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1. 发明授权

US5639922A Process for treatment of hydroperoxide mixture 失效
标题翻译：氢过氧化物混合物的处理方法
公开(公告)号：US5639922A
公开(公告)日：1997-06-17
申请号：US502537
申请日：1995-07-14
申请人： Yoichi Ikeda , Motoo Hazama , Nobuhiro Kawara , Maki Okumura , Takanori Ito
发明人： Yoichi Ikeda , Motoo Hazama , Nobuhiro Kawara , Maki Okumura , Takanori Ito
IPC分类号： C07B63/02 , C07C37/08 , C07C407/00 , C07C409/06 , C07C409/08 , C07C409/10 , C07C409/12
CPC分类号： C07C37/08 , C07C407/00 , C07C409/08 , C07C2101/08 , C07C2101/14
摘要： A process is described for the selective decomposition of aromatic primary hydroperoxides by contacting a hydroperoxide mixture containing aromatic primary hydroperoxides and aromatic tertiary hydroperoxides obtained by oxidation of alkylaromatic compounds under non-aqueous conditions with an alkali and an organic aromatic carboxylic acid salt.
摘要翻译：描述了通过使含有芳族伯氢过氧化物的氢过氧化物混合物和通过在非水性条件下氧化烷基芳族化合物与碱和有机芳族羧酸盐获得的芳族叔氢过氧化物接触来选择性分解芳族伯氢过氧化物的方法。

2. 发明授权

US5399791A Process for production of cresols 失效
标题翻译：甲酚生产工艺
公开(公告)号：US5399791A
公开(公告)日：1995-03-21
申请号：US202160
申请日：1994-02-25
申请人： Kiyoshi Ikimi , Yoichi Ikeda , Akira Murakami , Kazushige Okamoto , Tooru Tokumaru , Motoo Hazama
发明人： Kiyoshi Ikimi , Yoichi Ikeda , Akira Murakami , Kazushige Okamoto , Tooru Tokumaru , Motoo Hazama
IPC分类号： C07C39/07 , C07C37/08 , C07C37/06
CPC分类号： C07C39/07
摘要： There is disclosed a process for the production of cresols, including the steps of: (a) conducting oxygenation of cymene with oxygen gas or an oxygen-containing gas without any addition of an alkali, thereby obtaining a solution of oxygenation products containing tertiary and primary hydroperoxides of cymene; (b) washing the solution of oxygenation products obtained in step (a) with an aqueous alkali solution at a temperature in the range of from 10.degree. to 95.degree. C.; (c) subjecting the solution of oxygenation products obtained in step (b) to hydrogenation at a temperature in the range of from 60.degree. to 100.degree. C. to decrease the content of primary hydroperoxide in such a manner that the weight ratio of primary hydroperoxide to tertiary hydroperoxide is not greater than 1/25 (w/w); (d) subjecting the solution treated in step (c) to decomposition in the presence of a catalyst; and (e) subjecting the solution treated in step (d) to hydrogenation to obtain cresols.
摘要翻译：公开了一种生产甲酚的方法，包括以下步骤：（a）在不加碱的条件下，用氧气或含氧气体进行甲基异丙基苯的氧化反应，从而得到含有叔，伞形氢过氧化物; （b）在10℃至95℃的温度范围内用碱水溶液洗涤步骤（a）中获得的氧合产物的溶液; （c）将步骤（b）中获得的氧合产物溶液在60℃至100℃的温度范围内进行氢化，以降低初级氢过氧化物的含量，使得初级氢过氧化物的重量比叔氢过氧化物不大于1/25（w / w）; （d）使在步骤（c）中处理的溶液在催化剂存在下进行分解; 和（e）使步骤（d）中处理的溶液进行氢化以获得甲酚。

3. 发明授权

US5600026A Process for production of cresols 失效
标题翻译：甲酚生产工艺
公开(公告)号：US5600026A
公开(公告)日：1997-02-04
申请号：US393031
申请日：1995-02-23
申请人： Kiyoshi Ikimi , Yoichi Ikeda , Akira Murakami , Kazushige Okamoto , Tooru Tokumaru , Motoo Hazama
发明人： Kiyoshi Ikimi , Yoichi Ikeda , Akira Murakami , Kazushige Okamoto , Tooru Tokumaru , Motoo Hazama
IPC分类号： C07C39/07 , C07C409/08 , C07C37/08 , C07C37/06 , C07C37/68
CPC分类号： C07C39/07 , C07C407/00 , C07C409/08
摘要： There is disclosed a process for the production of cresols, including the steps of: (a) conducting oxygenation of cymene with oxygen gas or an oxygen-containing gas, thereby obtaining a solution of oxygenation products containing tertiary and primary hydroperoxides of cymene; (b) reacting the solution of oxygenation products obtained in the step (a) with an organic quaternary ammonium salt and an alkali, or with an organic quaternary ammonium hydroxide, thereby decreasing the content of primary hydroperoxide; (c) subjecting the reaction mixture in the step (b) to decomposition in the presence of a catalyst; and (d) subjecting the decomposition mixture in the step (c) to hydrogenation, thereby obtaining the desired cresols.
摘要翻译：公开了一种生产甲酚的方法，包括以下步骤：（a）用氧气或含氧气体进行甲基异丙基苯的氧化反应，从而得到含有甲基异丙苯的叔级和过氧化氢过氧化氢的氧化产物溶液; （b）使步骤（a）中得到的氧合产物的溶液与有机季铵盐和碱或与有机季铵氢氧化物反应，从而降低初级氢过氧化物的含量; （c）使步骤（b）中的反应混合物在催化剂存在下分解; 和（d）使步骤（c）中的分解混合物进行氢化，从而得到所需的甲酚。

4. 发明授权

US4403096A Optically active imidazolidin-2-one derivatives 失效
标题翻译：光学活性的咪唑烷-2-酮衍生物
公开(公告)号：US4403096A
公开(公告)日：1983-09-06
申请号：US278350
申请日：1981-06-29
申请人： Motoo Hazama , Tadatoshi Aratani , Gohu Suzukamo , Takeo Takahashi
发明人： Motoo Hazama , Tadatoshi Aratani , Gohu Suzukamo , Takeo Takahashi
IPC分类号： C07D233/34 , C07D233/32 , C07D491/04
CPC分类号： C07D491/04 , C07D233/32
摘要： A novel optically active cis-4,5-disubstituted imidazolidin-2-one derivative of the formula: ##STR1## wherein R.sup.1 is a C.sub.1 -C.sub.4 alkyl group or benzyl and R.sup.2 is a chiral aralkyl group optionally having at least one of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and hydroxyl groups is produced asymmetrically by the reaction of 1,3-dibenzyl-cis-4,5-dicarboxy-imidazolidin-2-one or its anhydride with an optically active secondary amine of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are each as defined above and is transformed into the lactone of 1,3-dibenzyl-cis-4-carboxy-5-hydroxymethyl-imidazolidin-2-one, which is a key intermediate in the synthesis of d-biotin.
摘要翻译：一种新型的光学活性的顺式-4,5-二取代的咪唑烷-2-酮衍生物，其结构式如下：其中R 1是C 1 -C 4烷基或苄基，R 2是任选具有至少一个C 1 -C 4烷基的手性芳烷基， C4烷基，C1-C4烷氧基和羟基通过1,3-二苄基 - 顺-4,5-二羧基 - 咪唑烷-2-酮或其酸酐与下式的光学活性仲胺的反应不对称地制备：其中R1和R2各自如上所定义，并转化为1,3-二苄基 - 顺式-4-羧基-5-羟甲基 - 咪唑烷-2-酮的内酯，其是合成d中的关键中间体生物素

5. 发明授权

US4137417A Process for producing an enamide 失效
标题翻译：生产烯酰胺的方法
公开(公告)号：US4137417A
公开(公告)日：1979-01-30
申请号：US790908
申请日：1977-04-26
申请人： Motoo Hazama
发明人： Motoo Hazama
IPC分类号： C07B61/00 , B01J23/46 , C07C20060101 , C07C67/00 , C07C231/00 , C07C231/10 , C07C233/00 , C07C233/05 , C07C233/06 , C07C233/16 , C07C233/31 , C07C233/47 , C07C233/65 , C07C233/71 , C07C233/85 , C07C233/90 , C07C233/91 , C07C233/92 , C07C237/16 , C07C237/22 , C07C253/00 , C07C255/24 , C07C255/30 , C07D209/18 , C07D227/00 , C07D233/64 , C07C102/00
CPC分类号： C07C255/00
摘要： Enamides are prepared by hydrogenating oximes having at least one hydrogen atom at the .alpha.-position in the presence of a carboxylic anhydride using a ruthenium catalyst. These enamides are important to obtain amino group-containing compounds by reduction or polymerization.
摘要翻译：酰胺通过使用钌催化剂在羧酸酐存在下，通过氢化在α位上具有至少一个氢原子的肟来制备。这些酰胺对于通过还原或聚合获得含氨基化合物是重要的。

6. 发明授权

US06410279B1 Process for producing optically active azetidine-2-carboxylic acid derivative 有权
标题翻译：光学活性氮杂环丁烷-2-羧酸衍生物的制备方法
公开(公告)号：US06410279B1
公开(公告)日：2002-06-25
申请号：US09619386
申请日：2000-07-19
申请人： Junko Kudo , Motoo Hazama , Norihiko Hirata
发明人： Junko Kudo , Motoo Hazama , Norihiko Hirata
IPC分类号： C12P1710
CPC分类号： C12P17/10 , C12P41/005
摘要： There is provided a process for producing N-substituted azetidine-2-carboxylic acid of the formula I: wherein R1 denotes an aralkyl group or an arylated lower alkoxycarbonyl group and * designates an asymmetric carbon atom, which is characterized by: reacting an N-substituted azetidine-2-carboxylic acid ester of the formula II: wherein R1 has the same meaning as defined above and R2 denotes an alkyl group, an aralkyl group or an allyl group, with an enzyme capable of selectively hydrolyzing a stereoisomer based on the carbon atom of the 2-position of the azetidine ring.
摘要翻译：提供了制备式I的N-取代的氮杂环丁烷-2-羧酸的方法：其中R1表示芳烷基或芳基化低级烷氧基羰基，*表示不对称碳原子，其特征在于：使N- 取代的氮杂环丁烷-2-羧酸酯，其中R 1具有与上述相同的含义，R 2表示烷基，芳烷基或烯丙基，具有能够基于碳选择性水解立体异构体的酶氮杂环丁烷2位的原子。

7. 发明授权

US06348617B1 Method for purifying pyruvic acid compounds 失效
标题翻译：丙酮酸化合物的纯化方法
公开(公告)号：US06348617B1
公开(公告)日：2002-02-19
申请号：US09284263
申请日：1999-06-21
申请人： Hideki Ushio , Motoo Hazama , Toshikazu Yagi , Akihiko Nakamura , Masahiko Mizuno
发明人： Hideki Ushio , Motoo Hazama , Toshikazu Yagi , Akihiko Nakamura , Masahiko Mizuno
IPC分类号： C09C6966
CPC分类号： C07C67/343 , C07C67/60 , C07C69/716
摘要： The present invention is directed to a method for purifying pyruvic acid compounds, which method comprises reacting a pyruvic acid compound of general formula (I): wherein R1 is an optionally substituted lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl group, an aryl group, or a heterocyclic group, and R2 is a lower alkyl group, with a bisulfite of general formula (II): MHSO3 (II) wherein M is NH4 or an alkali metal, to give a bisulfite adduct of the pyruvic acid compound and then decomposing the adduct with an acid. According to the present invention, pyruvic acid compounds can be purified by simple and easy procedures without using purification techniques such as distillation or column chromatography, and the above method is advantageous as a process for the production on an industrial scale.
摘要翻译：本发明涉及一种纯化丙酮酸化合物的方法，该方法包括使通式（I）的丙酮酸化合物：其中R 1为任选取代的低级烷基，低级烯基，低级炔基，环烷基，芳基或杂环基，R2是低级烷基，与通式（II）的亚硫酸氢盐反应：其中M是NH 4或碱金属，得到丙酮酸化合物的亚硫酸氢盐加合物和然后用酸分解加合物。根据本发明，丙酮酸化合物可以通过简单且简单的方法纯化，而不使用蒸馏或柱色谱法等纯化技术，上述方法作为工业规模生产的方法是有利的。

8. 发明授权

US06162621A Process for producing optically active azetidine-2-carboxylic acid derivative 失效
标题翻译：光学活性氮杂环丁烷-2-羧酸衍生物的制备方法
公开(公告)号：US06162621A
公开(公告)日：2000-12-19
申请号：US12227
申请日：1998-01-23
申请人： Junko Kudo , Motoo Hazama , Norihiko Hirata
发明人： Junko Kudo , Motoo Hazama , Norihiko Hirata
IPC分类号： C12P17/10 , C12P41/00
CPC分类号： C12P17/10 , C12P41/005
摘要： There is provided a process for producing N-substituted azetidine-.2-carboxylic acid of the formula I: ##STR1## wherein R.sup.1 denotes an aralkyl group or an arylated lower alkoxycarbonyl group and * designates an asymmetric carbon atom, which is characterized by:reacting an N-substituted azetidine-2-carboxylic acid ester of the formula II: ##STR2## wherein R.sup.1 has the same meaning as defined above and R.sup.2 denotes an alkyl group, an aralkyl group or an allyl group, with an enzyme capable of selectively hydrolyzing a stereoisomer based on the carbon atom of the 2-position of the azetidine ring.
摘要翻译：提供了制备式I的N-取代的氮杂环丁烷-2-羧酸的方法：其中R1表示芳烷基或芳基化低级烷氧基羰基，*表示不对称碳原子，其特征在于：使N 取代的氮杂环丁烷-2-羧酸酯：其中R 1具有与上述相同的含义，并且R 2表示烷基，芳烷基或烯丙基，具有能够选择性地水解立体异构体的酶基于氮原子环的2位的碳原子。

9. 发明授权

US5880291A Process for producing optically active azetidine-2-carboxylic acid 失效
标题翻译：光学活性氮杂环丁烷-2-羧酸的制备方法
公开(公告)号：US5880291A
公开(公告)日：1999-03-09
申请号：US924320
申请日：1997-09-05
申请人： Hideki Ushio , Naoyuki Takano , Yukihiro Honda , Shinzo Seko , Motoo Hazama
发明人： Hideki Ushio , Naoyuki Takano , Yukihiro Honda , Shinzo Seko , Motoo Hazama
IPC分类号： C07D205/04
CPC分类号： C07D205/04
摘要： The present invention provides a process for preparing optically active azetidine-2-carboxylic acids using readily available reagents of relatively low price in the industry. Thus, there is provided optically active azetidine-2-carboxylic acid, and a process for producing the same by subjecting optically active N-(alkylbenzyl)azetidine-2-carboxylic acid represented by the formula (1): ##STR1## to hydrogenolysis in the presence of a catalyst.
摘要翻译：本发明提供了使用工业中价格相对较低的容易获得的试剂制备光学活性氮杂环丁烷-2-羧酸的方法。因此，提供光学活性的氮杂环丁烷-2-羧酸及其制备方法，该方法是使式（1）表示的旋光性N-（烷基苄基）氮杂环丁烷-2-羧酸：（1）在催化剂存在下氢解。

10. 发明授权

US4169207A Racemization of an optically active lysine alkyl ester 失效
标题翻译：光学活性赖氨酸烷基酯的外消旋化
公开(公告)号：US4169207A
公开(公告)日：1979-09-25
申请号：US916939
申请日：1978-06-19
申请人： Motoo Hazama , Gohu Suzukamo
发明人： Motoo Hazama , Gohu Suzukamo
IPC分类号： C07C227/36 , A61K20060101 , C07C20060101 , C07C229/26 , C07C99/00 , C07C101/24
CPC分类号： C07C233/36
摘要： An optically active lysine alkyl ester.dihydrochloride is racemized by heating at 100.degree. C. to 250.degree. C. under an atmosphere of hydrogen. By combining this process with asymmetric hydrolysis of racemic lysine alkyl ester with enzymes, racemic lysine alkyl ester can be converted all to L-lysine.
摘要翻译：光学活性赖氨酸烷基酯二盐酸盐通过在氢气气氛下在100℃加热至250℃进行外消旋化。通过将该方法与外消旋赖氨酸烷基酯与酶的不对称水解相结合，外消旋赖氨酸烷基酯可全部转化为L-赖氨酸。

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