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1. 发明授权

US07220828B2 Haemopoietin receptor and genetic sequence encoding same 失效
标题翻译：促血细胞生成素受体和编码相同的遗传序列
公开(公告)号：US07220828B2
公开(公告)日：2007-05-22
申请号：US09037657
申请日：1998-03-10
申请人： Tracy Willson , Nicos A. Nicola , Douglas J. Hilton , Jian-Guo Zhang , Alison Farley , Warren Alexander , Steven Rakar , Yasufumi Kikuchi , Tetsuo Kojima , Masatsugu Maeda , Louis Fabri , Andrew Nash
发明人： Tracy Willson , Nicos A. Nicola , Douglas J. Hilton , Jian-Guo Zhang , Alison Farley , Warren Alexander , Steven Rakar , Yasufumi Kikuchi , Tetsuo Kojima , Masatsugu Maeda , Louis Fabri , Andrew Nash
IPC分类号： C07K14/715 , C12N15/09 , A61K38/00
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00
摘要： The present invention relates generally to a novel haemopoietin receptor or derivatives thereof and to genetic sequences encoding same. Interaction between the novel receptor of the present invention and a cytokine ligand facilitates proliferation, differentiation and survival of a wide variety of cells. The novel receptor and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor.
摘要翻译：本发明一般涉及一种新型促血细胞生成素受体或其衍生物和编码该基因的遗传序列。本发明的新型受体与细胞因子配体之间的相互作用促进多种细胞的增殖，分化和存活。本发明的新受体及其衍生物和编码本发明的遗传序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂，治疗剂和诊断试剂。

2. 发明申请

US20060294608A1 Novel haemopoietin receptor and genetic sequences encoding same 审中-公开
标题翻译：新型造血素受体和编码相同的遗传序列
公开(公告)号：US20060294608A1
公开(公告)日：2006-12-28
申请号：US11509410
申请日：2006-08-24
申请人： Douglas Hilton , Nicos Nicola , Alison Farley , Tracy Willson , Jian-Guo Zhang , Warren Alexander , Steven Rakar , Louis Fabri , Tetsuo Kojima , Masatsugu Maeda , Yasufumi Kikuchi , Andrew Nash
发明人： Douglas Hilton , Nicos Nicola , Alison Farley , Tracy Willson , Jian-Guo Zhang , Warren Alexander , Steven Rakar , Louis Fabri , Tetsuo Kojima , Masatsugu Maeda , Yasufumi Kikuchi , Andrew Nash
IPC分类号： A01K67/027 , C07H21/04 , C12P21/06 , C07K14/71 , C07K16/28
CPC分类号： C07K14/715 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0381 , C07K16/2866 , C12N15/8509
摘要： The present invention relates generally to a novel haemopoietin receptor or derivatives thereof and to genetic sequences encoding same. Interaction between the novel receptor of the present invention and a cytokine ligand facilitates proliferation, differentiation and survival of a wide variety of cells. The novel receptor and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor.
摘要翻译：本发明一般涉及一种新型促血细胞生成素受体或其衍生物和编码该基因的遗传序列。本发明的新型受体与细胞因子配体之间的相互作用促进多种细胞的增殖，分化和存活。本发明的新受体及其衍生物和编码本发明的遗传序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂，治疗剂和诊断试剂。

3. 发明授权

US09493569B2 Structural isomers of sc(Fv)2 有权
标题翻译： sc（Fv）2的结构异构体
公开(公告)号：US09493569B2
公开(公告)日：2016-11-15
申请号：US11910117
申请日：2006-03-31
申请人： Tomoyuki Igawa , Hiroyuki Tsunoda , Akiko Koga , Yasufumi Kikuchi
发明人： Tomoyuki Igawa , Hiroyuki Tsunoda , Akiko Koga , Yasufumi Kikuchi
IPC分类号： C07K16/00 , C12P21/08 , A61K39/00 , A61K51/10 , C07K16/28
CPC分类号： C07K16/2866 , C07K2317/622 , C07K2317/626 , C07K2317/75
摘要： Structural isomers in sc(Fv)2 compositions of anti-human Mpl antibody and humanized anti-human Mpl antibody were separated, and the obtained structural isomers were cleaved at their linkers to confirm that the structural isomers are of single chain diabody type and bivalent scFv type. In addition, the agonistic activities of these structural isomers were revealed to be significantly different. Furthermore, the present inventors discovered that the content ratio of the structural isomers in sc(Fv)2 compositions could be regulated by altering temperature, modifying lengths of the linkers of sc(Fv)2, or amino acids in their variable regions.
摘要翻译：分离抗人Mpl抗体和人源化抗人Mpl抗体的sc（Fv）2组合物中的结构异构体，将得到的结构异构体在其接头上切割，以确认结构异构体是单链双抗体型和二价scFv 类型。此外，这些结构异构体的激动活性显示出显着差异。此外，本发明人发现sc（Fv）2组合物中的结构异构体的含量比可以通过改变温度，改变sc（Fv）2的接头的长度或其可变区中的氨基酸来调节。

4. 发明授权

US08759025B2 Humanized anti-CD47 antibody 有权
标题翻译：人源化抗CD47抗体
公开(公告)号：US08759025B2
公开(公告)日：2014-06-24
申请号：US13329658
申请日：2011-12-19
申请人： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
发明人： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
IPC分类号： C12P21/06 , C12N15/87 , C12N5/02 , C12N5/20 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C07K16/2803 , C07K2317/24 , C07K2317/50 , C07K2317/73
摘要： The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host cells containing said vectors; processes for preparing antibodies comprising the step of culturing said host cells; and therapeutic agents for hematological disorders comprising said antibodies.
摘要翻译：本发明涉及与CD47结合的人源化抗体; 结合人CD47的双抗体，其特征在于二糖键存在于形成双抗体的片段之间; 编码任何一种所述抗体的基因; 含有所述基因的载体; 含有所述载体的宿主细胞; 制备抗体的方法包括培养所述宿主细胞的步骤; 和包含所述抗体的血液病症治疗剂。

5. 发明授权

US07696325B2 Polypeptide inducing apoptosis 失效
标题翻译：多肽诱导细胞凋亡
公开(公告)号：US07696325B2
公开(公告)日：2010-04-13
申请号：US10221131
申请日：2001-03-12
申请人： Naoshi Fukushima , Masayuki Tsuchiya , Masayoshi Oh-Eda , Shinsuke Uno , Yasufumi Kikuchi
发明人： Naoshi Fukushima , Masayuki Tsuchiya , Masayoshi Oh-Eda , Shinsuke Uno , Yasufumi Kikuchi
IPC分类号： C07K16/00
CPC分类号： C07K16/28 , A61K38/00 , A61K2039/505 , C07K16/18 , C07K16/3061 , C07K2317/56 , C07K2317/622 , C07K2317/73
摘要： This invention relates to reconstructed polypeptides which have properties of inducing apoptosis of nucleated blood cells having Integrin Associated Protein (IAP) and causing no hemagglutination. The reconstructed polypeptides comprise two or more H chain V regions and two or more L chain V regions of a monoclonal antibody which induces apoptosis of nucleated blood cells having IAP. The reconstructed polypeptides are useful as a therapeutic agent for blood dyscrasia such as leukemia.
摘要翻译：本发明涉及具有诱导具有整合素相关蛋白（IAP）的有核血细胞凋亡的特性并且不引起血细胞凝集的重建多肽。重建的多肽包含诱导具有IAP的有核血细胞凋亡的单克隆抗体的两个或更多个H链V区和两个或更多个L链V区。重建的多肽可用作血液dyscrasia如白血病的治疗剂。

6. 发明申请

US20120156724A1 HUMANIZED ANTI-CD47 ANTIBODY 有权
标题翻译：人类抗CD47抗体
公开(公告)号：US20120156724A1
公开(公告)日：2012-06-21
申请号：US13329658
申请日：2011-12-19
申请人： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
发明人： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
IPC分类号： C12P21/00 , C12N15/63 , C12N1/19 , C12N5/10 , C12N1/15 , C12N15/13 , C12N1/21
CPC分类号： C07K16/2803 , C07K2317/24 , C07K2317/50 , C07K2317/73
摘要： The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host cells containing said vectors; processes for preparing antibodies comprising the step of culturing said host cells; and therapeutic agents for hematological disorders comprising said antibodies.
摘要翻译：本发明涉及与CD47结合的人源化抗体; 结合人CD47的双抗体，其特征在于二糖键存在于形成双抗体的片段之间; 编码任何一种所述抗体的基因; 含有所述基因的载体; 含有所述载体的宿主细胞; 制备抗体的方法包括培养所述宿主细胞的步骤; 和包含所述抗体的血液病症治疗剂。

7. 发明申请

US20090297501A1 Structural Isomers of sc(Fv)2 有权
标题翻译： sc（Fv）2的结构异构体
公开(公告)号：US20090297501A1
公开(公告)日：2009-12-03
申请号：US11910117
申请日：2006-03-31
申请人： Tomoyuki Igawa , Hiroyuki Tsunoda , Akiko Koga , Yasufumi Kikuchi
发明人： Tomoyuki Igawa , Hiroyuki Tsunoda , Akiko Koga , Yasufumi Kikuchi
IPC分类号： A61K39/395 , C12Q1/00 , A61P43/00
CPC分类号： C07K16/2866 , C07K2317/622 , C07K2317/626 , C07K2317/75
摘要： Structural isomers in sc(Fv)2 compositions of anti-human Mpl antibody and humanized anti-human Mpl antibody were separated, and the obtained structural isomers were cleaved at their linkers to confirm that the structural isomers are of single chain diabody type and bivalent scFv type. In addition, the agonistic activities of these structural isomers were revealed to be significantly different. Furthermore, the present inventors discovered that the content ratio of the structural isomers in sc(Fv)2 compositions could be regulated by altering temperature, modifying lengths of the linkers of sc(Fv)2, or amino acids in their variable regions.
摘要翻译：分离抗人Mpl抗体和人源化抗人Mpl抗体的sc（Fv）2组合物中的结构异构体，将得到的结构异构体在其接头上切割，以确认结构异构体是单链双抗体型和二价scFv 类型。此外，这些结构异构体的激动活性显示出显着差异。此外，本发明人发现sc（Fv）2组合物中的结构异构体的含量比可以通过改变温度，改变sc（Fv）2的接头的长度或其可变区中的氨基酸来调节。

8. 发明授权

US08101719B2 Humanized anti-CD47 antibody 有权
标题翻译：人源化抗CD47抗体
公开(公告)号：US08101719B2
公开(公告)日：2012-01-24
申请号：US10578840
申请日：2004-11-11
申请人： Yasufumi Kikuchi , Shinsuke Uno , Yasuka Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
发明人： Yasufumi Kikuchi , Shinsuke Uno , Yasuka Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
IPC分类号： C07K16/00 , C07K16/28
CPC分类号： C07K16/2803 , C07K2317/24 , C07K2317/50 , C07K2317/73
摘要： The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host cells containing said vectors; processes for preparing antibodies comprising the step of culturing said host cells; and therapeutic agents for hematological disorders comprising said antibodies.
摘要翻译：本发明涉及与CD47结合的人源化抗体; 结合人CD47的双抗体，其特征在于二糖键存在于形成双抗体的片段之间; 编码任何一种所述抗体的基因; 含有所述基因的载体; 含有所述载体的宿主细胞; 制备抗体的方法包括培养所述宿主细胞的步骤; 和包含所述抗体的血液病症治疗剂。

9. 发明申请

US20110065149A1 METHOD OF PRODUCING FUSED PROTEIN 审中-公开
标题翻译：生产融合蛋白的方法
公开(公告)号：US20110065149A1
公开(公告)日：2011-03-17
申请号：US12310258
申请日：2007-08-21
申请人： Shigeo Kato , Yoichi Kumada , Tomomi Kawasaki , Yasufumi Kikuchi
发明人： Shigeo Kato , Yoichi Kumada , Tomomi Kawasaki , Yasufumi Kikuchi
IPC分类号： C12P21/00 , C07H21/04 , C12N15/63 , C12N1/21 , C07H21/00
CPC分类号： C12N15/62 , C07K16/44 , C07K2317/622
摘要： Described herein is a polynucleotide encoding a fusion protein comprising two or more polypeptide domains and a polypeptide linker joining the domains, wherein the sequence of the polynucleotide encoding the polypeptide linker is selected such that when the mRNA transcribed from the polynucleotide is translated in a host cell transfected with the polynucleotide, the translation rate of the mRNA region encoding the polypeptide linker is slower than the translation rate of the mRNA region encoding the polypeptide domain immediately upstream thereof. Also provided are a vector transfected with the polynucleotide of the present invention so that the polynucleotide can be expressed in the host cell; a host cell transformed by that vector; and a process for producing a fusion protein comprising culturing the host cell, and recovering the fusion protein thus produced.
摘要翻译：本文描述了编码融合蛋白的多核苷酸，其包含两个或多个多肽结构域和连接结构域的多肽接头，其中选择编码多肽接头的多核苷酸序列，使得当从多核苷酸转录的mRNA在宿主细胞中翻译时用多核苷酸转染，编码多肽接头的mRNA区的翻译速率比编码紧邻其上游的多肽结构域的mRNA区的翻译速度慢。还提供了用本发明的多核苷酸转染的载体，使得多核苷酸可以在宿主细胞中表达; 由该载体转化的宿主细胞; 以及生产融合蛋白的方法，包括培养宿主细胞，并回收由此产生的融合蛋白。

10. 发明申请

US20080107654A1 Humanized Anti-Cd47 Antibody 有权
标题翻译：人源化抗Cd47抗体
公开(公告)号：US20080107654A1
公开(公告)日：2008-05-08
申请号：US10578840
申请日：2004-11-11
申请人： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
发明人： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , A61P7/00 , C12N5/06 , C12P21/04
CPC分类号： C07K16/2803 , C07K2317/24 , C07K2317/50 , C07K2317/73
摘要： The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host cells containing said vectors; processes for preparing antibodies comprising the step of culturing said host cells; and therapeutic agents for hematological disorders comprising said antibodies.
摘要翻译：本发明涉及与CD47结合的人源化抗体; 结合人CD47的双抗体，其特征在于二糖键存在于形成双抗体的片段之间; 编码任何一种所述抗体的基因; 含有所述基因的载体; 含有所述载体的宿主细胞; 制备抗体的方法包括培养所述宿主细胞的步骤; 和包含所述抗体的血液病症治疗剂。

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