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    • 93. 发明授权
    • Protein and monoclonal antibody specific thereto
    • 与其特异的蛋白质和单克隆抗体
    • US06191255B1
    • 2001-02-20
    • US09000041
    • 1998-02-20
    • Motoharu SeikiHiroshi SatoAkira Shinagawa
    • Motoharu SeikiHiroshi SatoAkira Shinagawa
    • A61K3843
    • C12N9/6491A61K38/00C07K16/40Y02A50/473
    • A novel protein which is useful as a diagnostic means for studies relating to the diagnosis and treatment of cancer (detection of cancer cells, estimation of the malignity, etc.) and for other medicinal and physiological purposes; a gene encoding the same; and an antibody, in particular, a monoclonal antibody specific to the protein. MT-MMP-3, which is a pro MMP-2 activator having the ability to activate pro MMP-2 which is under expression specifically on the surface layer of a human cancer cell and falling within the category of MMP but being different from MT-MMP-1; a DNA containing the base sequence encoding the same; host cells transformed by the DNA; a process for producing a matrix metalloproteinase protein by using the host cells; a monoclonal antibody binding specifically to the matrix metalloproteinase protein; and use of the protein and antibody.
    • 一种新的蛋白质,其可用于诊断和治疗癌症的诊断手段(癌细胞的检测,恶性的估计等)和其他药物和生理目的; 编码该基因的基因; 和抗体,特别是针对蛋白质的单克隆抗体。 MT-MMP-3,其是具有活化pro MMP-2的能力的促MMP-2激活剂,其特异性在人癌细胞的表面上表达并且属于MMP类别,但不同于MT- MMP-1; 含有编码其的碱基序列的DNA; 由DNA转化的宿主细胞; 通过使用宿主细胞产生基质金属蛋白酶蛋白质的方法; 与基质金属蛋白酶蛋白特异性结合的单克隆抗体; 并使用蛋白质和抗体。