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1. 发明申请

US20080113351A1 Polynucleotides for causing RNA interference and method for inhibiting gene expression using the same 审中-公开
标题翻译：用于引起RNA干扰的多核苷酸和使用其抑制基因表达的方法
公开(公告)号：US20080113351A1
公开(公告)日：2008-05-15
申请号：US11598052
申请日：2006-11-13
申请人： Yuki Naito , Masato Fujino , Shinobu Oguchi , Yukikazu Natori
发明人： Yuki Naito , Masato Fujino , Shinobu Oguchi , Yukikazu Natori
IPC分类号： A61K48/00 , C12Q1/68 , C07H21/02
CPC分类号： C12N15/111 , A61K31/713 , A61K48/00 , C12N2310/14 , C12N2320/11 , C12N2330/30
摘要： The present invention provides a polynucleotide that not only has a high RNA interference effect on its target gene, but also has a very small risk of causing RNA interference against a gene unrelated to the target gene. A sequence segment conforming to the following rules (a) to (d) is searched from the base sequences of a target gene for RNA interference and, based on the search results, a polynucleotide capable of causing RNAi is designed, synthesized, etc.: (a) The 3′ end base is adenine, thymine, or uracil, (b) The 5′ end base is guanine or cytosine, (c) A 7-base sequence from the 3′ end is rich in one or more types of bases selected from the group consisting of adenine, thymine, and uracil, and (d) The number of bases is within a range that allows RNA interference to occur without causing cytotoxicity.
摘要翻译：本发明提供了不仅对其靶基因具有高RNA干扰效应，而且对与靶基因无关的基因造成RNA干扰的风险很小的多核苷酸。从用于RNA干扰的靶基因的碱基序列中搜索符合以下规则（a）至（d）的序列区段，并且基于搜索结果，设计，合成等能够引起RNAi的多核苷酸：（a）3'末端碱基是腺嘌呤，胸腺嘧啶或尿嘧啶，（b）5'末端碱基是鸟嘌呤或胞嘧啶，（c）3'末端的7碱基序列富含一种或多种选自腺嘌呤，胸腺嘧啶和尿嘧啶的碱基，（d）碱基数在允许RNA干扰发生而不引起细胞毒性的范围内。

2. 发明申请

US20110054005A1 Polynucleotides for causing RNA interference and method for inhibiting gene expression using the same 审中-公开
标题翻译：用于引起RNA干扰的多核苷酸和使用其抑制基因表达的方法
公开(公告)号：US20110054005A1
公开(公告)日：2011-03-03
申请号：US12662904
申请日：2010-05-11
申请人： Yuki Naito , Masato Fujino , Shinobu Oguchi , Yukikazu Natori
发明人： Yuki Naito , Masato Fujino , Shinobu Oguchi , Yukikazu Natori
IPC分类号： A61K31/713 , C07H21/00 , C12Q1/68 , C12N5/071 , A61P25/28 , A61P25/00 , A61P35/00 , A61P7/06 , A61P35/02 , A61P21/00 , A61P5/26
CPC分类号： C12N15/111 , A61K31/713 , A61K48/00 , C12N2310/14 , C12N2320/11 , C12N2330/30
摘要： The present invention provides a polynucleotide that not only has a high RNA interference effect on its target gene, but also has a very small risk of causing RNA interference against a gene unrelated to the target gene. A sequence segment conforming to the following rules (a) to (d) is searched from the base sequences of a target gene for RNA interference and, based on the search results, a polynucleotide capable of causing RNAi is designed, synthesized, etc.: (a) The 3′ end base is adenine, thymine, or uracil, (b) The 5′ end base is guanine or cytosine, (c) A 7-base sequence from the 3′ end is rich in one or more types of bases selected from the group consisting of adenine, thymine, and uracil, and (d) The number of bases is within a range that allows RNA interference to occur without causing cytotoxicity.
摘要翻译：本发明提供了不仅对其靶基因具有高RNA干扰效应，而且对与靶基因无关的基因造成RNA干扰的风险很小的多核苷酸。从用于RNA干扰的靶基因的碱基序列中搜索符合以下规则（a）至（d）的序列区段，并且基于搜索结果，设计，合成等能够引起RNAi的多核苷酸：（a）3'末端碱基是腺嘌呤，胸腺嘧啶或尿嘧啶，（b）5'末端碱基是鸟嘌呤或胞嘧啶，（c）3'末端的7碱基序列富含一种或多种选自腺嘌呤，胸腺嘧啶和尿嘧啶的碱基，（d）碱基数在允许RNA干扰发生而不引起细胞毒性的范围内。

3. 发明授权

US08487988B2 Fingerprint authentication apparatus and fingerprint authentication method 有权
标题翻译：指纹认证装置和指纹认证方法
公开(公告)号：US08487988B2
公开(公告)日：2013-07-16
申请号：US13362062
申请日：2012-01-31
申请人： Shinobu Oguchi
发明人： Shinobu Oguchi
IPC分类号： H04N7/18 , G06K9/00
CPC分类号： A61B5/1172 , A61B2560/0242 , A61B2562/14 , A61B2562/245 , A61L2/10 , A61L2/24 , G06K9/00013
摘要： A fingerprint authentication apparatus and a fingerprint authentication method are provided. The fingerprint authentication apparatus is configured to prevent infection from viruses or bacteria and quickly and accurately perform fingerprint authentication. The fingerprint authentication apparatus includes an irradiation section that irradiates a mounting section when a finger is not detected to prevent infection.
摘要翻译：提供了一种指纹认证装置和指纹认证方法。指纹认证装置被配置为防止感染病毒或细菌，并且快速且准确地执行指纹认证。指纹认证装置包括：当未检测到手指以防止感染时照射安装部的照射部。

4. 发明授权

US08404441B2 DNA intercalator detection 有权
标题翻译： DNA嵌入剂检测
公开(公告)号：US08404441B2
公开(公告)日：2013-03-26
申请号：US12762474
申请日：2010-04-19
申请人： Shinobu Oguchi
发明人： Shinobu Oguchi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6825 , C12Q2565/607 , C12Q2563/173
摘要： A DNA intercalator detection system can include a filtration unit a control sample conditioner operably coupled with the filtration unit and an analytic unit operably coupled with the filtration unit and control sample conditioner and having an electronic chemical array (ECA) reaction component. A data processing unit is operably coupled with the analytic unit and configured to compare and determine a difference between electronic data of a test sample and a conditioned control sample from the ECA reaction component. The difference provides an indication of whether or not a DNA intercalator is present in the test sample.
摘要翻译： DNA嵌入剂检测系统可以包括过滤单元，与过滤单元可操作地耦合的对照样品调节剂和与过滤单元和对照样品调理剂可操作地耦合并具有电子化学阵列（ECA）反应组分的分析单元。数据处理单元与分析单元可操作地耦合并且被配置为比较和确定来自ECA反应组件的测试样品的电子数据与经调节的对照样品之间的差异。该差异提供了DNA嵌入剂是否存在于测试样品中的指示。

5. 发明申请

US20120127296A1 FINGERPRINT AUTHENTICATION APPARATUS AND FINGERPRINT AUTHENTICATION METHOD 有权
标题翻译：指纹认证装置和指纹认证方法
公开(公告)号：US20120127296A1
公开(公告)日：2012-05-24
申请号：US13362062
申请日：2012-01-31
申请人： Shinobu Oguchi
发明人： Shinobu Oguchi
IPC分类号： H04N7/18 , G06K9/00
CPC分类号： A61B5/1172 , A61B2560/0242 , A61B2562/14 , A61B2562/245 , A61L2/10 , A61L2/24 , G06K9/00013
摘要： A fingerprint authentication apparatus and a fingerprint authentication are provided. The fingerprint authentication apparatus is configured to prevent infection from viruses or bacteria and quickly and accurately perform fingerprint authentication. The fingerprint authentication apparatus includes an irradiation section that irradiates a mounting section when a finger is not detected to prevent infection.
摘要翻译：提供了一种指纹认证装置和指纹认证方法。指纹认证装置被配置为防止感染病毒或细菌，并且快速且准确地执行指纹认证。指纹认证装置包括：当未检测到手指以防止感染时照射安装部的照射部。

6. 发明申请

US20070128645A1 Use of KIAA0172 gene in treatment and diagnosis of diseases as well as in pharmaceutical development 审中-公开
标题翻译：使用KIAA0172基因治疗和诊断疾病以及药物开发
公开(公告)号：US20070128645A1
公开(公告)日：2007-06-07
申请号：US11606148
申请日：2006-11-30
申请人： Ryoichi Kiyama , Keisuke Kitajima , Shinobu Oguchi , Michio Oishi , Osamu Ohara , Takahiro Nagase
发明人： Ryoichi Kiyama , Keisuke Kitajima , Shinobu Oguchi , Michio Oishi , Osamu Ohara , Takahiro Nagase
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C07K14/47 , C12Q2600/154 , C12Q2600/172 , G01N33/505
摘要： An object of the present invention is to provide use of the KIAA0172 gene in treatment and diagnosis of diseases as well as in pharmaceutical development. An agent for treating cancer which comprises as an active ingredient a polypeptide encoded by the KIAA0172 gene, a partial sequence thereof or a variant thereof; an agent for treating cancer which comprises as an active ingredient an oligonucleotide including the KIAA0172 gene sequence; an agent for detecting cancer which comprises an antibody which recognizes polypeptide encoded by the KIAA0172 gene; an agent for detecting cancer which comprises an oligonucleotide including the KIAA0172 gene sequence; a composition for treating cancer which comprises said agent for treating cancer and a pharmaceutically acceptable carrier; and a composition for detecting cancer which comprises said agent for detecting cancer and a pharmaceutically acceptable carrier.
摘要翻译：本发明的目的是提供KIAA0172基因在疾病和药物开发的治疗和诊断中的用途。一种用于治疗癌症的药物，其包含作为活性成分的由KIAA0172基因编码的多肽，其部分序列或其变体; 一种治疗癌症的药物，其包含作为活性成分的包含KIAA0172基因序列的寡核苷酸; 用于检测癌症的试剂，其包含识别由KIAA0172基因编码的多肽的抗体; 用于检测癌症的试剂，其包含含有KIAA0172基因序列的寡核苷酸; 用于治疗癌症的组合物，其包含所述治疗癌症的药物和药学上可接受的载体; 和用于检测癌症的组合物，其包含所述用于检测癌症的药物和药学上可接受的载体。

7. 发明授权

US08125517B2 Fingerprint authentication apparatus and fingerprint authentication method 有权
标题翻译：指纹认证装置和指纹认证方法
公开(公告)号：US08125517B2
公开(公告)日：2012-02-28
申请号：US12968952
申请日：2010-12-15
申请人： Shinobu Oguchi
发明人： Shinobu Oguchi
IPC分类号： H04N7/18 , G06K9/00
CPC分类号： A61B5/1172 , A61B2560/0242 , A61B2562/14 , A61B2562/245 , A61L2/10 , A61L2/24 , G06K9/00013
摘要： A fingerprint authentication apparatus and a fingerprint authentication are provided. The fingerprint authentication apparatus is configured to prevent infection from viruses or bacteria and quickly and accurately perform fingerprint authentication. The fingerprint authentication apparatus includes an irradiation section that irradiates a mounting section when a finger is not detected to prevent infection.
摘要翻译：提供了一种指纹认证装置和指纹认证方法。指纹认证装置被配置为防止感染病毒或细菌，并且快速且准确地执行指纹认证。指纹认证装置包括：当未检测到手指以防止感染时照射安装部的照射部。

8. 发明申请

US20110303554A1 DETECTION AND DECOMPOSITION OF BISPHENOL-A 有权
标题翻译：双酚A的检测和分解
公开(公告)号：US20110303554A1
公开(公告)日：2011-12-15
申请号：US12999469
申请日：2010-06-11
申请人： Shinobu Oguchi
发明人： Shinobu Oguchi
IPC分类号： C25B11/04 , C25B15/00
CPC分类号： C12Q1/005 , C12Q1/001 , G01N27/3275 , G01N27/3276 , Y10S435/817
摘要： An enzyme electrode that enables rapid degradation of bisphenol-A (BPA) in a contaminated sample and/or monitoring of BPA concentration in a contaminated sample. The enzyme electrode includes a working electrode having one or more selected enzymes that are capable of degrading BPA linked to the working electrode. The selected enzymes linked to the working electrode are capable of degrading BPA at an enhanced rate in response to an applied voltage. The electrode can be used to monitor BPA concentration in a contaminated sample by measuring current flow through the electrode in response to an applied voltage.
摘要翻译：能够使受污染样品中双酚-A（BPA）快速降解和/或监测污染样品中BPA浓度的酶电极。酶电极包括具有一种或多种能够降解与工作电极连接的BPA的选择的酶的工作电极。与工作电极连接的所选择的酶能够以增加的速率响应施加的电压而降解BPA。该电极可用于通过测量施加电压的电流来测量污染样品中的BPA浓度。

9. 发明授权

US09206459B2 Detection and decomposition of bisphenol-A 有权
标题翻译：双酚A的检测和分解
公开(公告)号：US09206459B2
公开(公告)日：2015-12-08
申请号：US12999469
申请日：2010-06-11
申请人： Shinobu Oguchi
发明人： Shinobu Oguchi
IPC分类号： C12Q1/00 , G01N27/327
CPC分类号： C12Q1/005 , C12Q1/001 , G01N27/3275 , G01N27/3276 , Y10S435/817
摘要： An enzyme electrode that enables rapid degradation of bisphenol-A (BPA) in a contaminated sample and/or monitoring of BPA concentration in a contaminated sample. The enzyme electrode includes a working electrode having one or more selected enzymes that are capable of degrading BPA linked to the working electrode. The selected enzymes linked to the working electrode are capable of degrading BPA at an enhanced rate in response to an applied voltage. The electrode can be used to monitor BPA concentration in a contaminated sample by measuring current flow through the electrode in response to an applied voltage.
摘要翻译：能够使受污染样品中双酚-A（BPA）快速降解和/或监测污染样品中BPA浓度的酶电极。酶电极包括具有一种或多种能够降解与工作电极连接的BPA的选择的酶的工作电极。与工作电极连接的所选择的酶能够以增加的速率响应施加的电压而降解BPA。该电极可用于通过测量施加电压的电流来测量污染样品中的BPA浓度。

10. 发明申请

US20050202431A1 Application of kiaa0172 gene to treatment and diagnosis of diseases and drug discovery 审中-公开
标题翻译：应用kiaa0172基因治疗和诊断疾病和药物发现
公开(公告)号：US20050202431A1
公开(公告)日：2005-09-15
申请号：US10509738
申请日：2002-07-26
申请人： Ryoichi Kiyama , Keisuke Kitajima , Shinobu Oguchi , Michio Oishi , Osamu Ohara , Takahiro Nagase
发明人： Ryoichi Kiyama , Keisuke Kitajima , Shinobu Oguchi , Michio Oishi , Osamu Ohara , Takahiro Nagase
IPC分类号： A61P35/00 , A61P43/00 , C07K14/47 , C12Q1/68 , G01N33/50 , A61K38/17 , C07H21/04 , C07K14/82 , C12N15/09 , G01N33/574
CPC分类号： C12Q1/6886 , C07K14/47 , C12Q2600/154 , C12Q2600/172 , G01N33/505
摘要： An object of the present invention is to provide use of the KIAA0172 gene in treatment and diagnosis of diseases as well as in pharmaceutical development. An agent for treating cancer which comprises as an active ingredient a polypeptide encoded by the KIAA0172 gene, a partial sequence thereof or a variant thereof; an agent for treating cancer which comprises as an active ingredient an oligonucleotide including the KIAA0172 gene sequence; an agent for detecting cancer which comprises an antibody which recognizes polypeptide encoded by the KIAA0172 gene; an agent for detecting cancer which comprises an oligonucleotide including the KIAA0172 gene sequence; a composition for treating cancer which comprises said agent for treating cancer and a pharmaceutically acceptable carrier; and a composition for detecting cancer which comprises said agent for detecting cancer and a pharmaceutically acceptable carrier.
摘要翻译：本发明的目的是提供KIAA0172基因在疾病和药物开发的治疗和诊断中的用途。一种用于治疗癌症的药物，其包含作为活性成分的由KIAA0172基因编码的多肽，其部分序列或其变体; 一种治疗癌症的药物，其包含作为活性成分的包含KIAA0172基因序列的寡核苷酸; 用于检测癌症的试剂，其包含识别由KIAA0172基因编码的多肽的抗体; 用于检测癌症的试剂，其包含含有KIAA0172基因序列的寡核苷酸; 用于治疗癌症的组合物，其包含所述治疗癌症的药物和药学上可接受的载体; 和用于检测癌症的组合物，其包含所述用于检测癌症的药物和药学上可接受的载体。

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