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91. 发明申请

US20090239891A1 Sustained Release Dosage Forms of Analgesic Medications 审中-公开
标题翻译：止痛药物的持续释放剂量形式
公开(公告)号：US20090239891A1
公开(公告)日：2009-09-24
申请号：US12087692
申请日：2007-02-28
申请人： Atul J. Shukla , James R. Johnson , Yichun Sun , Yingxu Peng , Shipeng Yu , Wen Qu , Timothy D. Mandrell
发明人： Atul J. Shukla , James R. Johnson , Yichun Sun , Yingxu Peng , Shipeng Yu , Wen Qu , Timothy D. Mandrell
IPC分类号： A61K31/4355 , A61K31/445
CPC分类号： A61K31/485 , A61K9/0019
摘要： Parenteral extravascular administration of a composition containing an analgesic medication of low water solubility that is dissolved, suspended, or emulsified in a solvent system results in the deposition of the analgesic medication at the site of administration and provides a controlled release of the analgesic medication from the site and a prolonged analgesia that may persist for several days following administration.
摘要翻译：包含在溶剂体系中溶解，悬浮或乳化的含有低水溶性的镇痛药物的组合物的肠外外血管内给药导致镇痛药物在给药部位的沉积，并提供止痛药物的控制释放部位和长时间的镇痛可能持续数日后给药。

92. 发明申请

US20090062821A1 COMPOSITE SCAFFOLD STRUCTURE 有权
标题翻译：复合材料结构
公开(公告)号：US20090062821A1
公开(公告)日：2009-03-05
申请号：US11849114
申请日：2007-08-31
申请人： James R. Johnson , Anita Tavakley
发明人： James R. Johnson , Anita Tavakley
IPC分类号： A61B17/08 , A61F2/28
CPC分类号： A61L27/46 , A61F2/30756 , A61F2002/30766 , A61F2310/00796
摘要： A composite resilient scaffold may be used to grow, repair, and/or regenerate tissue such as articular cartilage. The composite scaffold is porous and at least substantially bioremovable. The composite scaffold includes a support structure coated with a discontinuous coating of separate and discrete particles of a ceramic material such as calcium phosphate. The calcium phosphate material may have a porous reticulated structure.
摘要翻译：复合弹性支架可用于生长，修复和/或再生组织如关节软骨。复合支架是多孔的并且至少基本上可生物去除。复合支架包括涂覆有陶瓷材料如磷酸钙的分离和离散颗粒的不连续涂层的支撑结构。磷酸钙材料可以具有多孔网状结构。

93. 发明授权

US06849186B2 Composite particles 有权
标题翻译：复合颗粒
公开(公告)号：US06849186B2
公开(公告)日：2005-02-01
申请号：US09983322
申请日：2001-10-24
申请人： James R. Johnson , Majid Entezarian
发明人： James R. Johnson , Majid Entezarian
IPC分类号： B03C1/28 , H01F1/36 , C02F1/28
CPC分类号： H01F1/36 , B03C1/28 , H01F1/344 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： Buoyant, sphere-like materials on the order of about 10 to about 300 microns and surrounded, at least in part, by (1) a variable blend of a ferromagnetic and paramagnetic material and (2) an absorbing or adsorbing material are effective vehicles for isolating targeted materials. By virtue of its relatively low density, the composite material is capable of remaining sufficiently suspended in solution for a suitable amount of time. In addition, the blend of ferromagnetic and paramagnetic materials allows for the isolation of a composite material from an environment such as a solution, yet discourages substantial self-attachment of the composite materials in solution, when subject to a magnetic field. Accordingly, multiple embodiments of composite materials having these and other properties are disclosed, as well as methods for making and using the same.
摘要翻译：浮力的球形材料约为10至约300微米，并至少部分地通过（1）铁磁性和顺磁材料的可变共混物和（2）吸收或吸附材料而被包围的有效载体隔离目标材料。由于其相对低的密度，复合材料能够在适当的时间内保持充分悬浮在溶液中。此外，铁磁材料和顺磁性材料的混合物允许从诸如溶液的环境中分离复合材料，但是当受到磁场的影响时，阻止复合材料在溶液中的显着自身附着。因此，公开了具有这些和其它性质的复合材料的多个实施方案，以及制备和使用它们的方法。

94. 发明授权

US06814783B2 Filtration media of porous inorganic particles 有权
标题翻译：多孔无机颗粒的过滤介质
公开(公告)号：US06814783B2
公开(公告)日：2004-11-09
申请号：US10363849
申请日：2003-03-14
申请人： Tom Fitch , Majid Entezarian , James R. Johnson
发明人： Tom Fitch , Majid Entezarian , James R. Johnson
IPC分类号： B01D5304
CPC分类号： B01D46/30 , B01D39/04 , B01D46/0028 , B01D46/006 , Y10S55/30 , Y10S55/36
摘要： Inorganic, porous particles filter a substance or substances from a flow of fluid such as a gas. The particles can be arranged into a bed to filter a substance (filtrate substance) from a fluid. The filtrate substance can collect on or within the pores of the inorganic particles. Collection of the filtrate substance within the pores of the particles rather than within the interstices of the bed enhances the filtering capacity and does not impede the flow of fluid through the bed of particles. Furthermore, the inorganic particles are re-usable, in that they can be subjected to harsh filtrate-separation techniques, e.g., heat treatment, solvent extraction, detergent washing, and centrifugal separation, yet retain their desired properties.
摘要翻译：无机多孔颗粒从诸如气体的流体流中过滤物质或物质。颗粒可以布置在床中以从流体中过滤物质（滤液物质）。滤液物质可以收集在无机颗粒的孔内或内。在颗粒的孔内而不是在床的间隙内收集滤液物质增强了过滤能力，并且不阻碍流过颗粒床的流体流动。此外，无机颗粒可重复使用，因为它们可以经受苛刻的滤液分离技术，例如热处理，溶剂萃取，洗涤剂洗涤和离心分离，但保持其所需的性质。

95. 发明授权

US06662843B1 Apparatus for applying tape with fastener profiles to a web 失效
标题翻译：用于将带有紧固件轮廓的带施加到卷材的装置
公开(公告)号：US06662843B1
公开(公告)日：2003-12-16
申请号：US08899434
申请日：1997-07-24
申请人： James R. Johnson
发明人： James R. Johnson
IPC分类号： B32B3100
CPC分类号： B65B9/20 , A44B19/16 , B29C53/48 , B31B70/8133 , B32B5/04 , B65B9/2056 , B65B9/213 , B65B41/16 , B65B61/188 , B65D33/004 , B65D33/2533 , B65D33/2575 , B65D33/2583 , B65D2101/0015 , B65D2101/0023 , Y10S428/906 , Y10S493/927 , Y10T24/45168 , Y10T156/101 , Y10T156/1015 , Y10T156/1038 , Y10T156/1051 , Y10T156/1056 , Y10T156/1057 , Y10T156/1062 , Y10T156/1077 , Y10T156/1085 , Y10T156/1097 , Y10T156/133 , Y10T156/1343 , Y10T156/1734 , Y10T428/24008 , Y10T428/24017 , Y10T428/2419
摘要： Method an apparatus and a system in which reclosable bags and components thereof are formed are disclosed. The reclosable bags 2001 are made from base web material that has transversely applied fastener tape segments thereon. The web material is used in a vertical form, fill and seal bag forming method. The method includes the steps of supplying a continuous strip of tape, having male and female fasteners profiler across the web for sealing thereon. In one embodiment a continuous strip of barrier material, and a continuous strip of fastener having first and second interlocked fastener profile strips are positioned on the continuous strip of tape; and secured thereon, the barrier tape is folded to obtain a fold and two opposing barrier tape fastener strip connecting portions; and, the fold is slit to form two separate continuous strips of barrier material strips and two continuous strips of tape. In another embodiment a coating is applied to the tape itself to prevent sealing of the folded slit tape to itself. The resulting tape and fastener are cut 220 and portioned properly on the web by the unique vacuum belt system of the present invention and by the interconnected tape drive, web drive and the connection to the form fill seal machine.
摘要翻译：公开了一种其中形成可再闭合袋及其部件的装置和系统。可再封口袋2001由在其上横向施加有拉链带段的基网材料制成。网状材料以垂直形式使用，填充和密封袋形成方法。该方法包括以下步骤：提供带状的连续条带，其具有穿过网状物的阳和阴紧固件轮廓仪以便在其上密封。在一个实施例中，连续条带的阻挡材料和连续的紧固带具有第一和第二互锁的紧固件轮廓带，定位在连续带条上; 并固定在其上，将阻隔带折叠以获得折叠和两个相对的阻挡带紧固带连接部分; 并且折叠缝合以形成隔离材料带和两条连续条带的两个分离的连续条带。在另一个实施例中，涂层被施加到带本身以防止折叠的切割带对其自身的密封。所得到的带和紧固件被切割220并且通过本发明的独特的真空带系统以及通过互连的带驱动器，腹板驱动器和与成型填充密封机的连接在网上适当地分配。

96. 发明授权

US06527810B2 Bone substitutes 有权
标题翻译：骨替代品
公开(公告)号：US06527810B2
公开(公告)日：2003-03-04
申请号：US09740807
申请日：2000-12-21
申请人： James R. Johnson , Jeffrey G. Marx , Wesley D. Johnson
发明人： James R. Johnson , Jeffrey G. Marx , Wesley D. Johnson
IPC分类号： A61F228
CPC分类号： A61F2/28 , A61F2/30767 , A61F2/36 , A61F2/367 , A61F2/389 , A61F2002/2817 , A61F2002/30092 , A61F2002/30884 , A61F2002/30968 , A61F2210/0014 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00179 , A61F2310/00203 , A61F2310/00239 , A61F2310/00293 , A61L27/425 , A61L27/427 , A61L27/56 , A61L2400/18 , A61L2430/02
摘要： A strong, porous article useful as a bone substitute material. The article comprises a continuous strong framework structure having struts defining interstices which interconnect throughout the bulk volume, and may have ceramic or osteoconductive material occupying at least a portion of the same bulk volume as the framework structure. Either as a coating on the strong framework struts or between the framework struts and the ceramic or osteoconductive-osteoinductive materials is a resilient material which serves to distribute stresses within the article.
摘要翻译：用作骨替代材料的强力多孔制品。该制品包括连续的强骨架结构，其具有限定在整个本体体积上互连的间隙的支柱，并且可以具有占据与框架结构相同的体积体积的至少一部分的陶瓷或骨传导材料。作为在强框架支柱上的框架或框架支柱和陶瓷或骨传导 - 骨诱导材料之间的涂层是用于在制品内分布应力的弹性材料。

97. 发明授权

US06368703B1 Supported porous materials 有权
标题翻译：支撑多孔材料
公开(公告)号：US06368703B1
公开(公告)日：2002-04-09
申请号：US09375887
申请日：1999-08-17
申请人： James R. Johnson
发明人： James R. Johnson
IPC分类号： B32B326
CPC分类号： B32B5/18 , B32B7/02 , Y10T428/24992 , Y10T428/249957 , Y10T428/249969 , Y10T428/249981
摘要： A strong, porous article comprising a strong porous carrier having an outer surface defining a shape having a bulk volume and having pores defining interconnecting fluid flow openings extending throughout the bulk volume and opening through said surface. A second porous material, the mean pore size of which is at least an order of magnitude less than the mean pore size of the porous carrier, is nested within and structurally supported by the pore walls of the carrier so that the second porous material maintains its porous configuration and its pores are accessible to a fluid flowing through the pores of the porous carrier.
摘要翻译：一种强大的多孔制品，其包括强的多孔载体，其具有限定具有本体体积的形状的外表面，并且具有限定互连流体流动开口的孔，该流体流动开口延伸穿过整个体积并穿过所述表面。第二多孔材料的平均孔径比多孔载体的平均孔径小至少一个数量级，嵌入载体的孔壁内并在结构上由载体的孔壁支撑，使得第二多孔材料保持其多孔构造及其孔可通过流过多孔载体的孔的流体进入。

98. 发明授权

US06321423B1 Fastener assembly, fastener tape material, bag utilizing fastener tape material, and method of manufacture thereof 有权
标题翻译：紧固件组件，拉链带材料，利用拉链带材料的袋及其制造方法
公开(公告)号：US06321423B1
公开(公告)日：2001-11-27
申请号：US09133856
申请日：1998-08-13
申请人： James R. Johnson
发明人： James R. Johnson
IPC分类号： B32B306
CPC分类号： B65B9/20 , A44B19/16 , B29C53/48 , B31B70/8133 , B32B5/04 , B65B9/2056 , B65B9/213 , B65B41/16 , B65B61/188 , B65D33/004 , B65D33/2533 , B65D33/2575 , B65D33/2583 , B65D2101/0015 , B65D2101/0023 , Y10S428/906 , Y10S493/927 , Y10T24/45168 , Y10T156/101 , Y10T156/1015 , Y10T156/1038 , Y10T156/1051 , Y10T156/1056 , Y10T156/1057 , Y10T156/1062 , Y10T156/1077 , Y10T156/1085 , Y10T156/1097 , Y10T156/133 , Y10T156/1343 , Y10T156/1734 , Y10T428/24008 , Y10T428/24017 , Y10T428/2419
摘要： Methods, an apparatus and a system in which reclosable bags and components thereof are formed are disclosed. The reclosable bags 2001 are made from base web material that has transversely applied fastener tape segments thereon. The web material is used in a vertical form, fill and seal bag forming method. The method includes the steps of supplying a continuous strip of tape, having male and female fasteners profiler across the web for sealing thereon. In one embodiment a continuous strip of barrier material, and a continuous strip of fastener having first and second interlocked fastener profile strips are positioned on the continuous strip of tape; and secured thereon, the barrier tape is folded to obtain a fold and two opposing barrier tape fastener strip connecting portions; and, the fold is slit to form two separate continuous strips of barrier material strips and two continuous strips of tape. In another embodiment a coating is applied to the tape itself to prevent sealing of the folded slit tape to itself. The resulting tape and fastener are cut 220 and portioned properly on the web by the unique vacuum belt system of the present invention and by the interconnected tape drive, web drive and the connection to the form fill seal machine.
摘要翻译：公开了形成可再闭合袋及其部件的方法，装置和系统。可再封口袋2001由在其上横向施加有拉链带段的基网材料制成。网状材料以垂直形式使用，填充和密封袋形成方法。该方法包括以下步骤：提供带状的连续条带，其具有穿过网状物的阳和阴紧固件轮廓仪以便在其上密封。在一个实施例中，连续条带的阻挡材料和连续的紧固带具有第一和第二互锁的紧固件轮廓带，定位在连续带条上; 并固定在其上，将阻隔带折叠以获得折叠和两个相对的阻挡带紧固带连接部分; 并且折叠缝合以形成隔离材料带和两条连续条带的两个分离的连续条带。在另一个实施例中，涂层被施加到带本身以防止折叠的切割带对其自身的密封。所得到的带和紧固件被切割220并且通过本发明的独特的真空带系统以及通过互连的带驱动器，腹板驱动器和与成型填充密封机的连接在网上适当地分配。

99. 发明授权

US06273609B1 Pinch and pull open reclosable bag and zipper therefor 有权
标题翻译：夹紧和拉开可重新关闭的袋子和拉链
公开(公告)号：US06273609B1
公开(公告)日：2001-08-14
申请号：US09538631
申请日：2000-03-30
申请人： James R. Johnson
发明人： James R. Johnson
IPC分类号： B65D3316
CPC分类号： B65D75/5855 , B65D33/2508 , B65D33/2533 , Y10S24/39 , Y10S24/50 , Y10T24/15 , Y10T24/33 , Y10T24/45157 , Y10T24/45168
摘要： A recloseable package is disclosed having a front wall and a rear wall. A thermoplastic zipper male base member is disposed at a top end of the first wall and a thermoplastic zipper female base member is disposed at a top end of the second wall. The base members each have a profile which extends transversely across the walls. The profiles are each disposed between a product side web and a consumer side web. A heat resistant barrier is provided on facing surfaces of the male and female product side webs, extending from product side longitudinal edges of the base members toward the associated profiles. The male and female base members are heat sealed to the first and second walls, respectively, opposite to the heat resistant barriers which are resistant to heat sealing to each other. The facing surfaces of the consumer side webs may likewise have heat resistant barrier layers, in which case the package is sealed above the consumer side webs. Alternatively, the facing surfaces of the consumer side webs may be provided with peel seal layers which fuse together when the consumer side webs are heat sealed to the bag walls, thereby forming a top seal for the package. A zipper for use in the disclosed package is also disclosed.
摘要翻译：公开了一种具有前壁和后壁的可再封闭包装。热塑性拉链阳基底构件设置在第一壁的顶端，并且热塑性拉链阴底座构件设置在第二壁的顶端。基部构件各自具有横向延伸穿过壁的轮廓。型材分别设置在产品侧纤维网和消费者侧纤维网之间。在阳和阳产品侧腹板的相对表面上设置耐热屏障，从基部构件的产品侧纵向边缘向相关联的轮廓延伸。阳和阴基座部件分别热封在第一和第二壁上，与相互热封的耐热屏障相对。消费者侧腹板的相对表面同样可以具有耐热屏障层，在这种情况下，包装被密封在消费者侧腹板上方。或者，消费者侧腹板的相对表面可以设置有剥离密封层，当消费者侧腹板被热密封到袋壁时，其将熔接在一起，从而形成用于包装的顶部密封件。还公开了用于所公开的包装中的拉链。

100. 发明授权

US6159743A Method and apparatus for testing surfaces 有权
标题翻译：测试表面的方法和装置
公开(公告)号：US6159743A
公开(公告)日：2000-12-12
申请号：US268481
申请日：1999-03-16
申请人： James R. Johnson , Jerry J. Colahan
发明人： James R. Johnson , Jerry J. Colahan
IPC分类号： G01N1/02 , G01N33/48
CPC分类号： G01N1/02 , G01N2001/028 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： A test kit for testing substrates for soluble salts including a test sleeve, a pre-measured volume of solvent solution, and a soluble salt measuring device. The test sleeve includes a generally tubular body with a closed end and an open end. The open end includes a flange defining an aperture, and an attachment member coupled to the flange for removably securing the testing sleeve to a substrate.
摘要翻译：用于测试可溶性盐的底物的测试试剂盒，包括测试套筒，预先测量的溶剂溶液体积和可溶性盐测量装置。测试套筒包括具有封闭端和开口端的大致管状体。开口端包括限定孔的凸缘和联接到凸缘的附接构件，用于可拆卸地将测试套固定到衬底上。

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