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1. 发明申请

US20040235949A1 Use of branched-chain fatty acids and derivatives thereof for the treatment of pain 失效
标题翻译：支链脂肪酸及其衍生物用于治疗疼痛的用途
公开(公告)号：US20040235949A1
公开(公告)日：2004-11-25
申请号：US10481975
申请日：2004-04-28
发明人： Alexander Kozak , Revital Duvdevani , Firas M. Younis
IPC分类号： A61K031/20
CPC分类号： A61K31/22 , A61K31/16 , A61K31/20 , A61K31/66 , C07C53/128 , C07C69/30 , C07C233/05 , C07F9/10
摘要： The present invention relates to compounds and pharmaceutical compositions useful for treating pain. The invention also relates to methods of treating or alleviating pain in mammals, comprising administering to a mammal suffering from pain, a pain-alleviating amount of a compound of the general formula (I) or (II).

2. 发明申请

US20040192771A1 Ether compounds and compositions for cholesterol management and related uses 审中-公开
公开(公告)号：US20040192771A1
公开(公告)日：2004-09-30
申请号：US10743951
申请日：2003-12-24
发明人： Jean-Louis Henri Dasseux , Carmen Daniela Oniciu
IPC分类号： A61K031/275 , A61K031/20
CPC分类号： C07D257/04 , A61K31/20 , A61K31/275 , C07C43/132 , C07C43/135 , C07C43/1782 , C07C43/295 , C07C59/305 , C07C59/60 , C07C59/64 , C07C59/66 , C07C59/68 , C07C69/708 , C07C69/712 , C07C261/04 , C07C309/10 , C07D233/74 , C07D233/84 , C07D261/08 , C07D261/12 , C07D305/12 , C07D307/12 , C07D307/33 , C07D307/42 , C07D309/06 , C07D309/30 , C07D309/38 , C07D309/40
摘要： The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

3. 发明申请

US20040162248A1 Preparation and diabetic use of gibberellins 有权
标题翻译：制备和糖尿病使用赤霉素
公开(公告)号：US20040162248A1
公开(公告)日：2004-08-19
申请号：US10776188
申请日：2004-02-12
发明人： Peter James Jenkins , Minnie Wu , David Shine Wu
IPC分类号： A61K031/704 , A61K031/20
CPC分类号： A61K31/22 , A61K31/19 , A61K31/704
摘要： The present invention relates to application of compounds of formula (1) (Gibberellins) and their derivatives for the preparation of a pharmaceutical composition or medicaments for the treatment of diabetes, its complications and associated conditions, including obesity, micro and macro vascular diseases, nephropathy, neuropathy, eye diseases, diabetic ulcerations and the like. The method results the normalization of serum glucose level and other physiological conditions. 1
摘要翻译：本发明涉及式（1）化合物（赤霉素）及其衍生物在制备用于治疗糖尿病及其并发症及相关病症的药物组合物或药物中的应用，包括肥胖症，微血管病变和大血管病，肾病，神经病，眼病，糖尿病性溃疡等。该方法使血清葡萄糖水平和其他生理条件正常化。

4. 发明申请

US20040132818A1 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them 审中-公开
标题翻译：羧酸及其衍生物和含有它们的药物组合物
公开(公告)号：US20040132818A1
公开(公告)日：2004-07-08
申请号：US10680429
申请日：2003-10-08
发明人： Jacob Bar-Tana
IPC分类号： C07C059/185 , A61K031/20
CPC分类号： C07C69/602 , C07C55/02
摘要： The invention relates to carboxylic acids and derivatives thereof and pharmaceutical compound containing them. The active compounds are represented by the formula compound represented by formula I, wherin R1-R4 each independently represents an unsubstituted or substituted hydrocarbyl or heterocyclyl radical, Q represents a diradical consisting of a linear chain of 11 to 18 carbon atoms, one or more of which may be replaced by heteroatoms, said chain being optionally substituted by inert substituents and one or more of said carbon or heteroatom chain members optionally forming part of a ring structure, and where one or both of the carboxyl groups can be substituted by an in vitro hydrolyzable physiologically acceptable substituent; with the proviso that: compounds wherein R1-R4 each represents CH3 and Q represents a linear chain of 14 carbons, are excluded; and compounds wherein Q represents a linear chain of carbon atoms one of which is replaced by oxygen or sulfur, are excluded. 1
摘要翻译：本发明涉及羧酸及其衍生物和含有它们的药物化合物。活性化合物由式I表示的式化合物表示，R 1 -R 4各自独立地表示未取代或取代的烃基或杂环基，Q表示由11至18个碳原子的直链键组成的双基，其中一个或多个其可以被杂原子替代，所述链任选被惰性取代基取代，并且一个或多个所述碳或杂原子链构件任选地形成环结构的一部分，并且其中一个或两个羧基可被体外取代可水解的生理学上可接受的取代基; 条件是：其中R 1 -R 4各自表示CH 3且Q表示14个碳的直链的化合物; 和其中Q表示碳原子的直链链，其中一个被氧或硫取代的化合物被排除。

5. 发明申请

US20040116524A1 Method of administering opthalmic fluids 审中-公开
标题翻译：给予眼药水的方法
公开(公告)号：US20040116524A1
公开(公告)日：2004-06-17
申请号：US10467140
申请日：2004-01-28
发明人： Ben Z. Cohen , Nigel Kelly
IPC分类号： A61K031/20 , A01N037/00
CPC分类号： A61K31/20
摘要： A method is provided of treating an eye with ophthalmologically active compounds, particularly with intra-ocular pressure lowering (IOP) compounds, where a dose of 5-15 microliters is delivered at a standard concentration.
摘要翻译：提供了一种用眼科活性化合物治疗眼睛的方法，特别是眼压降低（IOP）化合物，其中以标准浓度递送5-15微升的剂量。

6. 发明申请

US20040024020A1 Biocidal agents and methods of use 失效
标题翻译：杀生物剂和使用方法
公开(公告)号：US20040024020A1
公开(公告)日：2004-02-05
申请号：US10202787
申请日：2002-07-24
申请人： MYRMECOL
发明人： James G. Holwerda , Bruce D. Levine
IPC分类号： A61K031/445 , A61K031/40 , A61K031/05 , A61K031/20
CPC分类号： A61Q17/005 , A61K8/0208 , A61K8/04 , A61K8/046 , A61K8/347 , A61K8/365 , A61K8/49 , A61K31/05 , A61K31/19 , A61K31/20 , A61K31/40 , A61K31/445 , D06M13/152 , D06M13/207 , D06M16/00 , Y02A50/473 , A61K2300/00
摘要： The present invention provides antimicrobial compositions and methods for treating medical conditions in mammals. The compositions provided herein are based on the surprising discovery that the metapleural gland extract from ants has biocidal activity that is useful against a variety of microorganisms, including bacteria, fungi and viruses. Accordingly, it has been discovered that the components of the metapleural gland extract are useful for the treatment and prevention of disease in mammals. The present invention provides a number of antimicrobial compounds which kill bacteria, fungi and viruses upon contact. In addition, the present invention provides methods for treating microorganism growths in mammals, including application of the antimicrobial compositions provided herein.
摘要翻译：本发明提供用于治疗哺乳动物的医疗状况的抗微生物组合物和方法。本文提供的组合物基于令人惊奇的发现，即来自蚂蚁的元代酸提取物具有杀生物活性，其可用于各种微生物，包括细菌，真菌和病毒。因此，已经发现，元代酸提取物的组分可用于治疗和预防哺乳动物的疾病。本发明提供了许多在接触时杀死细菌，真菌和病毒的抗微生物化合物。此外，本发明提供了治疗哺乳动物微生物生长的方法，包括施用本文提供的抗微生物组合物。

7. 发明申请

US20040001875A1 Dietary method for modulating glucose metabolism and associated conditions and increasing longevity 有权
标题翻译：用于调节葡萄糖代谢和相关条件以及延长寿命的膳食方法
公开(公告)号：US20040001875A1
公开(公告)日：2004-01-01
申请号：US10442521
申请日：2003-05-21
申请人： The IAMS Company
发明人： Gregory Dean Sunvold , Michael Anthony Ceddia , Jacqueline Sinclair Rand
IPC分类号： A61K031/70 , A23K001/165 , A23K001/17 , A61K031/20
CPC分类号： A61K45/06 , A23K20/147 , A23K20/158 , A23K20/163 , A23K50/40 , A23L33/20 , A23L33/30 , A23L33/40
摘要： The invention provides a method for treating abnormal glucose metabolism and insulin resistance in an animal by feeding a diet comprising high protein and moderate amounts of carbohydrate and fat. The invention also provides a method for treating conditions associated with insulin resistance or decreased longevity by feeding an animal such diets.
摘要翻译：本发明提供一种通过喂食包含高蛋白质和中等量的碳水化合物和脂肪的饮食来治疗动物中异常葡萄糖代谢和胰岛素抵抗的方法。本发明还提供了一种通过喂食动物这种饮食来治疗与胰岛素抵抗相关的病症或减少寿命的方法。

8. 发明申请

US20030096869A1 Method of stabilizing and potentiating the action of anti-angiogenic substances 失效
公开(公告)号：US20030096869A1
公开(公告)日：2003-05-22
申请号：US10083529
申请日：2002-02-27
发明人： Undurti Narasimha Das
IPC分类号： A61K031/20
CPC分类号： A61K45/06 , A61K31/33 , A61K31/445 , A61K38/195 , A61K38/208 , A61K38/39 , A61K38/484 , A61K31/20 , A61K2300/00
摘要： A method of stabilizing and potentiating action of molecules of known anti-angiogenic substances such as Angiostatinnull or Endostatinnull by using in coupling conjugation with cis-unsaturated fatty acids (c-UFAs) in the treatment of cell proliferative disorders uses c-UFAs chosen from linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid and cis-parinaric acid in predetermined quantities. Preferably, the c-UFAs are in the form of polyunsaturated fatty acids (PUFAs). Uncontrolled or undesirable angiogenic activity promotes cell proliferative disorders and tumor growth, which can be inhibited by the selective use of PUFAs with anti-angiogenic substances used selectively in conjunction with predetermined anti-cancer drugs. For a non-glioma type of cell proliferation disorder, a sodium, potassium or lithium salt of a PUFA is preferred to form an admixture with an anti-angiogenic substance. Anti-angiogenic substances envisaged in this invention include Angiostatinnull, Endostatinnull, platelet factor-4, TNP-470, thalidomide, interleukin-12 and metalloproteinase inhibitors (MMP). A preferred method of administration of the mixture to treat a tumor is intra-arterial administration into an artery which provides the main blood supply for the tumor.

9. 发明申请

US20030032827A1 Lipoxin compounds and their use in treating cell proliferative disorders 失效
公开(公告)号：US20030032827A1
公开(公告)日：2003-02-13
申请号：US10175268
申请日：2002-06-19
发明人： Charles N. Serhan
IPC分类号： A61K031/20 , C07C059/42
CPC分类号： C07C59/68 , A61K31/202 , A61K31/232 , A61K31/557 , A61K31/60 , C07C59/42 , C07C69/587 , C07C69/732 , C07C69/734 , C07C69/736 , A61K31/20 , A61K2300/00
摘要： Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed.

10. 发明申请

US20030004096A1 Zinc-free and low-zinc insulin preparations having improved stability 有权
公开(公告)号：US20030004096A1
公开(公告)日：2003-01-02
申请号：US10102862
申请日：2002-03-22
发明人： Peter Boderke
IPC分类号： A61K038/28 , A61K031/202 , A61K031/20
CPC分类号： A61K47/18 , A61K9/0019 , A61K38/28 , A61K47/10 , A61K47/26
摘要： The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, an insulin metabolite, an insulin analog, and an insulin derivative; at least one surfactant; optionally at least one preservative; and optionally at least one of an isotonicizing agent, a buffer or an excipient, wherein the formulation is free from or low in zinc. The invention also relates to the production of such insulin preparations and their use as pharmaceutical formulations.

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