专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明授权

US08618170B2 Oral formulations of bis(thiohydrazide amides) 失效
标题翻译：双（硫代酰肼）酰胺的口服制剂
公开(公告)号：US08618170B2
公开(公告)日：2013-12-31
申请号：US12741486
申请日：2008-11-07
申请人： Noriaki Tatsuta , Takayo Inoue , Keizo Koya
发明人： Noriaki Tatsuta , Takayo Inoue , Keizo Koya
IPC分类号： A61K31/16
CPC分类号： A61K9/19 , A61K9/1075 , A61K31/16 , A61K31/165
摘要： Disclosed herein are oral formulations of bis(thio-hydrazide amides) compounds of the following structural formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R7, R8, Z, and Y are defined herein.
摘要翻译：本文公开了以下结构式（I）的双（硫代酰肼酰胺）化合物或其药学上可接受的盐的口服制剂，其中R 1，R 2，R 3，R 4，R 7，R 8，Z和Y在本文中定义。

92. 发明申请

US20080119440A1 Combination with Bis(thiohydrazide amides) for treating cancer 有权
标题翻译：与双（硫酰肼酰胺）结合治疗癌症
公开(公告)号：US20080119440A1
公开(公告)日：2008-05-22
申请号：US11897538
申请日：2007-08-30
申请人： Keizo Koya
发明人： Keizo Koya
IPC分类号： A61K31/724 , A61K31/427 , A61K31/277 , A61K31/195 , A61K31/26 , A61K31/16 , A61K31/21
CPC分类号： A61K31/16 , A61K31/165 , A61K31/337 , A61K41/0052 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with hyperthermia treatment. Also disclosed are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with radiotherapy.
摘要翻译：本文公开了与双热（硫代酰肼）酰胺或其互变异构体，药学上可接受的盐，溶剂合物，包合物或前药，与热疗治疗结合治疗增殖性疾病如癌症的方法。还公开了与放射治疗组合的双（硫代 - 酰肼）酰胺或其互变异构体，药学上可接受的盐，溶剂合物，包合物或前药治疗增殖性疾病如癌症的方法。

93. 发明授权

US5618831A Composition and method for treating cancer 失效
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：US5618831A
公开(公告)日：1997-04-08
申请号：US242834
申请日：1994-05-16
申请人： Tadao Shishido , Masayuki Kawakami , Akihiko Ikegawa , Toshinao Ukai , Keizo Koya , Lan B. Chen
发明人： Tadao Shishido , Masayuki Kawakami , Akihiko Ikegawa , Toshinao Ukai , Keizo Koya , Lan B. Chen
IPC分类号： A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/505
CPC分类号： A61K31/541 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/506
摘要： A pharmaceutical composition for treatment of cancer in an animal comprising:(A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I). ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring;R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represents an alkyl group or an aryl group;L.sub.1 and L.sub.2 each represents a methine group or a substituted methine group;X represents a pharmaceutically acceptable anion;k represents a number necessary for electrical charge balance;n represents 0 or 1; and(B) a pharmaceutically acceptable carrier or diluent.
摘要翻译：一种用于治疗动物癌症的药物组合物，其包含：（A）治疗有效量的至少一种选自由通式（I）表示的化合物的化合物。（I）其中Z1和Z2可以相同或不同，分别代表形成5-或6-元环所必需的原子团; R 1，R 2和R 3可以相同或不同，表示烷基或芳基; L1和L2各自表示次甲基或取代的次甲基; X表示药学上可接受的阴离子; k表示电荷平衡所需的数字; n表示0或1; 和（B）药学上可接受的载体或稀释剂。

94. 发明授权

US4939066A Color diffusion transfer photographic element 失效
标题翻译：彩色扩散转印照相材料
公开(公告)号：US4939066A
公开(公告)日：1990-07-03
申请号：US115070
申请日：1987-10-30
申请人： Masaharu Toriuchi , Keizo Koya
发明人： Masaharu Toriuchi , Keizo Koya
IPC分类号： C07D261/12 , C07D413/12 , G03C7/00 , G03C7/305 , G03C8/08 , G03C8/40
CPC分类号： C07D413/12 , C07D261/12 , G03C7/30594 , G03C8/08 , Y10S430/158
摘要： A color diffusion transfer photographic material comprises a base having thereon at least one silver halide emulsion layer and a dye image-receiving layer, at least one layer thereof containing a dye-releasing redox compound and at least one layer thereof containing a development inhibitor-releasing compound represented by the following general formula (I):A--Time).sub.t DIG (I)wherein A represents ##STR1## linked to --Time).sub.t DIG through at least one of R.sup.1, R.sup.2 and EAG; R.sup.1 and R.sup.2, which may be the same or different, each represents a single bond or a substituent other than a hydrogen atom, provided that R.sup.1 and R.sup.2 may be linked to form a ring; EAG represents an electron-accepting group; Time represents a group capable of releasing DIG after EAG accepts an electron; DIG represents a development inhibitor precursor; and t is an integer of 0 or 1.
摘要翻译：彩色扩散转印照相材料包括其上具有至少一个卤化银乳剂层和染料影像接收层的基底，其至少一层含有释放染料的氧化还原化合物和至少一层含有显影抑制剂释放通过R1，R2和EAG中的至少一个，由以下通式（I）代表的化合物：A-time）tDIG（I）其中A表示与-Time连接的时间）tDIG; R 1和R 2可以相同或不同，各自表示单键或除氢原子以外的取代基，条件是R 1和R 2可以连接形成环; EAG代表电子接受基团; 时间表示EAG接受电子后能释放DIG的组; DIG代表发育抑制剂前体; t为0或1的整数。

95. 发明授权

US06616959B2 Water-soluble bean-based extracts 失效
标题翻译：水溶性豆类提取物
公开(公告)号：US06616959B2
公开(公告)日：2003-09-09
申请号：US10006326
申请日：2001-11-13
申请人： Mitsunori Ono , Keizo Koya , Noriaki Tatsuta , Naoto Yamaguchi , Lan Bo Chen
发明人： Mitsunori Ono , Keizo Koya , Noriaki Tatsuta , Naoto Yamaguchi , Lan Bo Chen
IPC分类号： A23L120
CPC分类号： A23L33/105 , A23V2002/00 , A23V2250/2116
摘要： This invention relates to a water-soluble bean-based extract including one or more isoflavone glycosides. Also shown is a method of preparing such a water-soluble bean-based extract.
摘要翻译：本发明涉及包含一种或多种异黄酮糖苷的水溶性豆类提取物。还示出了制备这种水溶性豆类提取物的方法。

96. 发明授权

US5599825A Water-soluble methine compound and pharmaceutical composition for treatment of cancer comprising the same 失效
标题翻译：水溶性次甲基化合物和用于治疗癌症的药物组合物
公开(公告)号：US5599825A
公开(公告)日：1997-02-04
申请号：US420481
申请日：1995-04-12
申请人： Noriaki Tatsuta , Akihiko Okegawa , Masayuki Kawakami , Keizo Koya
发明人： Noriaki Tatsuta , Akihiko Okegawa , Masayuki Kawakami , Keizo Koya
IPC分类号： C07D277/64 , C07D277/84 , C07D417/14 , A61K31/425 , C07D417/06
CPC分类号： C07D417/14 , C07D277/64 , C07D277/84
摘要： There are provided methine compounds having the following structure and their analogs, with a high solubility and are usefull as an active ingredient for pharmaceutical composition for treatment of cancer: ##STR1##
摘要翻译：提供具有以下结构的次甲基化合物及其类似物，具有高溶解性，并且作为用于治疗癌症的药物组合物的活性成分是有用的： + TR + TR

97. 发明授权

US5250692A Water-soluble methine compounds useful in photographic silver halide emulsions 失效
标题翻译：用于照相卤化银乳剂的水溶性次甲基化合物
公开(公告)号：US5250692A
公开(公告)日：1993-10-05
申请号：US686974
申请日：1991-04-18
申请人： Keizo Koya , Toshinao Ukai , Haruo Takei
发明人： Keizo Koya , Toshinao Ukai , Haruo Takei
IPC分类号： G03C1/12 , C09B23/00 , C09B23/01 , C09B69/06 , G03C1/26 , G03C1/40 , C09B23/02 , C09B23/06
CPC分类号： C09B69/06 , C09B23/0075 , G03C1/26
摘要： A water-soluble methine compound represented by the following general formula (I): ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents a non-metallic atomic group required for forming a 5-membered or 6-membered nitrogen-containing heterocyclic ring; R.sub.1 and R.sub.2, which may be the same or different, each represents an alkyl group; Q.sub.1 and Q.sub.2 each represents an atomic group required, in combination, for forming a 4-thiazolidinone ring, a 5-thiazolidinone ring, a 4-imidazolidinone ring, a 4-oxazolidinone ring, a 5-oxazolidinone ring, a 5-imidazolidinone ring or a 4-dithiolanone ring; L.sub.1, L.sub.2, L.sub.3, L.sub.4 and L.sub.5, which may be the same or different, each represents a methine group; R represents a hydrogen atom, an alkyl group, an aryl group or a heterocyclic group; m represents 1 or 2; i and h each represents 0 or 1; l represents 1 or 2; and j and k each represents 0, 1, 2 or 3.A photographic silver halide emulsion containing said methine compound added in the form of an aqueous solution is also disclosed.

98. 发明授权

US5049477A Radiation responsive composition 失效
标题翻译：辐射响应组合物
公开(公告)号：US5049477A
公开(公告)日：1991-09-17
申请号：US338089
申请日：1989-04-14
申请人： Koki Nakamura , Masayoshi Tsuboi , Keizo Koya
发明人： Koki Nakamura , Masayoshi Tsuboi , Keizo Koya
IPC分类号： G03C1/00 , C07D231/24 , C07D231/46 , C07D249/12 , C07D249/14 , C07D261/12 , C07D261/14 , C07D265/02 , C07D271/06 , C07D271/10 , C07D273/01 , C07D273/04 , C07D285/125 , C07D421/00 , C09K9/02 , G03C1/675 , G03C1/73 , G03C7/00 , G03C8/12 , G03C8/40 , G03F7/004
CPC分类号： G03C1/73
摘要： A radiation responsive composition containing a compound represented by the following formula (I) and a photoreducing agent capable of forming a redox couple together with said compound for many uses, e.g., image formation, etching, plating, etc.: ##STR1## wherein N represents a nitrogen atom; X represents an oxygen atom (--O--), a sulfur atom (--S--), or a nitrogen-containing group of formula, ##STR2## R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each represents a mere bond, a substituted or unsubstituted alkyl, aryl, heterocyclic, acyl, aralkyl, alkenyl, alkynyl or carbamoyl group, or a sulfonyl group into which a substituted or unsubstituted alkyl or aryl group has been introduced, provided that at least one of the substituents R.sup.1 to R.sup.3 be a substituted or unsubstituted aryl or heterocyclic group and that two or more of R.sup.1, R.sup.2 and R.sup.3, or of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 when X represents a nitrogen containing group of formula, ##STR3## may be taken together to form a ring; UG represents a group to be released from said compound of formula (I) taking advantage of the N--X bond cleavage as a trigger, which takes place when a redox couple is formed between said compound of formula (I) and the photoreducing agent irradiated with radiant rays; and the solid lines represent bonds, while broken lines indicate that a bond may or may not be present, but at least one of the broken lines forms a bond.
摘要翻译：含有由下式（I）表示的化合物和能够与所述化合物一起形成氧化还原对的许多用途的光致变化组合物，例如图像形成，蚀刻，电镀等。）其中N表示氮原子; X表示氧原子（-O-），硫原子（-S-）或式的含氮基团，R 1，R 2，R 3和R 4各自表示单键，取代或未取代的烷基，芳基，杂环，酰基，芳烷基，烯基，炔基或氨基甲酰基，或其中引入取代或未取代的烷基或芳基的磺酰基，条件是至少一个取代基R 1至R 3为取代或未取代的芳基或杂环基，当X代表含氮基团时，R 1，R 2和R 3，或R 1，R 2，R 3和R 4中的两个或多个可以一起形成环; UG表示利用NX键断裂作为触发剂从式（I）化合物释放的基团，当在所述式（I）化合物与用辐射剂照射的光还原剂之间形成氧化还原对时发生射线而实线表示键，而虚线表示键可以存在或不存在，但至少一个虚线形成键。

99. 发明授权

US4942114A Silver halide photographic materials with reducible brightening agent releaser 失效
标题翻译：卤化银照相材料与可还原增亮剂释放剂
公开(公告)号：US4942114A
公开(公告)日：1990-07-17
申请号：US189003
申请日：1988-05-02
申请人： Keisuke Shiba , Keizo Koya
发明人： Keisuke Shiba , Keizo Koya
IPC分类号： G03C7/26 , C07D213/64 , C07D213/70 , C07D215/38 , C07D249/12 , C07D249/14 , C07D249/20 , C07D249/22 , C07D251/20 , C07D251/42 , C07D251/52 , C07D261/12 , C07D261/14 , C07D261/20 , C07D263/56 , C07D271/06 , C07D273/01 , C07D273/04 , C07D311/86 , C07D311/92 , G03C1/06 , G03C1/815 , G03C7/305
CPC分类号： G03C1/8155 , G03C7/30541 , Y10S430/134 , Y10S430/156
摘要： A silver halide photographic material having at least one silver halide emulsion layer on a support, comprising a compound of formula (I):PWR--(Time).sub.t --FWA (I)in which PWR represents a group capable of releasing (Time).sub.t --FWA upon reduction; FWA represents a group which functions as a brightening agent; Time represents a group capable of releasing FWA through a reaction which follows the release of (Time).sub.t --FWA from PWR; and t represents an integer of 0 or 1.
摘要翻译：一种卤化银照相材料，其在载体上具有至少一个卤化银乳剂层，其包含式（I）化合物：PWR-（时间）t-FWA（I），其中PWR表示能够释放（时间）t -FWA减量 FWA表示作为增白剂起作用的基团; 时间表示能够通过PWR释放（Time）t-FWA后的反应释放FWA的组; t表示0或1的整数。

100. 发明授权

US5424442A Water-soluble methine compounds useful in photographic silver halide emulsion containing the same 失效
标题翻译：水溶性次甲基化合物可用于含有相同的照相卤化银乳剂
公开(公告)号：US5424442A
公开(公告)日：1995-06-13
申请号：US078110
申请日：1993-06-18
申请人： Keizo Koya , Toshinao Ukai , Haruo Takei
发明人： Keizo Koya , Toshinao Ukai , Haruo Takei
IPC分类号： G03C1/12 , C09B23/00 , C09B23/01 , C09B69/06 , G03C1/26 , G03C1/40 , C07D277/62
CPC分类号： C09B69/06 , C09B23/0075 , G03C1/26
摘要： A water-soluble methine compound represented by the following general formula (I): ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents a non-metallic atomic group required for forming a 5-membered or 6-membered nitrogen-containing heterocyclic ring; R.sub.1 and R.sub.2, which may be the same or different, each represents an alkyl group; Q.sub.1 and Q.sub.2 each represents an atomic group required, in combination, for forming a 4-thiazolidinone ring, a 5-thiazolidinone ring, a 4-imidazolidinone ring, a 4-oxazolidinone ring, a 5-oxazolidinone ring, a 5-imidazolidinone ring or a 4-dithiolanone ring; L.sub.1, L.sub.2, L.sub.3, L.sub.4 and L.sub.5, which may be the same or different, each represents a methine group; R represents a hydrogen atom, an alkyl group, an aryl group or a heterocyclic group; m represents 1 or 2; i and h each represents 0 or 1; l represents 1 or 2; and j and k each represents 0, 1, 2 or 3.A photographic silver halide emulsion containing said methine compound added in the form of an aqueous solution is also disclosed.
摘要翻译：由以下通式（I）表示的水溶性次甲基化合物：其中Z1和Z2可以相同或不同，分别表示形成一个或多个所需的非金属原子团 5元或6元含氮杂环; R 1和R 2可以相同或不同，各自表示烷基; Q1和Q2各自表示组合形成4-噻唑烷酮环，5-噻唑烷酮环，4-咪唑啉酮环，4-恶唑烷酮环，5-恶唑烷酮环，5-咪唑啉酮环所需的原子团或4-二硫戊环酮环; L1，L2，L3，L4和L5可以相同或不同，表示次甲基; R表示氢原子，烷基，芳基或杂环基; m表示1或2; i和h各自表示0或1; l表示1或2; 并且j和k各自表示0,1,2或3.还公开了含有以水溶液形式加入的次甲基化合物的照相卤化银乳剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式