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1. 发明公开

US20230321190A1 PHARMACEUTICAL AND COSMETIC COMPOSITIONS COMPRISING SECRETOMES 审中-公开
公开(公告)号：US20230321190A1
公开(公告)日：2023-10-12
申请号：US17969163
申请日：2022-10-19
申请人： ACCELERATED BIOSCIENCES CORP.
发明人： Jau-Nan LEE , Tony Tung-Yin LEE , Yuta LEE
IPC分类号： A61K38/19 , A61K38/20 , A61K38/18 , A61K9/127 , A61P17/00 , A61K45/06 , A61K38/39 , A61K31/201 , A61K31/728
CPC分类号： A61K38/195 , A61K9/127 , A61K31/201 , A61K31/728 , A61K38/1866 , A61K38/204 , A61K38/2053 , A61K38/39 , A61K45/06 , A61P17/00
摘要： Disclosed are pharmaceutical or cosmetic compositions comprising secretomes, for example secreted proteins from stem cells, and uses thereof. A composition that contains a secretome and an acceptable excipient may be free of a cell. The compositions are useful for inducing an immune response, treating an inflammatory response, treating a microbial infection, differentiating cells, wound healing, embryonic development, placental development, central nervous system development, or morphogenesis.

2. 发明公开

US20230158075A1 METHODS OF CONDITIONING PATIENTS FOR T CELL THERAPY 审中-公开
公开(公告)号：US20230158075A1
公开(公告)日：2023-05-25
申请号：US17954070
申请日：2022-09-27
申请人： Kite Pharma Inc. , United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： Adrian BOT , Jeffrey WIEZOREK , William GO , Rajul JAIN , James N. KOCHENDERFER , Steven A. ROSENBERG
IPC分类号： A61K35/17 , A61K31/664 , A61K31/7076 , A61K31/675 , A61K38/20 , A61P35/02 , A61K45/06
CPC分类号： A61K35/17 , A61K31/664 , A61K31/7076 , A61K31/675 , A61K38/2053 , A61P35/02 , A61K38/2013 , A61K45/06
摘要： The invention provides methods of increasing the efficacy of a T cell therapy in a patient in need thereof. The invention includes a method of conditioning a patient prior to a T cell therapy, wherein the conditioning involves administering a combination of cyclophosphamide and fludarabine.

3. 发明授权

US09757430B2 Bioactive compositions derivable from platelet concentrates, and methods for preparing and using same 有权
公开(公告)号：US09757430B2
公开(公告)日：2017-09-12
申请号：US14469963
申请日：2014-08-27
申请人： Cook General Biotechnology LLC
发明人： Erik J. Woods , Christopher Taylor
IPC分类号： A61K38/21 , A61K35/16 , A61K38/19 , A61K38/20 , A61K38/18 , A61K35/14 , A61K35/19 , C12N5/00
CPC分类号： A61K35/19 , A61K35/16 , A61K38/1709 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/191 , A61K38/195 , A61K38/20 , A61K38/2006 , A61K38/204 , A61K38/2053 , A61K38/2066 , A61K38/2086 , A61K38/217 , A61K38/363 , A61K38/38 , A61K47/02 , A61K47/14 , A61K47/26 , C12N5/0018 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/15 , C12N2501/165 , C12N2501/21 , C12N2501/998 , C12N2502/115
摘要： The present disclosure provides a composition comprising a bioactive fraction derived from a platelet concentrate, methods of making the bioactive fraction, and culture medium supplemented with the bioactive fraction. Preferred bioactive fractions have relatively low fibrinogen concentrations while retaining native growth factors in beneficial amounts and ratios.

4. 发明申请

US20170239299A1 POSTPARTUM CELLS DERIVED FROM PLACENTAL TISSUE, AND METHODS OF MAKING AND USING THE SAME 审中-公开
公开(公告)号：US20170239299A1
公开(公告)日：2017-08-24
申请号：US15443602
申请日：2017-02-27
申请人： DePuy Synthes Products, Inc.
发明人： Anthony J. Kihm , Ian Ross Harris , Sanjay Mistry , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
IPC分类号： A61K35/50 , C12N5/073
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.

5. 发明授权

US09717763B2 Postpartum cells derived from umbilical cord tissue, and methods of making and using the same 有权
公开(公告)号：US09717763B2
公开(公告)日：2017-08-01
申请号：US14018842
申请日：2013-09-05
申请人： DePuy Synthes Products, LLC.
发明人： Sanjay Mistry , Anthony J. Kihm , Ian R. Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
IPC分类号： A61K35/12 , A61K35/51 , A61K45/06 , C12N5/073 , C12N5/074
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.

6. 发明授权

US09498501B2 Postpartum cells derived from umbilical cord tissue, and methods of making and using the same 有权
公开(公告)号：US09498501B2
公开(公告)日：2016-11-22
申请号：US12389305
申请日：2009-02-19
申请人： Sanjay Mistry , Anthony J. Kihm , Ian R. Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Sanjay Mistry , Anthony J. Kihm , Ian R. Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
IPC分类号： C12N5/073 , A61K35/51 , A61K35/50 , C12N5/074 , A61K45/06 , A61K35/12
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.

7. 发明授权

US09492517B2 Vaccine immunotherapy 有权
标题翻译：疫苗免疫治疗
公开(公告)号：US09492517B2
公开(公告)日：2016-11-15
申请号：US12374732
申请日：2007-07-24
申请人： John W. Hadden , Kathy Signorelli , James Egan
发明人： John W. Hadden , Kathy Signorelli , James Egan
IPC分类号： A61K38/20 , A61K38/21 , A61K39/00 , A61K38/19
CPC分类号： A61K39/0011 , A61K38/191 , A61K38/2006 , A61K38/2013 , A61K38/204 , A61K38/2053 , A61K38/217 , A61K2300/00
摘要： The present invention provides compositions and methods of immunotherapy to treat cancer or other antigen-producing diseases or lesions. According to one embodiment of the invention, a composition is provided for eliciting an immune response to at least one antigen in a patient having an antigen-producing disease or lesion, the composition comprising an effective amount of a cytokine mixture, preferably comprising IL-1, IL-2, IL-6, IL-8, IFN-γ (gamma) and TNF-α (alpha). The cytokine mixture acts as an adjuvant with the antigen associated with the antigen-producing disease or lesion to enhance the immune response of the patient to the antigen. Methods are therefore also provided for eliciting an immune response to at least one antigen in a patient having an antigen-producing disease or lesion utilizing the cytokine mixture of the invention. The compositions and methods are useful in the treatment of antigen-producing diseases such as cancer, infectious diseases or persistent lesions.
摘要翻译：本发明提供用于治疗癌症或其他产生抗原的疾病或病变的免疫疗法的组合物和方法。根据本发明的一个实施方案，提供组合物，用于在患有抗原产生疾病或病变的患者中引发对至少一种抗原的免疫应答，所述组合物包含有效量的细胞因子混合物，优选包含IL-1 ，IL-2，IL-6，IL-8，IFN-γ（γ）和TNF-α（α）。细胞因子混合物作为与产生抗原的疾病或病变相关的抗原的佐剂，以增强患者对抗原的免疫应答。因此，还提供了使用本发明的细胞因子混合物引起具有产生抗原的疾病或病变的患者中至少一种抗原的免疫应答的方法。组合物和方法可用于治疗抗原产生性疾病如癌症，感染性疾病或持续性病变。

8. 发明申请

US20160279191A1 ANTIBIOTIC COMPOSITION COMPRISING A CHEMOTACTIC AGENT AND A NUTRIENT DISPERSION 审中-公开
标题翻译：包含化学药剂和营养分散剂的抗生素组合物
公开(公告)号：US20160279191A1
公开(公告)日：2016-09-29
申请号：US15179402
申请日：2016-06-10
申请人： Professional Compounding Centers of America (PCCA)
发明人： ANDREW B. GLASNAPP
IPC分类号： A61K38/12 , A61K47/18 , A61K47/26 , A61K47/42 , A61K31/351 , A61K31/5383 , A61K31/7036 , A61K47/12 , A61K47/34
CPC分类号： A61K38/12 , A23L5/00 , A61K31/202 , A61K31/351 , A61K31/496 , A61K31/5383 , A61K31/7036 , A61K38/06 , A61K38/1725 , A61K38/195 , A61K38/2053 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/34 , A61K47/42 , A61L27/16 , A61L27/52 , A61L27/54 , A61L2430/00 , Y02A50/473
摘要： Compositions and methods for treating infectious diseases produced by biofilms are disclosed. More specifically, the present disclosure refers to a pharmaceutical composition which may be used for treating biofilm infections, specifically, biofilms formed by bacteria such as Pseudomonas, E. coli, Klebsiella, and other human pathogens. Pharmaceutical compositions may include a nutrient dispersion that can include sodium citrate, succinic acid, xylitol, glutamic acid, and ethylenediaminetetraacetic acid (EDTA), among others. Additionally disclosed pharmaceutical composition may include API such as antibiotics. Subsequently, the antibiotics agent may be ciprofloxacin, amikacin, tobramycin, colistin methate, or polymixin, among others. Pharmaceutical compositions disclosed may employ chemotactic agents in order to disrupt biofilms and therefore enhance the antibiotic response. Pharmaceutical compositions disclosed may include suitable vehicles which may depend on the dosage form.
摘要翻译：公开了用于治疗由生物膜产生的感染性疾病的组合物和方法。更具体地，本公开涉及可用于治疗生物膜感染的药物组合物，具体地，由细菌如假单胞菌属，大肠杆菌，克雷伯杆菌和其他人类病原体形成的生物膜。药物组合物可以包括营养物分散体，其可以包括柠檬酸钠，琥珀酸，木糖醇，谷氨酸和乙二胺四乙酸（EDTA）等。另外公开的药物组合物可以包括API，例如抗生素。随后，抗生素剂可以是环丙沙星，阿米卡星，妥布霉素，甲硫氨酸粘多糖或多混合素等。所公开的药物组合物可以使用趋化剂以破坏生物膜并因此增强抗生素反应。所公开的药物组合物可包括可能取决于剂型的合适的载体。

9. 发明授权

US09333238B2 Method of immunotherapy for treament of human papillomavirus infection 有权
标题翻译：免疫治疗人乳头状瘤病毒感染的方法
公开(公告)号：US09333238B2
公开(公告)日：2016-05-10
申请号：US13514688
申请日：2010-12-08
申请人： James E. Egan , Martin Kast , Harvey Brandwein
发明人： James E. Egan , Martin Kast , Harvey Brandwein
IPC分类号： A61K38/20 , A61K38/21 , C07K14/52 , C07K14/525 , C07K14/53 , C07K14/54 , C07K14/57 , A61K38/19 , A61K31/675 , A61K45/06
CPC分类号： A61K38/217 , A61K9/0019 , A61K31/405 , A61K31/664 , A61K31/675 , A61K38/191 , A61K38/193 , A61K38/2006 , A61K38/2013 , A61K38/204 , A61K38/2046 , A61K38/2053 , A61K38/208 , A61K38/2086 , A61K45/06 , A61K2300/00
摘要： A method of treating human papillomavirus (HPV), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and inducing an immune response to HPV. A method of overcoming HPV-induced immune suppression of Langerhans cells (LC), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and activating LC. A method of increasing LC migration towards lymph nodes, by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, activating LC, and inducing LC migration towards lymph nodes. A method of generating immunity against HPV, by administering an effective amount of a primary cell derived biologic to a patient infected with HPV, generating immunity against HPV, and preventing new lesions from developing.
摘要翻译：一种治疗人乳头瘤病毒（HPV）的方法，其通过向感染HPV的患者施用治疗有效量的原代细胞来源的生物学，并诱导对HPV的免疫应答。通过对感染HPV的患者施用治疗有效量的原代细胞来源的生物学并激活LC，克服了HPV诱导的朗格汉斯细胞免疫抑制（LC）的方法。通过向感染HPV的患者施用治疗有效量的原代细胞来源的生物体，激活LC并诱导向淋巴结的LC迁移，增加LC向淋巴结迁移的方法。通过向感染HPV的患者施用有效量的原代细胞来源的生物学，产生针对HPV的免疫并防止新的病变发展，产生针对HPV的免疫力的方法。

10. 发明申请

US20150017122A1 CONDITIONED MEDIUM OBTAINED FROM PLACENTAL MESENCHYMAL STEM CELLS AND USE THEREOF IN THE THERAPEUTIC TREATMENT OF PREECLAMPSIA 审中-公开
标题翻译：从普通细胞干细胞获得的调节中药及其在治疗前列腺炎的治疗中的应用
公开(公告)号：US20150017122A1
公开(公告)日：2015-01-15
申请号：US14367604
申请日：2012-12-21
申请人： CORION BIOTECH S.R.L.
发明人： Alessandro Rolfo , Tullia Todros
IPC分类号： A61K38/20 , C12N5/073 , A61K38/19
CPC分类号： A61K35/50 , A61K35/28 , A61K38/19 , A61K38/195 , A61K38/204 , A61K38/2053 , A61K38/2066 , C12N5/0605 , C12N2502/025
摘要： It is described a conditioned medium (CM) obtainable by culturing, in a liquid culture medium, placental mesenchymal stem cells isolated from the placental tissue of pregnant women not affected by preeclampsia. The conditioned medium of the invention includes at least IL-6, IL-10 and MCP-1 proteins and it is effective for the therapeutic treatment of preeclampsia.
摘要翻译：描述了可通过在液体培养基中培养从胎儿组织中分离而不受先兆子痫影响的胎盘组织的胎盘间充质干细胞获得的条件培养基（CM）。本发明的条件培养基至少包含IL-6，IL-10和MCP-1蛋白，并且对先兆子痫的治疗有效。

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