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91. 发明授权

US08293897B2 Compounds comprising a spiro-ring and methods of use 有权
标题翻译：包含螺环的化合物和使用方法
公开(公告)号：US08293897B2
公开(公告)日：2012-10-23
申请号：US12576375
申请日：2009-10-09
申请人： Ning Xi
发明人： Ning Xi
IPC分类号： A61P35/04 , C07D403/14 , C07D413/14 , C07D471/04
CPC分类号： A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D471/04 , C07D491/107 , C07D493/10 , C07D495/04 , C07D498/04 , C07D519/00
摘要： The present invention provides novel compounds useful in modulating the protein tyrosine kinase activity, and in modulating inter—and/or intra—cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
摘要翻译：本发明提供了可用于调节蛋白酪氨酸激酶活性和调节细胞间和/或细胞内信号传导的新型化合物。本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗哺乳动物，特别是人类中过度增殖性疾病的方法。

92. 发明授权

US08079278B2 End effector for nano manufacturing 有权
标题翻译：用于纳米制造的末端执行器
公开(公告)号：US08079278B2
公开(公告)日：2011-12-20
申请号：US11989036
申请日：2006-07-21
申请人： Ning Xi , Uchechukwu Wejinya , Yantao Shen
发明人： Ning Xi , Uchechukwu Wejinya , Yantao Shen
IPC分类号： B01L3/02 , G01N1/02 , G01L23/10
CPC分类号： B81C99/002 , Y10S977/872 , Y10T29/49998 , Y10T29/53991
摘要： An end-effector is provided for use on a micro/nano manipulation device. The end-effector is comprised of: a micropump fluidly coupled to a microtube; a piezoelectric sensing structure disposed in the microtube; and a processing circuit electrically coupled to the sensing structure for determining the force of the fluid flowing through the microtube. The end-effector is a closed loop control-enabled micro/nano manipulation system.
摘要翻译：提供用于微/纳米操纵装置的末端执行器。末端执行器包括：流体耦合到微管的微型泵; 设置在微管中的压电感测结构; 以及电耦合到感测结构以用于确定流过微管的流体的力的处理电路。末端执行器是一个闭环控制的微/纳米操纵系统。

93. 发明授权

US07297946B2 Automated nanoassembly 有权
公开(公告)号：US07297946B2
公开(公告)日：2007-11-20
申请号：US11205201
申请日：2005-08-16
申请人： Ning Xi , Guangyong Li , Heping Chen
发明人： Ning Xi , Guangyong Li , Heping Chen
IPC分类号： G01N13/16 , G01B5/88 , G01B7/34
CPC分类号： B82B3/00 , G01Q30/04 , G01Q80/00
摘要： An automated nanomanipulation system is provided for manufacturing a nanoscale structure. The system includes: a design model for the nanoscale structure; image data of a sample surface upon which the nanoscale structure is to be manufactured; a movable member configured to perform a nanomanipulation operation on the sample surface; and a path planning subsystem adapted to receive the design model and the image data. The path planning subsystem generates path data indicative of a path for traversing the movable member along the sample surface such that the movable member manipulates one or more randomly distributed nanoobjects in accordance with the design model.

94. 发明申请

US20060284118A1 Process and apparatus for modifying a surface in a work region 有权
标题翻译：用于修改工作区域中的表面的工艺和设备
公开(公告)号：US20060284118A1
公开(公告)日：2006-12-21
申请号：US11452891
申请日：2006-06-14
申请人： Jes Asmussen , Timothy Grotjohn , Ning Xi , Timothy Hogan
发明人： Jes Asmussen , Timothy Grotjohn , Ning Xi , Timothy Hogan
IPC分类号： H01J37/08
CPC分类号： H01J37/32366 , H01J37/32357
摘要： An apparatus and process for manufacturing changes of a substrate in a work region which is 100×100×100 microns or smaller is described. The apparatus uses a plasma source adjacent to the work region to produce radiation or matter which changes the surface. An atomic force microscope or laser can be used in addition. The process and apparatus can be used to produce MEMS devices on a substrate for use in a wide variety of applications.
摘要翻译：描述了用于制造100×100×100微米或更小的工作区域中的衬底的变化的装置和工艺。该设备使用与工作区域相邻的等离子体源产生改变表面的辐射或物质。另外还可以使用原子力显微镜或激光。该方法和装置可用于在基板上制造用于各种应用的MEMS器件。

95. 发明申请

US20060196280A1 Active sensor for micro force measurement 失效
标题翻译：用于微力测量的主动传感器
公开(公告)号：US20060196280A1
公开(公告)日：2006-09-07
申请号：US11366014
申请日：2006-02-27
申请人： Ning Xi , Yantao Shen
发明人： Ning Xi , Yantao Shen
IPC分类号： G01L1/10
CPC分类号： G01L1/08
摘要： An active micro-force sensor is provided for use on a micromanipulation device. The active micro-force sensor includes a cantilever structure having an actuator layer of piezoelectric material and a sensing layer of piezoelectric material bonded together. When an external force is exerted on the sensor, the sensor deforms and an applied force signal is recorded by the sensing layer. The applied force signal is then fed back to the actuating layer of the sensor via a servoed transfer function or servo controller, so that a counteracting deformation can be generated by the bending moment from the servoed actuating layer to quickly balance the deformation caused by the external micro-force. Once balanced, the sensor beam comes back to straight status and the tip will remain in its equilibrium position, thus the sensor stiffness seems to be virtually improved so that the accurate motion control of the sensor tip can be reached, especially, at the same time, the micro-force can also be obtained by solving the counteracting balance voltage applied to the actuating layer.
摘要翻译：提供用于显微操作装置的主动微力传感器。有源微力传感器包括具有压电材料的致动器层和压电材料的感测层结合在一起的悬臂结构。当外力施加在传感器上时，传感器变形，施加的力信号由传感层记录。所施加的力信号然后通过伺服传递函数或伺服控制器反馈到传感器的致动层，使得可以通过来自伺服致动层的弯矩产生抵消变形，以快速平衡由外部引起的变形微力。一旦平衡，传感器光束返回到直线状态，并且尖端将保持在其平衡位置，因此传感器刚度似乎被实际改善，使得可以达到传感器尖端的精确运动控制，特别是同时，也可以通过求解施加到致动层的抵消平衡电压来获得微力。

96. 发明授权

US06456901B1 Hybrid robot motion task level control system 有权
标题翻译：混合机器人运动任务级控制系统
公开(公告)号：US06456901B1
公开(公告)日：2002-09-24
申请号：US09838894
申请日：2001-04-20
申请人： Ning Xi , Jindong Tan
发明人： Ning Xi , Jindong Tan
IPC分类号： G06F1900
CPC分类号： B25J9/1607
摘要： A hybrid control system is provided for controlling the movement of a robot. The hybrid control system includes a singularity detector; a task level controller that receives a motion plan and determines a first set of control commands which are defined in a task space; and a joint level controller that receives the motion plan and determines a second set of control commands which are defined in a joint space. The singularity detector monitors the movement of the robot and detects robot movement in a region about a singularity configuration. When robot movement occurs outside of this region, the task level controller is operable to issue the first set of control commands to the robot. When the robot movement occurs inside of this region, the joint level controller is operable to issue the second set of control commands to the robot. In this way, the hybrid control system ensures feasible robot motion in the neighborhood of and at kinematic singularity configuration.
摘要翻译：提供了一种用于控制机器人运动的混合控制系统。混合控制系统包括奇点检测器; 任务级别控制器，其接收运动计划并确定在任务空间中定义的第一组控制命令; 以及联合级别控制器，其接收运动计划并确定在联合空间中限定的第二组控制命令。奇点检测器监视机器人的运动并检测机器人在关于奇异构型的区域中的运动。当机器人移动发生在该区域之外时，任务级别控制器可操作以向机器人发出第一组控制命令。当机器人移动发生在该区域内时，联合液位控制器可操作以向机器人发出第二组控制命令。以这种方式，混合控制系统确保在运动学奇异性配置附近和运动学上的可行机器人运动。

97. 发明申请

US20190224197A1 SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE 审中-公开
公开(公告)号：US20190224197A1
公开(公告)日：2019-07-25
申请号：US16251114
申请日：2019-01-18
申请人： Ning Xi , Liang Wang , Xuejin Feng , Min Liao
发明人： Ning Xi , Liang Wang , Xuejin Feng , Min Liao
IPC分类号： A61K31/506 , C07D413/14 , C07D403/14
摘要： The invention relates to the preparation and use of new aminopyrirnidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans.

98. 发明申请

US20150274705A1 SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE 有权
标题翻译：取代异腈化合物及其使用方法
公开(公告)号：US20150274705A1
公开(公告)日：2015-10-01
申请号：US14670422
申请日：2015-03-27
申请人： Ning Xi , Minxiong Li , Xiaobo Li , Tao Zhang , Yanjun Wu
发明人： Ning Xi , Minxiong Li , Xiaobo Li , Tao Zhang , Yanjun Wu
IPC分类号： C07D403/14 , A61K45/06 , C07D401/14 , A61K31/527 , A61K31/506
CPC分类号： C07D403/14 , A61K31/506 , A61K31/527 , A61K45/06 , C07D401/14 , C07D403/12 , C07D493/04
摘要： The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of a protein-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.
摘要翻译：本发明提供了用于预防，治疗或减轻蛋白质介导的疾病的严重性的新颖的杂芳基化合物，其药学上可接受的盐和制剂。本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗蛋白激酶介导的疾病的方法。

99. 发明申请

US20150087663A1 SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE 有权
标题翻译：取代的氨基嘧啶化合物及其使用方法
公开(公告)号：US20150087663A1
公开(公告)日：2015-03-26
申请号：US14488294
申请日：2014-09-17
申请人： Ning Xi , Liang Wang , Zuping Wu , Xuejin Feng , Yanjun Wu
发明人： Ning Xi , Liang Wang , Zuping Wu , Xuejin Feng , Yanjun Wu
IPC分类号： C07D413/14 , C07D403/14 , C07D401/14 , A61K31/517
CPC分类号： C07D413/14 , A61K31/506 , A61K31/517 , A61K45/06 , C07D401/14 , C07D403/14 , C07D417/14 , Y02A50/409 , A61K2300/00
摘要： The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not limited to leukemias and solid tumors, in mammals, especially humans.
摘要翻译：本发明涉及新的氨基嘧啶衍生物作为游离形式的候选药物或其药学上可接受的盐形式及其制剂用于调节由PI3K酶的活性介导的病症或疾病的制备和用途。本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗疾病或疾病的方法，例如PI3K酶在白细胞功能中起作用的免疫和炎症紊乱，以及与PI3K活性相关的过度增生性疾病，包括但不限于白血病和实体瘤，在哺乳动物，特别是人类中。

100. 发明申请

US20140002610A1 REAL-TIME 3D SHAPE MEASUREMENT SYSTEM 审中-公开
标题翻译：实时三维形状测量系统
公开(公告)号：US20140002610A1
公开(公告)日：2014-01-02
申请号：US14005207
申请日：2012-03-14
申请人： Ning Xi , Jing Xu , Chi Zhang
发明人： Ning Xi , Jing Xu , Chi Zhang
IPC分类号： G01B11/25
CPC分类号： G01B11/2545 , G01B11/2513
摘要： Improved method and system for performing three-dimensional shape inspection by: projecting a pattern of light onto an object of interest with a projector, the pattern of light being constituted by a plurality of symbols of different shapes; capturing an image of the illuminated object with an image capturing device; determining the 3D shape of the object from the image data and the projected light pattern with a processor using triangulation. The pattern of light is projected in an omnidirectional plane by means of a first mirrored surface having hyperbolic shape to provide an alternative to traditional monochromatic light based patterns.
摘要翻译：改进的方法和系统，用于通过以下方式执行三维形状检查：通过投影仪将光图案投影到感兴趣的对象上，所述图案由多个不同形状的符号构成; 用图像捕获装置拍摄被照明物体的图像; 使用三角测量法利用处理器从图像数据和投影光图案确定对象的3D形状。光的图案通过具有双曲线形状的第一镜像表面投影在全向平面中，以提供传统的基于单色光的图案的替代。

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