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91. 发明授权

US07970470B2 Diagnosis and/or therapy using blood chemistry/expired gas parameter analysis 有权
标题翻译：使用血液化学/过期气体参数分析的诊断和/或治疗
公开(公告)号：US07970470B2
公开(公告)日：2011-06-28
申请号：US10929830
申请日：2004-08-30
申请人： Jesse W. Hartley , Jeffrey E. Stahmann , Kent Lee , Quan Ni
发明人： Jesse W. Hartley , Jeffrey E. Stahmann , Kent Lee , Quan Ni
IPC分类号： A61N1/00 , A61B5/00 , A61B5/05
CPC分类号： A61N1/36557 , A61M16/0051 , A61M16/024 , A61M2016/0021 , A61M2230/202 , A61M2230/205 , A61M2230/208 , A61M2230/432 , A61M2230/435 , A61M2230/65 , A61N1/3601 , A61N1/36521
摘要： Methods and systems for diagnosing disorders, including, for example, disordered breathing, involve sensing one or more of a blood chemistry parameter and/or an expired gas parameter, such as expired respiratory gas concentration, blood gas concentration, and blood pH. Diagnosis of the disorder may be performed by a medical device, such as a respiratory therapy device or a cardiac therapy device, based on implantably detected blood gas/pH concentration/level or externally detected expired respiratory gas concentration. Cardiac and respiratory therapies for addressing the disorder may be adjusted based on the detected parameters.
摘要翻译：用于诊断疾病（包括例如无序呼吸）的方法和系统涉及感测血液化学参数和/或呼出气体参数中的一种或多种，例如呼出气体浓度，血气浓度和血液pH。基于可植入检测的血液/ pH浓度/水平或外部检测到的呼出气体浓度，可以通过医疗装置（例如呼吸治疗装置或心脏治疗装置）进行障碍的诊断。可以基于检测到的参数来调整用于解决紊乱的心脏和呼吸治疗。

92. 发明授权

US07887493B2 Implantable device employing movement sensing for detecting sleep-related disorders 有权
标题翻译：使用移动感测来检测睡眠相关障碍的植入式装置
公开(公告)号：US07887493B2
公开(公告)日：2011-02-15
申请号：US10939834
申请日：2004-09-13
申请人： Jeffrey E. Stahmann , Jesse W. Hartley , Kent Lee , Quan Ni
发明人： Jeffrey E. Stahmann , Jesse W. Hartley , Kent Lee , Quan Ni
IPC分类号： A61B5/08 , A61B5/04 , A61B5/05
CPC分类号： A61N1/36135 , A61B5/4818 , A61M16/024 , A61M16/10 , A61M2205/3561 , A61M2205/3584 , A61M2230/04 , A61M2230/60 , A61M2230/63 , A61M2230/65 , A61N1/3601 , A61N1/3611
摘要： Methods and systems for evaluating a pathological condition include acquiring movement information, such as electromyogram (EMG) information, and sleep disordered breathing (SDB) information, and detecting the presence of a pathological condition using both movement and SDB information. Methods may involve sensing physiological signals including at least muscle movement signals. Sleep-related disorders are detected using the sensed physiological signals, the sleep-related disorders including at least an involuntary muscle movement disorder and sleep-disordered breathing. Methods and systems also provide for detecting and treating a sleep-related disorder using movement and SDB information. Cardiac, respiratory, nerve stimulation, drug, or a combination of such therapies may be delivered to treat a detected or diagnosed pathological condition.
摘要翻译：用于评估病理状况的方法和系统包括获取运动信息，例如肌电图（EMG）信息和睡眠呼吸障碍（SDB）信息，以及使用运动和SDB信息检测病态的存在。方法可以包括感测至少包括肌肉运动信号的生理信号。使用感测到的生理信号检测睡眠相关疾病，睡眠相关障碍至少包括不自主的肌肉运动障碍和睡眠呼吸紊乱。方法和系统还提供使用运动和SDB信息来检测和治疗睡眠相关疾病。可以输送心脏，呼吸，神经刺激，药物或这些疗法的组合以治疗检测或诊断的病理状况。

93. 发明授权

US07764996B2 Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device 有权
标题翻译：使用一个或多个可植入装置监测疾病和药物管理的计时生理节律
公开(公告)号：US07764996B2
公开(公告)日：2010-07-27
申请号：US11554986
申请日：2006-10-31
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61B5/00
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译：使用至少一个可植入装置自动评价或预测受试者的健康状况。在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。也可以使用昼夜节律以外的其他时间生理节律。可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

94. 发明申请

US20100174154A1 Therapy Control Based on Cardiopulmonary Status 有权
标题翻译：基于心肺状态的治疗控制
公开(公告)号：US20100174154A1
公开(公告)日：2010-07-08
申请号：US12688274
申请日：2010-01-15
申请人： Kent Lee , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
发明人： Kent Lee , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
IPC分类号： A61B5/00
CPC分类号： A61B5/4818 , A61B5/0205 , A61B5/0809 , A61B5/083 , A61B5/087 , A61B5/091 , A61B5/7275 , A61M11/00 , A61M16/026 , A61M2016/0021 , A61M2016/0036 , A61M2205/3523 , A61M2205/3569 , A61N1/3601 , A61N1/365 , A61N1/36521 , A61N1/3684
摘要： Methods and systems provide an approach to therapy control based on assessment of a patient's cardiopulmonary status. Conditions sensed via sensors of an external respiratory therapy device are used to assess a patient's cardiopulmonary status. The respiratory therapy device sensors may be utilized alone or in combination with other sensors to determine cardiopulmonary status of a patient. Therapy delivered to the patient is controlled based on the cardiopulmonary status assessment. For example, therapy delivered to the patient may be initiated, terminated, and/or modified based on the assessed cardiopulmonary status of the patient. Cardiopulmonary status assessment, therapy control, or both, are performed by an implantable device.
摘要翻译：方法和系统提供了一种基于患者心肺状态评估的治疗控制方法。通过外部呼吸治疗装置的传感器检测到的状况用于评估患者的心肺状态。呼吸治疗装置传感器可以单独使用或与其他传感器组合使用以确定患者的心肺状态。基于心肺状态评估来控制输送给患者的治疗。例如，可以基于评估的患者的心肺状态来开始，终止和/或修改递送给患者的治疗。心肺状态评估，治疗控制或两者都由可植入装置进行。

95. 发明申请

US20100121406A1 NEURAL STIMULATOR TO TREAT SLEEP DISORDERED BREATHING 有权
标题翻译：神经刺激器治疗睡眠障碍性呼吸
公开(公告)号：US20100121406A1
公开(公告)日：2010-05-13
申请号：US12691392
申请日：2010-01-21
申请人： Imad Libbus , Anthony Caparso , M. Jason Brooke , Jonathan Kwok , Kent Lee , Yachuan Pu
发明人： Imad Libbus , Anthony Caparso , M. Jason Brooke , Jonathan Kwok , Kent Lee , Yachuan Pu
IPC分类号： A61N1/36
CPC分类号： A61N1/36185 , A61N1/3611
摘要： Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.
摘要翻译：各种方面涉及可植入装置。各种装置实施例包括用于检测睡眠无序呼吸的至少一个传感器，适于通过至少一个电极传递第一电信号以刺激神经靶的脉冲发生器，以及适于与至少一个传感器和与脉冲发生器。所述控制器适于使用所述至少一个传感器检测睡眠呼吸障碍，并响应于检测到的呼吸暂停事件提供针对睡眠呼吸障碍的治疗。用于睡眠呼吸紊乱的治疗适于通过至少一个电极传递第一电信号以引起咳嗽反射以终止呼吸暂停事件。各种实施方案刺激上喉神经，各种实施方案刺激复发性喉神经，并且各种实施方案刺激迷走神经。本文提供了其它方面和实施例。

96. 发明授权

US07668591B2 Automatic activation of medical processes 失效
标题翻译：自动激活医疗过程
公开(公告)号：US07668591B2
公开(公告)日：2010-02-23
申请号：US10922663
申请日：2004-08-20
申请人： Kent Lee , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
发明人： Kent Lee , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
IPC分类号： A61B5/04
CPC分类号： A61N1/3601 , A61B5/04012 , A61B5/1107 , A61B5/4094 , A61B5/4818 , A61B5/6869 , A61B2505/09 , A61M16/024 , A61M16/10 , A61M2016/0039 , A61M2016/0042 , A61M2205/3561 , A61M2205/3584 , A61M2230/04 , A61M2230/10 , A61M2230/63 , A61N1/3611 , A61N1/36114 , A61N1/36135 , A61N1/36514
摘要： Systems and methods involve automatic activation, de-activation or modification of therapies or other medical processes based on brain state. A medical system includes a sensor system having one or more sensors configured to sense signals related to the brain state of the patient. A brain state analyzer detects various brain states, including sleep stage and/or brain seizures. A controller uses the brain state detection information to control a medical system configured to perform at least one respiratory or cardiac process. Methods involve sensing signals related to brain state and determining the brain state of a patient based on the sensed signals. At least one respiratory or cardiac medical process is controlled based on the patient's brain state.
摘要翻译：系统和方法涉及基于脑状态的治疗或其他医疗过程的自动激活，去激活或修饰。医疗系统包括具有一个或多个传感器的传感器系统，该传感器被配置为感测与患者的脑状态相关的信号。脑状态分析仪检测各种脑状态，包括睡眠阶段和/或脑癫痫发作。控制器使用脑状态检测信息来控制被配置为执行至少一个呼吸或心脏过程的医疗系统。方法涉及感测与脑状态相关的信号，并且基于感测到的信号来确定患者的大脑状态。至少一个呼吸或心脏医疗过程是根据患者的大脑状态进行控制的。

97. 发明申请

US20090281589A1 Methods and Devices for Implementing Time of Day Pacing Adjustments 有权
标题翻译：实施时间调节的方法和设备
公开(公告)号：US20090281589A1
公开(公告)日：2009-11-12
申请号：US12508317
申请日：2009-07-23
申请人： Jesse W. Hartley , Kent Lee , Quan Ni , Michael A. Querimit , Kenneth L. Baker , Ankur Garg , Kenneth L. Tobacman , Corey J. Miklos
发明人： Jesse W. Hartley , Kent Lee , Quan Ni , Michael A. Querimit , Kenneth L. Baker , Ankur Garg , Kenneth L. Tobacman , Corey J. Miklos
IPC分类号： A61N1/365
CPC分类号： A61B5/4812 , A61B5/4815 , A61N1/368 , A61N1/3688 , G06F19/00
摘要： Methods and systems are directed to delivering cardiac pacing therapy to a patient. A pacing therapy associated with one or more pacing parameters is delivered. Alternate cardiac pacing therapies associated with one or more alternate pacing parameters are transitioned to, based on a sleep/wake cycle of the patient. Interactions between the pacing parameters of the pacing therapy and the alternate pacing parameters are resolved. Resolving pacing parameters may be based on analysis of lower rate limits and/or lower rate hysteresis, for example.
摘要翻译：方法和系统旨在向患者输送心脏起搏治疗。提供与一个或多个起搏参数相关的起搏疗法。与一个或多个替代起搏参数相关联的替代心脏起搏疗法基于患者的睡眠/唤醒周期而被转换。起搏治疗起搏参数与替代起搏参数之间的相互作用得到解决。例如，解析起搏参数可以基于较低速率限制和/或较低速率滞后的分析。

98. 发明授权

US07577479B2 Methods and devices for implementing time of day pacing adjustments 有权
标题翻译：实施时间调节的方法和设备
公开(公告)号：US07577479B2
公开(公告)日：2009-08-18
申请号：US11083136
申请日：2005-03-17
申请人： Jesse W. Hartley , Kent Lee , Quan Ni , Michael A. Querimit , Kenneth L. Baker , Ankur Garg , Kenneth I. Tobacman , Corey J. Miklos
发明人： Jesse W. Hartley , Kent Lee , Quan Ni , Michael A. Querimit , Kenneth L. Baker , Ankur Garg , Kenneth I. Tobacman , Corey J. Miklos
IPC分类号： A61N1/365
CPC分类号： A61B5/4812 , A61B5/4815 , A61N1/368 , A61N1/3688 , G06F19/00
摘要： Methods and systems are directed to delivering cardiac pacing therapy to a patient. A pacing therapy associated with one or more pacing parameters is delivered. Alternate cardiac pacing therapies associated with one or more alternate pacing parameters are transitioned to, based on a sleep/wake cycle of the patient. Interactions between the pacing parameters of the pacing therapy and the alternate pacing parameters are resolved. Resolving pacing parameters may be based on analysis of lower rate limits and/or lower rate hysteresis.
摘要翻译：方法和系统旨在向患者输送心脏起搏治疗。提供与一个或多个起搏参数相关的起搏疗法。与一个或多个替代起搏参数相关联的替代心脏起搏疗法基于患者的睡眠/唤醒周期而被转换。起搏治疗起搏参数与替代起搏参数之间的相互作用得到解决。分析起搏参数可以基于较低速率限制和/或较低速率滞后的分析。

99. 发明申请

US20090177702A1 Medical Event Logbook System and Method 有权
标题翻译：医疗事故日志系统与方法
公开(公告)号：US20090177702A1
公开(公告)日：2009-07-09
申请号：US12403880
申请日：2009-03-13
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Jesse W. Hartley , Quan Ni , Kent Lee
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Jesse W. Hartley , Quan Ni , Kent Lee
IPC分类号： G06F17/30 , G06F3/048
CPC分类号： A61B5/0803 , A61B5/02405 , A61N1/3601
摘要： An event-based approach to collecting and organizing information associated with events affecting respiration is presented. The detection or prediction of an event affecting the respiration of a patient initiates acquisition of information associated with the event. The respiratory logbook system acquires information associated with the event during the event and during intervals proximate in time to the event. The information is organized as a respiratory log entry. The user can access the information by operating a user interface. The information may be presented in textual or graphical form.
摘要翻译：提出了一种基于事件的方法来收集和组织与影响呼吸的事件相关的信息。影响患者呼吸的事件的检测或预测启动与事件相关联的信息的获取。呼吸记录系统在事件期间以及在时间上接近事件的间隔期间获取与事件相关联的信息。信息被组织为呼吸日志条目。用户可以通过操作用户界面访问信息。信息可以以文本或图形形式呈现。

100. 发明授权

US07510531B2 System and method for discrimination of central and obstructive disordered breathing events 有权
标题翻译：用于区分中枢性和阻塞性无序呼吸事件的系统和方法
公开(公告)号：US07510531B2
公开(公告)日：2009-03-31
申请号：US10824776
申请日：2004-04-15
申请人： Kent Lee , John D. Hatlestad , Qingsheng Zhu , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
发明人： Kent Lee , John D. Hatlestad , Qingsheng Zhu , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
IPC分类号： A61B5/08
CPC分类号： A61B5/7264 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0478 , A61B5/0488 , A61B5/0496 , A61B5/08 , A61B5/0809 , A61B5/11 , A61B5/113 , A61B5/1135 , A61B5/4818
摘要： Disordered breathing events may be classified as central, obstructive or a combination of central an obstructive in origin based on patient motion associated with respiratory effort. Central disordered breathing is associated with disrupted respiration with reduced respiratory effort. Obstructive disordered breathing is associated with disrupted respiration accompanied by respiratory effort. A disordered breathing classification system includes a disordered breathing detector and a respiratory effort motion sensor. Components of the disordered breathing classification system may be fully or partially implantable.
摘要翻译：基于与呼吸努力相关的患者运动，无序呼吸事件可被分类为中枢性，阻塞性或中枢性阻塞性组合。呼吸中枢紊乱与呼吸力下降相关联。阻塞性无序呼吸与伴随呼吸功能的呼吸中断有关。无序呼吸分类系统包括无序呼吸检测器和呼吸力运动传感器。无序呼吸分类系统的组成部分可以完全或部分植入。

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