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91. 发明申请

US20110201969A1 METHODS FOR CONSTRUCTING POSTURE CALIBRATION MATRICES 审中-公开
标题翻译：建立姿势校准矩阵的方法
公开(公告)号：US20110201969A1
公开(公告)日：2011-08-18
申请号：US13024823
申请日：2011-02-10
申请人： John D. Hatlestad , Tsz Ping Chan
发明人： John D. Hatlestad , Tsz Ping Chan
IPC分类号： A61B5/103
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1117 , A61B5/1118 , A61B5/686 , A61B2560/0223 , A61B2562/0219 , A61N1/3925 , G01P15/18
摘要： A device can include a multi-dimensional posture sensor that provides an electrical sensor output representative of alignment of first, second, and third non-parallel axes of the device with the gravitational field of the earth, and a processor that includes a calibration circuit and a posture circuit. The calibration circuit measures a first sensor output for the first device axis and a second sensor output for one of a second device axis while the subject is in a first specified posture, measures sensor outputs for the first, second, and third device axes while the subject is in a second specified posture, calculates one or more coordinate transformations, generates transformed sensor outputs using the coordinate transformations, and calibrates the posture sensor by calculating a calibration transformation using the first and second sensor outputs and the transformed sensor outputs. The posture circuit determines a subsequent posture of the subject using the posture sensor.
摘要翻译：设备可以包括多维姿态传感器，其提供表示设备的第一，第二和第三非平行轴线与地球的重力场的对准的电传感器输出，以及包括校准电路和姿势电路。校准电路测量第一设备轴的第一传感器输出和第二设备轴的第二传感器输出，同时对象处于第一指定姿势，测量第一，第二和第三设备轴的传感器输出，同时受试者处于第二指定姿势，计算一个或多个坐标变换，使用坐标变换生成变换的传感器输出，并且通过使用第一和第二传感器输出和变换的传感器输出计算校准变换来校准姿势传感器。姿势电路使用姿态传感器来确定对象的后续姿势。

92. 发明授权

US07993280B2 Rapid shallow breathing detection for use in congestive heart failure status determination 有权
标题翻译：快速浅呼吸检测用于充血性心力衰竭状态测定
公开(公告)号：US07993280B2
公开(公告)日：2011-08-09
申请号：US12847645
申请日：2010-07-30
申请人： Yi Zhang , John D. Hatlestad , Yousufali H. Dalal , Marina Brockway
发明人： Yi Zhang , John D. Hatlestad , Yousufali H. Dalal , Marina Brockway
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/053 , A61B5/0816 , A61B5/411 , A61B2562/0219 , A61N1/3627 , A61N1/36521
摘要： Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient's congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient's measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.
摘要翻译：系统和方法涉及使用包括感测电路的医疗装置。使用该装置检测一个或多个呼吸参数。提供患者基线重量，并且基于一个或多个呼吸参数的变化和患者相对于患者基线重量的测量重量或预测体重的变化来生成指示患者充血性心力衰竭状态的输出信号。呼吸参数可以包括呼吸速率，相对潮气量，指示患者快速浅呼吸的指标，通过计算呼吸速率导出的指数和每个患者呼吸的潮气量以及指示呼吸困难的指数中的一个或多个，例如。

93. 发明申请

US20100280564A1 MONITORING OF CHRONOBIOLOGICAL RHYTHMS FOR DISEASE AND DRUG MANAGEMENT USING ONE OR MORE IMPLANTABLE DEVICE 有权
标题翻译：使用一个或多个可植入装置监测疾病和药物管理的血液生殖系统
公开(公告)号：US20100280564A1
公开(公告)日：2010-11-04
申请号：US12836441
申请日：2010-07-14
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61N1/02 , A61B5/00
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译：使用至少一个可植入装置自动评价或预测受试者的健康状况。在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。也可以使用昼夜节律以外的其他时间生理节律。可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

94. 发明申请

US20090312973A1 POSTURE SENSOR AUTOMATIC CALIBRATION 有权
标题翻译：自动传感器自动校准
公开(公告)号：US20090312973A1
公开(公告)日：2009-12-17
申请号：US12425195
申请日：2009-04-16
申请人： John D. Hatlestad , Aaron Lewicke
发明人： John D. Hatlestad , Aaron Lewicke
IPC分类号： G01P21/00
CPC分类号： G01P21/00 , A61B5/0031 , A61B5/103 , A61B5/1038 , A61B5/1116 , A61B5/686 , A61B2560/0223 , A61B2562/0219 , G01C22/00 , G01C25/00 , G01D18/00 , G01P13/00 , G06F17/40 , G06F19/00
摘要： A system and method automatically calibrate a posture sensor, such as by detecting a walking state or a posture change. For example, a three-axis accelerometer can be used to detect a patient's activity or posture. This information can be used to automatically calibrate subsequent posture or acceleration data.
摘要翻译：系统和方法通过检测步行状态或姿势变化来自动校准姿势传感器。例如，三轴加速度计可用于检测患者的活动或姿势。该信息可用于自动校准后续姿势或加速度数据。

95. 发明申请

US20090069708A1 HISTOGRAM-BASED THORACIC IMPEDANCE MONITORING 有权
标题翻译：基于组织学的THORACIC阻抗监测
公开(公告)号：US20090069708A1
公开(公告)日：2009-03-12
申请号：US11853590
申请日：2007-09-11
申请人： John D. Hatlestad , Cal Roeske , Loell Boyce Moon , Jeffrey P. Cook
发明人： John D. Hatlestad , Cal Roeske , Loell Boyce Moon , Jeffrey P. Cook
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0535 , A61B5/0537 , A61B5/08 , A61B5/0809 , A61B5/416 , A61B5/6846 , A61N1/36521
摘要： Systems and methods for monitoring pulmonary edema or other thoracic fluid status in a subject use thoracic impedance histogram information. An internal or external processor circuit receives the thoracic impedance histogram information and uses it to compute and provide a lung fluid status indication. The thoracic impedance histogram information can include a count, mean or median of a histogram bin or subrange of bins within the histogram range.
摘要翻译：用于监测受试者的肺水肿或其他胸腔液状态的系统和方法使用胸阻抗直方图信息。内部或外部处理器电路接收胸部阻抗直方图信息并使用它来计算和提供肺液体状态指示。胸廓阻抗直方图信息可以包括直方图区块的计数，平均值或中值或直方图范围内的区域的子范围。

96. 发明授权

US07471986B2 System and method for transmitting energy to and establishing a communications network with one or more implanted devices 失效
标题翻译：用于向一个或多个植入装置发送能量并建立通信网络的系统和方法
公开(公告)号：US07471986B2
公开(公告)日：2008-12-30
申请号：US10783285
申请日：2004-02-20
申请人： John D. Hatlestad
发明人： John D. Hatlestad
IPC分类号： A61N1/00 , A61N1/08
CPC分类号： A61N1/3787
摘要： Systems and methods for automatically powering and communicating with an implantable medical device through an inductive link are disclosed. A preferred embodiment comprises an inductive coil or set of such coils. One coil may be mounted or installed on or near the bed of a patient as a component of a transmission module. Another coil may a component of an implantable medical device. The coils are energized by a resonant circuit to generate an electromagnetic field in the vicinity of the bedside. Without any action on the patient's part, the implantable device receives the inductively transmitted energy to power its immediate operation or recharge its battery, thereby extending its longevity, potentially indefinitely. The inductive link also enables data transfer communication between the transmission module and implantable device. Some embodiments of a system disclosed herein also can be configured as a component of an Advanced Patient Management System that helps better monitor, predict and manage chronic diseases.
摘要翻译：公开了通过电感链路自动供电和与可植入医疗装置通信的系统和方法。优选实施例包括一个感应线圈或一组这样的线圈。一个线圈可以作为传输模块的组件安装或安装在患者床上或其附近。另一个线圈可以是可植入医疗装置的部件。线圈由谐振电路通电，以在床边附近产生电磁场。无需对患者进行任何动作，可植入装置接收感应发射的能量来为其即时操作提供动力或对其电池进行再充电，从而可能无限期地延长其寿命。感应链路还使得传输模块和可植入设备之间的数据传输通信。本文公开的系统的一些实施例还可以被配置为高级患者管理系统的组件，其有助于更好地监测，预测和管理慢性疾病。

97. 发明申请

US20080312541A1 Daytime/nighttime respiration rate monitoring 有权
标题翻译：白天/夜间呼吸率监测
公开(公告)号：US20080312541A1
公开(公告)日：2008-12-18
申请号：US11820002
申请日：2007-06-15
申请人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
发明人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
IPC分类号： A61B5/0205
CPC分类号： A61B5/0816 , A61B5/0205 , A61B5/1116 , A61B5/7264 , G06F19/00
摘要： A device and method can monitor or trend a patient's respiration rate measurements according to the time of day. The device, which may be implantable or external, collects and classifies respiration rate measurements over time. The trended information about particular classes of respiration rate measurements is then communicated to a remote external device, which in turn provides an indication of heart failure decompensation. Examples of classes of respiration rate measurements include a daily maximum respiration rate value, a daily minimum respiration rate value, a daily maximum respiration rate variability value, a daily minimum respiration rate variability value, and a daily central respiration rate value. These respiration rate measurements can be further classified into daytime or nighttime respiration rate measurements.
摘要翻译：一种装置和方法可以根据一天中的时间来监视或趋向于患者的呼吸速率测量。该装置可以植入或外部收集和分类呼吸速率测量随时间的变化。关于呼吸率测量的特定类别的趋势化信息然后被传送到远程外部设备，远程外部设备又提供心力衰竭失代偿指示。呼吸速率测量类别的实例包括每日最大呼吸率值，每日最小呼吸率值，每日最大呼吸率变异值，每日最小呼吸率变异性值和每日中心呼吸率值。这些呼吸率测量可以进一步分为白天或夜间呼吸率测量。

98. 发明授权

US07189204B2 Sleep detection using an adjustable threshold 有权
标题翻译：使用可调阈值进行睡眠检测
公开(公告)号：US07189204B2
公开(公告)日：2007-03-13
申请号：US10309771
申请日：2002-12-04
申请人： Quan Ni , Zoe Hajenga , Douglas R. Daum , Jeff E. Stahmann , John D. Hatlestad , Kent Lee
发明人： Quan Ni , Zoe Hajenga , Douglas R. Daum , Jeff E. Stahmann , John D. Hatlestad , Kent Lee
IPC分类号： A61B5/02 , A61B5/00 , A61B5/08
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/021 , A61B5/085 , A61B5/1116 , A61B5/4809 , A61B5/686 , A61B5/7271 , A61B5/7282 , A61N1/362 , A61N1/365 , A61N1/36542 , G16H40/63 , G16H50/20
摘要： Devices and methods for sleep detection involve the use of an adjustable threshold for detecting sleep onset and termination. A method for detecting sleep includes adjusting a sleep threshold associated with a first sleep-related signal using a second sleep-related signal. The first sleep-related signal is compared to the adjusted threshold and sleep is detected based on the comparison. The sleep-related signals may be derived from implantable or external sensors. Additional sleep-related signals may be used to confirm the sleep condition. A sleep detector device implementing a sleep detection method may be a component of an implantable pulse generator such as a pacemaker or defibrillator.
摘要翻译：用于睡眠检测的装置和方法涉及使用可调阈值来检测睡眠开始和终止。一种用于检测睡眠的方法包括使用第二睡眠相关信号来调整与第一睡眠相关信号相关联的睡眠阈值。将第一睡眠相关信号与调整后的阈值进行比较，并根据比较检测睡眠。睡眠相关信号可以从可植入或外部传感器得到。可以使用额外的睡眠相关信号来确认睡眠状况。实现睡眠检测方法的睡眠检测器装置可以是诸如起搏器或除颤器的可植入脉冲发生器的部件。

99. 发明授权

US5621460A Optical differentiation between plants and background utilizing a single CCD camera 失效
标题翻译：使用单个CCD相机的植物和背景之间的光学差异
公开(公告)号：US5621460A
公开(公告)日：1997-04-15
申请号：US496615
申请日：1995-06-29
申请人： John D. Hatlestad , Gerald F. Sauter
发明人： John D. Hatlestad , Gerald F. Sauter
IPC分类号： A01M7/00 , H04N5/33 , H04N9/097
CPC分类号： H04N5/332 , A01M7/0089 , H04N5/33 , H04N9/097
摘要： An optical system for detecting vegetation with the use of a single image sensor, such as a charge coupled device (CCD) camera is provided by optical elements which project separate red and near infrared (NIR) images onto the CCD camera. The camera then can supply output signals representative of the two images to a signal processing device that determines the nature of the vegetation that provided the original image. Embodiments are described where the imaging sensor utilizes unitary optical splitters to provide wide-angle separate images. In another version a single lens and a group of mirrors provide a narrow-angle telescope device. Another version includes two separate lens, red and NIR filters, each adjacent to one of the lenses so as to project an image on separate areas of the CCD camera.
摘要翻译：通过将单独的红色和近红外（NIR）图像投影到CCD照相机上的光学元件，提供了使用诸如电荷耦合器件（CCD）照相机的单个图像传感器来检测植被的光学系统。相机然后可以将表示两个图像的输出信号提供给确定提供原始图像的植被的性质的信号处理装置。描述实施例，其中成像传感器利用单一分光器来提供广角分离的图像。在另一个版本中，单个透镜和一组镜子提供了一个窄角望远镜装置。另一个版本包括两个独立的镜头，红色和NIR滤镜，每个镜头都与其中一个镜头相邻，以便在CCD相机的不同区域上投影图像。

100. 发明授权

US09393415B2 Systems and methods for using electrical impedance for neuro cardiac therapy 有权
标题翻译：使用电阻抗进行神经心脏治疗的系统和方法
公开(公告)号：US09393415B2
公开(公告)日：2016-07-19
申请号：US13309320
申请日：2011-12-01
申请人： Shantha Arcot-Krishnamurthy , Yi Zhang , John D. Hatlestad
发明人： Shantha Arcot-Krishnamurthy , Yi Zhang , John D. Hatlestad
IPC分类号： A61B5/02 , A61N1/36 , A61B5/053 , A61N1/365
CPC分类号： A61N1/36053 , A61B5/0538 , A61N1/36117 , A61N1/36135 , A61N1/36521
摘要： A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable impedance sensor and an impedance analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable impedance sensor is configured to detect impedance changes in a cervical region of the patient caused by laryngeal vibrations. The impedance sensor is configured to generate sensed impedance values. The impedance analyzer is configured to analyze the sensed impedance values generated by the sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed impedance values.
摘要翻译：设备实施例被配置为将迷走神经刺激治疗（VST）递送到患者的迷走神经。装置实施例包括神经刺激器，可植入阻抗传感器和阻抗分析器。神经刺激器被配置成将VST输送到患者的颈部区域中的迷走神经。可植入阻抗传感器被配置为检测由喉部振动引起的患者的颈部区域中的阻抗变化。阻抗传感器被配置为产生感测的阻抗值。阻抗分析器被配置为分析由传感器产生的感测阻抗值。分析器被配置为检测来自感测的阻抗值的喉部振动或咳嗽。

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