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    • 97. 发明授权
    • 2′, 5′-oligoadenylate analogs
    • 2',5'-寡腺苷酸类似物
    • US07651999B2
    • 2010-01-26
    • US11131412
    • 2005-05-16
    • Makoto KoizumiKoji Morita
    • Makoto KoizumiKoji Morita
    • A61K31/70C07H21/02
    • C12N15/113C07H21/00C12N2310/11C12N2310/315C12N2310/319C12N2310/321C12N2310/3231C12N2310/3515Y02P20/55C12N2310/3521
    • A 2-5A analog represented by the formula (1): wherein m is 0 or 1; n is 0 to 2; R1 represents an alkoxy group having from 1 to 6 carbon atoms which may be substituted, an unprotected mercapto group, a mercapto group protected by a nucleic acid synthesis protecting group, or an alkylthio group having from 1 to 4 carbon atoms which may be substituted; R2, R3, R4, R5 and R6 represent an unprotected hydroxyl group, a hydroxyl group protected by a nucleic acid synthesis protecting group, an alkoxy group having from 1 to 6 carbon atoms which may be substituted, an unprotected mercapto group, a mercapto group protected by a nucleic acid synthesis protecting group, or an alkylthio group having from 1 to 4 carbon atoms which may be substituted; R7 represents an oxygen atom, or a —O(CH2CH2O)q- group, wherein q is 2 to 6; R8 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms which may be substituted, or a 5′-phosphorylated oligonucleotide analog which has one hydroxyl group removed from the 5′-phosphoric acid group; E1, E2, E3 and E4 represent a naturally occurring or modified nucleic acid unit, or a pharmacologically acceptable salt thereof.
    • 由式(1)表示的2-5A类似物:其中m为0或1; n为0〜2; R1表示可被取代的具有1至6个碳原子的烷氧基,未保护的巯基,被核酸合成保护基保护的巯基或可被取代的具有1至4个碳原子的烷硫基; R2,R3,R4,R5和R6表示未被保护的羟基,被核酸合成保护基保护的羟基,可被取代的具有1至6个碳原子的烷氧基,未保护的巯基,巯基 被核酸合成保护基保护,或可以被取代的具有1至4个碳原子的烷硫基; R 7表示氧原子,或-O(CH 2 CH 2 O)q-基,其中q为2-6。 R8表示氢原子,可以被取代的碳原子数为1〜6的烷基或从5'-磷酸基除去一个羟基的5'-磷酸化寡核苷酸类似物; E1,E2,E3和E4表示天然存在或修饰的核酸单元或其药理学上可接受的盐。
    • 99. 发明申请
    • FUEL INJECTION CONTROL APPARATUS AND FUEL INJECTION CONTROL METHOD FOR INTERNAL COMBUSTION ENGINE
    • 燃油喷射控制装置和燃油喷射控制方法内燃机
    • US20090271091A1
    • 2009-10-29
    • US12301625
    • 2007-07-23
    • Koji Morita
    • Koji Morita
    • F02D41/30F02B17/00
    • F02D41/064F02D41/3064F02D41/3076F02D41/3094F02D2200/0406Y02T10/128
    • A fuel injection control apparatus for an internal combustion engine includes a fuel injection portion that performs each of first fuel injection for performing stratified-charge combustion, and second fuel injection for performing homogeneous-charge combustion; and an injection distribution ratio control portion that controls an injection distribution ratio. The injection distribution ratio control portion controls the injection distribution ratio to a target injection distribution ratio set based on a predetermined engine condition after start of the engine. An initial injection distribution ratio is set based on an engine condition at a time of start of the engine, and a change in the injection distribution ratio is controlled by referring to the engine condition after the start of the engine, when the injection distribution ratio is changed from the initial injection distribution ratio to the target injection distribution ratio.
    • 一种用于内燃机的燃料喷射控制装置,包括执行各自进行分层充气燃烧的第一燃料喷射的燃料喷射部和进行均匀充气燃烧的第二燃料喷射; 以及控制喷射分配比的喷射分配比控制部。 喷射分配比率控制部分将喷射分配比控制为基于发动机起动之后的预定发动机状态设定的目标喷射分配比。 基于发动机起动时的发动机状态来设定初始喷射分配比,并且通过参照发动机起动后的发动机状态来控制喷射分配比的变化,当喷射分配比为 从初始喷射分配比改变为目标喷射分配比。