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91. 发明申请

US20210102223A1 N-Glycosylation 有权
公开(公告)号：US20210102223A1
公开(公告)日：2021-04-08
申请号：US17090677
申请日：2020-11-05
申请人： University of Copenhagen , Danmarks Tekniske Universitet
发明人： Henrik Clausen , Zhang Yang , Adnan Fevzi Halim , Eric Bennett , Carsten Behrens , Malene Bech Vester-Christensen , Shamim Herbert Rahman
IPC分类号： C12N15/90 , C12P21/00 , C07K14/505 , C07K16/46
摘要： The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.

92. 发明授权

US10961556B2 Method for reducing ammonium and lactate production in CHO cells 有权
公开(公告)号：US10961556B2
公开(公告)日：2021-03-30
申请号：US16325583
申请日：2017-08-15
申请人： DANMARKS TEKNISKE UNIVERSITET
发明人： Daniel Ley , Mikael Rørdam Andersen , Helene Faustrup Kildegaard
IPC分类号： C12P21/02 , C12N5/071 , C12N15/52 , C12N9/02
摘要： The present invention relates to modified producer cells for improved production of therapeutic proteins. Specifically, the inventors have found that removing genes involved in amino acid catabolism in Chinese Hamster Ovary (CHO) cells improves the cell growth and viability and likely also the yield of a recombinant therapeutic protein produced by the cells.

93. 发明授权

US10900056B2 Use of octaketide synthases to produce kermesic acid and flavokermesic acid 有权
公开(公告)号：US10900056B2
公开(公告)日：2021-01-26
申请号：US16506256
申请日：2019-07-09
申请人： Danmarks Tekniske Universitet , Københavns Universitet
发明人： Birger Lindberg Møller , Bjørn Madsen , Dan Stærk , Finn Thyge Okkels , Johan Andersen-Ranberg , Kenneth Thermann Kongstad , Kim Binderup , Mads Bennedsen , Majse Nafisi , Paiman Khorsand-Jamal , Rubini Maya Kannangara , Uffe Hasbro Mortensen , Ulf Thrane , Rasmus John Normand Frandsen
IPC分类号： C12P7/66 , C12N9/00 , C12P19/18 , C12N9/10 , C12P17/06 , C12P7/26
摘要： A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).

94. 发明授权

US10598769B2 Coaxial direct-detection LIDAR-system 有权
公开(公告)号：US10598769B2
公开(公告)日：2020-03-24
申请号：US14889404
申请日：2014-05-06
申请人： Danmarks Tekniske Universitet
发明人： Peter John Rodrigo , Christian Pedersen
IPC分类号： G01S7/481 , G01S17/58 , G01S17/95 , G01S7/491 , G01S7/4912
摘要： The invention relates to a coaxial direct-detection LIDAR system for measuring velocity, temperature and/or particulate density. The system comprises a laser source for emitting a laser light beam having a lasing center frequency along an emission path. The system further comprises an optical delivery system arranged in the emission path of the laser source, the optical delivery system being arranged for delivering the laser light beam in a measuring direction, the optical delivery system further being configured for collecting a return signal backscattered along the measuring direction. Finally, the system comprises a detector system arranged to receive the return signal from the optical delivery system, the detector system comprising a narrowband optical filter and a detector, the narrowband optical filter having a filter center frequency of a pass-band, wherein the center lasing frequency and/or the center filter frequency may be scanned. The invention further relates to an aircraft airspeed measurement device, and a wind turbine airspeed measurement device comprising the LIDAR system.

95. 发明授权

US10563271B2 High-level production of diacetyl in a metabolically engineered lactic acid bacterium 有权
公开(公告)号：US10563271B2
公开(公告)日：2020-02-18
申请号：US15766461
申请日：2016-10-07
申请人： Danmarks Tekniske Universitet
发明人： Christian Solem , Peter Ruhdal Jensen , Jianming Liu
IPC分类号： C12R1/225 , A23L27/24 , C12P7/26
摘要： The present invention provides a genetically modified lactic acid bacterium capable of producing diacetyl under aerobic conditions. Additionally the invention provides a method for producing diacetyl using the genetically modified lactic acid bacterium under aerobic conditions in the presence of a source of iron-containing porphyrin and a metal ion selected from Fe3+, Fe2+ and Cu2+. The lactic acid bacterium is genetically modified by deletion of those genes in its genome that encode polypeptides having lactate dehydrogenase (E.C 1.1.1.27/E.C.1.1.1.28); α-acetolactate decarboxylase (E.C 4.1.1.5); water-forming NADH oxidase (E.C. 1.6.3.4); phosphotransacetylase (E.C.2.3.1.8) activity; and optionally devoid of or deleted for genes encoding polypeptides having diacetyl reductase ((R)-acetoin forming; EC:1.1.1.303); D-acetoin reductase; butanediol dehydrogenase ((R,R)-butane-2,3-diol forming; E.C. 1.1.1.4/1.1.1.-) and alcohol dehydrogenase (E.C. 1.2.1.10) activity. The invention provides for use of the genetically modified lactic acid bacterium for the production of diacetyl and a food product.

96. 发明授权

US10544414B2 Two-cassette reporter system for assessing target gene translation and target gene product inclusion body formation 有权
公开(公告)号：US10544414B2
公开(公告)日：2020-01-28
申请号：US15521195
申请日：2015-10-22
申请人： Danmarks Tekniske Universitet
发明人： Alex Toftgaard Nielsen , Ariane Zutz , Rebecca Lennen
IPC分类号： C12N15/10 , C12Q1/6897 , C12N15/70 , G01N33/50
摘要： The present invention relates to a dual cassette reporter system capable of assessing target gene translation and target gene product folding. The present invention further relates to vectors and host cells comprising the dual cassette reporter system. In addition the invention relates to the use of the dual cassette reporter system for assessing target gene translation and target gene product folding.

97. 发明授权

US10381930B2 Three-port direct current converter 有权
公开(公告)号：US10381930B2
公开(公告)日：2019-08-13
申请号：US15568649
申请日：2016-04-25
申请人： Danmarks Tekniske Universitet
发明人： Maria Del Carmen Mira Albert
IPC分类号： H02M3/158 , H02J7/35 , H02M1/00 , H05B33/08
摘要： The three-port direct current converter comprising: at least one input direct current source; at least one storage battery; a primary side circuit; a secondary side circuit; a first single magnetic component shared by the primary side circuit and the secondary side circuit, wherein the primary side circuit comprises a connection between the at least one input direct current source and the at least one storage battery, the primary side circuit configured for operating as a buck converter; a second magnetic component serially coupled to the first single magnetic component, wherein the first and second magnetic components are configured to perform a voltage step-up, wherein the secondary side circuit comprises a connection between the at least one storage battery and at least one load, the secondary side configured for operating as a tapped boost converter; wherein the three-port direct current converter is configured to operate in two mutually exclusive power flow configurations.

98. 发明授权

US10340805B2 Resonant step down DC-DC power converter and methods of converting a resonant step down DC-DC converter 有权
公开(公告)号：US10340805B2
公开(公告)日：2019-07-02
申请号：US15103819
申请日：2015-01-20
申请人： Danmarks Tekniske Universitet
发明人： Milovan Kovacevic , Mickey P. Madsen
IPC分类号： H02M3/335 , H02M1/08 , H02M1/42 , H05B33/08 , H02M1/00
摘要： The present invention relates to a resonant step-down DC-DC power converter which comprises a primary side circuit and a secondary side circuit coupled through a galvanic isolation barrier. The primary side circuit comprises a positive and a negative input terminal for receipt of an input voltage and an input capacitor coupled between the positive and negative input terminals and the secondary side circuit comprises an output capacitor chargeable to a converter output voltage between a first positive electrode and a second negative electrode. A resonant network is con-figured for alternatingly being charged from the input voltage and discharged to the output capacitor through the galvanic isolation barrier by a semiconductor switch arrangement in accordance with a switch control signal to produce the converter output voltage. The resonant step-down DC-DC power converter comprises an electrical short-circuit connection across the galvanic isolation barrier connecting, in a first case, the second negative electrode of the output capacitor to the positive input terminal of the primary side circuit or, in a second case, connecting the second positive electrode of the output capacitor to the negative input terminal of the primary side circuit thereby establishing in both the first and second cases a series coupling of the output capacitor and the input capacitor. A load connection is established, in the first case, between the first positive electrode of the output capacitor and the positive input terminal or, in the second case, between the second negative electrode of the output capacitor and the negative input terminal.

99. 发明申请

US20190136198A1 ENGINEERED MAMMALIAN CELLS FOR PRODUCTION OF RECOMBINANT PROTEINS 审中-公开
公开(公告)号：US20190136198A1
公开(公告)日：2019-05-09
申请号：US16095975
申请日：2017-04-25
申请人： DANMARKS TEKNISKE UNIVERSITET
发明人： Bjørn Gunnar Voldborg , Lasse Ebdrup Pedersen
IPC分类号： C12N5/071 , C12N15/113 , C12N15/62 , C12N15/79
摘要： The present invention relates to mammalian cells modified to provide for improved expression of a recombinant protein of interest. In particular, the invention relates to CHO cells and other host cells in which the expression of one or more endogenous secreted proteins has been disrupted, as well as to the preparation, identification and use of such cells in the production of recombinant proteins.

100. 发明申请

US20180370792A1 A METHOD FOR MANUFACTURING A HOLLOW MEMS STRUCTURE 审中-公开
公开(公告)号：US20180370792A1
公开(公告)日：2018-12-27
申请号：US16062312
申请日：2016-09-19
申请人： Danmarks Tekniske Universitet
发明人： Hoa Thanh LE , Anpan HAN , Karen BIRKELUND , Anders Michael JORGENSEN , Flemming JENSEN
IPC分类号： B81C1/00 , H01F17/00 , H01L23/532
CPC分类号： B81C1/00119 , H01F17/0006 , H01L23/53295
摘要： The present invention relates to a method for manufacturing an at least partly hollow MEMS structure. In a first step one or more through-going openings is/are provided in core material. The one or more through-going openings is/are then covered by an etch-stop layer. After this step, a bottom electrically conducting layer, one or more electrically conducting vias and a top electrically conducting layer are created. The bottom layer is connected to the vias and vias are connected to the top layer. The vias are formed by filling at least one of the one or more through-going openings. The method further comprises the step of creating bottom and top conductors in the respective bottom and top layers. Finally, excess core material is removed in order to create the at least partly hollow MEMS structure which may include a MEMS inductor.

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