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1. 发明申请

US20030003564A1 Methods and compositions for modulating ubiquitin dependent proteolysis 审中-公开
公开(公告)号：US20030003564A1
公开(公告)日：2003-01-02
申请号：US10060019
申请日：2002-01-29
申请人： Mount Sinai Hospital Corporation
发明人： Mike Tyers , Andrew Willems
IPC分类号： A61K038/48 , C12N009/64
CPC分类号： C07K14/395 , A61K38/00 , C07K14/4738
摘要： The invention relates to methods and compositions for modulating ubiquitin dependent proteolysis.

2. 发明授权

US5998187A Receptor tyrosine kinase 失效
标题翻译：受体酪氨酸激酶
公开(公告)号：US5998187A
公开(公告)日：1999-12-07
申请号：US838957
申请日：1997-04-23
申请人： Martin L. Breitman , Janet Rossant , Daniel J. Dumont , Terry P. Yamaguchi , Jo-Ann Breitman
发明人： Martin L. Breitman , Janet Rossant , Daniel J. Dumont , Terry P. Yamaguchi , Jo-Ann Breitman
IPC分类号： A01K67/027 , A61K38/00 , C07K14/705 , C07K14/71 , C12N15/12 , C12N15/85
CPC分类号： C07K14/71 , A01K67/0275 , A01K67/0276 , C12N15/8509 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , A61K38/00 , C07K2319/00
摘要： Novel receptor tyrosine kinase protein and isoforms thereof which are expressed in cells of the endothelial lineage, and DNA segments encoding the novel protein and isoforms thereof are disclosed. Methods for identifying ligands which are capable of binding to the receptor protein and methods for screening for agonist or antagonist substances of the interaction of the protein and a ligand are also disclosed.
摘要翻译：公开了在内皮谱系的细胞中表达的新型受体酪氨酸激酶蛋白及其同种型，以及编码新蛋白及其同种型的DNA片段。还公开了鉴定能够结合受体蛋白质的配体的方法和用于筛选蛋白质和配体的相互作用的激动剂或拮抗剂物质的方法。

3. 发明授权

US5667980A Method for assaying for a substance that affects an SH2 phosphorylated ligand regulatory system 失效
标题翻译：测定影响SH2磷酸化配体调节系统的物质的方法
公开(公告)号：US5667980A
公开(公告)日：1997-09-16
申请号：US221699
申请日：1994-03-28
申请人： Anthony Pawson , Michael Reedijk
发明人： Anthony Pawson , Michael Reedijk
IPC分类号： G01N33/566 , G01N33/573 , G01N33/74 , C12Q1/48 , G01N33/53 , G01N33/68
CPC分类号： G01N33/573 , G01N33/566 , G01N33/74 , G01N2333/71 , G01N2333/9121 , G01N2500/20
摘要： A method for assaying a medium for the presence of a substance that affects an SH2-phosphorylated ligand regulatory system. The method employs an SH2-like domain or a subdomain thereof and a phosphorylated ligand. The phosphophorylated ligand is capable of interacting with the SH2-like domain or a subdomain thereof to form an SH2-phosphorylated ligand complex. The SH2-like domain or subdomain and/or the phosphorylated ligand are present in a known concentration. The SH2-like domain or a subdomain thereof and the phosphorylated ligand are incubated with a substance which is suspected of affecting an SH2-phosphorylated ligand regulatory system. The method is carried out under conditions which permit the formation of the SH2-phosphorylated ligand complex. SH2-phosphorylated ligand complex, free SH2-like domain or subdomains thereof, or non-complexed phosphorylated ligand are assayed. The invention also relates to an isolated SH2-phosphorylated ligand complex; a method of using an isolated SH2-like domain or a subdomain thereof to screen for phosphorylated ligands which are active in an SH2-phosphorylated ligand regulatory system; a method of using an isolated SH2-like domain or a subdomain thereof to regulate the interaction of a signalling protein with a related phosphorylated ligand; and a pharmaceutical composition comprising an isolated SH2-like domain or a subdomain thereof for use as an agohist or antagonist of the interaction of a signalling protein with a related phosphorylated ligand.
摘要翻译：用于测定培养基中存在影响SH2磷酸化配体调节系统的物质的方法。该方法采用SH2样结构域或其亚结构域和磷酸化配体。磷酰化配体能够与SH2样结构域或其亚结构域相互作用形成SH2-磷酸化的配体复合物。 SH2样结构域或亚结构域和/或磷酸化配体以已知浓度存在。将SH2样结构域或其亚结构域和磷酸化配体与怀疑影响SH2-磷酸化配体调节系统的物质一起温育。该方法在允许形成SH2-磷酸化配体络合物的条件下进行。测定SH2-磷酸化配体复合物，游离SH2样结构域或其子结构域，或非络合磷酸化配体。本发明还涉及分离的SH2-磷酸化配体复合物; 使用分离的SH2样结构域或其亚结构域筛选在SH2磷酸化配体调节系统中有活性的磷酸化配体的方法; 使用分离的SH2样结构域或其亚结构域来调节信号蛋白与相关磷酸化配体的相互作用的方法; 以及包含分离的SH2样结构域或其子结构域的药物组合物，用作信号蛋白与相关磷酸化配体的相互作用的前组或拮抗剂。

4. 发明授权

US5501957A Method for measuring glycosyltransferase activity 失效
标题翻译：测定糖基转移酶活性的方法
公开(公告)号：US5501957A
公开(公告)日：1996-03-26
申请号：US293940
申请日：1994-08-22
申请人： James W. Dennis , Katherine A. Siminovitch , Alessandro Datti
发明人： James W. Dennis , Katherine A. Siminovitch , Alessandro Datti
IPC分类号： C12Q1/48 , A01N43/04 , C12Q1/00 , G01N33/00
CPC分类号： C12Q1/48 , Y10S435/81 , Y10T436/141111 , Y10T436/143333
摘要： A method of assaying for glycosyltransferase activity in a sample. In a first step, a sample is reacted with a first sugar donor and an acceptor substrate to produce a transferase product. The first sugar donor and acceptor substrate are selected such that the sugar from the first sugar donor is capable of being transferred to the acceptor substrate in the presence of the glycosyltransferase to be assayed. In a second step, the transferase product is reacted with a second sugar donor having a sugar which is labelled with a labelling agent and an enzyme which is capable of transferring the sugar from the second sugar donor to the transferase product to produce a labelled transferase product and which has a higher affinity for the glycosyltransferase product compared to the affinity of the glycosyltransferase for the acceptor substrate. The labelling agent activity of the labelled transferase product or unreacted second sugar donor is assayed to determine transferase activity in the sample. A kit for assaying for glycosyltransferase activity in a sample is also described.
摘要翻译：测定样品中糖基转移酶活性的方法。在第一步中，将样品与第一糖供体和受体底物反应以产生转移酶产物。选择第一糖供体和受体底物使得来自第一糖供体的糖能够在待测定的糖基转移酶存在下转移到受体底物。在第二步中，将转移酶产物与具有用标记试剂标记的糖的第二糖供体进行反应，所述糖能够将糖从第二糖供体转移到转移酶产物以产生标记的转移酶产物并且与糖基转移酶对受体底物的亲和力相比，其对糖基转移酶产物具有更高的亲和力。测定标记的转移酶产物或未反应的第二糖供体的标记试剂活性，以确定样品中的转移酶活性。还描述了用于测定样品中糖基转移酶活性的试剂盒。

5. 发明授权

US5427914A Diagnostic method to screen tumors 失效
标题翻译：诊断方法筛选肿瘤
公开(公告)号：US5427914A
公开(公告)日：1995-06-27
申请号：US571069
申请日：1990-08-23
申请人： James W. Dennis
发明人： James W. Dennis
IPC分类号： C12Q1/48 , G01N33/574 , G01N33/53
CPC分类号： C12Q1/48 , G01N33/57484 , Y10S435/81 , Y10S435/96 , Y10S436/813 , Y10S436/815 , Y10S436/827
摘要： A process is disclosed for the determination of the malignant potential of a tumor. The process comprises the steps of determining the amount of BBO in a tumor sample by reacting the BBO in a tumor sample with a BBO-binding lectin or a BBO-specific antibody to form a BBO-lectin or a BBO-specific antibody complex. Then, the amount of BBO-lectin or BBO-antibody complex or of unreacted BBO can be measured.
摘要翻译：公开了用于确定肿瘤恶性潜能的方法。该方法包括通过使肿瘤样品中的BBO与BBO结合凝集素或BBO特异性抗体反应形成BBO-凝集素或BBO-特异性抗体复合物来确定肿瘤样品中BBO的量的步骤。然后，可以测量BBO-凝集素或BBO-抗体复合物或未反应的BBO的量。

6. 发明授权

US5326357A Reconstituted cartridge tissue 失效
标题翻译：重建软骨组织
公开(公告)号：US5326357A
公开(公告)日：1994-07-05
申请号：US835831
申请日：1992-03-18
申请人： Rita A. Kandel
发明人： Rita A. Kandel
IPC分类号： A61F2/00 , A61F2/30 , A61K35/12 , A61K35/32 , A61K38/17 , A61L27/00 , A61L27/36 , A61P43/00 , C12N5/077 , A61F2/28 , A61F2/02 , A61F13/00 , C12N5/00
CPC分类号： A61L27/3612 , A61L27/3633 , A61L27/365 , A61L27/3654 , C12N5/0655 , A61F2/30756 , A61F2310/00365 , A61K35/12 , A61L2430/06 , C12N2501/23 , C12N2533/54
摘要： The present invention relates to cartilage tissue reconstituted on a substrate; to a method for producing reconstituted cartilage tissue; and to cartilage tissue reconstituted in vitro from isolated chondrocytes cultured on a substrate.
摘要翻译：本发明涉及在基质上重构的软骨组织; 涉及一种生产重构软骨组织的方法; 以及从在基质上培养的分离的软骨细胞体外重组的软骨组织。

7. 发明授权

US4857315A Compositions containing golgi alpha-mannosidase II inhibitors 失效
标题翻译：含有高尔基体α-甘露糖苷酶II抑制剂的组合物
公开(公告)号：US4857315A
公开(公告)日：1989-08-15
申请号：US65248
申请日：1987-06-18
申请人： James W. Dennis
发明人： James W. Dennis
IPC分类号： A61K31/435 , A61K38/00 , A61K38/21 , A61K45/06 , A61P31/12 , A61P35/00 , A61P43/00 , C07D471/04
CPC分类号： A61K38/005 , A61K38/21
摘要： The invention relates to compositions containing an inhibitor of the Golgi enzyme .alpha.-mannosidase II and which may contain an interferon or interferon inducer and to methods of preventing and treating diseases, such as proliferative diseases, viral infections and neoplastic growth and metastasis with the compositions.

8. 发明授权

US5773239A Mannosidase inhibitors, process for their preparation and their use as therapeutic agents 失效
标题翻译：甘露糖苷酶抑制剂，其制备方法及其作为治疗剂的用途
公开(公告)号：US5773239A
公开(公告)日：1998-06-30
申请号：US568127
申请日：1995-12-06
申请人： Jeremy Carver , James Wilson Dennis , Rajan Shah
发明人： Jeremy Carver , James Wilson Dennis , Rajan Shah
IPC分类号： C07D207/12 , C07D491/04 , C12Q1/02 , C12Q1/00 , C12Q1/34 , C12Q1/48
CPC分类号： C07D491/04 , C07D207/12
摘要： The invention relates to novel mannosidase inhibitors, processes for their preparation and their use as therapeutic agents. The invention also relates to the use of compounds of the formula II as described herein as prodrugs.
摘要翻译：本发明涉及新型甘露糖苷酶抑制剂，其制备方法及其作为治疗剂的用途。本发明还涉及本文所述的式II化合物作为前药的用途。

9. 发明授权

US5650501A Serine/threonine kinase and nucleic acids encoding same 失效
标题翻译：丝氨酸/苏氨酸激酶和编码相同的核酸
公开(公告)号：US5650501A
公开(公告)日：1997-07-22
申请号：US252995
申请日：1994-06-02
申请人： James W. Dennis , Mike Heffernan , Carol Fode
发明人： James W. Dennis , Mike Heffernan , Carol Fode
IPC分类号： C12N9/12 , C07K14/705 , C07K14/00 , C12N5/10 , C12N15/52
CPC分类号： C12N9/1205 , G01N2333/9121 , G01N2500/04
摘要： A serine/threonine kinase protein which is associated with mitotic and meiotic cell division and which is characterized by having a kinase domain in its N-terminus and three PEST regions in the C-terminus, and nucleic acid molecules encoding the protein. Diagnostic and therapeutic methods using the serine/threonine kinase protein and nucleic acid molecules are also described.
摘要翻译：与有丝分裂和减数分裂细胞分裂相关的丝氨酸/苏氨酸激酶蛋白，其特征在于在其N-末端具有激酶结构域，在C末端具有三个PEST区域，以及编码该蛋白质的核酸分子。还描述了使用丝氨酸/苏氨酸激酶蛋白和核酸分子的诊断和治疗方法。

10. 发明申请

US20020111695A1 Reconstituted mineralized cartilage tissue 审中-公开
标题翻译：重建矿化软骨组织
公开(公告)号：US20020111695A1
公开(公告)日：2002-08-15
申请号：US10121738
申请日：2002-04-12
申请人： Mount Sinai Hospital Corporation
发明人： Rita Kandel
IPC分类号： A61F002/28
CPC分类号： C12N5/0068 , A61K35/12 , A61K48/00 , A61L27/3608 , A61L27/3633 , A61L27/365 , A61L27/3654 , A61L27/3817 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L2430/06 , C12N5/0655 , C12N2500/42 , C12N2533/90
摘要： A biological material comprising a continuous layer of cartilaginous tissue reconstituted in vitro which contains components associated with cartilage mineralization. The biological material may be cultured with a mineralizing agent to form a mineralized biological material. The mineralized biological material is characterized by having a biochemical composition and physiological organization substantially similar to the deep and contiguous calcified cartilage zones of articular cartilage found in animals in vivo. Methods for preparing the biological materials and methods of using the biological materials are described.
摘要翻译：一种生物材料，其包含体外重组的软骨组织的连续层，其含有与软骨矿化相关的成分。生物材料可以与矿化剂一起培养以形成矿化生物材料。矿化生物材料的特征在于具有与动物体内发现的关节软骨的深层和连续钙化软骨区基本相似的生化组成和生理组织。描述了制备生物材料的方法和使用生物材料的方法。

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