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91. 发明申请

US20090257994A1 Chimeric immunoreceptor useful in treating human cancers 审中-公开
标题翻译：嵌合免疫受体可用于治疗人类癌症
公开(公告)号：US20090257994A1
公开(公告)日：2009-10-15
申请号：US12314195
申请日：2008-12-05
申请人： Michael Jensen
发明人： Michael Jensen
IPC分类号： A61K45/00 , C07K14/00 , C12N15/74 , A61P35/00
CPC分类号： A61K38/2086 , A61K35/17 , A61K38/1774 , C07H21/04 , C07K14/5437 , C07K14/7051 , C07K14/70514 , C07K14/7155 , C07K16/46 , C07K19/00 , C07K2319/00 , C07K2319/30 , C12N5/0636 , C12N15/63
摘要： The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human malignancy. In a preferred embodiment is a glioma-specific immunoreceptor comprising the extracellular targetting domain of the IL-13Rα2-specific IL-13 mutant IL-13(E13Y) linked to the Fc region of IgG, the transmembrane domain of human CD4, and the human CD3 zeta chain.
摘要翻译：本发明涉及由跨膜结构域组成的嵌合跨膜免疫受体，其包含与能够将细胞外结构域连接至细胞表面的支持区连接的可溶性受体配体，跨膜区和细胞内信号结构域。当在T淋巴细胞表面上表达时，Zetakines将T细胞活性直接导向表达可溶性受体配体特异性受体的那些特异性细胞。 Zetakine嵌合免疫受体代表了用于重定向T细胞的抗原特异性的基于抗体的免疫受体的新的延伸，其应用于治疗多种癌症，特别是通过人类恶性肿瘤使用的自身免疫/旁分泌细胞因子系统。在一个优选的实施方案中是包含与IgG的Fc区连接的IL-13Ralpha2特异性IL-13突变体IL-13（E13Y）的细胞外靶向结构域的人胶质瘤特异性免疫受体，人CD4的跨膜结构域和人 CD3ζ链。

92. 发明申请

US20090048436A1 Methods of synthesizing chemically cleavable phosphoramidite linkers 审中-公开
标题翻译：化学可裂解亚磷酰胺接头的合成方法
公开(公告)号：US20090048436A1
公开(公告)日：2009-02-19
申请号：US11893614
申请日：2007-08-15
申请人： Keith Anderson , Michael Jensen , Ronald W. Davis , Charles K. Brush , Kaizhang He
发明人： Keith Anderson , Michael Jensen , Ronald W. Davis , Charles K. Brush , Kaizhang He
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： The present invention provides a method of synthesizing phosphoramidite linkers that are useful for the production of synthesizing two or more oligonucleotides in tandem. The inventive linker has the following desirable properties: (i) enhanced stability to alkali conditions versus the linkers previously published, (ii) cleaves to produce 5′ and 3′ ends that are fully biologically compatible, (iii) cleaves completely under conditions that are already used in cleavage/deprotection processes so it is fully compatible with conditions that are common in laboratories and does not require additives that necessitate further purification after cleavage, (iv) integrates easily onto commercially available synthesizers because it is compatible with standard coupling chemistry, and (v) is compatible with DNA, RNA, forward, reverse, and LNA, synthesis chemistries. In addition, the inventive linkers may be coupled to a solid support. Thus, the inventive linkers provide a significant advancement in the state of the art.
摘要翻译：本发明提供了一种合成亚磷酰胺接头的方法，其可用于串联合成两种或多种寡核苷酸。本发明的接头具有以下所需的性质：（i）与先前公开的接头相比，提高了对碱性条件的稳定性，（ii）切割产生完全生物相容的5'和3'末端，（iii）在条件下完全切割已经用于裂解/去保护过程，因此它与实验室常见的条件完全相容，并且不需要在裂解后需要进一步纯化的添加剂，（iv）容易地与市售合成仪整合，因为它与标准偶联化学相容，并且（v）与DNA，RNA，正向，反向和LNA的合成化学物质相容。此外，本发明的接头可以连接到固体支持物。因此，本发明的接头提供了现有技术的显着进步。

93. 发明授权

US07427930B2 Vehicular traffic sensor 有权
标题翻译：车载交通传感器
公开(公告)号：US07427930B2
公开(公告)日：2008-09-23
申请号：US10744686
申请日：2003-12-23
申请人： David V. Arnold , Logan Harris , Michael Jensen , Thomas William Karlinsey , Ryan Smith , Jonathan L. Waite , John B. Dougall, Jr.
发明人： David V. Arnold , Logan Harris , Michael Jensen , Thomas William Karlinsey , Ryan Smith , Jonathan L. Waite , John B. Dougall, Jr.
IPC分类号： G08G1/01 , G01S3/02
CPC分类号： H01Q21/0006 , G01S7/032 , G01S7/352 , G01S13/04 , G01S13/34 , G08G1/042 , H01Q13/106 , H01Q21/08
摘要： A vehicle traffic sensor for detecting and monitoring vehicular targets is presented. The sensor employs a planar design resulting in a reduced profile sensor. The sensor includes a multi-layer radio frequency board with RF components on one of the sides and both isolation and planar array antennas on the opposing side. The antennas are preferably tapered planar array antennas which include one transmit antenna and one receive antenna. The sensor also includes at least one logic or signal processing board populated with components on a first side and a ground plane on a second side positioned toward the RF componentry of the RF board to form an RF shield. The boards are housed within a housing that is permeable, at least on the side through which the antenna structures propagate.
摘要翻译：提出了一种用于检测和监控车辆目标的车辆交通传感器。该传感器采用平面设计，从而减少轮廓传感器。该传感器包括在其一侧具有RF部件的多层射频板以及相对侧的隔离和平面阵列天线。天线优选是包括一个发射天线和一个接收天线的锥形平面阵列天线。该传感器还包括至少一个逻辑或信号处理板，其填充有第一侧上的部件和位于RF板的RF部件的第二侧上的接地平面，以形成RF屏蔽。板被容纳在可透气的壳体内，至少在天线结构传播的一侧。

94. 发明申请

US20080075813A1 Seasoning and method for enhancing and potentiating food flavor utilizing microencapsulation while reducing dietary sodium intake 审中-公开
标题翻译：调味和增强食用香料的方法，同时减少膳食中的钠摄入
公开(公告)号：US20080075813A1
公开(公告)日：2008-03-27
申请号：US11904554
申请日：2007-09-27
申请人： Gordon Smith , Michael Jensen
发明人： Gordon Smith , Michael Jensen
IPC分类号： A23P1/04 , A23L1/22
CPC分类号： A23C19/09 , A23L27/40 , A23L27/72
摘要： An encapsulated seasoning and method for seasoning for preserving, seasoning, enhancing, and potentiating flavor in a variety of foods and beverages is disclosed. The encapsulated seasoning may include shell and a core, the core comprising at least one seasoning particle having a particle size less than 25 microns and a non-aqueous composition. The encapsulated seasoning particle may include sodium chloride, as a seasoning, and a hydrophobic shell. Encapsulated small sodium chloride may be more effective in delivering taste impact than larger sized sodium chloride. Therefore, less sodium chloride may be required for the same taste effect resulting in less dietary sodium intake.
摘要翻译：公开了一种用于调味，调味，增强和增强各种食品和饮料中的风味的调味料的封装调味料和方法。包封的调味料可以包括壳和芯，芯包含至少一种粒度小于25微米的调味颗粒和非水组合物。包封的调味颗粒可以包括氯化钠，调味料和疏水壳。与较大尺寸的氯化钠相比，包封的小氯化钠可能更有效地提供味觉冲击。因此，对于相同的味道效果可能需要较少的氯化钠，导致较少的膳食钠摄入量。

95. 发明申请

US20080051545A1 Polymers Having Broad Molecular Weight Distributions and Methods of Making the Same 有权
标题翻译：具有广泛分子量分布的聚合物及其制备方法
公开(公告)号：US20080051545A1
公开(公告)日：2008-02-28
申请号：US11929448
申请日：2007-10-30
申请人： Max McDaniel , Elizabeth Benham , Steven Secora , Michael Jensen , Kathy Collins
发明人： Max McDaniel , Elizabeth Benham , Steven Secora , Michael Jensen , Kathy Collins
IPC分类号： C08F10/14
CPC分类号： C08F10/00 , C08F210/16 , C08F4/24 , C08F4/623 , C08F4/69 , C08F210/14 , C08F2500/04 , C08F2500/07 , C08F2500/13 , C08F2500/12
摘要： Methods of polymerizing at least one olefin include contacting the olefin with a catalyst comprising chromium and with a cocatalyst comprising a non-transition metal cyclopentadienyl (Cp) compound. The polymerization may be performed in the presence of hydrogen. Using the cocatalyst in conjunction with the catalyst increases several properties, such as the high load melt index (HLMI), the MW, and the MN, of the polymers produced by this polymerization method. Polymer compositions produced by such methods have various unique properties, including a PDI greater than about 30. Additional embodiments include articles of manufacture or end use articles formed from such polymer compositions.
摘要翻译：聚合至少一种烯烃的方法包括使烯烃与包含铬的催化剂和包含非过渡金属环戊二烯基（Cp）化合物的助催化剂接触。聚合可以在氢的存在下进行。与催化剂一起使用助催化剂增加了几种性质，例如所生产的聚合物的高负载熔体指数（HLMI），M W W N N N N N N N N 通过该聚合方法。通过这种方法制备的聚合物组合物具有各种独特的性质，包括大于约30的PDI。另外的实施方案包括由这种聚合物组合物形成的制品或最终用途制品。

96. 发明申请

US20080004460A1 Polymerization catalysts and process for producing bimodal polymers in a single reactor 有权
标题翻译：聚合催化剂和在单个反应器中生产双峰聚合物的方法
公开(公告)号：US20080004460A1
公开(公告)日：2008-01-03
申请号：US11705695
申请日：2007-02-12
申请人： Kumudini Jayaratne , Michael Jensen , Qing Yang
发明人： Kumudini Jayaratne , Michael Jensen , Qing Yang
IPC分类号： C07F17/00
CPC分类号： B01J31/2295 , B01J31/143 , B01J2531/0263 , B01J2531/48 , B01J2531/49 , C08F4/65912 , C08F4/65925 , C08F4/65927 , C08F10/00 , C08F210/16 , Y10S526/941 , Y10S526/943 , C08F4/65904 , C08F210/14 , C08F2500/05 , C08F2500/07 , C08F2500/12
摘要： Catalyst compositions comprising a first metallocene compound, a second metallocene compound, an activator-support, and an organoaluminum compound are provided. An improved method for preparing cyclopentadienyl complexes used to produce polyolefins is also provided.
摘要翻译：提供了包含第一茂金属化合物，第二茂金属化合物，活化剂 - 载体和有机铝化合物的催化剂组合物。还提供了用于制备用于制备聚烯烃的环戊二烯基络合物的改进方法。

97. 发明申请

US20070234020A1 INSTRUCTION ENCODING FOR SYSTEM REGISTER BIT SET AND CLEAR 有权
标题翻译：用于系统寄存器位设置和清除的指令编码
公开(公告)号：US20070234020A1
公开(公告)日：2007-10-04
申请号：US11567290
申请日：2006-12-06
申请人： Michael Jensen
发明人： Michael Jensen
IPC分类号： G06F9/48
CPC分类号： G06F9/462 , G06F9/30018 , G06F9/3004 , G06F9/30101 , G06F9/30185 , G06F9/4812
摘要： An instruction encoding architecture is provided for a microprocessor to allow atomic modification of privileged architecture registers. The instructions include an opcode that designates to the microprocessor that the instructions are to execute in privileged (kernel) state only, and that the instructions are to communicate with privileged control registers, a field for designating which of a plurality of privileged architecture registers is to be modified, a field for designating which bit fields within the designated privileged architecture register is to be modified, and a field to designate whether the whether the designated bit fields are to be set or cleared. The instruction encoding allows a single instruction to atomically set or clear bit fields within privileged architecture registers, without reading the privileged architecture registers into a general purpose register. In addition, the instruction encoding allows a programmer to specify whether the previous content of a privileged architecture register is to be saved to a general purpose register during the atomic modification.
摘要翻译：为微处理器提供指令编码架构，以允许对特权架构寄存器进行原子修改。指令包括指定给微处理器的操作码，指令仅在特权（内核）状态下执行，并且指令将与特权控制寄存器进行通信，该字段用于指定多个特权体系结构寄存器中的哪一个到被修改，用于指定要修改指定的特权体系结构寄存器中的哪些位字段的字段以及用于指定是否要设置或清除指定位字段的字段。指令编码允许单个指令在特权体系结构寄存器中原子地设置或清除位字段，而不将特权体系结构寄存器读入通用寄存器。此外，指令编码允许程序员指定在原子修改期间是否将特权架构寄存器的先前内容保存到通用寄存器。

98. 发明申请

US20070179044A1 Polymerization catalysts for producing high molecular weight polymers with low levels of long chain branching 有权
标题翻译：用于生产具有低水平长链支化的高分子量聚合物的聚合催化剂
公开(公告)号：US20070179044A1
公开(公告)日：2007-08-02
申请号：US11345966
申请日：2006-02-02
申请人： Qing Yang , Michael Jensen , Joel Martin , Matthew Thorn , Max McDaniel , Youlu Yu , David Rohlfing
发明人： Qing Yang , Michael Jensen , Joel Martin , Matthew Thorn , Max McDaniel , Youlu Yu , David Rohlfing
IPC分类号： C08F4/02 , C08F4/44
CPC分类号： C08F10/00 , C08F4/65912 , C08F4/65916 , C08F110/02 , Y10S526/943 , C08F4/65927 , C08F2500/03
摘要： This invention relates to catalyst compositions, methods, and polymers encompassing at least one Group 4 metallocene compound comprising bridging η5-cyclopentadienyl-type ligands, typically in combination with at least one cocatalyst, and at least one activator. The compositions and methods disclosed herein provide ethylene polymers with low levels of long chain branching.
摘要翻译：本发明涉及催化剂组合物，方法和聚合物，其包括至少一种包含桥连五元环戊二烯基型配体的至少一种第四族金属茂化合物，通常与至少一种助催化剂组合，以及至少一种活化剂。本文公开的组合物和方法提供具有低水平长链支化的乙烯聚合物。

99. 发明申请

US20070166327A1 Mammalian antigen-presenting T cells and bi-specific T cells 审中-公开
标题翻译：哺乳动物抗原呈递T细胞和双特异性T细胞
公开(公告)号：US20070166327A1
公开(公告)日：2007-07-19
申请号：US11700762
申请日：2007-02-01
申请人： Laurence Cooper , Michael Jensen
发明人： Laurence Cooper , Michael Jensen
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： A61K35/12 , A61K35/17 , A61K39/0011 , A61K39/145 , A61K39/245 , A61K2039/5158 , C12N5/0636
摘要： The present invention is directed to mammalian bi-specific T cells and methods for using these bi-specific T cells. More specifically, the invention relates to viral specific T cells that express chimeric anti-tumor receptors. These bi-specific T cell clones are a source of effector cells that persist in vivo in response to stimulation with viral antigen, leading to long-term function after their transfer to patients with cancer and autoimmune diseases.
摘要翻译：本发明涉及哺乳动物双特异性T细胞和使用这些双特异性T细胞的方法。更具体地，本发明涉及表达嵌合抗肿瘤受体的病毒特异性T细胞。这些双特异性T细胞克隆是效应细胞的来源，其在体内依赖于用病毒抗原的刺激而持续存在，导致其转移到患有癌症和自身免疫疾病的患者之后的长期功能。

100. 发明申请

US20070094482A1 Boundary address registers for selection of ISA mode 有权
标题翻译：用于选择ISA模式的边界地址寄存器
公开(公告)号：US20070094482A1
公开(公告)日：2007-04-26
申请号：US11636462
申请日：2006-12-11
申请人： Michael Jensen , Morten Stribaek
发明人： Michael Jensen , Morten Stribaek
IPC分类号： G06F9/40
CPC分类号： G06F9/44547 , G06F9/30076 , G06F9/30189 , G06F9/30196 , G06F9/3802
摘要： An apparatus and method are provided that enable a multiple instruction set architecture (ISA) central processing unit (CPU) to distinguish between different program instructions corresponding to different ISAs during execution of a multiple-ISA application program. The apparatus allows the multiple-ISA CPU to select a particular ISA decoding mode corresponding to a program instruction. The program instruction is located at an address within an address space of the multiple-ISA CPU. The apparatus includes a plurality of boundary address registers and ISA mode selection logic. The plurality of boundary address registers can be dynamically loaded to partition the address space into a plurality of address ranges, where each of the plurality of address ranges corresponds to each of a plurality of ISA decoding modes. The ISA mode selection logic is coupled to the plurality of boundary address registers. The ISA mode selection logic receives the particular address, and compares it against the plurality of address ranges to determine the particular ISA decoding mode for the particular program instruction.
摘要翻译：提供了一种装置和方法，其使多个指令集体系结构（ISA）中央处理单元（CPU）在执行多个ISA应用程序期间区分与不同ISA相对应的不同程序指令。该装置允许多ISA CPU选择与程序指令相对应的特定ISA解码模式。程序指令位于多ISA CPU的地址空间内的地址。该装置包括多个边界地址寄存器和ISA模式选择逻辑。可以动态地加载多个边界地址寄存器以将地址空间分割成多个地址范围，其中多个地址范围中的每一个对应于多个ISA解码模式中的每一个。 ISA模式选择逻辑耦合到多个边界地址寄存器。 ISA模式选择逻辑接收特定地址，并将其与多个地址范围进行比较，以确定特定程序指令的特定ISA解码模式。

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