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91. 发明申请

US20150196497A1 CONTROLLED RELEASE MATRIX BARRIER STRUCTURE FOR SUBCUTANEOUS MEDICAL DEVICES 有权
标题翻译：用于辅助医疗器械的控制释放矩阵障碍物结构
公开(公告)号：US20150196497A1
公开(公告)日：2015-07-16
申请号：US14669571
申请日：2015-03-26
申请人： SurModics, Inc.
发明人： Joseph Schmidt McGonigle , Aleksey V. Kurdyumov , Jeffrey J. Missling , Nathan A. Lockwood , Kevin W. Burton , Beth A. Petersen
IPC分类号： A61K9/70 , A61K31/573
CPC分类号： A61K9/7007 , A61F2/07 , A61F2/82 , A61K9/0024 , A61K31/573 , A61K47/34 , A61L29/06 , A61L29/14 , A61L29/16 , A61L31/04 , A61L31/10 , A61L2300/404 , A61L2300/406 , C08L67/04
摘要： A biocompatible polymeric controlled release matrix barrier structure for delivery of one or more bioactive agents from an implantable medical device is described. In an embodiment, a biocompatible polymeric controlled release matrix barrier structure is included. The biocompatible polymeric controlled release matrix can include a body structure formed of a compliant material comprising one or more compliant biocompatible polymers and one or more bioactive agents. The body structure can define a central aperture through which a subcutaneous element of an implantable medical device passes. Other embodiments are included herein.
摘要翻译：描述了用于从可植入医疗装置递送一种或多种生物活性剂的生物相容性聚合物控制释放基质屏障结构。在一个实施方案中，包括生物相容性聚合物控制释放基质屏障结构。生物相容性聚合物控制释放基质可以包括由包含一种或多种顺应性生物相容性聚合物和一种或多种生物活性剂的柔顺材料形成的体结构。身体结构可以限定可植入医疗装置的皮下元件通过的中心孔。本文还包括其它实施例。

92. 发明申请

US20150017219A1 SOLVENT METHODS FOR PREPARING CRYSTALLINE MACROLIDE PARTICULATES, COMPOSITIONS, AND ARTICLES CONTAINING PARTICULATES 有权
标题翻译：用于制备晶体结构的颗粒，组合物和含有颗粒物的制品的溶剂方法
公开(公告)号：US20150017219A1
公开(公告)日：2015-01-15
申请号：US14303309
申请日：2014-06-12
申请人： SURMODICS, INC.
发明人： Joram Slager , Aleksey V. Kurdyumov , Toni M. Heyer
IPC分类号： A61L29/16 , C07D498/18
CPC分类号： A61L29/16 , A61K9/0019 , A61K9/14 , A61K31/436 , A61L2300/416 , C07D498/18 , Y10T428/2982
摘要： The invention provides therapeutic particulates including a macrolide, such as rapamycin, in solid state crystalline form, having a size of 20 μm or less, or 10 μm or less. The particulates are formed in one method by preparing a composition with a macrolide and first (e.g., xylene) and second (e.g., an alcohol, acetone, or acetonitrile) solvents. In the composition a maximum solubility for the macrolide that is greater than a maximum solubility of the macrolide dissolved in either the first or second solvent individually. The first and second solvents are then evaporated from the composition to provide the macrolide particulates. In another method, the particulates can be formed by a method including sonication and stirring/evaporation steps, and the particulates can be obtained from a supersaturated solution, formed during the process. Particulates display desirable low polydispersity, and can be used in therapeutic compositions, or can be associated with an implantable or insertable medical device for the treatment of a subject.
摘要翻译：本发明提供治疗性微粒，其包括固体状结晶形式的大环内酯如雷帕霉素，其尺寸为20μm或更小或10μm或更小。通过制备具有大环内酯和第一（例如二甲苯）和第二（例如醇，丙酮或乙腈）溶剂的组合物来形成颗粒。在组合物中，大环内酯的最大溶解度大于单独溶解在第一或第二溶剂中的大环内酯的最大溶解度。然后将第一和第二溶剂从组合物中蒸发以提供大环内酯颗粒。在另一种方法中，颗粒可以通过包括超声处理和搅拌/蒸发步骤的方法形成，并且颗粒可以从在过程中形成的过饱和溶液获得。颗粒显示出期望的低多分散性，并且可以用于治疗组合物，或者可以与用于治疗受试者的可植入或可插入的医疗装置相关联。

93. 发明授权

US08927226B2 Compositions and methods for in vitro diagnostic tests including sulfonic acid 有权
标题翻译：用于体外诊断测试的组合物和方法，包括磺酸
公开(公告)号：US08927226B2
公开(公告)日：2015-01-06
申请号：US14266143
申请日：2014-04-30
申请人： SurModics, Inc.
发明人： Gary Opperman , Wendy Nelson
IPC分类号： G01N33/58 , C12Q1/28 , G01N21/78 , G01N33/52 , G01N33/535 , G01N33/558
CPC分类号： G01N33/581 , C12Q1/28 , G01N21/78 , G01N33/52 , G01N33/535 , G01N33/558
摘要： The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product. The absorbance properties of the chromogenic reaction product can be maintained over significantly longer periods of time of that of conventional reagents and methods. The sulfonic acid can be used in assays such as ELISAs in order to provide a more accurate and safer detection of analytes in a biological sample.
摘要翻译：本发明提供用于进行比色分析的组合物，试剂盒和方法。使底物反应生成显色反应产物，并加入作为磺酸的反应停止试剂以停止并稳定反应产物。显色反应产物的吸光度特性可以在常规试剂和方法的显着更长的时间内保持。磺酸可用于诸如ELISA的测定中，以便提供对生物样品中分析物的更准确和更安全的检测。

94. 发明申请

US20140336571A1 COMPOSITIONS AND METHODS FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS 审中-公开
标题翻译：用于输送疏水活性剂的组合物和方法
公开(公告)号：US20140336571A1
公开(公告)日：2014-11-13
申请号：US14280170
申请日：2014-05-16
申请人： SurModics, Inc.
发明人： Joram Slager , Dale G. Swan , Darin DuMez , Joseph Ventura , Shannon Wadman , Joseph Schmidt McGonigle , Robert W. Hergenrother
IPC分类号： A61K47/32 , A61K31/436 , A61L29/04 , A61M25/10 , A61L29/08 , A61L29/16 , A61K31/337 , A61K9/14
CPC分类号： A61L29/041 , A61K9/0019 , A61K31/337 , A61K31/436 , A61K47/34 , A61L29/085 , A61L29/16 , A61L2300/416 , A61L2300/62 , A61L2300/63 , A61L2400/06 , A61L2420/06 , A61L2420/08 , A61M25/10 , A61M2025/105 , C08L79/02
摘要： Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.
摘要翻译：本文公开了用于施用疏水性活性剂的递送组合物。在一个实施方案中，公开了用于向患者的组织或器官局部施用疏水性活性剂的递送组合物。在一个实施方案中，递送组合物包括阳离子递送剂，治疗有效量的疏水活性剂和药学上可接受的水性载体。在一个实施方案中，阳离子递送剂包括聚乙烯亚胺（PEI）。在一个实施方案中，本发明包括药物递送装置，其包括基底; 以及设置在基材上的被覆治疗剂颗粒，所述涂敷的治疗剂颗粒包含颗粒状疏水性治疗剂; 和乙烯基胺聚合物。制备递送组合物的方法以及试剂盒和使用方法也包括在本文中。

95. 发明申请

US20140328998A1 APPARATUS AND METHODS FOR COATING MEDICAL DEVICES 有权
标题翻译：用于涂敷医疗器械的装置和方法
公开(公告)号：US20140328998A1
公开(公告)日：2014-11-06
申请号：US14272204
申请日：2014-05-07
申请人： SurModics, Inc.
发明人： Ralph A. Chappa , Andrew G. Bach , Mark MacGregor
IPC分类号： A61M25/10
CPC分类号： A61M25/1029 , A61M2025/1031 , B05B13/0442
摘要： Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
摘要翻译：本发明的实施方案包括用于涂敷药物洗脱医学装置的装置和方法。在一个实施例中，本发明包括涂覆装置，其包括包括运动限制结构的涂布施加单元; 流体施加器; 和空气喷嘴。该装置还可包括旋转机构和轴向运动机构，所述轴向运动机构构造成使涂层施加单元和旋转机构中的至少一个相对于彼此移动。本文还包括其它实施例。

96. 发明申请

US20140234874A1 COMPOSITIONS AND METHODS FOR IN VITRO DIAGNOSTIC TESTS INCLUDING SULFONIC ACID 有权
标题翻译：用于体液检测的组合物和方法，包括硫酸
公开(公告)号：US20140234874A1
公开(公告)日：2014-08-21
申请号：US14266143
申请日：2014-04-30
申请人： SurModics, Inc.
发明人： Gary Opperman , Wendy Nelson
IPC分类号： G01N33/58 , C12Q1/28
CPC分类号： G01N33/581 , C12Q1/28 , G01N21/78 , G01N33/52 , G01N33/535 , G01N33/558
摘要： The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product. The absorbance properties of the chromogenic reaction product can be maintained over significantly longer periods of time of that of conventional reagents and methods. The sulfonic acid can be used in assays such as ELISAs in order to provide a more accurate and safer detection of analytes in a biological sample.
摘要翻译：本发明提供用于进行比色分析的组合物，试剂盒和方法。使底物反应生成显色反应产物，并加入作为磺酸的反应停止试剂以停止并稳定反应产物。显色反应产物的吸光度特性可以在常规试剂和方法的显着更长的时间内保持。磺酸可用于诸如ELISA的测定中，以便提供对生物样品中分析物的更准确和更安全的检测。

97. 发明申请

US20140162083A1 STILBENE-BASED REACTIVE COMPOUNDS, POLYMERIC MATRICES FORMED THEREFROM, AND ARTICLES VISUALIZABLE BY FLUORESCENCE 有权
标题翻译：基于STILBENE的反应性化合物，其形成的聚合物和可透过荧光的物质
公开(公告)号：US20140162083A1
公开(公告)日：2014-06-12
申请号：US14104208
申请日：2013-12-12
申请人： SurModics, Inc.
发明人： Aleksey V. Kurdyumov , Dale G. Swan , Nathan A. Lockwood , Bruce M. Jelle
IPC分类号： A61L31/14 , C07C233/81 , A61L31/10 , C07D251/68
CPC分类号： A61L31/14 , A61B1/00135 , A61B1/005 , A61L31/10 , C07C235/84 , C07C309/46 , C07D251/54 , C07D251/68 , Y10T428/31942
摘要： The invention is directed to latent reactive and polymerizable derivatives of fluorescent stilbene-based compounds. The compounds can be used to provide articles with a fluorescence property, such as medical devices (e.g., catheters). The fluorescent compounds can be used in association with polymers, or can be incorporated into polymers, and the polymers used in a coating composition on the article surface. The compounds allow for visual or machine inspection of coating properties such as uniformity of coverage.
摘要翻译：本发明涉及荧光芪类化合物的潜在反应性和可聚合衍生物。这些化合物可用于提供具有荧光性质的制品，例如医疗装置（例如导管）。荧光化合物可以与聚合物结合使用，或者可以并入聚合物中，以及用于制品表面上的涂料组合物中的聚合物。这些化合物允许对涂层性能进行视觉或机器检查，例如覆盖的均匀性。

98. 发明申请

US20140161964A1 COATING APPARATUS AND METHODS 有权
标题翻译：涂装装置及方法
公开(公告)号：US20140161964A1
公开(公告)日：2014-06-12
申请号：US14063124
申请日：2013-10-25
申请人： SurModics, Inc.
发明人： Ralph A. Chappa , Timothy M. Kloke
IPC分类号： A61M25/00
CPC分类号： A61M25/0009 , A61M25/1029 , A61M2025/1031 , B05C1/00 , B05C1/06 , B05C13/02 , Y10S901/43
摘要： Embodiments of the invention include coating apparatuses and related methods. In an embodiment, the invention includes a coating apparatus. The coating apparatus can include a motor, a rotating contact member, a fluid applicator, a fluid pump, and a base member. The fluid applicator can include an orifice. The rotating contact member can be configured to rotate around a device to be coated that does not rotate. The rotating contact member can be configured to move along the lengthwise axis of a device to be coated. In an embodiment, the invention includes a method of coating a medical device. The method of coating a medical device can include a rotating a contact member around the outer diameter of a non-rotating medical device, applying a coating solution to the outer diameter of the non-rotating medical device at a position adjacent to the contact member, and moving at least one of the contact member and the non-rotating medical device with respect to one another so that the contact member moves with respect to the lengthwise axis of the non-rotating medical device. Other embodiments are also included herein.
摘要翻译：本发明的实施例包括涂覆装置和相关方法。在一个实施例中，本发明包括涂覆装置。涂布装置可以包括马达，旋转接触构件，流体施加器，流体泵和基座构件。流体施加器可以包括孔口。旋转接触构件可以构造成围绕不旋转的待涂覆装置旋转。旋转接触构件可以构造成沿待涂覆的装置的纵向轴线移动。在一个实施例中，本发明包括涂覆医疗装置的方法。医疗装置的涂敷方法可以包括使非旋转医疗装置的外径附近的接触部件旋转，在与所述接触部件相邻的位置向所述非旋转医疗装置的外径施加涂布溶液，并且相对于彼此移动所述接触构件和所述非旋转医疗装置中的至少一个，使得所述接触构件相对于所述非旋转医疗装置的纵向轴线移动。本文还包括其它实施例。

99. 发明申请

US20140142166A1 COMPOSITION AND METHOD FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS 有权
标题翻译：用于输送疏水活性剂的组合物和方法
公开(公告)号：US20140142166A1
公开(公告)日：2014-05-22
申请号：US14072520
申请日：2013-11-05
申请人： SurModics, Inc.
发明人： Joseph Ventura , Shannon Wadman , Joram Slager , Joseph Schmidt McGonigle , Robert W. Hergenrother
IPC分类号： A61K47/34 , A61K31/337
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/08 , A61K31/337 , A61L27/18 , A61L27/54 , A61L2300/416 , A61L2300/63 , A61L2400/06 , C08L79/02
摘要： Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.
摘要翻译：本文公开了用于施用疏水性活性剂的递送组合物。在一个实施方案中，公开了用于向患者的组织或器官局部施用疏水性活性剂的递送组合物。在一个实施方案中，递送组合物包括阳离子递送剂，治疗有效量的疏水活性剂和药学上可接受的水性载体。在一个实施方案中，阳离子递送剂包括聚乙烯亚胺（PEI）。在更具体的实施方案中，阳离子递送剂包括支链PEI。还公开了制备递送组合物的方法，以及试剂盒和使用方法。

100. 发明申请

US20030215649A1 SILANE COATING COMPOSITION 有权
标题翻译：硅烷涂料组合物
公开(公告)号：US20030215649A1
公开(公告)日：2003-11-20
申请号：US10147098
申请日：2002-05-16
申请人： SurModics, Inc.
发明人： Bruce M. Jelle
IPC分类号： B32B009/04
CPC分类号： A61L31/10 , A61L27/34 , A61L29/085 , A61L2420/08 , Y10T428/31663 , Y10T428/31667 , C08L83/04
摘要： An inorganic substrate with two or more coating layers is provided. The first coating layer is attached to the inorganic substrate and includes the polymeric reaction product formed upon hydrolysis of a silane compound having at least two tri(C1-C3)alkoxysilyl groups. The second and subsequent coating layers include at least one hydrophilic polymer and at least one photoactivatable cross-linking agent. The inorganic substrate can be a medical device suitable for insertion into the body of a mammal. The coatings are tenacious and not easily removed from the inorganic substrate by abrasion.
摘要翻译：提供具有两层以上涂层的无机基材。第一涂层附着到无机基材上，包括在具有至少两个三（C 1 -C 3）烷氧基甲硅烷基的硅烷化合物的水解时形成的聚合反应产物。第二和随后的涂层包括至少一种亲水聚合物和至少一种可光活化的交联剂。无机基质可以是适于插入哺乳动物体内的医疗装置。涂层是韧性的，并且不容易通过磨损从无机基材上除去。

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