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1. 发明授权

US11975019B2 Sulfated glycosaminoglycan biomaterials as proteoglycan mimics 有权
公开(公告)号：US11975019B2
公开(公告)日：2024-05-07
申请号：US17372102
申请日：2021-07-09
申请人： Glycologix, LLC
发明人： Thomas H. Jozefiak
IPC分类号： A61K31/726 , A61K9/00 , A61K47/61 , A61P13/10 , C07C317/08 , C08B15/00 , C08B37/00 , C08B37/08
CPC分类号： A61K31/726 , A61K9/0019 , A61K47/61 , A61P13/10 , C07C317/08 , C08B15/005 , C08B37/0063 , C08B37/0072
摘要： Polymer conjugates are provided that are capable of mimicking functions of natural proteoglycans found in the extracellular matrix of connective tissues. The polymer conjugates of the invention have utility in treating a subject suffering soft tissue conditions. Also provided are simple and scalable chemical processes for the preparation of the polymer conjugates of the invention.

2. 发明授权

US11912831B2 Hydroxyethylpyrrolidone ethacrylate/glycidyl ethacrylate copolymers 有权
公开(公告)号：US11912831B2
公开(公告)日：2024-02-27
申请号：US16615001
申请日：2018-04-24
申请人： ISP INVESTMENTS LLC
发明人： Michael A Tallon , Alaa Alharizah
IPC分类号： C08G81/02 , A61K47/58 , A61K31/135 , C04B24/38 , C08B15/00 , C08B37/00 , C08F220/36 , C08F265/06 , C08G77/442 , C09C1/30 , C09D11/101 , C09D11/107 , D01F1/10 , H01M4/62 , C08F220/28 , C08F222/10
CPC分类号： C08G81/027 , A61K31/135 , A61K47/58 , C04B24/383 , C08B15/005 , C08B37/00 , C08F220/281 , C08F220/36 , C08F222/102 , C08F265/06 , C08G77/442 , C08G81/024 , C08G81/025 , C09C1/3072 , C09D11/101 , C09D11/107 , D01F1/10 , H01M4/622 , C08F2800/20 , C08F2810/20 , C08F2810/50 , C08F222/102 , C08F220/281 , C08F220/36 , C08F220/325
摘要： This application provides reactive, flexible, water-resistant hydroxyethylpyrrolidone methacrylate/glycidyl methacrylate copolymers having the structure:

wherein a and b are integers, the sum of which less than 100, covalently linked to active agents that are useful in a wide variety of compositions. The present application also discloses hydroxyethylpyrrolidonemethacrylate/glycidyl methacrylate copolymer convently linked to one or more surface active moiety having a structure:

wherein a, b, and c are integers, the sum of which equals 100, and M is a surface-active moiety.

3. 发明授权

US11661486B1 Crystalline nano cellulose reinforced chitosan based films for packaging and other biodegradeable applications 有权
公开(公告)号：US11661486B1
公开(公告)日：2023-05-30
申请号：US17845143
申请日：2022-06-21
申请人： TUSKEGEE UNIVERSITY
发明人： Vijaya K. Rangari , Samia Islam , Woubit Abebe
IPC分类号： C08J5/00 , C08J5/18 , C08L1/04 , C08B15/00 , C08B3/12 , C08B37/08 , C08L1/10 , C08L5/08
CPC分类号： C08J5/18 , C08B3/12 , C08B15/005 , C08B37/003 , C08L1/04 , C08L1/10 , C08L5/08 , C08J2301/02 , C08J2401/10 , C08J2405/08 , C08L2201/06 , C08L2203/16 , C08L2205/02 , C08L2205/03
摘要： A biopolymer film is provided that comprises a combination of crystalline nano cellulose (CNC)/esterified crystalline nano cellulose (ECNC) reinforced with chitosan. The two polymer components can be present in any ratio, but an approximate CNC to ECNC 70:30 ratio is preferred. The chitosan component is derived from exoskeletons of crustaceans. Also provided are methods of preparing biopolymer film and preparing food packaging components from said biopolymer film. The CNC/ECNC mixture is dissolved in an ethanol solution and the chitin is dissolved in acetic acid and mixed together to form a polymer blend.

4. 发明申请

US20180319899A1 CELLULOSE ETHERS WITH TEMPORARY CROSS-LINKS, A PROCESS TO MAKE THEM, AND THEIR USE 审中-公开
公开(公告)号：US20180319899A1
公开(公告)日：2018-11-08
申请号：US15768338
申请日：2016-10-13
申请人： Akzo Nobel Chemicals International B.V.
发明人： Hans Jonas KARLSSON
IPC分类号： C08B15/00 , C08B11/20 , C08L1/26
CPC分类号： C08B15/005 , C08B11/20 , C08L1/26 , C08L2312/00 , C09D101/26 , C09J101/26
摘要： The invention relates to temporary cross-linked cellulose ethers, a process to make them, as well as their use to influence the rheological profile of an aqueous medium in which they are dissolved. The temporary cross-linked cellulose ethers are characterized in that they are cellulose ethers that are Cross-linked with at least one or more compounds of the formula (C1-4 alkyl)-OC(O)CHOHO—(C1-4 alkyl).

5. 发明申请

US20170066865A1 GRAFTED CROSSLINKED CELLULOSE 审中-公开
公开(公告)号：US20170066865A1
公开(公告)日：2017-03-09
申请号：US15355697
申请日：2016-11-18
申请人： WEYERHAEUSER NR COMPANY
发明人： Karen Brogan , Charles E. Miller , Angel Stoyanov , Torsten Linder , Maike Siemons
IPC分类号： C08F251/02 , B01J20/26 , B01J20/28 , B01J20/24
CPC分类号： C08F251/02 , B01J20/24 , B01J20/265 , B01J20/267 , B01J20/28023 , C08B3/08 , C08B15/005 , D01F2/00 , D01F11/02 , D21H11/16 , D21H11/20 , D21H17/37 , D21H27/002
摘要： Grafted, crosslinked cellulosic materials include cellulose fibers and polymer chains composed of at least one monoethylenically unsaturated acid group-containing monomer (such as acrylic acid) grafted thereto, in which one or more of said cellulose fibers and said polymer chains are crosslinked (such as by intra-fiber chain-to-chain crosslinks). Some of such materials are characterized by a wet bulk of about 10.0-17.0 cm3/g, an IPRP value of about 1000 to 7700 cm2/MPa·sec, and/or a MAP value of about 7.0 to 38 cm H2O. Methods for producing such materials may include grafting polymer chains from a cellulosic substrate, followed by treating the grafted material with a crosslinking agent adapted to effect crosslinking of one or more of the cellulosic substrate or the polymer chains. Example crosslinking mechanisms include esterfication reactions, ionic reactions, and radical reactions, and example crosslinking agents include pentaerythritol, homopolymers of the graft species monomer, and hyperbranched polymers.

6. 发明授权

US09499636B2 Dissolution of oxidized cellulose and particle preparation by cross-linking with multivalent cations 有权
标题翻译：通过与多价阳离子交联，氧化纤维素和颗粒制剂的溶解
公开(公告)号：US09499636B2
公开(公告)日：2016-11-22
申请号：US13927316
申请日：2013-06-26
申请人： Confluent Surgical, Inc. , Covidien LP
发明人： Phillip Blaskovich , Valentino Tramontano , Rachit Ohri , Daniel S. Costa , Joshua Kennedy , Sajida Farooqi
IPC分类号： C08L1/02 , C08B15/00 , C08B15/02 , C08B1/00 , C08J3/09 , C08J3/14
CPC分类号： C08B1/003 , C08B15/00 , C08B15/005 , C08B15/02 , C08J3/075 , C08J3/096 , C08J3/14 , C08J2301/04 , C08L1/04
摘要： A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one multivalent cation to form a plurality of modified cellulose particles.
摘要翻译：溶解改性纤维素的方法包括将改性纤维素溶液与至少一种多价阳离子接触以形成多个改性纤维素颗粒。

7. 发明授权

US09341622B2 Cellulose derivative fine particle, dispersion liquid thereof, dispersion body thereof and diagnostic reagent 有权
公开(公告)号：US09341622B2
公开(公告)日：2016-05-17
申请号：US14750970
申请日：2015-06-25
申请人： Asahi Kasei Fibers Corporation
发明人： Yoshiyuki Shiomi , Toshihiko Matsui , Masanori Doi
IPC分类号： G01N33/544 , G01N33/548 , C08B1/00 , C08B1/08 , C08B5/14 , C08B11/02 , C08B11/04 , C08B11/08 , C08B11/10 , C08B11/12 , C08B11/145 , C08B11/155 , C08B11/20 , C08B15/00 , C08B15/04 , C08B15/10 , C08B16/00 , C08J3/16 , C08L1/08 , C08L1/26 , C08L1/28
CPC分类号： G01N33/548 , C08B1/006 , C08B1/08 , C08B5/14 , C08B11/02 , C08B11/04 , C08B11/08 , C08B11/10 , C08B11/12 , C08B11/145 , C08B11/155 , C08B11/20 , C08B15/005 , C08B15/04 , C08B15/10 , C08B16/00 , C08J3/16 , C08J2301/28 , C08L1/08 , C08L1/26 , C08L1/28 , C08L1/282 , C08L1/284 , C08L1/286 , C08L1/288 , G01N2400/26 , Y10T428/2982
摘要： An object of the present invention is to provide a hydrophilic cellulose derivative fine particle having a small particle size, a dispersion liquid thereof and a dispersion body thereof; and provide a diagnostic reagent composed of the hydrophilic particle, which is excellent in storage stability and does not require excess components, such as an emulsifier or surfactant. The cellulose derivative fine particle of the present invention is a cellulose derivative fine particle comprising a cellulose derivative with a part of hydroxyl groups of cellulose being substituted with a substituent, wherein the average particle diameter is from 9 to 1,000 nm; and the diagnostic reagent of the present invention is a diagnostic reagent obtained by loading a substance differentially interacting with a test object substance on the above-described cellulose derivative fine particle.

8. 发明申请

US20150376300A1 BIODEGRADABLE SUPERABSORBENT HYDROGELS 审中-公开
标题翻译：可生物降解超吸附剂
公开(公告)号：US20150376300A1
公开(公告)日：2015-12-31
申请号：US14768203
申请日：2014-02-12
申请人： JABER INNOVATION S.R.L.
发明人： Stefania COMETA , Domenico MILESI , Giuseppe IANNACCONE
IPC分类号： C08B15/00 , A61L15/60 , A61L15/62 , B01J20/26 , A61K47/38 , B01J20/12 , B01J20/10 , A61F13/00 , A61L15/28
CPC分类号： C08B15/005 , A61F13/00 , A61F13/0209 , A61F13/49 , A61F13/53 , A61F2013/530708 , A61K47/38 , A61L15/28 , A61L15/60 , A61L15/62 , B01J20/10 , B01J20/12 , B01J20/267 , C08J3/075 , C08J2301/28 , C08L1/286
摘要： The present invention is directed to natural polymer-based biodegradable superabsorbent hydrogels and to methods for making them. These hydrogels can be employed in hygienic-health products, in the sector of food product packaging and in medical products.
摘要翻译：本发明涉及基于天然聚合物的可生物降解的超吸收水凝胶及其制备方法。这些水凝胶可用于卫生保健产品，食品包装和医疗产品领域。

9. 发明申请

US20150375177A1 CROSSLINKED CELLULOSIC MEMBRANES 有权
标题翻译：交联的细胞膜
公开(公告)号：US20150375177A1
公开(公告)日：2015-12-31
申请号：US14320481
申请日：2014-06-30
申请人： PALL CORPORATION
发明人： Lixiang XIAO , Hassan AIT-HADDOU , Frank ONYEMAUWA , Lauren A. SPIELMAN , Shant M. HAMBARSOOMIAN
IPC分类号： B01D71/12 , C08J9/34 , B29C39/14 , B01D71/20 , B01D61/14 , B01D71/22 , B01D71/80 , B01D71/68 , B01D71/52 , C08B15/00 , B01D71/16
CPC分类号： B01D71/12 , B01D61/145 , B01D69/02 , B01D71/08 , B01D71/10 , B01D71/16 , B01D71/20 , B01D71/22 , B01D71/52 , B01D71/68 , B01D71/80 , B01D2323/02 , B01D2323/12 , B01D2323/18 , B01D2325/36 , B29C39/14 , B29K2001/00 , B29L2031/755 , C08B15/005 , C08J9/34 , C08J2301/00
摘要： Disclosed are crosslinked porous membranes comprising a cellulosic material and an aromatic hydrophobic moiety or a copolymer of the formula A-B-A (I) or A-B (II), wherein block A, for example, polyglycerol, a polymer of allylglycidyl ether, or a copolymer of glycidol and allyl glycidyl ether, or a polymer of allyl glycidyl ether or a copolymer of glycidol and allyl glycidyl ether wherein one or more allyl groups having been replaced by hydrophilic groups. Block B is an aromatic hydrophobic moiety. An example of the aromatic hydrophobic moiety is polyethersulfone. Also disclosed is a method for preparing such membranes.
摘要翻译：公开了包含纤维素材料和芳族疏水部分或式ABA（I）或AB（II）的共聚物的交联多孔膜，其中嵌段A，例如聚甘油，烯丙基缩水甘油醚的聚合物或缩水甘油的共聚物烯丙基缩水甘油醚或烯丙基缩水甘油醚的聚合物或缩水甘油和烯丙基缩水甘油醚的共聚物，其中一个或多个已被亲水基团取代的烯丙基。嵌段B是芳族疏水部分。芳族疏水部分的实例是聚醚砜。还公开了制备这种膜的方法。

10. 发明授权

US09200084B2 Method for the preparation of a particulate reversibly crosslinked polymeric material 有权
标题翻译：用于制备颗粒可逆交联的聚合物材料的方法
公开(公告)号：US09200084B2
公开(公告)日：2015-12-01
申请号：US13700263
申请日：2010-06-08
申请人： Purnendu Mukherjee , Eric P. Wasserman
发明人： Purnendu Mukherjee , Eric P. Wasserman
IPC分类号： C08B15/00 , C08B3/10 , A61L15/32 , A61K47/48
CPC分类号： C08B3/10 , C08B15/005
摘要： The present invention relates to method for the preparation of a particulate reversibly-crosslinked polymeric material comprising: treating a particulate water-soluble hydroxyl-functional polymer in a liquid phase comprising a solvent mixture in that the hydroxyl-functional polymer is insoluble containing an organic solvent and water; a tetracarboxylic acid dianhydride represented by formula (I), 10 (I) wherein: U and V are independently selected from CH, N and P; 15 X is selected from a single bond, a saturated divalent (C1-C10) hydrocarbon group, O, S, NR, and PR, wherein R is selected from hydrogen and (C1-C4) alkyl; n and m are independently selected from 0 and 1; w is 1 or 2 with the proviso that; 20 if w is 1 then Y is X and if w is 2 then Y is selected from H and (C1-C4) alkyl, whereby there is no bond between both Y; and optionally a catalyst; to form a particulate reversibly-crosslinked polymeric material and 25 to a particulate reversibly-crosslinked polymeric material obtainable thereby.
摘要翻译：本发明涉及制备颗粒可逆交联的聚合物材料的方法，包括：在包含溶剂混合物的液相中处理颗粒状水溶性羟基官能聚合物，因为羟基官能聚合物不溶于含有机溶剂和水; 由式（I）表示的四羧酸二酐，10（I）其中：U和V独立地选自CH，N和P; 15 X选自单键，饱和二价（C1-C10）烃基，O，S，NR和PR，其中R选自氢和（C1-C4）烷基; n和m独立地选自0和1; w为1或2，条件是： 20，如果w为1，则Y为X，如果w为2，则Y选自H和（C 1 -C 4）烷基，由此两者之间不存在键; 和任选的催化剂; 以形成可逆交联的聚合物颗粒和25至可由其获得的可逆交联的聚合物颗粒。

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