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91. 发明申请

US20130253415A1 IRREVERSIBLE ELECTROPORATION USING TISSUE VASCULATURE TO TREAT ABERRANT CELL MASSES OR CREATE TISSUE SCAFFOLDS 有权
标题翻译：不可逆电气使用组织血管来治疗细胞质量或产生组织病变
公开(公告)号：US20130253415A1
公开(公告)日：2013-09-26
申请号：US13989175
申请日：2011-11-23
申请人： Michael B. Sano , Rafael V. Davalos , John L. Robertson , Paulo A. Garcia , Robert E. Neal
发明人： Michael B. Sano , Rafael V. Davalos , John L. Robertson , Paulo A. Garcia , Robert E. Neal
IPC分类号： A61B18/14 , A61M5/00
CPC分类号： A61B18/14 , A61B18/1492 , A61B2018/00613 , A61B2018/1472 , A61B2218/002 , A61K48/0075 , A61M5/00 , A61N1/327
摘要： The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
摘要翻译：本发明涉及疾病和病症的医疗领域以及生物医学工程领域。本发明的实施方案涉及通过器官脉管系统递送不可逆电穿孔（IRE）以治疗深入组织或器官内的肿瘤，或者使现有动物组织脱细胞从而使现有的脉管系统完整地产生支架。特别地，提供了在体内施用非热不可逆电穿孔（IRE）的方法用于治疗位于血管化组织和器官中的肿瘤。本发明的实施方案进一步提供了使用IRE离体产生的来自天然来源的支架和组织，以去除细胞碎片，最大限度地获得细胞结合潜能，并使异物免疫应答最小化。工程组织可用于治疗受试者的方法，例如需要组织置换或增生的方法。

92. 发明授权

US08483351B2 Cardiac computed tomography methods and systems using fast exact/quasi-exact filtered back projection algorithms 失效
标题翻译：心脏计算机断层扫描方法和系统使用快速精确/准精确滤波反投影算法
公开(公告)号：US08483351B2
公开(公告)日：2013-07-09
申请号：US12914790
申请日：2010-10-28
申请人： Ge Wang , Jun Zhao , Yang Lu , Hengyong Yu , Alexander Katsevich
发明人： Ge Wang , Jun Zhao , Yang Lu , Hengyong Yu , Alexander Katsevich
IPC分类号： A61B6/00
CPC分类号： A61B6/4085 , A61B6/027 , A61B6/032 , A61B6/503 , A61B6/508 , A61B6/5205 , G06T11/006 , G06T2211/412 , G06T2211/416 , G06T2211/421
摘要： The present invention provides systems, methods, and devices for improved computed tomography (CT). More specifically, the present invention includes methods for improved cone-beam computed tomography (CBCT) resolution using improved filtered back projection (FBP) algorithms, which can be used for cardiac tomography and across other tomographic modalities. Embodiments provide methods, systems, and devices for reconstructing an image from projection data provided by a computed tomography scanner using the algorithms disclosed herein to generate an image with improved temporal resolution.
摘要翻译：本发明提供用于改进计算机断层摄影（CT）的系统，方法和装置。更具体地，本发明包括使用改进的滤波反投影（FBP）算法改进锥束计算机断层摄影（CBCT）分辨率的方法，其可用于心脏层析成像和跨其他断层摄影模式。实施例提供用于使用本文公开的算法由计算机断层摄影扫描仪提供的投影数据重建图像以生成具有改进的时间分辨率的图像的方法，系统和装置。

93. 发明授权

US08473754B2 Hardware-facilitated secure software execution environment 失效
标题翻译：硬件安全软件执行环境
公开(公告)号：US08473754B2
公开(公告)日：2013-06-25
申请号：US11707951
申请日：2007-02-20
申请人： Mark T. Jones , Peter M. Athanas , Cameron D. Patterson , Joshua N. Edmison , Anthony Mahar , Benjamin J. Muzal , Barry L. Polakowski , Jonathan P. Graf
发明人： Mark T. Jones , Peter M. Athanas , Cameron D. Patterson , Joshua N. Edmison , Anthony Mahar , Benjamin J. Muzal , Barry L. Polakowski , Jonathan P. Graf
IPC分类号： G06F11/30 , H04L9/32 , H04L9/00 , H04K1/00
CPC分类号： G06F21/53 , G06F21/72
摘要： A hardware-facilitated secure software execution environment provides protection of both program instructions and data against unauthorized access and/or execution to maintain confidentiality and integrity of the software or the data during distribution, in external memories, and during execution. The secure computing environment is achieved by using a hardware-based security method and apparatus to provide protection against software privacy and tampering. A Harvard architecture CPU core is instantiated on the same silicon chip along with encryption management unit (EMU) circuitry and secure key management unit (SKU) circuitry. Credential information acquired from one or more sources is combined by the SKU circuitry to generate one or more security keys provided to the EMU for use in decrypting encrypted program instructions and/or data that is obtained from a non-secure, off-chip source such as an external RAM, an information storage device or other network source. In a non-limiting illustrative example implementation, the EMU decrypts a single memory page of encrypted instructions or data per a corresponding encryption key provided by the SKU. Although instantiated on the same chip, the CPU core does not have direct access to the SKU circuitry or to encryption key information generated by the SKU.
摘要翻译：硬件便利的安全软件执行环境提供对程序指令和数据的保护，以防止未经授权的访问和/或执行，以在分发，外部存储器和执行期间保持软件或数据的机密性和完整性。安全计算环境通过使用基于硬件的安全方法和装置来提供防止软件隐私和篡改的保护来实现。哈佛架构CPU内核与加密管理单元（EMU）电路和安全密钥管理单元（SKU）电路一起在同一硅芯片上实例化。从一个或多个源获取的凭证信息由SKU电路组合以产生提供给EMU的一个或多个安全密钥，用于解密加密的程序指令和/或从非安全的片外来源获得的数据，例如作为外部RAM，信息存储设备或其他网络源。在非限制性说明性示例实现中，EMU根据由SKU提供的相应加密密钥对加密指令的单个存储器页面或数据进行解密。虽然在同一芯片上实例化，但是CPU内核不能直接访问SKU电路或者由SKU生成的加密密钥信息。

94. 发明授权

US08445475B2 Supramolecular complexes as photoactivated DNA cleavage agents 有权
公开(公告)号：US08445475B2
公开(公告)日：2013-05-21
申请号：US12610729
申请日：2009-11-02
申请人： Karen Brewer , Shawn Swavey
发明人： Karen Brewer , Shawn Swavey
IPC分类号： A61K31/555 , A01N55/02
CPC分类号： C07F15/0026 , C07F15/0053 , C07F15/008
摘要： The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e.g. Ru or Os) to an electron accepting metal (e.g. Rh) via a bridging π-acceptor ligand. A bioactive metal-to-metal charge transfer state capable of cleaving DNA is thus generated. The complexes function when irradiated with low energy visible light with or without molecular oxygen.

95. 发明申请

US20130111808A1 CLEANING AND DEWATERING FINE COAL 有权
标题翻译：清洁和清洁精细煤
公开(公告)号：US20130111808A1
公开(公告)日：2013-05-09
申请号：US13576067
申请日：2011-01-31
申请人： Roe-Hoan Yoon , Mert K. Eraydin , Chad Freeland
发明人： Roe-Hoan Yoon , Mert K. Eraydin , Chad Freeland
IPC分类号： C10L5/04
CPC分类号： B03B9/005 , B03B1/04 , C10L5/366 , C10L9/10
摘要： Fine coal is cleaned of its mineral matter impurities and dewatered by mixing the aqueous slurry containing both with a hydrophobic liquid, subjecting the mixture to a phase separation. The resulting hydrophobic liquid phase contains coal particles free of surface moisture and droplets of water stabilized by coal particles, while the aqueous phase contains the mineral matter. By separating the entrained water droplets from the coal particles mechanically, a clean coal product of substantially reduced mineral matter and moisture contents is obtained. The spent hydrophobic liquid is separated from the clean coal product and recycled. The process can also be used to separate one type of hydrophilic particles from another by selectively hydrophobizing one.
摘要翻译：通过将含有两者的含水浆料与疏水性液体混合，使混合物进行相分离，精细煤清除其矿物质杂质并脱水。所得到的疏水性液相含有不含表面水分的煤颗粒和由煤颗粒稳定的水滴，而水相含有矿物质。通过机械地将夹带的水滴从煤颗粒中分离出来，获得了基本上减少的矿物质和水分含量的干净的煤制品。将废弃的疏水性液体与清洁煤产品分离并再循环。该方法还可用于通过选择性疏水化一种亲水颗粒与另一种亲水颗粒分离。

96. 发明申请

US20130009589A1 SYSTEM AND METHOD FOR CONTROLLING FOUR-QUADRANT OPERATION OF A SWITCHED RELUCTANCE MOTOR DRIVE THROUGH A SINGLE CONTROLLABLE SWITCH 有权
标题翻译：通过单个可控开关控制切换式电动机驱动的四次运行的系统和方法
公开(公告)号：US20130009589A1
公开(公告)日：2013-01-10
申请号：US13460911
申请日：2012-05-01
申请人： Krishnan RAMU , Keunsoo Ha , Sung-Yeul Park
发明人： Krishnan RAMU , Keunsoo Ha , Sung-Yeul Park
IPC分类号： H02P1/40
CPC分类号： H02P25/092
摘要： Regulating the speed of a two-phase switched reluctance machine (TPSRM) rotor includes selecting either a motoring mode or braking mode of operation for the TPSRM, regulating the rotor speed, when the motoring mode is selected, using a control signal cooperatively produced by a speed control feedback loop and a current control feedback loop; and regulating the rotor speed, when the braking mode is selected, using a control signal produced by the current control feedback loop without the cooperation of the speed control feedback loop. The speed control feedback loop uses an established speed control signal and a signal indicative of the rotor's speed to dynamically adjust a first parameter governing the control signal. The current control feedback loop uses an established current control signal and a signal indicative of the current flowing through a stator winding of the TPSRM to dynamically adjust a second parameter governing the control signal.
摘要翻译：调节二相开关磁阻电机（TPSRM）转子的转速包括：选择电机运行模式或TPSRM的制动运行模式，当选择运行模式时，使用协调制作的控制信号来调节转子转速速度控制反馈回路和电流控制反馈回路; 并且当选择制动模式时，使用由电流控制反馈回路产生的控制信号，而不需要速度控制反馈回路的协调来调节转子速度。速度控制反馈回路使用已建立的速度控制信号和指示转子速度的信号来动态调整控制控制信号的第一参数。电流控制反馈回路使用建立的电流控制信号和指示流过TPSRM的定子绕组的电流的信号来动态地调整控制控制信号的第二参数。

97. 发明授权

US08294883B2 Doppler sensor for the derivation of torsional slip, friction and related parameters 有权
标题翻译：用于推导扭转滑移，摩擦和相关参数的多普勒传感器
公开(公告)号：US08294883B2
公开(公告)日：2012-10-23
申请号：US12749301
申请日：2010-03-29
申请人： Carvel Holton , Mehdi Ahmadian
发明人： Carvel Holton , Mehdi Ahmadian
IPC分类号： G01P3/36
CPC分类号： G01P3/366 , B60W40/06 , G01S17/58 , G01S17/88
摘要： An optical method and apparatus are described for the measurement of properties of a travel vehicle or a travel surface upon which the travel vehicle travels, which includes providing an incident light from a light source to the travel surface, collecting light reflected from the travel surface, determining a surface induced Doppler shift from the incident and collected light and determining at least one of a motion property of the travel vehicle and a surface property of the travel surface based on the determined surface induced Doppler shift.
摘要翻译：描述了用于测量旅行车辆或旅行车辆行进的行进表面的性质的光学方法和装置，其包括将来自光源的入射光提供到行进表面，收集从行进表面反射的光，基于所确定的表面感应多普勒频移，确定来自所述入射和收集的光的表面感应多普勒频移，并且基于所确定的表面感应多普勒频移来确定所述行驶车辆的运动特性和所述行驶表面的表面特性中的至少一个。

98. 发明授权

US08257795B2 Nanoscale metal paste for interconnect and method of use 有权
标题翻译：用于互连的纳米金属膏和使用方法
公开(公告)号：US08257795B2
公开(公告)日：2012-09-04
申请号：US12019450
申请日：2008-01-24
申请人： Guo-Quan Lu , Guangyin Lei , Jesus Calata
发明人： Guo-Quan Lu , Guangyin Lei , Jesus Calata
IPC分类号： B05D3/02 , B22F7/02
CPC分类号： B22F1/0059 , B22F7/064 , B22F2001/0066 , B22F2998/00 , B22F2998/10 , H01L24/29 , H01L24/75 , H01L24/83 , H01L2224/29082 , H01L2224/29101 , H01L2224/29111 , H01L2224/29139 , H01L2224/2919 , H01L2224/29339 , H01L2224/83101 , H01L2224/83192 , H01L2224/83204 , H01L2224/83439 , H01L2224/83444 , H01L2224/83801 , H01L2224/8384 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01019 , H01L2924/01023 , H01L2924/01029 , H01L2924/01033 , H01L2924/01046 , H01L2924/01047 , H01L2924/01049 , H01L2924/0105 , H01L2924/01074 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/0132 , H01L2924/01322 , H01L2924/014 , H01L2924/0665 , H01L2924/12041 , H01L2924/14 , H01L2924/19041 , H01L2924/203 , H01L2924/3025 , H05K3/321 , H05K3/341 , H05K2201/0257 , H05K2203/1126 , H05K2203/1131 , B22F1/0018 , B22F3/1021 , B22F3/15 , H01L2924/00 , H01L2924/3512 , H01L2924/00014 , H01L2924/00015 , H01L2924/0002
摘要： A paste including metal or metal alloy particles (which are preferably silver or silver alloy), a dispersant material, and a binder is used to form an electrical, mechanical or thermal interconnect between a device and a substrate. By using nanoscale particles (i.e., those which are less than 500 nm in size and most preferably less than 100 nm in size), the metal or metal alloy particles can be sintered at a low temperature to form a metal or metal alloy layer which is desired to allow good electrical, thermal and mechanical bonding, yet the metal or metal alloy layer can enable usage at a high temperature such as would be desired for SiC, GaN, or diamond (e.g., wide bandgap devices). Furthermore, significant application of pressure to form the densified layers is not required, as would be the case with micrometer sized particles. In addition, the binder can be varied so as to insulate the metal particles until a desired sintering temperature is reached; thereby permitting fast and complete sintering to be achieved.
摘要翻译：包括金属或金属合金颗粒（其优选为银或银合金），分散剂材料和粘合剂的糊料用于在器件和衬底之间形成电，机械或热互连。通过使用纳米级粒子（即，尺寸小于500nm，最优选小于100nm的纳米级粒子），可以在低温下烧结金属或金属合金粒子，形成金属或金属合金层，该金属或金属合金层是期望允许良好的电，热和机械结合，但是金属或金属合金层可以使得能够在诸如SiC，GaN或金刚石（例如，宽带隙器件）所期望的高温下使用。此外，不需要显着施加压力以形成致密层，如微米尺寸颗粒的情况。此外，可以改变粘合剂以使金属颗粒绝缘直到达到所需的烧结温度; 从而可以实现快速和完全的烧结。

99. 发明申请

US20120063659A1 EXACT LOCAL COMPUTED TOMOGRAPHY BASED ON COMPRESSIVE SAMPLING 有权
标题翻译：基于压缩采样的局部计算机图像
公开(公告)号：US20120063659A1
公开(公告)日：2012-03-15
申请号：US13264834
申请日：2010-04-15
申请人： Ge Wang , Hengyong Yu
发明人： Ge Wang , Hengyong Yu
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , A61B6/583 , G06T2211/424
摘要： A system and method for tomographic image reconstruction using truncated projection data that allows exact interior reconstruction (interior tomography) of a region of interest (ROI) based on the known sparsity models of the ROI, thereby improving image quality while reducing radiation dosage. In addition, the method includes parallel interior tomography using multiple sources beamed at multiple angles through an ROI and that enables higher temporal resolution.
摘要翻译：基于ROI的已知稀疏模型，使用截断的投影数据进行断层图像重建的系统和方法，其允许感兴趣区域（ROI）的精确内部重建（内部层析成像），从而在降低辐射剂量的同时提高图像质量。另外，该方法包括使用通过ROI以多个角度射束的多个源的并行内部层析成像，并且能够实现更高的时间分辨率。

100. 发明授权

US08125291B2 Electromagnetic interference noise separator 有权
标题翻译：电磁干扰噪声分离器
公开(公告)号：US08125291B2
公开(公告)日：2012-02-28
申请号：US12548030
申请日：2009-08-26
申请人： Shuo Wang , Fred C. Lee
发明人： Shuo Wang , Fred C. Lee
IPC分类号： H03H7/38
CPC分类号： H03H7/0115 , H03H1/0007 , H03H2001/0057
摘要： Improved performance of a noise separator circuit capable of separating common mode (CM) and differential mode (DM) components of electromagnetic interference (EMI) noise are provided by arrangement of terminating impedances such that the circuit is fully symmetric with respect of a pair of input ports. The noise separator circuit is further improved by perfecting features for canceling effects of parasitic inductances and capacitances, parasitic capacitance and inductance between circuit connections such as printed circuit board traces, minimizing leakage inductance effects of pairs of coupled inductors and mutual inductance effects between pairs of coupled inductors, providing sufficient magnetizing inductance for low frequency response, and preventing saturation of inductors using switched attenuators, providing a plurality of ground planes, choices of terminating resistors and circuit layout.
摘要翻译：通过排列端接阻抗来提供能够分离电磁干扰（EMI）噪声的共模（CM）和差模（DM）分量的噪声分离器电路的改进的性能，使得电路相对于一对输入完全对称港口。噪声分离器电路通过完善消除寄生电感和电容的影响的特征，电路连接之间的寄生电容和电感（如印刷电路板迹线），使耦合电感对中的漏电感效应最小化，耦合对之间的互感效应电感器，为低频响应提供足够的磁化电感，并防止使用开关衰减器的电感器饱和，提供多个接地平面，终端电阻和电路布局的选择。

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