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91. 发明申请

US20100069768A1 USE OF CARDIOHEMIC VIBRATION FOR PACING THERAPIES 有权
标题翻译：用于治疗的心脏震颤的使用
公开(公告)号：US20100069768A1
公开(公告)日：2010-03-18
申请号：US12211760
申请日：2008-09-16
申请人： Xiaoyi Min , Gene A. Bornzin , Jay Snell , Josh Reiss
发明人： Xiaoyi Min , Gene A. Bornzin , Jay Snell , Josh Reiss
IPC分类号： A61B5/02
CPC分类号： A61N1/365 , A61B5/0215 , A61B5/026 , A61B7/023 , A61B8/08 , A61B2562/0219 , A61N1/3627 , A61N1/36578
摘要： An exemplary method includes receiving a signal from an intrathoracic vibration sensor, analyzing the signal for vibration associated with deceleration of blood flow into the left ventricle, based at least in part on the analyzing, deciding whether to call for adjustment to one or more parameters of a bi-ventricular pacing therapy. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括从胸腔内振动传感器接收信号，至少部分地基于分析来分析与进入左心室的血流减速相关的振动信号，决定是否要调整一个或多个参数双心室起搏治疗。还公开了其它示例性方法，装置，系统等。

92. 发明授权

US07668593B1 System and method to accelerate individualized gain adjustment in implantable medical device systems 有权
标题翻译：用于加速植入式医疗设备系统中个体化增益调整的系统和方法
公开(公告)号：US07668593B1
公开(公告)日：2010-02-23
申请号：US11694534
申请日：2007-03-30
申请人： Xing Pei , Xiaoyi Min
发明人： Xing Pei , Xiaoyi Min
IPC分类号： A61N1/36
CPC分类号： A61N1/3704 , A61B5/0452 , A61N1/3622 , A61N1/368
摘要： A system and method for increasing the speed of individualizing amplifier gain optimization in implantable medical devices. A variable amplifier gain is initially set at a relatively high level such that the amplifier experiences at least intervals of saturation. A saturation indicator is determined which is indicative of the relative degree of saturation. The gain is then adjusted as a function of the saturation indicator. Relative larger degrees of saturation result in more aggressive gain adjustment. This increases the speed of adjustment with reduced likelihood of loss of sensing. In one implementation, one or more discrete amplifier gain adjustment steps are made in a single adjustment to effectively skip over intermediate adjustments. In another implementation, an estimate is made of a signal peak during a saturating interval. The gain is adjusted directly based on the estimated peak with appropriate sensing safety margins. The method can be implemented with a system including a programmer in communication with an implantable device.
摘要翻译：一种用于提高可植入医疗设备中个性化放大器增益优化的速度的系统和方法。可变放大器增益最初设置在相对高的电平，使得放大器经历至少饱和的间隔。确定饱和指示符，其表示相对饱和度。然后根据饱和指标调整增益。相对较大的饱和度导致更积极的增益调整。这增加了调节速度，减少了感测丢失的可能性。在一个实现中，在单个调整中进行一个或多个离散放大器增益调整步骤以有效跳过中间调整。在另一实现中，在饱和间隔期间估计信号峰值。基于具有适当感应安全裕度的估计峰值直接调整增益。该方法可以利用包括与可植入装置通信的编程器的系统来实现。

93. 发明申请

US20080215127A1 Medical Electrical Lead Providing Far-Field Signal Attenuation 审中-公开
标题翻译：医疗电气铅提供远场信号衰减
公开(公告)号：US20080215127A1
公开(公告)日：2008-09-04
申请号：US12122458
申请日：2008-05-16
申请人： Yougandh Chitre , Xiaoyi Min , Gene A. Bornzin
发明人： Yougandh Chitre , Xiaoyi Min , Gene A. Bornzin
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0573
摘要： A bipolar pacing and sensing lead incorporates a range of active surface areas for each of the anode and cathode electrodes, and a range of inter-electrode spacings between the anode and cathode electrodes which, in combination, provide acceptable near-field signal amplitudes and attenuate the amplitudes of unwanted signals, such as far-field R-waves, far-field P-waves, and T-waves.
摘要翻译：双极起搏和感测引线包括用于阳极和阴极电极中的每一个的一系列活性表面积，以及阳极和阴极电极之间的一系列电极间间隔，其组合提供可接受的近场信号幅度并衰减不想要的信号的幅度，例如远场R波，远场P波和T波。

94. 发明申请

US20070203473A1 APPARATUS AND SYSTEM FOR DELIVERY OF DRUG THERAPIES 有权
标题翻译：用于输送药物治疗的装置和系统
公开(公告)号：US20070203473A1
公开(公告)日：2007-08-30
申请号：US11675693
申请日：2007-02-16
申请人： Michael Ujhelyi , Rahul Mehra , Xiaoyi Min
发明人： Michael Ujhelyi , Rahul Mehra , Xiaoyi Min
IPC分类号： A61M25/00
CPC分类号： A61M5/14276 , A61M5/14244 , A61M5/16813 , A61M2205/0266 , A61N1/0568
摘要： A medical delivery system for delivering a fluid to a desired location within a body that includes a first member having an aperture, and a second member adapted to be positioned over the first member. The fluid to be delivered is contained within a fluid storage device, formed by at least one of the first member and the second member. The medical delivery system includes means for repositioning the first member relative to the second member between a first state preventing passage of the fluid through the aperture and a second state enabling passage of the fluid outward from the fluid storage device through the aperture.
摘要翻译：一种用于将流体输送到包括具有孔的第一构件的主体内的期望位置的医疗输送系统，以及适于定位在第一构件上方的第二构件。待输送的流体被包含在由第一构件和第二构件中的至少一个形成的流体存储装置内。医疗输送系统包括用于在通过孔的流体的第一状态阻止通道和允许流体从流体存储装置向外通过孔的第二状态之间相对于第二构件重新定位第一构件的装置。

95. 发明申请

US20060276848A1 Evoked response and impedance measures for monitoring heart failure and respiration 有权
标题翻译：用于监测心力衰竭和呼吸的诱发反应和阻抗措施
公开(公告)号：US20060276848A1
公开(公告)日：2006-12-07
申请号：US11149058
申请日：2005-06-06
申请人： Xiaoyi Min , Euljoon Park , Malin Ohlander
发明人： Xiaoyi Min , Euljoon Park , Malin Ohlander
IPC分类号： A61N1/365
CPC分类号： A61B5/0535 , A61B5/0402 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61N1/3601 , A61N1/365 , A61N1/36521 , A61N1/371
摘要： An exemplary method includes acquiring impedance values over one or more respiratory cycles, determining an impedance span based on the impedance values and, based at least in part on the impedance span, determining cardiac condition or respiratory condition. Another exemplary method includes acquiring IEGMs over one or more respiratory cycles, determining evoked response measure values based on the IEGMs, determining an evoked response span based on the evoked response measure values and, based at least in part on the evoked response span, determining cardiac condition or respiratory condition. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括：通过一个或多个呼吸周期获取阻抗值，基于阻抗值确定阻抗跨度，并且至少部分地基于阻抗跨度，确定心脏状况或呼吸状况。另一示例性方法包括通过一个或多个呼吸周期获取IEGM，基于IEGM确定诱发的应答测量值，基于诱发的响应测量值确定诱发的应答跨度，并且至少部分地基于诱发的响应跨度，确定心脏病情或呼吸状况。还公开了其它示例性方法，装置，系统等。

96. 发明授权

US07139609B1 System and method for monitoring cardiac function via cardiac sounds using an implantable cardiac stimulation device 有权
标题翻译：使用可植入心脏刺激装置通过心脏声音监测心脏功能的系统和方法
公开(公告)号：US07139609B1
公开(公告)日：2006-11-21
申请号：US10346809
申请日：2003-01-17
申请人： Xiaoyi Min , Paul A. Levine , Euljoon Park
发明人： Xiaoyi Min , Paul A. Levine , Euljoon Park
IPC分类号： A61B5/02 , A61N1/365
CPC分类号： A61N1/36585 , A61B5/02 , A61B5/04004 , A61B5/0402 , A61B5/7239 , A61B7/04 , A61N1/3627
摘要： Techniques are provided for performing internal measurement of heart sounds to estimate patient cardiac function in terms of stroke volume, cardiac output, or a maximum rate of change of aortic pressure with time (max dP/dt). Control parameters of the medical device are then automatically adjusted so as to optimize overall cardiac function or to provide for ventricular resynchronization therapy. In one example, heart sound signals are derived from acceleration signals received from an accelerometer. The heart sound signals are analyzed to identify S1 and S2 heart sounds as well as ejection period and isovolumic interval (ISOV). Proxies for max dP/dt, stroke volume and cardiac output are then derived from the S1 and S2 heart sounds, the ejection period and the ISOV. Alternative techniques, not requiring detection of ISOV, are employed for use if the patient has heart value regurgitation.
摘要翻译：提供技术用于进行心脏声音的内部测量，以根据中风量，心输出量或主动脉压随时间的最大变化率（最大dP / dt）来估计患者心脏功能。然后自动调节医疗装置的控制参数，以便优化整体心脏功能或提供心室再同步治疗。在一个示例中，从加速度计接收的加速度信号导出心音信号。分析心音信号以识别S1和S2心音，以及射血期和等容间隔（ISOV）。然后从S1和S2心脏声音，射血期和ISOV导出最大dP / dt，搏出量和心输出量的代理。如果患者有心脏反流，则采用不需要检测ISOV的替代技术。

97. 发明授权

US5871530A Intracardiac defibrillation leads 失效
标题翻译：心脏除颤引导
公开(公告)号：US5871530A
公开(公告)日：1999-02-16
申请号：US62373
申请日：1998-04-17
申请人： Terrell M. Williams , Peter M. J. Mulier , John G. Keimel , Timothy G. Laske , Gregory A. Boser , Mary M. Morris , Xiaoyi Min
发明人： Terrell M. Williams , Peter M. J. Mulier , John G. Keimel , Timothy G. Laske , Gregory A. Boser , Mary M. Morris , Xiaoyi Min
IPC分类号： A61N1/04 , A61N1/05
CPC分类号： A61N1/0565 , A61N1/0563
摘要： A lead and a lead system for dispersion of a cardioversion/defibrillation electrode formed of one or more small diameter defibrillation electrodes in a heart chamber and for attaching a pace/sense electrode in contact with the heart. The small diameter defibrillation electrode or electrodes extend distally from the distal end of the lead body. If multiple electrodes are employed, they are preferably biased to spread apart when unrestrained and have a cross-section size small enough to be inserted into interstices of trabeculae in the ventricular chamber. The distal ends of the defibrillation electrodes may be free of attachment to the lead body or may be attached by a weak bond to the distal portion of the lead.
摘要翻译：一种用于在心室中由一个或多个小直径除颤电极形成的复律/除颤电极的分散的引线和引导系统，并且用于附接与心脏接触的步调/感测电极。小直径除颤电极或电极从引线体的远端向远端延伸。如果使用多个电极，则它们优选地被偏置以在不受限制的情况下展开，并且具有足够小的横截面尺寸以插入心室中的小梁的间隙中。除颤电极的远端可以没有附着到引线体，或者可以通过弱接合附着到引线的远端部分。

98. 发明授权

US5836976A Cardioversion energy reduction system 失效
标题翻译：心律转换能量减少系统
公开(公告)号：US5836976A
公开(公告)日：1998-11-17
申请号：US846747
申请日：1997-04-30
申请人： Xiaoyi Min , Li Wang , Rahul Mehra , Paul J. DeGroot , Walter H. Olson , Luc R. Mongeon , Michael R. S. Hill
发明人： Xiaoyi Min , Li Wang , Rahul Mehra , Paul J. DeGroot , Walter H. Olson , Luc R. Mongeon , Michael R. S. Hill
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3925 , A61N1/3987
摘要： In an implantable pacemaker/cardioverter/defibrillator, a system for correlating the delivery of a cardioversion therapy to an optimum point or phase of the respiratory cycle of the patient to effect delivery of the therapy when the impedance between the cardioversion electrodes is minimized. In a first application for use with cardioversion electrodes located substantially in contact with the heart chamber, the optimum point or phase is at the end of inspiration. In a second application for use with at least one cardioversion electrode located remotely from the heart chamber, the optimum point or phase is at end expiration or beginning of inspiration. The cardioversion therapy is delivered in synchrony with a ventricular sense event, if present. If the optimum point or phase of the respiratory cycle cannot be determined during a therapy time, a pre-shock may be delivered to elicit a respiration cycle through a stimulated contraction of the diaphragm.
摘要翻译：在植入式心脏起搏器/心律转复除颤器中，用于将心脏复律治疗的输送与患者呼吸周期的最佳点或阶段相关联的系统，以在心脏复律电极之间的阻抗最小化时实现治疗的传递。在与基本上与心脏腔室接触的心脏复律电极一起使用的第一个应用中，最佳点或阶段在吸气结束时。在与远离心脏室的位置的至少一个心脏复律电极一起使用的第二个应用中，最佳点或阶段是结束期满或开始吸气。复发疗法与心室感觉事件（如果存在）同步传递。如果在治疗时间内不能确定呼吸周期的最佳点或相位，则可以传送预休克以通过振膜的刺激收缩引起呼吸循环。

99. 发明授权

US5713924A Defibrillation threshold reduction system 失效
标题翻译：除颤门限降低系统
公开(公告)号：US5713924A
公开(公告)日：1998-02-03
申请号：US495251
申请日：1995-06-27
申请人： Xiaoyi Min , Luc R. Mongeon , Michael R. S. Hill
发明人： Xiaoyi Min , Luc R. Mongeon , Michael R. S. Hill
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/395
摘要： A method an apparatus for treating fibrillation, particularly atrial fibrillation. In response to detection of fibrillation, a high frequency, low energy pulse burst is delivered via pacing electrodes, accompanied by a high energy pulse delivered via defibrillation electrodes. The low energy pulse burst is preferably delivered to an area of the heart which exhibits relatively lower current density during delivery of the high energy pulse.
摘要翻译：一种用于治疗纤维性颤动，特别是心房颤动的装置的方法。响应于原纤维的检测，通过起搏电极输送高频，低能脉冲脉冲，伴随着通过除颤电极传送的高能量脉冲。低能量脉冲脉冲优选地被传送到在高能量脉冲传送期间呈现相对较低的电流密度的心脏区域。

100. 发明授权

US09399129B2 MRI compatible implantable medical lead and method of making same 有权
标题翻译： MRI兼容的植入式医用引线及其制造方法
公开(公告)号：US09399129B2
公开(公告)日：2016-07-26
申请号：US12262083
申请日：2008-10-30
申请人： Yong D. Zhao , Xiaoyi Min , Virote Indravudh
发明人： Yong D. Zhao , Xiaoyi Min , Virote Indravudh
IPC分类号： A61N1/00 , A61N1/05 , A61N1/08
CPC分类号： A61N1/056 , A61N1/086
摘要： An implantable medical lead is disclosed herein. The lead may include a body and an electrical pathway. The body may include a distal portion with an electrode and a proximal portion with a lead connector end. The electrical pathway may extend between the electrode and lead connector end and may include a coiled inductor including first and second electrically conductive filar cores. The first and second filar cores may be physically joined into a unified single piece proximal terminal on a proximal end of the coiled inductor. The first and second cores may be physically joined into a unified single piece distal terminal on a distal end of the coiled inductor. The first and second filar cores may be helically wound into a coiled portion between the proximal and distal terminals, the filar cores being electrically isolated from each other in the coiled portion. The proximal terminal may be electrically coupled to a portion of the electrical pathway extending to the lead connector end, and the distal terminal may be electrically coupled to a portion of the electrical pathway extending to the electrode.
摘要翻译：本文公开了可植入医疗引线。引线可以包括主体和电路径。主体可以包括具有电极的远端部分和具有引线连接器端部的近端部分。电路可以在电极和引线连接器端之间延伸并且可以包括包括第一和第二导电丝芯的线圈电感器。第一和第二丝状芯可以物理地连接到线圈电感器的近端上的统一的单件式近端端子。第一和第二芯可以物理地连接到线圈电感器的远端上的统一的单件式远端终端。第一和第二丝芯可以螺旋地缠绕在近端和远端之间的线圈部分中，丝芯在线圈部分中彼此电隔离。近端端子可以电连接到延伸到引线连接器端的电路径的一部分，并且远端端子可电耦合到延伸到电极的电路径的一部分。

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