申请

US20060216233A1 Cytotoxicity mediation of cells evidencing surface expression of CD44 有权
标题翻译：证实CD44表面表达的细胞的细胞毒性调解
公开(公告)号：US20060216233A1
公开(公告)日：2006-09-28
申请号：US11364013
申请日：2006-02-28
申请人： David Young , Helen Findlay , Susan Hahn , Lisa Cechetto , Fortunata McConkey
发明人： David Young , Helen Findlay , Susan Hahn , Lisa Cechetto , Fortunata McConkey
IPC分类号： A61K51/00 , G01N33/574 , A61K39/395 , C12N5/06 , C07K16/30 , C07K16/46
CPC分类号： C07K16/2884 , A61K47/6849 , A61K47/6897 , A61K49/0013 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K2317/24 , C07K2317/56 , C07K2317/73 , G01N33/5082 , G01N33/574 , G01N33/57492 , G01N2333/70585
摘要： This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMAB of the instant invention.
摘要翻译：本发明涉及癌症的诊断和治疗，特别涉及肿瘤细胞的细胞毒性的介导; 并且最特别地涉及使用任选与一种或多种化学治疗剂组合的癌性疾病修饰抗体（CDMAB）作为起始细胞毒性应答的手段。本发明还涉及利用本发明的CDMAB的结合测定法。

96. 发明申请

US20060210474A1 Cytotoxicity mediation of cells evidencing surface expression of CD63 审中-公开
公开(公告)号：US20060210474A1
公开(公告)日：2006-09-21
申请号：US11367798
申请日：2006-03-03
申请人： David Young , Helen Findlay , Susan Hahn , Luis da Cruz , Daad Sayegh , Kristian Rogers
发明人： David Young , Helen Findlay , Susan Hahn , Luis da Cruz , Daad Sayegh , Kristian Rogers
IPC分类号： A61K51/00 , A61K39/395 , C07K16/46 , C07K16/30 , C07K14/82
CPC分类号： A61K51/1027 , A61K47/6849 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K16/2896 , C07K16/30 , C07K2317/732 , C07K2317/92 , G01N33/5743 , G01N33/57438 , G01N33/57449 , G01N33/57492 , G01N2333/70596
摘要： This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMAB of the instant invention.

97. 发明申请

US20060204497A1 Cytotoxicity mediation of cells evidencing surface expression of CD63 失效
公开(公告)号：US20060204497A1
公开(公告)日：2006-09-14
申请号：US11321624
申请日：2005-12-29
申请人： David Young , Susan Hahn , Helen Findlay , Luis da Cruz
发明人： David Young , Susan Hahn , Helen Findlay , Luis da Cruz
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/92 , G01N33/5743 , G01N2333/70596
摘要： This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMABs of the instant invention.

98. 发明申请

US20060179191A1 Covert channel firewall 审中-公开
标题翻译：隐蔽通道防火墙
公开(公告)号：US20060179191A1
公开(公告)日：2006-08-10
申请号：US11056540
申请日：2005-02-10
申请人： David Young
发明人： David Young
IPC分类号： G06F13/00
CPC分类号： G06F13/1668
摘要： A method and apparatus for restricting an access operation on a bus cycle to a particular address range. The method may include receiving, by a controller hub, a cycle's address from a device and comparing the address against a valid address list stored in the controller hub to determine if the address is a valid address or an invalid address. The method also includes permitting or denying an access operation by the device based on whether the address is determined to be a valid address or invalid address, respectively.
摘要翻译：一种用于将总线周期上的访问操作限制到特定地址范围的方法和装置。该方法可以包括由控制器集线器从设备接收周期的地址，并将地址与存储在控制器集线器中的有效地址列表进行比较，以确定地址是有效地址还是无效地址。该方法还包括分别基于地址被确定为有效地址还是无效地址来允许或拒绝设备的访问操作。

99. 发明申请

US20060161408A1 Population pharmacokinetic modeling and analysis (PDX-POP™) 审中-公开
标题翻译：群体药动学模型和分析（PDX-POP（TM））
公开(公告)号：US20060161408A1
公开(公告)日：2006-07-20
申请号：US11375753
申请日：2006-03-15
申请人： William Bachman , Sian Bigora , Marc Gastonguay , David Young
发明人： William Bachman , Sian Bigora , Marc Gastonguay , David Young
IPC分类号： G06G7/48 , G06G7/58
CPC分类号： G16C20/30 , G16B5/00 , G16B50/00
摘要： A biological modeling system and method for enhanced computer-aided analysis of biological response data provides information synthesized from multiple sources. An executable model of a biological system is developed from information and structures based on multiple sources. In a preferred embodiment, biological data sets are selected by a user from a first active viewer window on a user computer display. A model is created and then run using integrated pharmacokinetic software. The output is next analyzed using integrated analysis tools. Once analyzed, the model is balanced to ensure that it matches the information and structures. Once the model is created, run, and balanced, it can be used to draw attention to important relations through integrated reporting functions. This program could be run with such programs as NONMEM®.
摘要翻译：用于增强生物反应数据计算机辅助分析的生物建模系统和方法提供从多个来源合成的信息。基于多个来源的信息和结构开发了生物系统的可执行模型。在优选实施例中，用户从用户计算机显示器上的第一活动查看器窗口选择生物数据集。创建一个模型，然后使用集成的药代动力学软件运行。接下来使用集成分析工具对输出进行分析。一旦分析，模型是平衡的，以确保它与信息和结构匹配。一旦模型创建，运行和平衡，它可以用于通过集成报告功能来引起对重要关系的关注。该程序可以使用诸如NONMEM（R）这样的程序来运行。

100. 发明申请

US20060102787A1 Aircraft archway 有权
公开(公告)号：US20060102787A1
公开(公告)日：2006-05-18
申请号：US11300020
申请日：2005-12-14
申请人： David Young , Richard Fraker , R. Brauer , Peter Guard
发明人： David Young , Richard Fraker , R. Brauer , Peter Guard
IPC分类号： B64C1/00
CPC分类号： B64D11/00 , B64C1/066 , B64D11/0023 , B64D11/02 , B64D11/0691 , B64D2011/0046
摘要： An architectural archway for an aircraft. The archways can be positioned individually, or in pairs or other sets along the length of an aircraft fuselage. The archways are used to run or connect various transport elements, such as electrical wiring, water lines, and environmental control system conduits, between the upper crown, lower bay and passenger cabin of the aircraft. The invention simplifies installation complexity and eliminates the installation and variability associated with running transport elements between the various sections of the aircraft.

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