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1. 发明申请

US20180164320A1 METHOD FOR DIAGNOSIS OF COLORECTAL CANCER USING MASS SPECTROMETRY OF N-GLYCANS 审中-公开
公开(公告)号：US20180164320A1
公开(公告)日：2018-06-14
申请号：US15580662
申请日：2015-12-16
申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人： Jung Hoe Kim , Sung Hyeon Lee , Seung Yeol Park , Hyun Joo An , Jae-Han Kim , Myung Jin Oh , Jin Man Kim , Ju A Lee
IPC分类号： G01N33/574 , G01N30/86 , G01N30/72 , C07H5/04
CPC分类号： G01N33/57419 , C07H5/04 , G01N30/7233 , G01N30/8631 , G01N2030/027 , G01N2560/00
摘要： The present invention relates to a method of diagnosing colorectal cancer by detection of glycan changes, and more particularly to a method of diagnosing colorectal cancer using mass spectrometry, in which, when specific glycan structures increase, decrease or significantly change due to a change in N-linked glycosylation of a colorectal cancer patient-derived glycoprotein, as detected by mass spectrometry, the glycan structures are selected as diagnostic markers.

2. 发明申请

US20180002577A1 BINDERS AND ASSOCIATED PRODUCTS 审中-公开
公开(公告)号：US20180002577A1
公开(公告)日：2018-01-04
申请号：US15702087
申请日：2017-09-12
申请人： KNAUF INSULATION SPRL , KNAUF INSULATION, INC.
发明人： Carl HAMPSON , Benedicte PACOREL , Roger JACKSON
IPC分类号： C09J105/00 , F16L59/02 , B29C71/00 , C07H5/04 , B27N3/00 , B29K79/00
CPC分类号： C09J105/00 , B27N3/002 , B29C71/00 , B29K2079/00 , B29K2405/00 , C07H5/04 , C09J161/20 , C09J161/22 , F16L59/028
摘要： The present invention relates to a water-soluble pre-reacted binder composition, a method of its manufacture, a use of said pre-reacted binder composition, a method of manufacturing a collection of matter bound by a polymeric binder, a binder solution or dispersion comprising said pre-reacted binder composition, as well as products comprising the pre-reacted binder composition in a cured state.

3. 发明授权

US09856283B2 Thiosaccharide mucolytic agents 有权
公开(公告)号：US09856283B2
公开(公告)日：2018-01-02
申请号：US14847439
申请日：2015-09-08
申请人： The Regents of The University of California , University College Dublin
发明人： Stefan Oscarson , John Vincent Fahy , Shaopeng Yuan , Stephen Carrington
IPC分类号： C07H15/04 , C07H5/04 , A61K31/7028 , A61K31/70 , A61K31/7016 , A61K31/702 , C07D309/10 , C07H13/04
CPC分类号： C07H15/04 , A61K31/70 , A61K31/7016 , A61K31/702 , A61K31/7028 , C07D309/10 , C07H5/04 , C07H13/04
摘要： There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.

4. 发明授权

US09434854B2 Binders and materials made therewith 有权
公开(公告)号：US09434854B2
公开(公告)日：2016-09-06
申请号：US13866419
申请日：2013-04-19
申请人： Knauf Insulation, Inc. , Knauf Insulation SPRL
发明人： Brian Lee Swift , Ronald E. Kissell
IPC分类号： C08L1/00 , C08L3/00 , C08L5/00 , C09D101/00 , C09D103/00 , C09D105/00 , C09J101/00 , C09J103/00 , C09J105/00 , C09D167/04 , C07H5/04 , C08F251/02 , C08L51/02 , B29C70/68 , E04B1/78 , E04B1/84 , C03C17/28 , F16L59/02 , F16L59/14
CPC分类号： C09D167/04 , B29C70/68 , C03C17/28 , C03C25/14 , C07H5/04 , C08F251/02 , C08L51/02 , C09D5/08 , C09D105/00 , E04B1/78 , E04B1/84 , E04B1/88 , F16L59/026 , F16L59/14 , Y10T428/31971 , Y10T442/60 , Y10T442/691 , C08L2666/02
摘要： A curable aqueous composition is disclosed comprising a carbohydrate, a crosslinking agent, and an amine base, wherein the curable aqueous composition has a pH adjusted by the amine base. Further disclosed is a method of forming a curable aqueous solution.

5. 发明申请

US20160213763A1 NOVEL GLYCAN CONJUGATES AND METHODS OF USE THEREOF 审中-公开
标题翻译：新型糖果混合物及其使用方法
公开(公告)号：US20160213763A1
公开(公告)日：2016-07-28
申请号：US14832993
申请日：2015-08-21
申请人： Academia Sinica
发明人： Chi-Huey Wong , Chung-Yi Wu
IPC分类号： A61K39/00 , C07H7/02 , C07H15/04 , C07K16/30
CPC分类号： A61K39/0011 , A61K31/7028 , A61K31/715 , A61K2039/55511 , A61K2039/6037 , A61K2039/627 , C07H5/02 , C07H5/04 , C07H5/06 , C07H15/04 , C07H15/26 , C07K16/3076 , C07K16/44 , C08B37/006
摘要： The present disclosure is directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA3/SSEA4/GloboH associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globo-series glycosphingolipid synthesis. The present disclosure relates to methods and compositions which can modulate the globo-series glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globo-series glycosphingolipid SSEA3/SSEA4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globo-series synthetic pathway. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.
摘要翻译：本公开涉及针对SSEA3 / SSEA4 / GloboH相关表位（天然和修饰）的疫苗，抗体和/或免疫原性缀合物组合物，其引发可用于调节globo系列鞘糖脂合成的抗体和/或结合片段生产。本公开涉及可以调节globo系列鞘糖脂合成的方法和组合物。特别地，本公开涉及可以调节生物合成途径中的globo系列鞘糖脂SSEA3 / SSEA4 / GloboH的合成的糖酵母抑制剂化合物及其组合物和使用方法; 特别是糖酵解抑制剂靶向α-4GalT; β-4GalNAcT-I; 或β-3GalT-V酶在globo系列合成途径中。此外，本公开还涉及使用本文所述的组合物治疗或检测过度增殖性疾病和/或病症的方法。

6. 发明申请

US20160185881A1 Oligosaccharide Compounds 审中-公开
标题翻译：寡糖化合物
公开(公告)号：US20160185881A1
公开(公告)日：2016-06-30
申请号：US15063272
申请日：2016-03-07
申请人： Victoria Link Limited , The University of Liverpool
发明人： Ralf Schwörer , Jeremy E. Turnbull , Peter Charles Tyler , Olga Vladimirovna Zubkova
IPC分类号： C08B37/00 , C07H5/04
CPC分类号： C08B37/0063 , A61K31/726 , A61K31/727 , A61K31/737 , C07H5/04 , C08B37/006 , C08B37/0075 , C08B37/0078
摘要： The invention relates generally to oligosaccharide compounds and the use of these compounds as pharmaceuticals for treating diseases or conditions in which it is desirable to inhibit β-secretase.
摘要翻译：本发明一般涉及寡糖化合物以及这些化合物作为药物用于治疗其中期望抑制和分泌酶的疾病或病症的用途。

7. 发明授权

US09346844B2 Process for the production of fondaparinux sodium 有权
标题翻译：磺达肝素钠生产工艺
公开(公告)号：US09346844B2
公开(公告)日：2016-05-24
申请号：US13950716
申请日：2013-07-25
申请人： Scinopharm Taiwan, LTD.
发明人： Lung-Huang Kuo , Shang-Hong Chen , Li-Ting Wang , Wen-Li Shih , Yuan-Xiu Liao
IPC分类号： C07H1/00 , C07H5/04 , C07H15/04 , C07H15/203
CPC分类号： C07H15/04 , C07H1/00 , C07H5/04 , C07H15/203
摘要： The present invention provides novel processes for the preparation of Fondaparinux sodium by using the compound of formula ABC5 In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.
摘要翻译：本发明提供了通过使用式ABC5化合物制备磺达肝素钠的新方法。在一些实施方案中，还提供了用于合成磺达肝素钠的中间体。

8. 发明授权

US09238669B2 Oligosaccharides and oligosaccharide-protein conjugates derived from Clostridium difficile polysaccharide PS-I, methods of synthesis and uses thereof, in particular as vaccines and diagnostic tools 有权
标题翻译：衍生自艰难梭菌多糖PS-I的寡糖和寡糖 - 蛋白质缀合物，其合成方法及其用途，特别是疫苗和诊断工具
公开(公告)号：US09238669B2
公开(公告)日：2016-01-19
申请号：US14236620
申请日：2012-07-30
申请人： Peter H. Seeberger , Christopher E. Martin , Felix Broecker , Chakkumkal Anish
发明人： Peter H. Seeberger , Christopher E. Martin , Felix Broecker , Chakkumkal Anish
IPC分类号： C07H15/04 , C07H3/06 , C07H5/04 , C07H3/08 , C07H13/08 , C07H15/20 , C07K16/12 , G01N33/569
CPC分类号： C07H3/06 , C07H3/08 , C07H5/04 , C07H13/08 , C07H15/04 , C07H15/20 , C07K16/1282 , G01N33/56911
摘要： The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the Clostridium difficile glycopolymer PS-I and having the sequence of the pentasaccharide a-L-Rhap-(1→3)-β-D-Glcp-(1→4)-[a-L-Rhap-(1→3]-a-D-Glcp-(1→2)-a-D-Glcp or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at least one linker L for conjugation to a carrier protein or for immobilization on a surface. Further aspects of the invention relate to advantageous methods for synthesizing said synthetic oligosaccharide and oligosaccharide-protein conjugate as well as to uses thereof, in particular as vaccines and diagnostic tools.
摘要翻译：本发明涉及代表艰难梭菌聚糖聚合物PS-1的重复单元的一部分的合成寡糖，其具有五糖aL-Rhap-（1→3） - ＆amp; Gr-D-Glcp-（1→4） - [aL-Rhap-（1→3）-aD-Glcp-（1→2）-aD-Glcp或其合成片段或衍生物。优选地，所要求保护的合成寡糖至少具有一个连接体L，本发明的其它方面涉及用于合成所述合成寡糖和寡糖 - 蛋白质结合物的有利方法以及其用途，特别是疫苗和诊断工具。

9. 发明授权

US09045512B2 6″-amino-6″-deoxygalactosylceramides 有权
标题翻译： 6“ - 氨基-6” - 脱氧半乳糖神经酰胺
公开(公告)号：US09045512B2
公开(公告)日：2015-06-02
申请号：US13898070
申请日：2013-05-20
申请人： The Scripps Research Institute , Brigham Young University , The University of Chicago
发明人： Paul B. Savage , Albert Bendelac , Luc Teyton
IPC分类号： A61K39/00 , A61K38/17 , C07H15/04 , C07H5/04 , C07H13/04 , C07H15/06 , C07H7/06
CPC分类号： C07H5/04 , C07H7/06 , C07H13/04 , C07H15/06
摘要： This invention relates to galactosylceramide compounds.
摘要翻译：本发明涉及半乳糖神经酰胺化合物。

10. 发明申请

US20150093412A1 USE OF SACCHARIDES CROSS-REACTIVE WITH BACILLUS ANTHRACIS SPORE GLYCOPROTEIN AS A VACCINE AGAINST ANTHRAX 审中-公开
标题翻译：使用与BACILLUS ANTHRACIS SPORE GLYCOPROTEIN作为抗血清的疫苗的交叉反应
公开(公告)号：US20150093412A1
公开(公告)日：2015-04-02
申请号：US14563920
申请日：2014-12-08
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv , National Research Council of Canada
发明人： Joanna Kubler-Kielb , Evguenii Vinogradov , Rachel Schneerson , Haijing Hu , Stephen H. Leppla , John B. Robbins
IPC分类号： A61K39/07 , A61K47/48 , A61K39/104 , C07H5/04 , A61K39/02
CPC分类号： A61K39/07 , A61K39/00 , A61K39/0208 , A61K39/104 , A61K47/643 , A61K47/646 , A61K2039/521 , A61K2039/6081 , C07H3/06 , C07H5/04
摘要： Provided are immunogenic compositions and methods for eliciting an immune response against B. anthracis and other bacteria that contain 3-methyl-3-hydroxybutyrate- or 3-hydroxybutyrate-substituted saccharides. Conjugates of 3-methyl-3-hydroxybutyrate- or 3-hydroxybutyrate-substituted saccharides elicit an effective immune response against B. anthracis spores in mammalian hosts to which the conjugates are administered.
摘要翻译：提供免疫原性组合物和引发针对炭疽杆菌和含有3-甲基-3-羟基丁酸酯或3-羟基丁酸酯取代的糖的其它细菌的免疫应答的方法。 3-甲基-3-羟基丁酸酯或3-羟基丁酸酯取代的糖的结合物在施用共轭物的哺乳动物宿主中引发针对炭疽芽孢杆菌孢子的有效免疫应答。

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