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    • 98. 发明授权
    • Tumor necrosis factor-gamma
    • 抗肿瘤坏死因子-γ的抗体
    • US07820798B2
    • 2010-10-26
    • US11837082
    • 2007-08-10
    • Guo-Liang YuJian NiCraig A. RosenJun Zhang
    • Guo-Liang YuJian NiCraig A. RosenJun Zhang
    • C07K16/28C07K16/18C07K16/22C07K16/46C12N5/00G01N33/53
    • A61K51/08C07K16/241Y10S930/144
    • Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
    • 公开了人类TNF-γ-α和TNF-γ-β多肽和编码这种多肽的DNA(RNA)以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽抑制细胞生长的方法,例如在肿瘤或癌症中,用于促进伤口愈合,提供抗感染,诱导炎症活性和刺激某些细胞类型的生长以治疗疾病, 示例再狭窄。 还公开了用于检测TNF-γ-α和TNF-γ-β核酸序列中的突变或TNF-γ-α和/或TNF-γ-β多肽的过表达的诊断方法。 还公开了抗这些多肽的拮抗剂及其作为治疗性恶病质,败血性休克,脑疟疾,炎症,关节炎和移植排斥的治疗剂的用途。