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1. 发明授权

US08137980B2 On-board control for analytical elements 有权
标题翻译：分析元件的车载控制
公开(公告)号：US08137980B2
公开(公告)日：2012-03-20
申请号：US13032443
申请日：2011-02-22
申请人： Volker Unkrig , Christine Nortmeyer , Carina Horn , Michael Marquant , Mihail Onoriu Lungu , Joachim Hoenes , Holger Kotzan , Joerg Dreibholz
发明人： Volker Unkrig , Christine Nortmeyer , Carina Horn , Michael Marquant , Mihail Onoriu Lungu , Joachim Hoenes , Holger Kotzan , Joerg Dreibholz
IPC分类号： G01N21/00 , G01N27/28
CPC分类号： G01N33/54386 , G01N31/22 , G01N33/52 , G01N33/86 , Y10T436/104998 , Y10T436/144444 , Y10T436/17 , Y10T436/170769 , Y10T436/179228
摘要： The invention concerns a reagent system for the so-called on-board control of analytical elements, in particular test strips, containing an organic N-oxide or a nitroso compound. The invention also concerns analytical elements containing a reagent system for a detection reaction and a reagent system for an on-board control. Furthermore, the invention concerns a method for checking analytical elements in which a reagent system for an on-board control is examined optically or electrochemically with the aid of a measuring instrument for changes which could indicate a stress of the analytical element.
摘要翻译：本发明涉及用于所谓的对含有有机N-氧化物或亚硝基化合物的分析元素，特别是试纸的板载控制的试剂系统。本发明还涉及包含用于检测反应的试剂系统和用于车载控制的试剂系统的分析元件。此外，本发明涉及一种用于检查分析元件的方法，其中用于车载控制的试剂系统借助于可以指示分析元件的应力的测量仪器被光学或电化学地检查。

2. 发明申请

US20110177605A1 On-Board Control for Analytical Elements 有权
标题翻译：分析元件的车载控制
公开(公告)号：US20110177605A1
公开(公告)日：2011-07-21
申请号：US13032443
申请日：2011-02-22
申请人： Volker Unkrig , Christine Nortmeyer , Carina Horn , Michael Marquant , Mihail-Onoriu Lungu , Joachim Hoenes , Holger Kotzan , Joerg Dreibholz
发明人： Volker Unkrig , Christine Nortmeyer , Carina Horn , Michael Marquant , Mihail-Onoriu Lungu , Joachim Hoenes , Holger Kotzan , Joerg Dreibholz
IPC分类号： G01N21/00 , G01N27/28
CPC分类号： G01N33/54386 , G01N31/22 , G01N33/52 , G01N33/86 , Y10T436/104998 , Y10T436/144444 , Y10T436/17 , Y10T436/170769 , Y10T436/179228
摘要： The invention concerns a reagent system for the so-called on-board control of analytical elements, in particular test strips, containing an organic N-oxide or a nitroso compound. The invention also concerns analytical elements containing a reagent system for a detection reaction and a reagent system for an on-board control. Furthermore, the invention concerns a method for checking analytical elements in which a reagent system for an on-board control is examined optically or electrochemically with the aid of a measuring instrument for changes which could indicate a stress of the analytical element.
摘要翻译：本发明涉及用于所谓的对含有有机N-氧化物或亚硝基化合物的分析元素，特别是试纸的板载控制的试剂系统。本发明还涉及包含用于检测反应的试剂系统和用于车载控制的试剂系统的分析元件。此外，本发明涉及一种用于检查分析元件的方法，其中用于车载控制的试剂系统借助于可以指示分析元件的应力的测量仪器被光学或电化学地检查。

3. 发明授权

US07914752B2 On-board control for analytical elements 有权
标题翻译：分析元件的车载控制
公开(公告)号：US07914752B2
公开(公告)日：2011-03-29
申请号：US10962796
申请日：2004-10-12
申请人： Volker Unkrig , Christine Nortmeyer , Carina Horn , Michael Marquant , Mihail-Onoriu Lungu , Joachim Hoenes , Holger Kotzan , Joerg Dreibholz
发明人： Volker Unkrig , Christine Nortmeyer , Carina Horn , Michael Marquant , Mihail-Onoriu Lungu , Joachim Hoenes , Holger Kotzan , Joerg Dreibholz
IPC分类号： G01N31/22
CPC分类号： G01N33/54386 , G01N31/22 , G01N33/52 , G01N33/86 , Y10T436/104998 , Y10T436/144444 , Y10T436/17 , Y10T436/170769 , Y10T436/179228
摘要： The invention concerns a reagent system for the so-called on-board control of analytical elements, in particular test strips, containing an organic N-oxide or a nitroso compound. The invention also concerns analytical elements containing a reagent system for a detection reaction and a reagent system for an on-board control. Furthermore, the invention concerns a method for checking analytical elements in which a reagent system for an on-board control is examined optically or electrochemically with the aid of a measuring instrument for changes which could indicate a stress of the analytical element.
摘要翻译：本发明涉及用于所谓的对含有有机N-氧化物或亚硝基化合物的分析元素，特别是试纸的板载控制的试剂系统。本发明还涉及包含用于检测反应的试剂系统和用于车载控制的试剂系统的分析元件。此外，本发明涉及一种用于检查分析元件的方法，其中用于车载控制的试剂系统借助于可以指示分析元件的应力的测量仪器被光学或电化学地检查。

4. 发明申请

US20050123441A1 On-board control for analytical elements 有权
标题翻译：分析元件的车载控制
公开(公告)号：US20050123441A1
公开(公告)日：2005-06-09
申请号：US10962796
申请日：2004-10-12
申请人： Volker Unkrig , Christine Nortmeyer , Carina Horn , Michael Marquant , Mihail-Onoriu Lungu , Joachim Hoenes , Holger Kotzan , Joerg Dreibholz
发明人： Volker Unkrig , Christine Nortmeyer , Carina Horn , Michael Marquant , Mihail-Onoriu Lungu , Joachim Hoenes , Holger Kotzan , Joerg Dreibholz
IPC分类号： G01N33/96 , B65D79/02 , C12Q1/00 , G01N21/17 , G01N21/77 , G01N21/78 , G01N27/26 , G01N27/327 , G01N27/416 , G01N31/00 , G01N31/22 , G01N33/487 , G01N33/49 , G01N33/52 , G01N33/53 , G01N33/543 , G01N33/58 , G01N33/86 , G01N37/00
CPC分类号： G01N33/54386 , G01N31/22 , G01N33/52 , G01N33/86 , Y10T436/104998 , Y10T436/144444 , Y10T436/17 , Y10T436/170769 , Y10T436/179228
摘要： The invention concerns a reagent system for the so-called on-board control of analytical elements, in particular test strips, containing an organic N-oxide or a nitroso compound. The invention also concerns analytical elements containing a reagent system for a detection reaction and a reagent system for an on-board control. Furthermore, the invention concerns a method for checking analytical elements in which a reagent system for an on-board control is examined optically or electrochemically with the aid of a measuring instrument for changes which could indicate a stress of the analytical element.
摘要翻译：本发明涉及用于所谓的对含有有机N-氧化物或亚硝基化合物的分析元素，特别是试纸的板载控制的试剂系统。本发明还涉及包含用于检测反应的试剂系统和用于车载控制的试剂系统的分析元件。此外，本发明涉及一种用于检查分析元件的方法，其中用于车载控制的试剂系统借助于可以指示分析元件的应力的测量仪器被光学或电化学地检查。

5. 发明申请

US20050191431A1 Method for the production of a hydrophilic substrate provided with a layer electrode 审中-公开
标题翻译：制备具有层状电极的亲水性基材的方法
公开(公告)号：US20050191431A1
公开(公告)日：2005-09-01
申请号：US11043536
申请日：2005-01-26
申请人： Carina Horn , Volker Unkrig , Christine Nortmeyer
发明人： Carina Horn , Volker Unkrig , Christine Nortmeyer
IPC分类号： C23C8/02 , C23C26/00 , C23C28/00 , C23C28/02 , G01N27/30 , G01N33/487 , G01N27/26
CPC分类号： C23C26/00 , C23C8/02 , G01N27/3272
摘要： The present invention is generally directed towards a method for producing an analytical test strip. More particularly to a method of producing a test strip having an insulating substrate provided with a layer electrode wherein the test strip has an increased hydrophilic property.
摘要翻译：本发明通常涉及用于生产分析测试条的方法。更具体地说，涉及制造具有设置有层状电极的绝缘基板的测试条的方法，其中测试条具有增加的亲水性。

6. 发明申请

US20050142032A1 Test system for determining an analyte in a liquid sample 审中-公开
标题翻译：用于测定液体样品中分析物的测试系统
公开(公告)号：US20050142032A1
公开(公告)日：2005-06-30
申请号：US10977379
申请日：2004-10-29
申请人： Joachim Hoenes , Christine Nortmeyer , Carina Horn
发明人： Joachim Hoenes , Christine Nortmeyer , Carina Horn
IPC分类号： G01N33/48 , G01N33/483 , G01N33/52 , G01N33/72 , G01N33/86 , G01N33/543
CPC分类号： G01N33/86 , G01N33/526 , G01N33/723
摘要： A test system for determining an analyte in a liquid sample is provided comprising at least two compartments, wherein the detection reactions necessary to determine the analyte are carried out in a first compartment and an analytical determination of at least one substance which participates in the detection reactions and is different from the analyte, the indicator substance, takes place in a second compartment. The two compartments are separated from one another in a manner which allows the indicator substance to pass into the second compartment and at least partially prevents passage of other substances that could interfere with the analytical determination of the indicator substance in the second compartment. At least one other substance is present in an immobilized form in the second compartment which, as a capture substance, selectively enriches the indicator substance in the second compartment. The indicator substance is not a coenzyme and at the same time the capture substance is not a catalytically inactive coenzyme-binding protein.
摘要翻译：提供了用于确定液体样品中的分析物的测试系统，其包括至少两个隔室，其中确定分析物所需的检测反应在第一隔室中进行，并且对参与检测反应的至少一种物质进行分析测定并且与分析物不同，指示剂物质发生在第二隔室中。两个隔室以允许指示剂物质进入第二隔室的方式彼此分开，并且至少部分地防止可能干扰第二隔室中指示剂物质的分析确定的其它物质的通过。至少一种其它物质以固定形式存在于第二隔室中，其作为捕获物质选择性地富集第二隔室中的指示剂物质。指示物质不是辅酶，同时捕获物质不是催化活性的辅酶结合蛋白。

7. 发明授权

US09359634B2 Fast reaction kinetics of enzymes having low activity in dry chemistry layers 有权
标题翻译：在干化学层中具有低活性的酶的快速反应动力学
公开(公告)号：US09359634B2
公开(公告)日：2016-06-07
申请号：US13210564
申请日：2011-08-16
申请人： Carina Horn , Claudia Gaessler-Dietsche , Dieter Heindl , Joachim Hoenes , Thomas Meier , Rainer Schmuck
发明人： Carina Horn , Claudia Gaessler-Dietsche , Dieter Heindl , Joachim Hoenes , Thomas Meier , Rainer Schmuck
IPC分类号： C12Q1/54 , C12N11/00 , C12N11/02 , C12N11/14 , C12N9/04 , C12Q1/32
CPC分类号： C12Q1/54 , C12N9/0006 , C12N11/00 , C12N11/02 , C12N11/14 , C12Q1/32
摘要： The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer. The dry reagent layer contains a mutated dehydrogenase which is specific for the analyte and an artificial coenzyme. The method also includes determining at least one of analyte presence and an amount of the analyte.
摘要翻译：本发明涉及一种用于确定分析物的方法以及因此合适的诊断元件。在一种具体形式中，用于确定分析物的方法包括使含有分析物的样品与包含干试剂层的诊断元件接触。干试剂层含有对分析物和人工辅酶特异的突变脱氢酶。该方法还包括确定分析物存在和分析物的量中的至少一种。

8. 发明申请

US20140322737A1 FAST REACTION KINETICS OF ENZYMES HAVING LOW ACTIVITY IN DRY CHEMISTRY LAYERS 有权
标题翻译：在干燥化学物质层中具有低活性的酶的快速反应动力学
公开(公告)号：US20140322737A1
公开(公告)日：2014-10-30
申请号：US13210564
申请日：2011-08-16
申请人： Carina Horn , Claudia Gaessler-Dietsche , Dieter Heindl , Joachim Hoenes , Thomas Meier , Rainer Schmuck
发明人： Carina Horn , Claudia Gaessler-Dietsche , Dieter Heindl , Joachim Hoenes , Thomas Meier , Rainer Schmuck
IPC分类号： C12Q1/54 , C12Q1/32
CPC分类号： C12Q1/54 , C12N9/0006 , C12N11/00 , C12N11/02 , C12N11/14 , C12Q1/32
摘要： The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer. The dry reagent layer contains a mutated dehydrogenase which is specific for the analyte and an artificial coenzyme. The method also includes determining at least one of analyte presence and an amount of the analyte.
摘要翻译：本发明涉及一种用于确定分析物的方法以及因此合适的诊断元件。在一种具体形式中，用于确定分析物的方法包括使含有分析物的样品与包含干试剂层的诊断元件接触。干试剂层含有对分析物和人工辅酶特异的突变脱氢酶。该方法还包括确定分析物存在和分析物的量中的至少一种。

9. 发明申请

US20100221699A1 AMINE-N-OXIDE REDOX INDICATORS FOR FLUORIMETRIC DETERMINATION OF ANALYTES 有权
标题翻译：用于荧光测定分析仪的胺-N-氧化物氧化还原指示剂
公开(公告)号：US20100221699A1
公开(公告)日：2010-09-02
申请号：US12757372
申请日：2010-04-09
申请人： Carina Horn , Joachim Hoenes , Jürgen Spinke
发明人： Carina Horn , Joachim Hoenes , Jürgen Spinke
IPC分类号： C12Q1/00 , C07D271/12 , G01N21/64
CPC分类号： G01N21/6428 , G01N2021/7786 , Y10T436/104998 , Y10T436/106664 , Y10T436/144444
摘要： A reagent for detecting an analyte by a redox reaction and a fluorimetric determination is disclosed. The reagent comprises a compound of formula (I): wherein R1 and R2 are each independently selected from R, (CH2CH2O)mR, COR, COOR, and OCOR; each R3 is independently selected from NO2, CN, R, OR, OCOR, COOR, SR, and halogen; R is H or C1-C4 alkyl, where alkyl is optionally substituted with one or more functional group independently selected from the group consisting of halogen, OR, SR, NR2, COOR, CONR2, SO3R and salts thereof, and PO(OR)3 and salts thereof; m is an integer from 1 to 20; and n is 1, 2, or 3. The reagent may further comprise an enzyme or a coenzyme for reducing or oxidizing an analyte.
摘要翻译：公开了一种用于通过氧化还原反应和荧光测定来检测分析物的试剂。试剂包含式（I）化合物：其中R 1和R 2各自独立地选自R，（CH 2 CH 2 O）m R，COR，COOR和OCOR; 每个R 3独立地选自NO 2，CN，R，OR，OCOR，COOR，SR和卤素; R是H或C 1 -C 4烷基，其中烷基任选被一个或多个独立地选自卤素，OR，SR，NR 2，COOR，CONR 2，SO 3 R及其盐和PO（OR）3的官能团取代及其盐; m为1〜20的整数; 并且n为1,2或3.试剂可以进一步包含用于还原或氧化分析物的酶或辅酶。

10. 发明授权

US07553615B2 Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH 有权
标题翻译：与稳定形式的NAD / NADH相关的化合物，方法，复合物，装置和用途
公开(公告)号：US07553615B2
公开(公告)日：2009-06-30
申请号：US11460366
申请日：2006-07-27
申请人： Dieter Heindl , Joachim Hoenes , Carina Horn , Piet Herdewijn
发明人： Dieter Heindl , Joachim Hoenes , Carina Horn , Piet Herdewijn
IPC分类号： C12Q1/00 , C12Q1/32 , C07H19/207
CPC分类号： C07D405/14 , C07D403/12 , C07D403/14 , C07H19/04 , C07H19/167 , C12Q1/32 , C12Q1/54 , G01N2333/90209
摘要： The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their use in biochemical detection methods and reagent matrices.
摘要翻译：本发明涉及稳定的烟酰胺腺嘌呤二核苷酸（NAD / NADH）和烟酰胺腺嘌呤二核苷酸磷酸（NADP / NADPH）衍生物，这些衍生物的酶复合物及其在生化检测方法和试剂基质中的应用。

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