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91. 发明申请

US20130150440A1 USE OF BIS [THIOHYDRAZIDE AMIDE] COMPOUNDS SUCH AS ELESCLOMOL FOR TREATING CANCERS 有权
标题翻译：使用BIS [硫羟酰胺酰胺]化合物作为ELESCLOMOL治疗癌症
公开(公告)号：US20130150440A1
公开(公告)日：2013-06-13
申请号：US13642275
申请日：2011-04-20
申请人： Masazumi Nagai , Ronald K. Blackman , Patricia E. Rao , Yumiko Wada , Keizo Koya
发明人： Masazumi Nagai , Ronald K. Blackman , Patricia E. Rao , Yumiko Wada , Keizo Koya
IPC分类号： A61K31/30 , A61K31/337 , A61K45/06 , A61K31/19 , A61K31/16 , A61K31/28
CPC分类号： A61K31/30 , A61K31/00 , A61K31/16 , A61K31/18 , A61K31/19 , A61K31/195 , A61K31/28 , A61K31/337 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： Improved cancer treatments with bis[thiohydrazide amide] compounds such as elesclomol, in particular for identifying patient populations that would benefit from such treatments.
摘要翻译：改进的双[硫代酰肼]化合物如elesclomol的癌症治疗，特别是用于鉴定将受益于这种治疗的患者群体。

92. 发明授权

US07939564B2 Combination with bis(thiohydrazide amides) for treating cancer 有权
标题翻译：与双（硫代酰肼酰胺）结合治疗癌症
公开(公告)号：US07939564B2
公开(公告)日：2011-05-10
申请号：US11897538
申请日：2007-08-30
申请人： Keizo Koya
发明人： Keizo Koya
IPC分类号： A61K31/16
CPC分类号： A61K31/16 , A61K31/165 , A61K31/337 , A61K41/0052 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with hyperthermia treatment. Also disclosed are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with radiotherapy.
摘要翻译：本文公开了与双热（硫代酰肼）酰胺或其互变异构体，药学上可接受的盐，溶剂合物，包合物或前药，与热疗治疗结合治疗增殖性疾病如癌症的方法。还公开了与放射治疗组合的双（硫代 - 酰肼）酰胺或其互变异构体，药学上可接受的盐，溶剂合物，包合物或前药治疗增殖性疾病如癌症的方法。

93. 发明申请

US20100311840A1 ORAL FORMULATIONS OF BIS(THIOHYDRAZIDE AMIDES) 失效
标题翻译： BIS（THIOHYDRAZIDE AMIDES）的口服制剂
公开(公告)号：US20100311840A1
公开(公告)日：2010-12-09
申请号：US12741486
申请日：2008-11-07
申请人： Noriaki Tatsuta , Takayo Inoue , Keizo Koya
发明人： Noriaki Tatsuta , Takayo Inoue , Keizo Koya
IPC分类号： A61K31/165 , A61P25/28 , A61P25/16 , A61P25/14 , A61P21/00 , A61P9/10 , A61P27/06 , A61P31/04 , A61P31/12 , A61P33/00 , A61P31/10
CPC分类号： A61K9/19 , A61K9/1075 , A61K31/16 , A61K31/165
摘要： Disclosed herein are oral formulations of bis(thio-hydrazide amides) compounds of the following structural formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R7, R8, Z, and Y are defined herein.
摘要翻译：本文公开了以下结构式（I）的双（硫代酰肼酰胺）化合物或其药学上可接受的盐的口服制剂，其中R 1，R 2，R 3，R 4，R 7，R 8，Z和Y在本文中定义。

94. 发明申请

US20080118562A1 Bis(thiohydrazide amides) formulation 审中-公开
标题翻译：双（硫代酰肼酰胺）配方
公开(公告)号：US20080118562A1
公开(公告)日：2008-05-22
申请号：US11900201
申请日：2007-09-10
申请人： Keizo Koya
发明人： Keizo Koya
IPC分类号： A61K47/48 , A61P35/00 , A61K31/16
CPC分类号： A61K31/16 , A61K9/0019 , A61K9/167 , A61K9/19 , A61K9/5031 , A61K9/5052 , A61K31/337
摘要： Disclosed herein are compositions and methods useful for the in vivo delivery bis(thiohydrazide amides), encased in a polymeric biocompatible shell.
摘要翻译：本文公开的是用于体内递送双（硫代酰肼酰胺），包裹在聚合物生物相容性壳中的组合物和方法。

95. 发明授权

US4965170A Silver halide photographic material and method for forming super high contrast images therewith 失效
标题翻译：卤化银照相材料和用于形成超高对比度图像的方法
公开(公告)号：US4965170A
公开(公告)日：1990-10-23
申请号：US489872
申请日：1990-03-06
申请人： Toshinao Ukai , Kazuhiro Shirasu , Koki Nakamura , Keizo Koya , Masahiro Okada , Kazunobu Katoh
发明人： Toshinao Ukai , Kazuhiro Shirasu , Koki Nakamura , Keizo Koya , Masahiro Okada , Kazunobu Katoh
IPC分类号： G03C1/06 , G03C1/83 , G03C7/305
CPC分类号： G03C1/83 , G03C1/061 , G03C7/30547 , Y10S430/156 , Y10S430/159
摘要： A silver halide photographic material comprising a support having thereon at least one silver halide emulsion layer, said emulsion layer or at least one of other hydrophilic colloid layers containing a compound represented by formula (I):PWR--Time--.sub.T LA (I)wherein PWR represents a group which undergoes reduction to release (Time).sub.t LA; Time represents a group which release LA upon reaction following release of (Time).sub.t LA from PWR; t represents an integer of 0 or 1; and LA represents a group having a maximum light absorption in a wavelength range of 310 nm or more. In a preferred embodiment, one of said other hydrophilic colloid layers substantially free of the compound represented by formula (I) is provided between said at least one silver halide emulsion layer in said silver halide photographic material and one of said other hydrophilic colloid layers containing the compound represented by formula (I), and at least one of these hydrophilic colloid layers or at least one other of said other hydrophilic colloid layers contains a hydrazine derivative. A process for the formation of an ultrahigh contrast image, which comprises exposing the above-described silver halide photographic material to light, and then developing the silver halide photographic material with a developing solution having a pH of 11.0 to 12.3 and containing 0.15 mol/l or more of sulfite ions.

96. 发明授权

US08618170B2 Oral formulations of bis(thiohydrazide amides) 失效
标题翻译：双（硫代酰肼）酰胺的口服制剂
公开(公告)号：US08618170B2
公开(公告)日：2013-12-31
申请号：US12741486
申请日：2008-11-07
申请人： Noriaki Tatsuta , Takayo Inoue , Keizo Koya
发明人： Noriaki Tatsuta , Takayo Inoue , Keizo Koya
IPC分类号： A61K31/16
CPC分类号： A61K9/19 , A61K9/1075 , A61K31/16 , A61K31/165
摘要： Disclosed herein are oral formulations of bis(thio-hydrazide amides) compounds of the following structural formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R7, R8, Z, and Y are defined herein.
摘要翻译：本文公开了以下结构式（I）的双（硫代酰肼酰胺）化合物或其药学上可接受的盐的口服制剂，其中R 1，R 2，R 3，R 4，R 7，R 8，Z和Y在本文中定义。

97. 发明申请

US20080119440A1 Combination with Bis(thiohydrazide amides) for treating cancer 有权
标题翻译：与双（硫酰肼酰胺）结合治疗癌症
公开(公告)号：US20080119440A1
公开(公告)日：2008-05-22
申请号：US11897538
申请日：2007-08-30
申请人： Keizo Koya
发明人： Keizo Koya
IPC分类号： A61K31/724 , A61K31/427 , A61K31/277 , A61K31/195 , A61K31/26 , A61K31/16 , A61K31/21
CPC分类号： A61K31/16 , A61K31/165 , A61K31/337 , A61K41/0052 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with hyperthermia treatment. Also disclosed are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with radiotherapy.
摘要翻译：本文公开了与双热（硫代酰肼）酰胺或其互变异构体，药学上可接受的盐，溶剂合物，包合物或前药，与热疗治疗结合治疗增殖性疾病如癌症的方法。还公开了与放射治疗组合的双（硫代 - 酰肼）酰胺或其互变异构体，药学上可接受的盐，溶剂合物，包合物或前药治疗增殖性疾病如癌症的方法。

98. 发明授权

US5618831A Composition and method for treating cancer 失效
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：US5618831A
公开(公告)日：1997-04-08
申请号：US242834
申请日：1994-05-16
申请人： Tadao Shishido , Masayuki Kawakami , Akihiko Ikegawa , Toshinao Ukai , Keizo Koya , Lan B. Chen
发明人： Tadao Shishido , Masayuki Kawakami , Akihiko Ikegawa , Toshinao Ukai , Keizo Koya , Lan B. Chen
IPC分类号： A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/505
CPC分类号： A61K31/541 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/506
摘要： A pharmaceutical composition for treatment of cancer in an animal comprising:(A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I). ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring;R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represents an alkyl group or an aryl group;L.sub.1 and L.sub.2 each represents a methine group or a substituted methine group;X represents a pharmaceutically acceptable anion;k represents a number necessary for electrical charge balance;n represents 0 or 1; and(B) a pharmaceutically acceptable carrier or diluent.
摘要翻译：一种用于治疗动物癌症的药物组合物，其包含：（A）治疗有效量的至少一种选自由通式（I）表示的化合物的化合物。（I）其中Z1和Z2可以相同或不同，分别代表形成5-或6-元环所必需的原子团; R 1，R 2和R 3可以相同或不同，表示烷基或芳基; L1和L2各自表示次甲基或取代的次甲基; X表示药学上可接受的阴离子; k表示电荷平衡所需的数字; n表示0或1; 和（B）药学上可接受的载体或稀释剂。

99. 发明授权

US4939066A Color diffusion transfer photographic element 失效
标题翻译：彩色扩散转印照相材料
公开(公告)号：US4939066A
公开(公告)日：1990-07-03
申请号：US115070
申请日：1987-10-30
申请人： Masaharu Toriuchi , Keizo Koya
发明人： Masaharu Toriuchi , Keizo Koya
IPC分类号： C07D261/12 , C07D413/12 , G03C7/00 , G03C7/305 , G03C8/08 , G03C8/40
CPC分类号： C07D413/12 , C07D261/12 , G03C7/30594 , G03C8/08 , Y10S430/158
摘要： A color diffusion transfer photographic material comprises a base having thereon at least one silver halide emulsion layer and a dye image-receiving layer, at least one layer thereof containing a dye-releasing redox compound and at least one layer thereof containing a development inhibitor-releasing compound represented by the following general formula (I):A--Time).sub.t DIG (I)wherein A represents ##STR1## linked to --Time).sub.t DIG through at least one of R.sup.1, R.sup.2 and EAG; R.sup.1 and R.sup.2, which may be the same or different, each represents a single bond or a substituent other than a hydrogen atom, provided that R.sup.1 and R.sup.2 may be linked to form a ring; EAG represents an electron-accepting group; Time represents a group capable of releasing DIG after EAG accepts an electron; DIG represents a development inhibitor precursor; and t is an integer of 0 or 1.
摘要翻译：彩色扩散转印照相材料包括其上具有至少一个卤化银乳剂层和染料影像接收层的基底，其至少一层含有释放染料的氧化还原化合物和至少一层含有显影抑制剂释放通过R1，R2和EAG中的至少一个，由以下通式（I）代表的化合物：A-time）tDIG（I）其中A表示与-Time连接的时间）tDIG; R 1和R 2可以相同或不同，各自表示单键或除氢原子以外的取代基，条件是R 1和R 2可以连接形成环; EAG代表电子接受基团; 时间表示EAG接受电子后能释放DIG的组; DIG代表发育抑制剂前体; t为0或1的整数。

100. 发明授权

US5424442A Water-soluble methine compounds useful in photographic silver halide emulsion containing the same 失效
标题翻译：水溶性次甲基化合物可用于含有相同的照相卤化银乳剂
公开(公告)号：US5424442A
公开(公告)日：1995-06-13
申请号：US078110
申请日：1993-06-18
申请人： Keizo Koya , Toshinao Ukai , Haruo Takei
发明人： Keizo Koya , Toshinao Ukai , Haruo Takei
IPC分类号： G03C1/12 , C09B23/00 , C09B23/01 , C09B69/06 , G03C1/26 , G03C1/40 , C07D277/62
CPC分类号： C09B69/06 , C09B23/0075 , G03C1/26
摘要： A water-soluble methine compound represented by the following general formula (I): ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents a non-metallic atomic group required for forming a 5-membered or 6-membered nitrogen-containing heterocyclic ring; R.sub.1 and R.sub.2, which may be the same or different, each represents an alkyl group; Q.sub.1 and Q.sub.2 each represents an atomic group required, in combination, for forming a 4-thiazolidinone ring, a 5-thiazolidinone ring, a 4-imidazolidinone ring, a 4-oxazolidinone ring, a 5-oxazolidinone ring, a 5-imidazolidinone ring or a 4-dithiolanone ring; L.sub.1, L.sub.2, L.sub.3, L.sub.4 and L.sub.5, which may be the same or different, each represents a methine group; R represents a hydrogen atom, an alkyl group, an aryl group or a heterocyclic group; m represents 1 or 2; i and h each represents 0 or 1; l represents 1 or 2; and j and k each represents 0, 1, 2 or 3.A photographic silver halide emulsion containing said methine compound added in the form of an aqueous solution is also disclosed.
摘要翻译：由以下通式（I）表示的水溶性次甲基化合物：其中Z1和Z2可以相同或不同，分别表示形成一个或多个所需的非金属原子团 5元或6元含氮杂环; R 1和R 2可以相同或不同，各自表示烷基; Q1和Q2各自表示组合形成4-噻唑烷酮环，5-噻唑烷酮环，4-咪唑啉酮环，4-恶唑烷酮环，5-恶唑烷酮环，5-咪唑啉酮环所需的原子团或4-二硫戊环酮环; L1，L2，L3，L4和L5可以相同或不同，表示次甲基; R表示氢原子，烷基，芳基或杂环基; m表示1或2; i和h各自表示0或1; l表示1或2; 并且j和k各自表示0,1,2或3.还公开了含有以水溶液形式加入的次甲基化合物的照相卤化银乳剂。

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