专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07459451B2 Pyrazolopyridine derivatives 失效
标题翻译：吡唑并吡啶衍生物
公开(公告)号：US07459451B2
公开(公告)日：2008-12-02
申请号：US11171320
申请日：2005-07-01
申请人： Yoshito Abe , Kazuhiko Ohne , Kentaro Sato , Makoto Inoue , Mitsuaki Okumura
发明人： Yoshito Abe , Kazuhiko Ohne , Kentaro Sato , Makoto Inoue , Mitsuaki Okumura
IPC分类号： A61K31/535 , A61K31/44 , A01N43/42 , C07D413/00 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D471/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 4如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE- IV或TNF-α介导的疾病。

2. 发明申请

US20060004003A1 Pyrazolopyridine derivatives 失效
标题翻译：吡唑并吡啶衍生物
公开(公告)号：US20060004003A1
公开(公告)日：2006-01-05
申请号：US11171320
申请日：2005-07-01
申请人： Yoshito Abe , Kazuhiko Ohne , Kentaro Sato , Makoto Inoue , Mitsuaki Okumura
发明人： Yoshito Abe , Kazuhiko Ohne , Kentaro Sato , Makoto Inoue , Mitsuaki Okumura
IPC分类号： A61K31/5377 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 0 > 4 如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE-IV或TNF-α介导的疾病。

3. 发明授权

US06825200B1 Substituted dipeptides having nos inhibiting activity 失效
标题翻译：取代二肽具有抑制活性
公开(公告)号：US06825200B1
公开(公告)日：2004-11-30
申请号：US10111412
申请日：2002-05-06
申请人： Ichiro Shima , Takehiko Ohkawa , Kazuhiko Ohne , Kentaro Sato , Naoki Ishibashi , Kenichiro Imamura
发明人： Ichiro Shima , Takehiko Ohkawa , Kazuhiko Ohne , Kentaro Sato , Naoki Ishibashi , Kenichiro Imamura
IPC分类号： A61K31496
CPC分类号： C07K5/06191 , A61K38/05 , C07K5/06078 , C07K5/06139 , A61K2300/00
摘要： The present invention a compound represented by the formula (I): where the structural variables R1-R6 are defined herein.
摘要翻译：本发明由式（I）表示的化合物：其中结构变量R 1 -R 6在本文中定义。

4. 发明授权

US07129243B2 Peptide compounds 有权
标题翻译：肽化合物
公开(公告)号：US07129243B2
公开(公告)日：2006-10-31
申请号：US10250444
申请日：2001-12-18
申请人： Ichiro Shima , Takehiko Ohkawa , Kentaro Sato , Naoki Ishibashi , Kenichiro Imamura
发明人： Ichiro Shima , Takehiko Ohkawa , Kentaro Sato , Naoki Ishibashi , Kenichiro Imamura
IPC分类号： A61K31/50
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/06191
摘要： The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof. The compound (1) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals
摘要翻译：本发明涉及式（I）化合物，其中R 1为被卤素取代的苯并呋喃基或被卤素取代的苯乙烯基; R2是取代的羟基，取代的巯基或取代的磺酰基; X是其药学上可接受的盐。本发明化合物（1）及其药学上可接受的盐对一氧化氮（NO）的产生具有很强的抑制活性，可用于预防和/或治疗人和动物中NO介导的疾病

5. 发明授权

US07869061B2 Surface-distortion measuring device and method 有权
标题翻译：表面失真测量装置及方法
公开(公告)号：US07869061B2
公开(公告)日：2011-01-11
申请号：US11991788
申请日：2006-09-14
申请人： Kentaro Sato , Takanobu Saito , Takashi Iwama , Akihide Yoshitake , Mitsuaki Uesugi
发明人： Kentaro Sato , Takanobu Saito , Takashi Iwama , Akihide Yoshitake , Mitsuaki Uesugi
IPC分类号： G01B11/24
CPC分类号： G01B11/2536 , G01B11/2527 , G01B11/2531 , G01M11/005 , G01N21/8806 , G06T7/521
摘要： A surface-distortion measuring device and a surface-distortion measuring method can quantitatively, rapidly, and highly accurately measure and evaluate surface-distortion distribution at all of observable points on a specular or semi-specular surface of a measurement target. The device includes pattern displaying means 2 capable of switching and displaying a plurality of kinds of light-and-shade patterns 5, capturing means 3 for capturing mirror images, reflected in the specular or semi-specular surface of a measurement target 1, of the plurality of light-and-shade patterns displayed on the pattern displaying means, and surface-distortion distribution calculating means 10 for performing image processing on the captured mirror images of the plurality of light-and-shade patterns to calculate surface-distortion distribution of the measurement-target surface.
摘要翻译：表面失真测量装置和表面失真测量方法可以定量，快速和高精度地测量和评估测量目标的镜面或半镜面上的所有可观察点处的表面失真分布。该装置包括能够切换和显示多种光和阴影图案的图案显示装置2，用于捕获反射在测量对象1的镜面或半镜面中的镜像的拍摄装置3，在图案显示装置上显示的多个光和阴影图案;以及表面失真分布计算装置10，用于对多个光和阴影图案的所拍摄的镜像进行图像处理，以计算出测量目标表面。

6. 发明申请

US20100009972A1 Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Compound 有权
标题翻译：含吡啶基非芳香族氮的杂环-1-羧酸酯化合物
公开(公告)号：US20100009972A1
公开(公告)日：2010-01-14
申请号：US12543690
申请日：2009-08-19
申请人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
发明人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
IPC分类号： A61K31/4545 , C07D401/12 , C07D405/14 , A61K31/506 , A61K31/551 , A61K31/4725 , A61P13/00
CPC分类号： A61K31/44 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D401/12
摘要： A novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound and its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound of the present disclosure is also useful in the treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.
摘要翻译：新型吡啶基非芳族含氮杂环-1-羧酸酯化合物及其药学上可接受的盐具有有效的FAAH抑制活性。此外，本公开的吡啶基非芳族含氮杂环-1-羧酸酯化合物也可用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛。

7. 发明授权

US06333324B1 Piperazine compounds as inhibitors of MMP or TNF 失效
标题翻译：哌嗪化合物作为MMP或TNF的抑制剂
公开(公告)号：US06333324B1
公开(公告)日：2001-12-25
申请号：US09319928
申请日：1999-07-26
申请人： Masahiro Neya , Hitoshi Yamazaki , Natsuko Kayakiri , Kentaro Sato , Teruo Oku
发明人： Masahiro Neya , Hitoshi Yamazaki , Natsuko Kayakiri , Kentaro Sato , Teruo Oku
IPC分类号： C07D24104
CPC分类号： C07D405/12 , C07D241/04 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： A compound of formula (I) wherein A is a sulfonyl or a carbonyl; R1 is an optionally substituted aryl, an optionally substituted heterocyclic group, an optionally substituted lower alkyl or an optionally substituted lower alkenyl; R2 is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; R3 is an optionally substituted lower alkyl, an optionally substituted lower alkoxy, an optionally substituted aryloxy, an optionally substitued lower alkenyl, an optionally substituted aryl, an optionally substituted heterocyclic group or an optionally substitued amino; R4 is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; R5 is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; and R10 is a hydroxy or a protected hydroxy, and a pharmaceutically acceptable salt thereof. The compound of the present invention is useful as a medicament for prophylactic and therapeutic treatment of MMP- or TNF&agr;-mediated diseases.
摘要翻译：式（I）的化合物，其中A是磺酰基或羰基; R1是任选取代的芳基，任选取代的杂环基，任选取代的低级烷基或任选取代的低级烯基; R2是氢，任选取代的低级烷基，任选取代的芳基或任选取代的杂环基; R 3是任选取代的低级烷基，任选取代的低级烷氧基，任选取代的芳氧基，任选取代的低级烯基，任选取代的芳基，任选取代的杂环基或任选取代的氨基; R4是氢，任选取代的低级烷基，任选取代的芳基或任选取代的杂环基; R5是氢，任选取代的低级烷基，任选取代的芳基或任选取代的杂环基; R 10为羟基或被保护的羟基及其药学上可接受的盐。本发明的化合物可用作用于预防和治疗MMP或TNFα介导的疾病的药物。

8. 发明授权

US6054457A Benzamide derivatives and their use as vasopressin antagonists 失效
标题翻译：苯甲酰胺衍生物及其作为血管加压素拮抗剂的用途
公开(公告)号：US6054457A
公开(公告)日：2000-04-25
申请号：US973103
申请日：1997-12-09
申请人： Hiroyuki Setoi , Takehiko Ohkawa , Tatsuya Zenkoh , Hitoshi Sawada , Kentaro Sato , Hirokazu Tanaka
发明人： Hiroyuki Setoi , Takehiko Ohkawa , Tatsuya Zenkoh , Hitoshi Sawada , Kentaro Sato , Hirokazu Tanaka
IPC分类号： C07D243/08 , A61K31/165 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/55 , A61P1/16 , A61P3/00 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , A61P27/16 , A61P43/00 , C07C235/42 , C07C237/42 , C07C237/44 , C07C243/28 , C07C255/54 , C07C271/16 , C07C271/22 , C07C271/48 , C07C279/08 , C07C279/24 , C07D209/48 , C07D211/16 , C07D211/44 , C07D211/46 , C07D211/58 , C07D211/74 , C07D213/30 , C07D213/75 , C07D213/80 , C07D213/82 , C07D239/26 , C07D295/185 , C07D295/192 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D401/12 , A61K31/33 , C07D295/18 , C07D295/20
CPC分类号： C07D209/48 , C07C235/42 , C07C237/42 , C07C237/44 , C07C243/28 , C07C255/54 , C07C271/16 , C07C271/22 , C07C271/48 , C07C279/08 , C07C279/24 , C07D211/46 , C07D211/58 , C07D211/74 , C07D213/30 , C07D213/75 , C07D213/80 , C07D239/26 , C07D295/185 , C07D295/192 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32
摘要： This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): ##STR1## wherein R.sup.1 is aryl optionally substituted with lower alkoxy, etc., R.sup.2 is lower alkyl, etc.,R.sup.3 is hydrogen, etc.,R.sup.4 is lower alkoxy, etc.,R.sup.5 is hydrogen, etc.,A is NH, etc.,E is ##STR2## etc., X is --CH.dbd.CH--, --CH.dbd.N--, or S, andY is CH or N,and pharmaceutically acceptable salts thereof, to processes for preparation thereof and to a pharmaceutical composition comprising the same.
摘要翻译： PCT No.PCT / JP96 / 01533 Sec。 371日期1997年12月9日第 102（e）1997年12月9日PCT PCT 1996年6月6日PCT公布。公开号WO96 / 41795 日本本发明涉及具有加压素拮抗活性的新的苯甲酰胺衍生物，由通式（I）表示：其中R1为任选被低级烷氧基取代的芳基等，R2为低级烷基等， R3是氢等，R4是低级烷氧基等，R5是氢等，A是NH等，E是等等，X是-CH = CH-，-CH = N-或S ，Y为CH或N及其药学上可接受的盐，其制备方法和含有该化合物的药物组合物。

9. 发明申请

US20110172230A1 UREA COMPOUND OR SALT THEREOF 审中-公开
标题翻译：尿素化合物或其盐
公开(公告)号：US20110172230A1
公开(公告)日：2011-07-14
申请号：US12377918
申请日：2007-08-22
申请人： Takahiro Ishii , Takashi Sugane , Akio Kakefuda , Tatsuhisa Takahashi , Tokatoshi Kanayama , Kentaro Sato , Ikumi Kuriwaki , Chika Kitada , Jotaro Suzuki
发明人： Takahiro Ishii , Takashi Sugane , Akio Kakefuda , Tatsuhisa Takahashi , Tokatoshi Kanayama , Kentaro Sato , Ikumi Kuriwaki , Chika Kitada , Jotaro Suzuki
IPC分类号： A61K31/5377 , C07D401/12 , A61K31/4545 , C07D211/46 , A61K31/445 , C07D401/06 , A61K31/454 , A61K31/496 , C07D403/06 , C07D401/14 , A61K31/497 , C07D403/12 , A61K31/501 , A61K31/4725 , A61K31/4709 , C07D413/14 , A61K31/506 , A61K31/53 , A61P13/00
CPC分类号： C07D209/08 , C07D211/44 , C07D213/74 , C07D235/30 , C07D237/22 , C07D249/14 , C07D251/42 , C07D285/135 , C07D295/16 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： [Object] To provide a compound which can be used for the treatment of a disease associated with fatty acid amide hydrolase (FAAH), particularly urinary frequency, urinary incontinence and/or overactive bladder.[Means for solution] It is confirmed that a urea compound chemical-structurally characterized by having a piperidine or piperazine ring or a salt thereof has an excellent FAAH-inhibitory activity, and thus the present invention is completed. The urea compound or its pharmaceutically acceptable salt of the present invention can increase the effective bladder capacity and ameliorate the state of urinary frequency, and is therefore useful as an agent for treating urinary frequency, urinary incontinence and/or overactive bladder.
摘要翻译：提供可用于治疗与脂肪酰胺水解酶（FAAH）相关疾病，特别是尿频，尿失禁和/或膀胱过度活动症的化合物。 [解决方法]确认化学结构特征在于具有哌啶或哌嗪环或其盐的脲化合物具有优异的FAAH抑制活性，从而完成了本发明。本发明的尿素化合物或其药学上可接受的盐可以增加膀胱的有效性并改善尿频的状态，因此可用作治疗尿频，尿失禁和/或膀胱过度活动症的药剂。

10. 发明申请

US20110308297A1 BREATH ALCOHOL MEASURING APPARATUS 有权
标题翻译：呼吸酒精测量仪
公开(公告)号：US20110308297A1
公开(公告)日：2011-12-22
申请号：US13162030
申请日：2011-06-16
申请人： Hanzo Tsuzuki , Kentaro Sato , Yuji Yamazawa
发明人： Hanzo Tsuzuki , Kentaro Sato , Yuji Yamazawa
IPC分类号： G01N33/497
CPC分类号： G01N33/98 , G01N33/4972
摘要： When a pressure of a breath is kept to fall within a valid range, a CPU of a breath alcohol measuring apparatus updates a breath amount accumulation value that is an accumulation value of the amount of the breath blown into a mouth piece; when the breath pressure reaches the range outside the valid range, the CPU resets the breath amount accumulation value; and when the breath amount accumulation value reaches a valid breath amount, the CPU measures the alcohol concentration by an alcohol sensor. A breath pressure display portion is arranged at the position that can visually be recognized by a to-be-measured person who is blowing into the mouth piece.
摘要翻译：当呼吸压力保持在有效范围内时，呼吸酒精测量装置的CPU更新作为吹入口部件的呼吸量的累积值的呼吸量累积值; 当呼吸压力达到超出有效范围的范围时，CPU复位呼吸量积累值; 当呼吸量积累值达到有效呼吸量时，CPU通过酒精传感器测量酒精浓度。呼吸压力显示部配置在能够被吹入口部的被测量人物视觉识别的位置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式