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91. 发明授权

US06562579B1 Diagnostic methods using antibodies to Neutrokine-alpha 有权
标题翻译：使用Neutrokine-α抗体的诊断方法
公开(公告)号：US06562579B1
公开(公告)日：2003-05-13
申请号：US09588947
申请日：2000-06-08
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
IPC分类号： G01N3353
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

92. 发明授权

US06541224B2 Tumor necrosis factor delta polypeptides 有权
标题翻译：肿瘤坏死因子δ多肽
公开(公告)号：US06541224B2
公开(公告)日：2003-04-01
申请号：US09879919
申请日：2001-06-14
申请人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
IPC分类号： C12N1500
CPC分类号： A61K49/0004 , A61K47/6849 , A61K2039/505 , C07K14/52 , C07K14/70575 , C07K16/2875 , C07K2317/21 , C07K2317/622 , C07K2317/74 , G01N33/564 , G01N33/6863 , G01N2333/525
摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

93. 发明授权

US06482922B2 Mammary transforming protein 失效
标题翻译：乳腺转化蛋白
公开(公告)号：US06482922B2
公开(公告)日：2002-11-19
申请号：US09263811
申请日：1999-03-08
申请人： Jian Ni , Guo-Liang Yu , Reiner L. Gentz
发明人： Jian Ni , Guo-Liang Yu , Reiner L. Gentz
IPC分类号： C07K100
CPC分类号： C07K14/82 , A61K38/00 , A61K48/00 , C12N2799/026 , C12Q1/6886 , C12Q2600/136
摘要： A human mammary transforming protein and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for inhibiting such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了一种编码这种多肽的人类乳腺转化蛋白和DNA（RNA），以及通过重组技术产生这种多肽的方法。还公开了抑制这种多肽以预防和/或治疗瘤形成的方法。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

94. 发明授权

US06406867B1 Antibody to human endokine alpha and methods of use 失效
标题翻译：人内因素α抗体
公开(公告)号：US06406867B1
公开(公告)日：2002-06-18
申请号：US09513584
申请日：2000-02-25
申请人： Guo-Liang Yu , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Jian Ni , Craig A. Rosen
IPC分类号： C07K1622
CPC分类号： C07K14/7151 , A61K38/00 , C07K14/5255 , C07K16/24 , C07K2317/21 , C07K2317/622 , Y10S514/885
摘要： The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and antibody fragments which specifically bind the polypeptides of the invention are also provided, as well as methods for detecting the polypeptides of the invention using said antibodies and antibody fragments. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.
摘要翻译：本发明涉及细胞因子的肿瘤坏死因子（TNF）家族的新成员。特别地，提供了分离的核酸分子，其编码内丝蛋白α蛋白。还提供了内含子α多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还提供了特异性结合本发明多肽的抗体和抗体片段，以及使用所述抗体和抗体片段检测本发明的多肽的方法。还提供了关于TNF家族相关疾病的诊断和治疗方法。

95. 发明授权

US08173122B2 Methods of treatment using antibodies to neutrokine-alpha 有权
标题翻译：使用抗中性白细胞抗体α的治疗方法
公开(公告)号：US08173122B2
公开(公告)日：2012-05-08
申请号：US12170333
申请日：2008-07-09
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , A61K38/18 , A61K38/19 , A61K38/22 , C07K16/22 , C07K14/475
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

96. 发明申请

US20110165160A1 NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 审中-公开
标题翻译： NEUTROKINE-ALPHA和NEUTROKINE-ALPHA SPLICE变体
公开(公告)号：US20110165160A1
公开(公告)日：2011-07-07
申请号：US12965535
申请日：2010-12-10
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , C12N5/09 , A61K38/02 , C12Q1/02 , A61P35/02
CPC分类号： G01N33/56972 , A61K31/519 , A61K38/00 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/70575 , C07K14/715 , C07K16/24 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N2333/52 , G01N2800/24
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译：本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。

97. 发明申请

US20110052590A1 NEUTROKINE-ALPHA ANTIBODIES AND METHODS OF USE THEREOF 有权
标题翻译： NEUTROKINE-ALPHA抗体及其使用方法
公开(公告)号：US20110052590A1
公开(公告)日：2011-03-03
申请号：US12870548
申请日：2010-08-27
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , C07K16/24 , G01N33/53 , A61P37/06
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a Neutrokine-alpha antibody and a process for producing a Neutrokine-alpha antibody. The invention further relates to screening methods for identifying compounds that inhibit or enhance the action of Neutrokine-alpha. Also provided are diagnostic methods for detecting autoimmune disorders and therapeutic methods for treating autoimmune disorders using a Neutrokine-alpha antibody.
摘要翻译：本发明涉及一种Neutrokine-α抗体及其制备Neutrokine-α抗体的方法。本发明还涉及用于鉴定抑制或增强中枢神经素α作用的化合物的筛选方法。还提供了用于检测自身免疫疾病的诊断方法和使用中和碱α抗体治疗自身免疫疾病的治疗方法。

98. 发明授权

US07820798B2 Tumor necrosis factor-gamma 有权
标题翻译：抗肿瘤坏死因子-γ的抗体
公开(公告)号：US07820798B2
公开(公告)日：2010-10-26
申请号：US11837082
申请日：2007-08-10
申请人： Guo-Liang Yu , Jian Ni , Craig A. Rosen , Jun Zhang
发明人： Guo-Liang Yu , Jian Ni , Craig A. Rosen , Jun Zhang
IPC分类号： C07K16/28 , C07K16/18 , C07K16/22 , C07K16/46 , C12N5/00 , G01N33/53
CPC分类号： A61K51/08 , C07K16/241 , Y10S930/144
摘要： Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
摘要翻译：公开了人类TNF-γ-α和TNF-γ-β多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽抑制细胞生长的方法，例如在肿瘤或癌症中，用于促进伤口愈合，提供抗感染，诱导炎症活性和刺激某些细胞类型的生长以治疗疾病，示例再狭窄。还公开了用于检测TNF-γ-α和TNF-γ-β核酸序列中的突变或TNF-γ-α和/或TNF-γ-β多肽的过表达的诊断方法。还公开了抗这些多肽的拮抗剂及其作为治疗性恶病质，败血性休克，脑疟疾，炎症，关节炎和移植排斥的治疗剂的用途。

99. 发明授权

US07597886B2 Tumor necrosis factor-gamma 有权
公开(公告)号：US07597886B2
公开(公告)日：2009-10-06
申请号：US09899059
申请日：2001-07-06
申请人： Guo-Liang Yu , Jian Ni , Craig A. Rosen , Jun Zhang
发明人： Guo-Liang Yu , Jian Ni , Craig A. Rosen , Jun Zhang
IPC分类号： A61K39/395 , C07K14/525
CPC分类号： A61K31/713 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/241 , Y02A50/412 , Y10S930/144
摘要： Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.

100. 发明授权

US07534428B2 Antibodies to tumor necrosis factor receptors 6α and 6β 有权
标题翻译：肿瘤坏死因子受体6alpha和6beta的抗体
公开(公告)号：US07534428B2
公开(公告)日：2009-05-19
申请号：US11416310
申请日：2006-05-03
申请人： Reiner L. Gentz , Reinhard Ebner , Guo-Liang Yu , Steven M. Ruben , Jian Ni , Ping Feng
发明人： Reiner L. Gentz , Reinhard Ebner , Guo-Liang Yu , Steven M. Ruben , Jian Ni , Ping Feng
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： A61K48/005 , A61K38/00 , A61K48/0058 , C07K14/4703 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides and antibodies that bind TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及新型肿瘤坏死因子受体蛋白。特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。还提供TNFR-6α和-6β多肽和结合TNFR-6α和-6β多肽的抗体，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

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