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    • 95. 发明授权
    • PROCESS FOR THE PRODUCTION OF 14{62 , 18- and 5{62 , 19-(EPOXYETHANOIMINO)-STEROIDS
    • 生产14(62,18和5(62,19-(环氧乙基) - 三异氰酸酯的方法
    • US3817989A
    • 1974-06-18
    • US20617071
    • 1971-12-08
    • CIBA GEIGY CORP
    • WEHRLI HJEGER O
    • C07J71/00C07C173/00
    • C07J71/0057
    • A new process for the production of 14 Beta , 18- and 5 Beta , 19-(epoxyethanoimino)-steroids is provided, which comprises reacting corresponding thiolactams, i.e. 2''-thioxo-14 Beta , 18and 5 Beta , 19-(epoxyethanoimino)-steroids, with Raney Nickel in an organic solvent. The 2''-thioxo-compounds are in turn obtained from corresponding lactams, i.e. 2''-oxo-14, 18- and 5 Beta , 19(epoxy-ethanoimino)-steroids, by heating with phosphorus pentasulfide in pyridine. By a specific embodiment 1''-methyl-2''thioxo-3 Beta -methoxy-3 Alpha , 9 Alpha -epoxy-11 Alpha , 20 xi -diacetoxy-14 Beta , 18-(epoxyethanoimino)-5 Beta , 17 Alpha pregnane is converted into 1''-methyl-3 Beta -methoxy-3 Alpha , 9 Alpha -epoxy-11 Alpha , 20 xi -diacetoxy-14 Beta , 18(epoxyethanoimino)-5 Beta , 17 Alpha -pregnane.
    • 提供了一种用于生产14β,18和5β,19-(环氧乙酰亚胺基) - 类似物的新方法,其包括使相应的硫代内酰胺反应,即2'-硫代-14β,18-和5β,19-( 环氧乙烷亚氨基) - 类似物,用有机溶剂中的阮内镍。 通过用吡啶中的五硫化二磷加热,2-thioxo化合物又通过相应的内酰胺,即2'-氧代-14,18-和5β,19-(环氧 - 乙酰亚氨基) - 类固醇获得。 通过具体实施方案,1'-甲基-2'-硫代-3β-甲氧基-3α,9α-环氧-11α,20×二乙酰氧基-14β,18-(环氧乙酰亚氨基)-5β,17α- 将孕烷转化成1'-甲基-3β-甲氧基-3α,9α-环氧-11α,20X-二乙酰氧基-14β,18-(环氧乙酰亚氨基)-5β,17α-孕烷。
    • 100. 发明授权
    • Flow compensating metering unit
    • 流量补偿计量单元
    • US3802605A
    • 1974-04-09
    • US18773571
    • 1971-10-08
    • CIBA GEIGY CORP
    • STANDLICK R
    • B01F15/04B29B7/00B29B7/60B29C39/00B29C39/02B29C39/24G05D11/00G05D11/02B67D5/60
    • G05D11/003B29B7/603Y10T137/2521
    • A metering, mixing and dispensing apparatus having a compensator metering assembly for providing proportionate flow of materials by mechanically compensating for changes in pressures of materials being dispensed therethrough. The compensator metering assembly is provided with a pair of material chambers having valve means proximate to discharge orifice outlets provided therein. The valve means are mechanically interconnected so that a change in orifice opening in one chamber due to change of material pressure is mechanically transmitted to the valve means in the other chamber so that a corresponding change in orifice size is effected so as to maintain equal pressures across the discharge orifice outlets, thus maintaining the desired predetermined equal or proportionate flow of the materials therethrough.
    • 一种具有补偿器计量组件的计量,混合和分配装置,用于通过机械补偿通过其分配的材料的压力变化来提供材料的比例流动。 补偿器计量组件设置有一对材料室,其具有靠近设置在其中的排出孔出口的阀装置。 阀装置机械地相互连接,使得由于材料压力的变化而在一个室中的孔口的变化被机械地传递到另一个室中的阀装置,使得孔尺寸的相应变化被实现以保持相等的压力 排出口出口,从而保持材料通过其中期望的预定相等或相称的流动。