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91. 发明授权

US10464100B2 System and process for formation of a time-released, drug-eluting transferable coating 有权
公开(公告)号：US10464100B2
公开(公告)日：2019-11-05
申请号：US14122862
申请日：2012-05-30
申请人： Dean W. Matson , Clement R. Yonker , John L. Fulton , George S. Deverman , Barbara J. Tarasevich , Wendy J. Shaw , Leonard S. Fifield , Krys Wallace , C. Douglas Taylor , James B. McClain
发明人： Dean W. Matson , Clement R. Yonker , John L. Fulton , George S. Deverman , Barbara J. Tarasevich , Wendy J. Shaw , Leonard S. Fifield , Krys Wallace , C. Douglas Taylor , James B. McClain
IPC分类号： B05D1/06 , B05D1/04 , A61L29/08 , A61L31/10 , A61F2/82 , A61K9/70 , A61M25/10
摘要： A system and method are disclosed for coating surfaces of expandable medical devices with composite coatings. Coatings are composed of various materials including, e.g., polymers and drugs. Transfer of the coatings within a patient or other host forms a drug-eluting coating that delivers time-released drugs over time for treatment of a medical condition.

92. 发明授权

US09636309B2 Macrolide dosage forms 有权
公开(公告)号：US09636309B2
公开(公告)日：2017-05-02
申请号：US13229473
申请日：2011-09-09
申请人： James B. McClain , Charles Douglas Taylor , Wenda C. Carlyle
发明人： James B. McClain , Charles Douglas Taylor , Wenda C. Carlyle
IPC分类号： A61K47/34 , A61K9/70 , A61K9/00
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0021 , A61K9/7007 , A61K31/436
摘要： Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.

93. 发明授权

US09539593B2 Holder for electrically charging a substrate during coating 有权
标题翻译：用于在涂覆期间对基底进行充电的支架
公开(公告)号：US09539593B2
公开(公告)日：2017-01-10
申请号：US11877591
申请日：2007-10-23
申请人： James B. McClain , Doug Taylor , Ed Dickinson , Steve Worm
发明人： James B. McClain , Doug Taylor , Ed Dickinson , Steve Worm
IPC分类号： B05C13/02 , B05B5/053 , A61L31/10 , B05B5/08
CPC分类号： B05B5/0533 , A61L31/10 , B05B5/082 , B05B13/0207 , B05C13/025
摘要： A stent holder for mounting and electrically charging a stent during coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. An assembly for supporting and electrically charging a stent during the coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A chamber for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A method for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles comprising inert polymers, pharmaceutical or biological agents is provided.
摘要翻译：提供一种用于在使用干燥颗粒涂覆支架期间安装和充电支架的支架支架，所述颗粒包括惰性聚合物，药物或生物制剂。提供了一种用于在使用干燥颗粒涂覆支架期间支撑和充电支架的组件，所述颗粒包含惰性聚合物，药物或生物制剂。提供了一种用于在支架周围产生电场并用于支撑，充电并将支架暴露于干颗粒的腔室，包括惰性聚合物，药物或生物制剂的颗粒。提供了一种用于在支架周围产生电场并用于支撑，充电和将支架暴露于包含惰性聚合物，药物或生物制剂的干燥颗粒的方法。

94. 发明授权

US09486431B2 Drug delivery medical device 有权
标题翻译：药物输送医疗器械
公开(公告)号：US09486431B2
公开(公告)日：2016-11-08
申请号：US12504597
申请日：2009-07-16
申请人： James B. McClain , Douglas Taylor , John Neet
发明人： James B. McClain , Douglas Taylor , John Neet
IPC分类号： A61K31/20 , A61K31/7088 , A61K31/7105 , A61K31/715 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61F2/30 , A61K9/00 , A61K38/00 , A61M25/10
CPC分类号： A61L29/16 , A61F2002/30535 , A61F2250/0058 , A61K9/0024 , A61K9/0034 , A61K31/20 , A61K31/7088 , A61K31/7105 , A61K31/715 , A61K38/00 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/50 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/14 , A61L29/148 , A61L31/08 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/406 , A61L2300/416 , A61L2300/426 , A61L2300/602 , A61L2300/608 , A61L2300/63 , A61L2420/08 , A61M2025/105
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，包括：基底; 以及设置在所述基底上的涂层，其中所述涂层包含至少一种聚合物和至少一种治疗上需要的形态和/或至少一种活性生物试剂和任选的一种或多种药物载体的药剂; 其中基本上所有的药剂和/或活性生物制剂都保留在所述涂层内和所述衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将所述医疗装置部署在所述受试者的身体中时所述药剂和/或活性生物剂的一部分与所述聚合物的至少一部分和/或所述药物载体的至少一部分在所述介入部位递送。

95. 发明授权

US09433516B2 Stents having controlled elution 有权
公开(公告)号：US09433516B2
公开(公告)日：2016-09-06
申请号：US12762007
申请日：2010-04-16
申请人： James B. McClain , Douglas Taylor
发明人： James B. McClain , Douglas Taylor
IPC分类号： A61F2/00 , A61K31/436 , A61P7/00 , A61F2/86 , A61F2/82 , A61L31/02 , A61L31/10 , A61L31/16 , A61L31/08 , A61L31/14
CPC分类号： A61F2/86 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61K31/436 , A61L31/022 , A61L31/06 , A61L31/08 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/204 , A61L2300/416 , A61L2300/426 , A61L2300/602 , A61L2300/604 , A61L2300/608 , A61L2300/63 , A61L2420/08 , C08L67/04
摘要： Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

96. 发明申请

US20140350522A1 DRUG DELIVERY MEDICAL DEVICE 审中-公开
标题翻译：药物递送医疗设备
公开(公告)号：US20140350522A1
公开(公告)日：2014-11-27
申请号：US14131878
申请日：2012-07-12
申请人： James B. McClain , Charles Douglas Taylor , Brett G. Zani , John Neet , Timothy Charles Kiorpes
发明人： James B. McClain , Charles Douglas Taylor , Brett G. Zani , John Neet , Timothy Charles Kiorpes
IPC分类号： A61L31/08 , A61L31/16 , B05D7/24 , A61B17/12 , A61M25/10
CPC分类号： A61L31/08 , A61B17/12136 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/602 , A61L2420/06 , A61M25/10 , A61M2025/1081 , A61M2210/12 , B05D7/24
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，包括：基底; 以及涂层，其设置在所述基底上，其中所述涂层包含至少一种聚合物和至少一种治疗期望形态的药剂和/或至少一种活性生物剂和任选的一种或多种药物载体; 其中基本上所有的药剂和/或活性生物制剂都保留在涂层内和衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将医疗装置部署在受试者的身体中时一部分药剂和/或活性生物剂在干预部位与至少一部分聚合物和/或药物载体的至少一部分一起递送。

97. 发明申请

US20120064124A1 MACROLIDE DOSAGE FORMS 有权
标题翻译： MACROLIDE剂型
公开(公告)号：US20120064124A1
公开(公告)日：2012-03-15
申请号：US13229473
申请日：2011-09-09
申请人： James B. McClain , Charles Douglas Taylor , Wenda C. Carlyle
发明人： James B. McClain , Charles Douglas Taylor , Wenda C. Carlyle
IPC分类号： A61K9/00 , A61P27/16 , A61P19/02 , A61P15/00 , A61P13/00 , A61M5/32 , A61P37/08 , A61P27/02 , A61P31/00 , A61P37/06 , A61M5/00 , A61M5/30 , A61K39/00 , A61P35/00
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0021 , A61K9/7007 , A61K31/436
摘要： Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.
摘要翻译：提供了包含至少一种聚合物和至少一种活性剂的药物递送组合物; 其中所述活性剂以结晶形式存在于所述组合物的外表面的至少一个区域上，并且其中调节活性剂表面含量以提供选定的活性剂释放曲线。

98. 发明申请

US20110257732A1 STENTS HAVING CONTROLLED ELUTION 审中-公开
标题翻译：具有控制力的手柄
公开(公告)号：US20110257732A1
公开(公告)日：2011-10-20
申请号：US13086335
申请日：2011-04-13
申请人： James B. McClain , Douglas Taylor
发明人： James B. McClain , Douglas Taylor
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61L31/022 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/63
摘要： Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
摘要翻译：本文提供的装置包括：a。支架; b。在所述支架框架上的多个层以形成所述装置; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

99. 发明申请

US20110159069A1 Medical Implants and Methods of Making Medical Implants 有权
标题翻译：医疗植入物和医疗植入物的方法
公开(公告)号：US20110159069A1
公开(公告)日：2011-06-30
申请号：US12648106
申请日：2009-12-28
申请人： Wendy J. Shaw , Clement R. Yonker , John L. Fulton , Barbara J. Tarasevich , James B. McClain , Doug Taylor
发明人： Wendy J. Shaw , Clement R. Yonker , John L. Fulton , Barbara J. Tarasevich , James B. McClain , Doug Taylor
IPC分类号： A61F2/02 , A61K31/727 , A61K38/16 , A61F11/00 , A61P43/00
CPC分类号： A61L31/10 , A61K31/727 , A61L31/16 , A61L2300/42 , A61L2400/18
摘要： A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.
摘要翻译：一种具有氧化表面的基底和与氧化表面共价结合的硅烷衍生物涂层的医用植入装置。生物活性剂与硅烷衍生物涂层共价键合。一种可植入支架装置，其包括具有氧化表面的支架芯，其具有与其共价键合的硅烷衍生物层。包含聚乙二醇（PEG）的间隔层与硅烷衍生物层共价键合，蛋白质与PEG共价键合。一种制造医疗植入装置的方法，包括提供具有表面的基底，氧化表面并与衍生的硅烷反应以形成共价键合到该表面的硅烷涂层。然后将生物活性剂共价键合到硅烷涂层。在特定情况下，生物吸收性聚合物和/或药剂的附加涂层沉积在生物活性剂上。

100. 发明申请

US20100256746A1 BIODEGRADABLE POLYMERS 审中-公开
标题翻译：生物可降解聚合物
公开(公告)号：US20100256746A1
公开(公告)日：2010-10-07
申请号：US12729603
申请日：2010-03-23
申请人： Douglas Taylor , James B. McClain , Edward E. Schmitt
发明人： Douglas Taylor , James B. McClain , Edward E. Schmitt
IPC分类号： A61F2/06 , C08G63/02 , A61K31/436 , B05D7/00
CPC分类号： A61L31/10 , A61K31/435 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2420/02 , A61L2420/06 , A61L2420/08 , B05D3/12 , B05D2254/06 , C08G63/06 , C08G63/08 , C08G63/90 , C08G2150/20 , C08G2230/00 , C08J7/047 , C08L67/04 , C09D5/033 , C09D167/04
摘要： Provided herein is a composition comprising a poly(alpha-hydroxycarboxylic acid) substantially free of acidic impurities wherein the poly(alpha-hydroxycarboxylic acid) is selected from poly(D,L-lactic-co-glycolic acid), poly(L-lactic acid), poly(D-lactic acid) and poly(D,L-lactic acid). Also provided is a device comprising: a substrate, and a coating wherein the coating comprises poly(D,L-lactic-co-glycolic acid) substantially free of acidic impurities.
摘要翻译：本文提供的是包含基本上不含酸性杂质的聚（α-羟基羧酸）的组合物，其中聚（α-羟基羧酸）选自聚（D，L-乳酸 - 共 - 乙醇酸），聚（L-乳酸酸），聚（D-乳酸）和聚（D，L-乳酸）。还提供了一种装置，其包括：基底和涂层，其中所述涂层包含基本上不含酸性杂质的聚（D，L-乳酸 - 共 - 乙醇酸）。

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