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91. 发明申请

US20090029976A1 BENZOFURAN AND BENZOTHIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES 失效
标题翻译：苯并呋喃和苯并二苯基-2-羧酸酰胺衍生物
公开(公告)号：US20090029976A1
公开(公告)日：2009-01-29
申请号：US12173888
申请日：2008-07-16
申请人： Peter Mohr , Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Tadakatsu Takahashi , Sven Taylor
发明人： Peter Mohr , Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Tadakatsu Takahashi , Sven Taylor
IPC分类号： A61K31/541 , C07D417/06 , C07D413/06 , A61K31/5377 , C07D403/06 , A61K31/497 , C07D401/06 , A61K31/4523
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of formula I wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译：本发明涉及式I化合物，其中X，A和R 1至R 4如说明书和权利要求书中所定义，及其药学上可接受的盐。该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。

92. 发明申请

US20090005379A1 Azaindole-2-Carboxamide Derivatives 失效
标题翻译： Azaindole-2-Carboxamide衍生物
公开(公告)号：US20090005379A1
公开(公告)日：2009-01-01
申请号：US12093669
申请日：2006-11-08
申请人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Sven Taylor
发明人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Sven Taylor
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/4353
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein R1 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译：本发明涉及其中R1至R5如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐。该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。

93. 发明申请

US20080188487A1 5-AMIDO-(1H-INDOL-2-YL)-PIPERAZIN-1-YL-METHANONE DERIVATIVES 失效
标题翻译： 5-氨基 - （1H-吲哚-2-基） - 哌嗪-1-基甲基酮衍生物
公开(公告)号：US20080188487A1
公开(公告)日：2008-08-07
申请号：US12020637
申请日：2008-01-28
申请人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Sven Taylor
发明人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Sven Taylor
IPC分类号： A61K31/497 , C07D403/02
CPC分类号： C07D209/42 , C07D401/04 , C07D403/06
摘要： The present invention relates to compounds of formula I wherein A, G and R1 to R3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译：本发明涉及式I化合物，其中A，G和R 1至R 3如在说明书和权利要求书中所定义，及其药学上可接受的盐。该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。

94. 发明申请

US20070244125A1 5-amido-indole-2-carboxamide derivatives 失效
标题翻译： 5-氨基 - 吲哚-2-甲酰胺衍生物
公开(公告)号：US20070244125A1
公开(公告)日：2007-10-18
申请号：US11784041
申请日：2007-04-05
申请人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Sven Taylor
发明人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Sven Taylor
IPC分类号： A61K31/4045 , C07D209/02
CPC分类号： C07D401/06 , C07D209/42 , C07D401/14 , C07D403/06 , C07D405/12 , C07D487/04 , C07D491/113
摘要： The present invention relates to compounds of formula I wherein G and R1 to R5 and R12 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译：本发明涉及式I化合物，其中G和R 1至R 5和R 12如在说明书和权利要求书中所定义，及其药学上可接受的盐。该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。

95. 发明申请

US20070135416A1 Tricyclic amide derivatives 失效
标题翻译：三环酰胺衍生物
公开(公告)号：US20070135416A1
公开(公告)日：2007-06-14
申请号：US11605899
申请日：2006-11-29
申请人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Sven Taylor
发明人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Sven Taylor
IPC分类号： A61K31/551 , A61K31/498 , C07D487/14
CPC分类号： C07D487/04 , C07D471/14
摘要： The present invention relates to compounds of formula I wherein A, G, r and R1 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译：本发明涉及式I化合物，其中A，G，r和R 1至R 5如在说明书和权利要求书中所定义，及其药学上可接受的盐。该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。

96. 发明授权

US07098337B2 1,2,3,4,9,9a-hexahydro-2,4a,5-triaza-fluorene and 1,2,3,4-tetrahydro-2,4a,5-triaza-fluorene derivatives 失效
标题翻译： 1,2,3,4,9,9a-六氢-2,4a，5-三氮杂芴和1,2,3,4-四氢-2,4a，5-三唑 - 芴衍生物
公开(公告)号：US07098337B2
公开(公告)日：2006-08-29
申请号：US10350616
申请日：2003-01-24
申请人： David Reginald Adams , Jonathan Mark Bentley , Toby Jonathan Blench , Paul Hebeisen , Nathaniel Julius Thomas Monck , Hans Richter , Stephan Roever , Jonathan Richard Anthony Roffey , Sven Taylor
发明人： David Reginald Adams , Jonathan Mark Bentley , Toby Jonathan Blench , Paul Hebeisen , Nathaniel Julius Thomas Monck , Hans Richter , Stephan Roever , Jonathan Richard Anthony Roffey , Sven Taylor
IPC分类号： C07D471/14 , A61K31/4985 , A61P3/04
CPC分类号： C07D471/14
摘要： The present invention relates to compounds of formula (I) as well as pharmaceutically acceptable salts, solvates and esters thereof. These compounds can be used to prepare pharmaceutical compositions for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes, obesity and sleep apnoea.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，溶剂化物和酯。这些化合物可用于制备用于治疗或预防中枢神经系统疾病，中枢神经系统损害，心血管疾病，胃肠道疾病，糖尿病，肥胖症和睡眠呼吸暂停的药物组合物。

97. 发明申请

US20050026925A1 5HT2c receptor agonists 失效
标题翻译： 5HT2c受体激动剂
公开(公告)号：US20050026925A1
公开(公告)日：2005-02-03
申请号：US10876954
申请日：2004-06-25
申请人： Toby Blench , Paul Hebeisen , Hans Richter , Stephan Roever
发明人： Toby Blench , Paul Hebeisen , Hans Richter , Stephan Roever
IPC分类号： C07D471/14 , A61K31/498 , C07D487/14
CPC分类号： C07D471/14
摘要： The present invention provides piperazine derivatives of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in the description. They can be used for the treatment of obesity.
摘要翻译：本发明提供式（I）的哌嗪衍生物及其药学上可接受的盐和酯，其中R 1至R 5在描述中具有重要性。它们可用于治疗肥胖。

98. 发明授权

US06844345B2 Piperazine derivatives 失效
标题翻译：哌嗪衍生物
公开(公告)号：US06844345B2
公开(公告)日：2005-01-18
申请号：US10092751
申请日：2002-03-07
申请人： Paul Hebeisen , Patrizio Mattei , Marc Muller , Hans Richter , Stephan Roever , Sven Taylor
发明人： Paul Hebeisen , Patrizio Mattei , Marc Muller , Hans Richter , Stephan Roever , Sven Taylor
IPC分类号： A61K31/337 , A61K31/4985 , A61P3/00 , A61P3/04 , A61P3/10 , A61P7/02 , A61P9/00 , A61P11/00 , A61P13/02 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P29/00 , A61P43/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides piperazine derivatives in accordance with formula (I) as well as salts, hydrates and esters thereof. The substituent designations are as provided in the specification. The compounds of the present invention can be used in the treatment of type II diabetes or obesity.
摘要翻译：本发明提供根据式（I）的哌嗪衍生物及其盐，水合物和酯。取代基名称如本说明书中所提供。本发明的化合物可用于治疗II型糖尿病或肥胖症。

99. 发明授权

US5925632A Derivatives of 3-pyrrolidylidene-2-one-cephalsporines 失效
标题翻译： 3-吡咯烷亚基-2-单头孢菌素的衍生物
公开(公告)号：US5925632A
公开(公告)日：1999-07-20
申请号：US875563
申请日：1997-07-25
申请人： Ingrid Heinze-Krauss , Hans Richter
发明人： Ingrid Heinze-Krauss , Hans Richter
IPC分类号： C07D501/04 , A61K31/545 , A61K31/546 , A61P31/04 , C07D501/00 , C07D501/06 , C07D501/48 , C07D501/56
CPC分类号： C07D501/00 , Y02P20/55
摘要： Compounds of formula (I) ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, aralkyl, cycloalkyl, R.sup.3 CO-- or --C(R.sup.4 R.sup.5)CO.sub.2 R.sup.6 ; where R.sup.4 and R.sup.5 are each independently hydrogen or lower alkyl, or R.sup.4 and R.sup.5 taken together with the carbon atom to which they are attached form a cycloalkyl group; R.sup.3 is hydrogen or lower alkyl and R.sup.6 is hydrogen, lower alkyl, lower alkenyl or a carboxylic acid protecting group;R.sup.2 is isobutyl, 2,2-dimethyl-propyl or cyclohexyl-methyl;n is 0, 1 or 2;X is CH or N;as well as readily hydrolyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and of their esters and salts are disclosed. These compounds have valuable antibacterial activity.
摘要翻译： PCT No.PCT / EP96 / 00667 Sec。 371日期1997年7月25日 102（e）日期1997年7月25日PCT提交1996年2月16日PCT公布。公开号WO96 / 26943 日期：1996年9月6日，式（I）化合物，其中R1为氢，低级烷基，芳烷基，环烷基，R3CO-或-C（R4R5）CO2R6; 其中R 4和R 5各自独立地为氢或低级烷基，或者R 4和R 5与它们所连接的碳原子一起形成环烷基; R3是氢或低级烷基，R6是氢，低级烷基，低级烯基或羧酸保护基; R2是异丁基，2,2-二甲基 - 丙基或环己基 - 甲基; n为0,1或2; X是CH或N; 以及其易水解的酯，所述化合物的药学上可接受的盐和式I化合物及其酯和盐的水合物被公开。这些化合物具有有价值的抗菌活性。

100. 发明授权

US5775171A Robot wrist mechanism 失效
标题翻译：机器人手腕机构
公开(公告)号：US5775171A
公开(公告)日：1998-07-07
申请号：US514248
申请日：1995-08-11
申请人： Hans Richter
发明人： Hans Richter
IPC分类号： B25J9/04 , B25J17/02 , B25J19/00
CPC分类号： B25J17/0283 , B25J19/0016 , B25J9/046 , Y10T74/20335
摘要： A robot wrist for the working hand of a robot has a connection element for connection to a robot arm along the main axis thereof, and a toolholder hinged to the connection element which has tool receiver axis and which can turn about a second axis normal to the main axis. One portion of the tool holder can pivot about a third axis parallel with the tool receiver axis and in the stretched position of the wrist in parallel with the main axis. The distances between the third axis and the tool receiver axis and between the third axis and the main axis are equal.
摘要翻译：用于机器人的工作手的机器人手腕具有用于连接到机器人手臂的主轴的连接元件，以及铰接到具有工具接收器轴线的连接元件的刀架，并且能够绕与第主轴。工具架的一部分可绕平行于工具接收器轴线的第三轴线和与主轴平行的手腕的拉伸位置枢转。第三轴与刀具接收器轴之间以及第三轴与主轴之间的距离相等。

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