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1. 发明授权

US5182404A Biphenyl derivatives, process for preparing the same and intermediates therefor 失效
标题翻译：联苯衍生物，其制备方法及其中间体
公开(公告)号：US5182404A
公开(公告)日：1993-01-26
申请号：US821215
申请日：1992-01-15
申请人： Tameo Iwasaki , Kazuhiko Kondo , Yuzo Matsuoka , Mamoru Matsumoto , Masaki Sugiura
发明人： Tameo Iwasaki , Kazuhiko Kondo , Yuzo Matsuoka , Mamoru Matsumoto , Masaki Sugiura
IPC分类号： C07C45/51 , C07C65/21 , C07C69/94 , C07D317/68
CPC分类号： C07D317/68 , C07C45/515 , C07C65/21 , C07C69/94
摘要： Novel biphenyl derivatives of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted aminocarbonyl group, aminothiocarbonyl group, a substituted or unsubstituted lower alkoxycarbonyl group, cyano group, or a group of the formula: ##STR2## one or two of R.sup.2 to R.sup.7 are hydrogen atom, and the remaining groups are the same or different and are each a lower alkoxy group, a phenyl-(lower)alkoxy group or hydroxy group, or the adjacent two groups thereof combine to form a lower alkylenedioxy group, and Alk.sup.1 is a lower alkylene group,or a pharmaceutically acceptable salt thereof, which are useful for the prophylaxis and treatment of hepatic diseases, and processes for preparing the same, and intermediates therefor.
摘要翻译：下式的新型联苯衍生物：其中R1是取代或未取代的氨基羰基，氨基硫代羰基，取代或未取代的低级烷氧基羰基，氰基或下式的基团：其中R 1〜 R7是氢原子，其余基团相同或不同，各自为低级烷氧基，苯基 - （低级）烷氧基或羟基，或其相邻的两个基团组合形成低级亚烷基二氧基，Alk1 是用于预防和治疗肝脏疾病的低级亚烷基或其药学上可接受的盐及其制备方法及其中间体。

2. 发明授权

US5233057A Biphenyl derivatives, process for preparing the same and intermediates therefor 失效
标题翻译：联苯衍生物，其制备方法及其中间体
公开(公告)号：US5233057A
公开(公告)日：1993-08-03
申请号：US955133
申请日：1992-10-01
申请人： Tameo Iwasaki , Kazuhiko Kondo , Yuzo Matsuoka , Mamoru Matsumoto , Masaki Sugiura
发明人： Tameo Iwasaki , Kazuhiko Kondo , Yuzo Matsuoka , Mamoru Matsumoto , Masaki Sugiura
IPC分类号： C07C45/51 , C07C65/21 , C07C69/94 , C07D317/68
CPC分类号： C07D317/68 , C07C45/515 , C07C65/21 , C07C69/94
摘要： Novel biphenyl derivatives of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted aminocarbonyl group, aminothiocarbonyl group, a substituted or unsubstituted lower alkoxycarbonyl group, cyano group, or a group of the formula: ##STR2## one or two of R.sup.2 to R.sup.7 are hydrogen atom, and the remaining groups are the same or different and are each a lower alkoxy group, a phenyl(lower)alkoxy group or hydroxy group, or the adjacent two groups thereof combine to form a lower alkylenedioxy group, and Alk.sup.1 is a lower alkylene group, or a pharmaceutically acceptable salt thereof, which are useful for the prophylaxis and treatment of hepatic diseases, and processes for preparing the same, and intermediates therefor.
摘要翻译：下式的新型联苯衍生物：其中R1是取代或未取代的氨基羰基，氨基硫代羰基，取代或未取代的低级烷氧基羰基，氰基或下式的基团：其中R 1〜 R7为氢原子，其余基团相同或不同，各自为低级烷氧基，苯基（低级）烷氧基或羟基，或其相邻的两个基团结合形成低级亚烷基二氧基，Alk1为可用于预防和治疗肝病的低级亚烷基或其药学上可接受的盐及其制备方法及其中间体。

3. 发明授权

US5103023A Biphenyl derivatives, process for preparing the same and intermediates therefor 失效
标题翻译：联苯衍生物，其制备方法及其中间体
公开(公告)号：US5103023A
公开(公告)日：1992-04-07
申请号：US529792
申请日：1990-05-29
申请人： Tameo Iwasaki , Kazuhiko Kondo , Yuzo Matsuoka , Mamoru Matsumoto , Masaki Sugiura
发明人： Tameo Iwasaki , Kazuhiko Kondo , Yuzo Matsuoka , Mamoru Matsumoto , Masaki Sugiura
IPC分类号： A61K31/165 , A61K31/235 , A61K31/275 , A61K31/357 , A61K31/36 , A61K31/42 , A61K31/421 , A61P1/16 , C07C45/51 , C07C65/105 , C07C65/21 , C07C65/24 , C07C69/94 , C07C231/02 , C07C235/46 , C07C235/48 , C07C253/06 , C07C255/53 , C07C255/54 , C07C327/48 , C07D263/14 , C07D317/68 , C07D413/04
CPC分类号： C07D317/68 , C07C45/515 , C07C65/21 , C07C69/94
摘要： Novel biphenyl derivatives of the formula: wherein R.sup.1 is a substituted or unsubstituted aminocarbonyl group, aminothiocarbonyl group, a substituted or unsubstituted lower alkoxycarbonyl group, cyano group, or a group of the formula: ##STR1## one or two of R.sup.2 to R.sup.7 are hydrogen atom, and the remaining groups are the same or different and are each a lower alkoxy group, a phenyl(lower)alkoxy group or hydroxy group, or the adjacent two groups thereof combine to form a lower alkylenedioxy group, and Alk.sup.1 is a lower alkylene group, or a pharmaceutically acceptable salt thereof, which are useful for the prophylaxis and treatment of hepatic diseases, and processes for preparing the same, and intermediates therefor.

4. 发明授权

US5066669A Benzofuran derivatives 失效
标题翻译： BENZOFURAN衍生物
公开(公告)号：US5066669A
公开(公告)日：1991-11-19
申请号：US489565
申请日：1990-03-07
申请人： Tameo Iwasaki , Masaki Sugiura , Yuzo Matsuoka , Mamoru Matsumoto , Kazuyuki Kitamura
发明人： Tameo Iwasaki , Masaki Sugiura , Yuzo Matsuoka , Mamoru Matsumoto , Kazuyuki Kitamura
IPC分类号： C07D333/54 , A61K31/34 , A61K31/365 , A61K31/38 , A61K31/381 , A61P1/16 , C07D307/79 , C07D307/83 , C07D333/64 , C07D407/04 , C07D409/04 , C07D493/04 , C07D495/04
CPC分类号： C07D493/04 , C07D495/04
摘要： A novel biphenyl derivative of the formula: ##STR1## wherein Ring A is a substituted or unsubstituted sulfur-containing or oxygen-containing heteromonocyclic ring; Ring B is a ring of the formula: ##STR2## each of R.sup.1 and R.sup.3 is hydrogen atom, a halogen atom or a lower alkoxy group, or R.sup.1 is hydrogen atom, and R.sup.2 and R.sub.3 are combined together to form a lower alkylenedioxy group; R.sup.4 is a lower alkyl group which may have a substituent selected from a lower alkoxy group and a lower alkoxycarbonyl group; Y is methylene group or carbonyl group, and a pharmaceutically acceptable salt thereof are disclosed. Said derivative and a pharmaceutically acceptable salt thereof are useful as a therapeutic or prophylactic agent for hepatic diseases.

5. 发明授权

US5169861A Benzothiophene compounds 失效
标题翻译：苯并噻吩化合物
公开(公告)号：US5169861A
公开(公告)日：1992-12-08
申请号：US645433
申请日：1991-01-24
申请人： Tameo Iwasaki , Masaki Sugiura , Yuzo Matsuoka , Mamoru Matsumoto , Kazuyuki Kitamura
发明人： Tameo Iwasaki , Masaki Sugiura , Yuzo Matsuoka , Mamoru Matsumoto , Kazuyuki Kitamura
IPC分类号： C07D493/04 , C07D495/04
CPC分类号： C07D493/04 , C07D495/04 , Y10S514/893 , Y10S514/894
摘要： A novel biphenyl derivative of the formula: ##STR1## wherein Ring A is a substituted or unsubstituted sulfur-containing or oxygen-containing heteromonocyclic ring; Ring B is a ring of the formula: ##STR2## each of R.sup.1 to R.sup.3 is hydrogen atom, a halogen atom or a lower alkoxy group, or R.sup.1 is hydrogen atom, and R.sup.2 and R.sup.3 are combined together to form a lower alkylenedioxy group; R.sup.4 is a lower alkyl group which may have a substituent selected from a lower alkoxy group and a lower alkoxycarbonyl group; Y is methylene group or carbonyl group, and a pharmaceutically acceptable salt thereof are disclosed. Said derivative and a pharmaceutically acceptable salt thereof are useful as a therapeutic or prophylactic agent for hepatic diseases.
摘要翻译：一种下式的新型联苯衍生物：其中环A是取代或未取代的含硫或含氧杂环; 环B是下式的环：R1至R3各自为氢原子，卤素原子或低级烷氧基，或R1为氢原子，R2和R3组合在一起形成低级亚烷基二氧基; R4是可以具有选自低级烷氧基和低级烷氧基羰基的取代基的低级烷基; Y是亚甲基或羰基，并且其药学上可接受的盐被公开。所述衍生物及其药学上可接受的盐可用作肝脏疾病的治疗或预防剂。

6. 发明授权

US4612317A Tetrahydro-.beta.-carboline dithioic acid derivatives and treatment of liver diseases 失效
标题翻译：四氢-β-咔啉二硫代酸衍生物和肝脏疾病的治疗
公开(公告)号：US4612317A
公开(公告)日：1986-09-16
申请号：US611965
申请日：1984-05-18
申请人： Ikuo Iijima , Yutaka Saiga , Toshikazu Miyagishima , Yuzo Matsuoka , Mamoru Matsumoto
发明人： Ikuo Iijima , Yutaka Saiga , Toshikazu Miyagishima , Yuzo Matsuoka , Mamoru Matsumoto
IPC分类号： C07D471/04 , A61K31/435 , A61K31/44 , A61P1/16 , C07D471/02 , H01H50/34 , H02K33/18
CPC分类号： C07D471/04
摘要： Tetrahydro-.beta.-carboline derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, a lower alkyl group, a cycloalkyl group, phenyl group or a hydroxy-substituted lower alkyl group, R.sup.2 is hydrogen atom, an alkyl group, or a group of the formula: --(CH.sub.2).sub.m Y, Y is thienyl or a substituted or unsubstituted phenyl group, and m and n are an integer of 1 or 2, which have excellent alleviating, curing and preventing hepatic damages and are useful as a therapeutic or prophylactic agent for hepatic diseases, and a process for the preparation of said compounds.
摘要翻译：下式的四氢-β-咔啉衍生物：其中R 1是氢原子，低级烷基，环烷基，苯基或羟基取代的低级烷基，R 2是氢原子，烷基，或下式的基团： - （CH 2）m Y，Y是噻吩基或取代或未取代的苯基，m和n是1或2的整数，其具有优异的缓解，固化和预防肝损伤，并且是有用的作为肝脏疾病的治疗或预防剂，以及所述化合物的制备方法。

7. 发明授权

US4663319A 3-(1,3-dithiol-2-ylidene)-2,4-dioxopyrrolidines, -piperidines, and -hexahydroazepines and use thereof against hepatic diseases 失效
标题翻译： 3-（1,3-二硫醇-2-亚基）-2,4-二氧代吡咯烷，哌啶和六氢吖庚因及其用于肝病
公开(公告)号：US4663319A
公开(公告)日：1987-05-05
申请号：US689261
申请日：1985-01-07
申请人： Ikuo Iijima , Koichi Homma , Yutaka Saiga , Yuzo Matsuoka , Mamoru Matsumoto
发明人： Ikuo Iijima , Koichi Homma , Yutaka Saiga , Yuzo Matsuoka , Mamoru Matsumoto
IPC分类号： C07D211/58 , A61K31/45 , A61K31/4523 , A61P1/16 , C07D207/38 , C07D211/86 , C07D211/90 , C07D213/02 , C07D213/38 , C07D213/40 , C07D213/69 , C07D223/10 , C07D295/06 , C07D339/06 , C07D401/06 , C07D409/04 , C07D409/12 , C07D409/14 , A61K31/55 , A61K31/445
CPC分类号： C07D213/40 , C07D207/38 , C07D211/86 , C07D211/90 , C07D213/38 , C07D213/69 , C07D223/10 , C07D339/06 , C07D401/06 , C07D409/04 , C07D409/12 , C07D409/14
摘要： Novel thioketene derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, an alkyl group, a lower alkenyl group, a phenyl group or a group of the formula: --B--Y;Y is a nitrogen-containing monocyclic heterocyclic group or a substituted or unsubstituted phenyl group;B is a straight or branched lower alkylene group;R.sup.2 and R.sup.3 are both a lower alkyl group or are combined together to form a group of the formula: --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--;R.sup.4 is hydrogen atom, a lower alkyl group or a (lower alkoxy)carbonyl group;A is a group of the formula: --(CH.sub.2).sub.n -- or --CH(COOR.sup.5)--;n is an integer of 0, 1 or 2 andR.sup.5 is a lower alkyl group,are disclosed. The compound (I) is useful as an agent for treating and protecting various liver diseases.
摘要翻译：具有下式的新型硫代烯酮衍生物：其中R 1是氢原子，烷基，低级烯基，苯基或下式基团：-B-Y; Y是含氮单环杂环基或取代或未取代的苯基; B是直链或支链低级亚烷基; R 2和R 3都是低级烷基或被结合在一起形成下式的基团：-CH 2 CH 2 - 或-CH = CH-; R4是氢原子，低级烷基或（低级烷氧基）羰基; A是下式的基团： - （CH 2）n - 或-CH（COOR 5） - ; n是0或1或2的整数，R5是低级烷基。化合物（I）可用作治疗和保护各种肝脏疾病的药剂。

8. 发明授权

US4762839A Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications 失效
标题翻译：喹唑啉酮可用于前列腺炎和治疗糖尿病并发症
公开(公告)号：US4762839A
公开(公告)日：1988-08-09
申请号：US866226
申请日：1986-05-22
申请人： Yoshihisa Yamada , Yuzo Matsuoka , Mamoru Matsumoto
发明人： Yoshihisa Yamada , Yuzo Matsuoka , Mamoru Matsumoto
IPC分类号： C07D239/96 , C07D487/10 , C07D491/20 , A61K31/505
CPC分类号： C07D487/10 , C07D239/96
摘要： Novel quinazolinone compounds of the formula: ##STR1## wherein R is hydrogen atom or a lower alkyl, R.sup.1 is a lower alkyl, a substituted or unsubstituted phenyl or an aralkyl, and R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and are each hydrogen atom, a halogen atom, a lower alkyl, a lower alkoxy, a lower alkoxycarbonyl or a lower alkoxycarbonyl-lower alkenyl, or two adjacent groups of R.sup.2,R.sup.3, R.sup.4 and R.sup.5 when taken together form methylenedioxy and the other two are hydrogen atom, and a salt thereof, which are useful for the prophylaxis and treatment of various diabetic complications, and processes for the preparation thereof, and a pharmaceutical composition containing said compound as an active ingredient.
摘要翻译：新的喹唑啉酮化合物，其结构式如下：其中R是氢原子或低级烷基，R 1是低级烷基，取代或未取代的苯基或芳烷基，R 2，R 3，R 4和R 5是相同或不同且各自为氢原子，卤素原子，低级烷基，低级烷氧基，低级烷氧基羰基或低级烷氧基羰基 - 低级烯基，或两个相邻的R 2，R 3，R 4和R 5组合在一起形成亚甲二氧基，而另一个两个是可用于预防和治疗各种糖尿病并发症的氢原子及其盐及其制备方法，以及含有所述化合物作为活性成分的药物组合物。

9. 发明授权

US4628057A Tetrahydro-.beta.-carboline derivatives and treatment of liver diseases 失效
标题翻译：四氢-β-咔啉衍生物和肝脏疾病的治疗
公开(公告)号：US4628057A
公开(公告)日：1986-12-09
申请号：US666481
申请日：1984-10-30
申请人： Ikuo Iijima , Yutaka Saiga , Toshikazu Miyagishima , Yuzo Matsuoka , Mamoru Matsumoto
发明人： Ikuo Iijima , Yutaka Saiga , Toshikazu Miyagishima , Yuzo Matsuoka , Mamoru Matsumoto
IPC分类号： A61K31/435 , A61P1/16 , A61P3/06 , C07D471/04 , C07D498/18 , A61K31/395 , C07D471/02
CPC分类号： C07D471/04
摘要： Novel tetrahydro-.beta.-carboline derivatives of the formula: ##STR1## wherein R.sup.1 is carboxyl, a lower alkoxycarbonyl, carbamoyl, an N,N-di-lower alkylcarbamoyl, an N-(phenyl-substituted lower alkylidenamino)carbamoyl, a [N,N-di(lower alkyl)amino]-lower alkyl, or a nitrogen-containing monocyclic heterocyclic group;R.sup.2 is hydrogen atom, a lower alkyl, or a hydroxy-lower alkyl group, or R.sup.2 is combined with R.sup.1 to form a group: --CO--O--CH.sub.2 --;R.sup.3 is hydrogen atom, a lower alkyl, a phenyl-lower alkyl, or a group: --CSS--R.sup.4 ;R.sup.4 is hydrogen atom, an alkyl, or a group: --(CH.sub.2).sub.n Y.sup.1 ;n is 0, 1 or 2,Y.sup.1 is a lower alkenyl, a phenyl-substituted lower alkenyl, an N,N-di(lower alkyl)amino, a lower alkylmercapto, a lower alkoxycarbonyl, benzoyl, naphthyl, a cycloalkyl, a monocyclic heterocyclic group, or a substituted or unsubstituted phenyl, which have excellent activities for alleviating, curing and preventing hepatic damages and are useful as a therapeutic or prophylactic agent for hepatic diseases,and processes for the preparation thereof, and a pharmaceutical composition containing the above compound as an active ingredient.
摘要翻译：其中R 1是羧基，低级烷氧基羰基，氨基甲酰基，N，N-二低级烷基氨基甲酰基，N-（苯基取代的低级亚烷基氨基）氨基甲酰基，[N ，N-二（低级烷基）氨基] - 低级烷基或含氮单环杂环基; R2是氢原子，低级烷基或羟基 - 低级烷基，或R2与R1结合形成基团：-CO-O-CH 2 - ; R3是氢原子，低级烷基，苯基 - 低级烷基或基团：-CSS-R4; R4是氢原子，烷基或基团： - （CH2）nY1; n是0,1或2，Y1是低级烯基，苯基取代的低级烯基，N，N-二（低级烷基）氨基，低级烷基巯基，低级烷氧基羰基，苯甲酰基，萘基，环烷基，单环杂环基或取代或未取代的苯基，其具有优异的缓解，固化和预防肝损伤的活性，并且可用作肝脏疾病的治疗或预防剂及其制备方法，以及含有上述化合物的药物组合物作为活性成分。

10. 发明授权

US4625032A Tetrahydro-.beta.-carboline derivatives 失效
标题翻译：四氢-β-咔啉衍生物
公开(公告)号：US4625032A
公开(公告)日：1986-11-25
申请号：US741133
申请日：1985-06-04
申请人： Ikuo Iijima , Yutaka Saiga , Toshikazu Miyagishima , Yuzo Matsuoka , Mamoru Matsumoto
发明人： Ikuo Iijima , Yutaka Saiga , Toshikazu Miyagishima , Yuzo Matsuoka , Mamoru Matsumoto
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Tetrahydro-.beta.-carboline derivative of the formula: ##STR1## wherein R.sup.2 is lower alkyl, and either (A)R.sup.1 is hydroxymethyl or carboxy,R.sup.3 and R.sup.4 are both hydrogen, andX is halogen, lower alkyl, lower alkoxy, hydroxy or benzyloxy; or(B)R.sup.1 is hydrogen, carboxy-lower alkyl or a group of the formula: --CH.sub.2 OY,Y is lower alkyl, lower alkanoyl or an oxygen-containing monocyclic heterocyclic group,R.sup.3 is hydrogen, hydroxy-lower alkyl or carboxy,R.sup.4 is hydrogen or hydroxy-lower alkyl, andX is hydrogen,or a salt thereof, which has excellent activities for alleviating, curing and preventing hepatic damages and is useful as a therapeutic or prophylactic agent for hepatic diseases.
摘要翻译：下式的四氢-β-咔啉衍生物：其中R 2是低级烷基，和（A）R 1是羟甲基或羧基，R 3和R 4都是氢，X是卤素，低级烷基，低级烷氧基，羟基或苄氧基; 或（B）R 1是氢，羧基 - 低级烷基或下式基团：-CH 2 OY，Y是低级烷基，低级烷酰基或含氧单环杂环基，R 3是氢，羟基 - 低级烷基或羧基，R 4 是氢或羟基 - 低级烷基，X是氢或其盐，其具有优异的缓解，固化和预防肝损伤的活性，并且可用作肝脏疾病的治疗或预防剂。

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