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91. 发明授权

US08576820B2 Standby mode for use in a device having a multiple channel physical layer 有权
公开(公告)号：US08576820B2
公开(公告)日：2013-11-05
申请号：US10882389
申请日：2004-07-02
申请人： Kevin Brown , Richard G. Thousand , John Creigh
发明人： Kevin Brown , Richard G. Thousand , John Creigh
IPC分类号： H04B7/216
CPC分类号： H04L12/12 , H04L12/40052 , H04L12/40097 , Y02D50/20 , Y02D50/40 , Y02D50/42
摘要： The present invention provides a way of placing a physical layer device into a standby mode. After a link is established between multiple devices, a determination is made whether the device has data to transmit or whether a standby request was received from a link partner. If a standby request was received or the device has no data to transmit, standby mode is entered. In standby mode, unneeded circuitry is powered down. A transmitter in a channel and a receive path in a separate channel remain powered. While operating in standby mode, the PHY layer continuously transmits a standby code on the one or more channels that are not powered down. Standby mode is discontinued when a transceiver has data to transmit or when energy is detected on the powered down channels. Standby mode is also discontinued when no standby code is received, indicating a disconnect between devices.

92. 发明授权

US08565105B2 Method and system for ethernet switching, conversion, and PHY optimization based on link length in audio/video systems 有权
标题翻译：基于音频/视频系统中链路长度的以太网交换，转换和PHY优化的方法和系统
公开(公告)号：US08565105B2
公开(公告)日：2013-10-22
申请号：US12495496
申请日：2009-06-30
申请人： Wael William Diab , Scott Powell , Michael Johas Teener , Kevin Brown
发明人： Wael William Diab , Scott Powell , Michael Johas Teener , Kevin Brown
IPC分类号： H04J3/14
CPC分类号： H04L41/0803 , H04B3/23 , H04B3/32 , H04L25/03006 , H04L2025/03356 , H04L2025/03535
摘要： Aspects of a method and system for Ethernet Switching, Conversion, and PHY optimization based on link length in Audio/Video Systems are provided. In this regard, the length of a link over which a first communication device communicates with a second communication device may be determined and Ethernet PHY's residing in the communication devices may be configured based on the determination. One or both of the communication devices may comprise an Ethernet switch operable to switch packetized audio and/or video content. The packetized audio and/or video may be switched between the configured Ethernet PHY and one or more other Ethernet PHYs. Audio and/or video data may be received via the one or more corresponding Ethernet PHYs, the received audio and/or video data may be reformatted to be compatible with an audio and/or video interface, and the reformatted audio and/or video data may be transmitted via the audio and/or video interface.
摘要翻译：提供了一种基于音频/视频系统中链路长度的以太网交换，转换和PHY优化方法和系统的方面。在这点上，可以确定第一通信设备与第二通信设备通信的链路的长度，并且可以基于该确定来配置驻留在通信设备中的以太网PHY。一个或两个通信设备可以包括可操作以切换分组化音频和/或视频内容的以太网交换机。打包的音频和/或视频可以在配置的以太网PHY和一个或多个其他以太网PHY之间切换。可以经由一个或多个对应的以太网PHY接收音频和/或视频数据，所接收的音频和/或视频数据可以被重新格式化为与音频和/或视频接口兼容，并且重新格式化的音频和/或视频数据可以经由音频和/或视频接口传输。

93. 发明授权

US08355482B2 Radiotherapy apparatus 有权
标题翻译：放射治疗仪
公开(公告)号：US08355482B2
公开(公告)日：2013-01-15
申请号：US12992727
申请日：2009-05-15
申请人： Kevin Brown , Maria Giulia Thompson , Vibeke Nordmark Hansen , Philip Mark Evans , David Anthony Roberts
发明人： Kevin Brown , Maria Giulia Thompson , Vibeke Nordmark Hansen , Philip Mark Evans , David Anthony Roberts
IPC分类号： A61N5/10 , H01J35/08 , G21K3/00
CPC分类号： A61N5/1049 , A61B6/06 , A61B6/4042 , A61B6/583 , A61N2005/1061 , G21K1/02 , G21K1/10 , H01J35/08 , H01J2235/081 , H01J2235/087
摘要： It is desirable to achieve a co-incident investigative kV source for a therapeutic MV source—a so-called “beams-eye-view” source. It has been suggested that bremsstrahlung radiation from an electron window be employed; we propose a practical structure for achieving this which can switch easily between a therapeutic beam and a beam-eye-view diagnostic beam capable of offering good image resolution. Such a radiation source comprises an electron gun, a pair of targets locatable in the path of a beam produced by the electron gun, one target of the pair being of a material with a lower atomic number than the other, and an electron absorber insertable into and withdrawable from the path of the beam. In a preferred form, the electron gun is within a vacuum chamber, and the pair of targets are located at a boundary of the vacuum chamber. The lower atomic number target can be Nickel and the higher atomic number target Copper and/or Tungsten. The electron absorber can be Carbon, and can be located within the primary collimator, or within one of a plurality of primary collimators interchangeably locatable in the path of the beam. Such a radiation source can be included within a radiotherapy apparatus, to which the present invention further relates. A flat panel imaging device for this source can be optimised for low energy x-rays rather than high energy; Caesium Iodide-based panels are therefore suitable.
摘要翻译：期望实现用于治疗性MV源的共同调查性kV源 - 所谓的束视野源。有人建议使用来自电子窗的bre致辐射; 我们提出了实现这一点的实际结构，其可以在能够提供良好的图像分辨率的治疗光束和眼睛视图诊断光束之间容易地切换。这样的辐射源包括电子枪，一对可定位在由电子枪产生的光束的路径中的一对靶，该对中的一个靶是具有比另一个更低原子序数的材料，以及电子吸收体可插入并从梁的路径中抽出。在优选形式中，电子枪位于真空室内，并且该对靶位于真空室的边界处。较低的原子序号目标可以是镍，较高原子序号的目标铜和/或钨。电子吸收器可以是碳，并且可以位于主准直器内，或者位于可互换定位在光束路径中的多个主准直仪之一内。这样的辐射源可以包括在本发明进一步涉及的放射治疗装置内。用于该源的平板成像装置可以针对低能x射线而不是高能量进行优化; 因此，基于碘化铯的面板是合适的。

94. 发明申请

US20110319741A1 Adapting radiotherapy treatment plans 审中-公开
标题翻译：适应放射治疗计划
公开(公告)号：US20110319741A1
公开(公告)日：2011-12-29
申请号：US12821660
申请日：2010-06-23
申请人： Kevin Brown
发明人： Kevin Brown
IPC分类号： A61B5/05
CPC分类号： G06F19/3481 , A61N5/1037
摘要： Embodiments of the present invention provide a method of pre-approving a range of hypothetical spatial variations of the target whilst an initial treatment plan is generated. This allows the treatment plan to be later adapted to account for spatial variations of the target region falling within those pre-approved ranges, without going through time-consuming steps of quality assurance on the adapted plan.
摘要翻译：本发明的实施例提供了一种在产生初始治疗计划时预先批准目标的假设空间变化范围的方法。这使得治疗计划稍后适应于考虑到落在那些预先批准的范围内的目标区域的空间变化，而不需要经过适应计划的质量保证的耗时步骤。

95. 发明申请

US20110243387A1 Analysis of Radiographic Images 有权
标题翻译：射线照相分析
公开(公告)号：US20110243387A1
公开(公告)日：2011-10-06
申请号：US13132805
申请日：2008-12-08
申请人： Kevin Brown
发明人： Kevin Brown
IPC分类号： G06K9/00
CPC分类号： A61B6/032 , A61B5/113
摘要： The present invention therefore provides a method for the analysis of radiographic images, comprising the steps of acquiring a plurality of projection images of a patient, acquiring a surrogate signal indicative of the location of a target structure in the patient, reconstructing a plurality of volumetric images of the patient from the projection images, each volumetric image being reconstructed from projection images having a like breathing phase, identifying the position of the target structure such as a tumour in each volumetric image, associating a surrogate signal with each of the projection images, and determining a relationship between the surrogate signal and the position of the target structure. Multiple projection images having a like breathing phase can be grouped for reconstruction, to provide sufficient numbers for reconstruction. The analysis of the multiple values of the surrogate associated with each breathing phase can be used to determine the mean surrogate value and its variation. Multiple values of the surrogate signal associated with the same nominal breathing phase can be used to determine a mean value of the surrogate signal for the target position associated with that phase and a variation of the value of the surrogate signal for the target position associated with that phase. The breathing phase of specific projection images can be obtained by analysis of one or more features in the images, such as the method we described in U.S. Pat. No. (7,356,112), or otherwise.
摘要翻译：因此，本发明提供了一种用于分析放射线图像的方法，包括以下步骤：获取患者的多个投影图像，获取指示患者中目标结构的位置的替代信号，重建多个体积图像从投影图像的患者的每个体积图像中，从具有相似呼吸相位的投影图像重建每个体积图像，识别每个体积图像中的诸如肿瘤的目标结构的位置，将替代信号与每个投影图像相关联，以及确定替代信号与目标结构的位置之间的关系。具有类似呼吸相位的多个投影图像可以被分组以进行重建，以提供足够数量的重建。可以使用与每个呼吸阶段相关联的代理的多个值的分析来确定平均替代值及其变化。可以使用与相同标称呼吸相位相关联的替代信号的多个值来确定与该相位相关联的目标位置的替代信号的平均值，以及与该相位相关联的目标位置的替代信号的值的变化相。特定投影图像的呼吸阶段可以通过分析图像中的一个或多个特征来获得，例如我们在美国专利中描述的方法。（7,356,112），否则。

96. 发明申请

US20110142202A1 Radiotherapy Apparatus 有权
标题翻译：放射治疗仪
公开(公告)号：US20110142202A1
公开(公告)日：2011-06-16
申请号：US12992727
申请日：2009-05-15
申请人： Kevin Brown , Maria Giulia Thompson , Vibeke Nordmark Hansen , Philip Mark Evans , David Anthony Roberts
发明人： Kevin Brown , Maria Giulia Thompson , Vibeke Nordmark Hansen , Philip Mark Evans , David Anthony Roberts
IPC分类号： A61N5/10 , H01J35/08
CPC分类号： A61N5/1049 , A61B6/06 , A61B6/4042 , A61B6/583 , A61N2005/1061 , G21K1/02 , G21K1/10 , H01J35/08 , H01J2235/081 , H01J2235/087
摘要： It is desirable to achieve a co-incident investigative kV source for a therapeutic MV source—a so-called “beams-eye-view” source. It has been suggested that bremsstrahlung radiation from an electron window be employed; we propose a practical structure for achieving this which can switch easily between a therapeutic beam and a beam-eye-view diagnostic beam capable of offering good image resolution. Such a radiation source comprises an electron gun, a pair of targets locatable in the path of a beam produced by the electron gun, one target of the pair being of a material with a lower atomic number than the other, and an electron absorber insertable into and withdrawable from the path of the beam. In a preferred form, the electron gun is within a vacuum chamber, and the pair of targets are located at a boundary of the vacuum chamber. The lower atomic number target can be Nickel and the higher atomic number target Copper and/or Tungsten. The electron absorber can be Carbon, and can be located within the primary collimator, or within one of a plurality of primary collimators interchangeably locatable in the path of the beam. Such a radiation source can be included within a radiotherapy apparatus, to which the present invention further relates. A flat panel imaging device for this source can be optimised for low energy x-rays rather than high energy; Caesium Iodide-based panels are therefore suitable.
摘要翻译：期望实现用于治疗性MV源的共同调查性kV源 - 所谓的“眼 - 视”源。有人建议使用来自电子窗的bre致辐射; 我们提出了实现这一点的实际结构，其可以在能够提供良好的图像分辨率的治疗光束和眼睛视图诊断光束之间容易地切换。这样的辐射源包括电子枪，一对可定位在由电子枪产生的光束的路径中的一对靶，该对中的一个靶是具有比另一个更低原子序数的材料，以及电子吸收体可插入并从梁的路径中抽出。在优选形式中，电子枪位于真空室内，并且该对靶位于真空室的边界处。较低的原子序号目标可以是镍，较高原子序号的目标铜和/或钨。电子吸收器可以是碳，并且可以位于主准直器内，或者位于可互换定位在光束路径中的多个主准直仪之一内。这样的辐射源可以包括在本发明进一步涉及的放射治疗装置内。用于该源的平板成像装置可以针对低能x射线而不是高能量进行优化; 因此，基于碘化铯的面板是合适的。

97. 发明授权

US07860215B2 Imaging systems for ionising radiation 有权
标题翻译：电离辐射成像系统
公开(公告)号：US07860215B2
公开(公告)日：2010-12-28
申请号：US12441005
申请日：2006-09-13
申请人： Andrew Long , Kevin Brown , John Allen
发明人： Andrew Long , Kevin Brown , John Allen
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61B6/032 , A61B6/4488 , A61N2005/1054
摘要： Flat panel images obtained during concurrent radiotherapy typically suffer from artefacts that relate to the pulses of MV energy. For a radiotherapeutic apparatus comprising a pulsed source of therapeutic radiation, a detector comprising control circuitry, an array of pixel elements, each having a signal output and an ‘enable’ input and being arranged to release a signal via the signal output upon being triggered by the enable input, and an interpreter arranged to receive the signal outputs of the pixel elements, the interpreter having a reset control, there are advantages in the control circuitry being adapted to reset the interpreter after a pulse of therapeutic radiation, prior to enabling at least one pixel of the array. Alternatively, the control circuitry can prompt a plurality of pulses by the pulsed source and then enable a plurality of pixels of the array. In effect, the therapeutic pulses are grouped into a short flurry of pulses. It is therefore preferred that the plurality of pixels comprises substantially all the pixels of the array.
摘要翻译：在同时放射治疗期间获得的平板图像通常遭受与MV能量的脉冲有关的伪像。对于包括脉冲的治疗辐射源的放射治疗装置，包括控制电路的检测器，每个具有信号输出和“使能”输入的像素元件阵列，并且被布置成在由...被触发时通过信号输出释放信号所述使能输入和解释器被布置为接收所述像素元件的信号输出，所述解释器具有复位控制，所述控制电路中的优点是适于在治疗辐射脉冲之后复位解释器，数组的一个像素。或者，控制电路可以通过脉冲源提示多个脉冲，然后启用阵列的多个像素。实际上，治疗脉冲被分组成短脉冲。因此，优选地，多个像素包括阵列的基本上所有的像素。

98. 发明申请

US20100252754A1 Radiotherapy Apparatus 有权
标题翻译：放射治疗仪
公开(公告)号：US20100252754A1
公开(公告)日：2010-10-07
申请号：US12740291
申请日：2007-10-30
申请人： Kevin Brown , Ralph Streamer , Duncan Bourne
发明人： Kevin Brown , Ralph Streamer , Duncan Bourne
IPC分类号： A61N5/10 , G21K1/02
CPC分类号： A61N5/1049 , A61N5/1042 , A61N5/1067 , A61N2005/1061
摘要： Realtime beam shape adjustment in response to (for example) online CT scanning of a patient during treatment is assisted by the radiotherapy apparatus comprising a source adapted to emit a beam of therapeutic radiation, a collimator for delimiting the radiation beam, the collimator comprising a plurality of leaves arranged alongside each other and be moveable longitudinally so that the tips of the leaves define a variable edge of the collimator, the leaves being mounted on a support that is moveable laterally with respect to the leaves. In this way, movements of the tumour that are perpendicular to the direction of leaf motion can be accommodated by simply moving the collimator bodily so as to accommodate this. It is preferred that the apparatus also includes a control means adapted to receive information as to the location of the target volume, and, on the basis of that information, control the longitudinal positions of the leaves and the lateral position of the support. It is also preferred that the support tilts as it moves laterally along a path. This can be achieved, by example, by bearings that are moveable on suitable guides, or by mounting the support on a plurality of pivot arms of unequal lengths. The lengths of such pivot arms can be adjusted as necessary.
摘要翻译：响应于（例如）治疗期间患者的在线CT扫描的实时波束形状调整由包括适于发射治疗辐射束的源的放射治疗装置辅助，用于限定辐射束的准直器，准直器包括多个的叶片彼此并排设置并且可纵向移动，使得叶片的尖端限定准直器的可变边缘，叶片安装在相对于叶片横向移动的支撑件上。以这种方式，垂直于叶片运动方向的肿瘤的运动可以通过简单地移动准直器以适应这一点来适应。优选地，该装置还包括适于接收关于目标体积的位置的信息的控制装置，并且基于该信息控制叶片的纵向位置和支撑件的横向位置。还优选的是，当支撑件沿着路径横向移动时，支撑件倾斜。这可以通过例如通过在合适的导轨上可移动的轴承，或者通过将支撑件安装在不等长度的多个枢轴臂上来实现。这种枢转臂的长度可以根据需要进行调节。

99. 发明授权

US07598071B2 Infectious clone of human parvovirus B19 and methods 有权
标题翻译：人类细小病毒B19的传染性克隆及方法
公开(公告)号：US07598071B2
公开(公告)日：2009-10-06
申请号：US10887770
申请日：2004-07-09
申请人： Kevin Brown , Ning Zhi , Peter Tijssen , Zoltan Zadori
发明人： Kevin Brown , Ning Zhi , Peter Tijssen , Zoltan Zadori
IPC分类号： C12N7/00 , C12N15/00 , C12N5/00 , C07H21/00
CPC分类号： C12Q1/701 , C12N7/00 , C12N2750/14251
摘要： The invention relates to infectious clones of parvovirus B19, methods of cloning infectious B19 clones, and methods of cloning viral genomes that have secondary DNA structures that are unstable in bacterial cells. A B19 infectious clone and methods of producing B19 infectious clones are useful for producing infectious virus. Infectious virus is useful for identifying and developing therapeutically effective compositions for treatment and/or prevention of human parvovirus B19 infections.
摘要翻译：本发明涉及细小病毒B19的感染性克隆，克隆感染性B19克隆的方法，以及克隆具有在细菌细胞中不稳定的二级DNA结构的病毒基因组的方法。 B19感染性克隆和生产B19感染性克隆的方法可用于产生感染性病毒。感染性病毒可用于鉴定和开发用于治疗和/或预防人细小病毒B19感染的治疗有效组合物。

100. 发明授权

US07593532B2 Management of the retention and/or discarding of stored data 有权
标题翻译：保存和/或丢弃存储数据的管理
公开(公告)号：US07593532B2
公开(公告)日：2009-09-22
申请号：US10830580
申请日：2004-04-22
申请人： Serge Plotkin , Hristo Iankov Bojinov , Kevin Brown
发明人： Serge Plotkin , Hristo Iankov Bojinov , Kevin Brown
IPC分类号： H04L9/00 , G06F12/14
CPC分类号： H04L9/0836 , H04L9/0894
摘要： Embodiments of methods, devices and/or systems for a method of managing the retention and/or discarding of stored data are described.
摘要翻译：描述了用于管理存储数据的保留和/或丢弃的方法的方法，设备和/或系统的实施例。

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