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1. 发明申请

US20100178268A1 BIOCIDIC PACKAGING FOR COSMETICS AND FOODSTUFFS 审中-公开
标题翻译：生物化学包装用于化妆品和食品
公开(公告)号：US20100178268A1
公开(公告)日：2010-07-15
申请号：US12598433
申请日：2008-04-03
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A61K31/74
CPC分类号： A61L2/16 , A01N25/34 , A01N37/08 , A01N37/20 , A01N41/04 , A01N61/00 , A23L3/3463
摘要： The present invention presents a biocidic packaging for cosmetics and/or foodstuffs, comprises at least one insoluble proton sink or source (PSS). The packaging is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of said LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of said LTCs' environment. The present invention also discloses a method for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of said LTC being in a packaging, especially cosmetic or foodstuffs' packaging.
摘要翻译：本发明提出了一种用于化妆品和/或食品的生物杀伤剂包装，包括至少一种不溶性质子沉或源（PSS）。提供的包装用于杀死活的靶细胞（LTC）或以其他方式破坏接触时所述LTC的细胞内过程和/或细胞间相互作用。 PSS尤其包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS有效地破坏LTC的限制体积内的pH稳态和/或电气平衡和/或破坏LTC的重要的细胞间相互作用，同时有效地保持所述LTC的环境的pH。本发明还公开了一种用于杀死活的靶细胞（LTC）或以其它方式破坏所述LTC在包装，特别是化妆品或食品包装中的细胞内过程和/或细胞间相互作用的方法。

2. 发明申请

US20080314751A1 Electrophoretic Separation of Analytes by Molecular Mass 审中-公开
标题翻译：分子质量分析物的电泳分离
公开(公告)号：US20080314751A1
公开(公告)日：2008-12-25
申请号：US11994791
申请日：2006-07-05
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： B01D59/42 , G01N27/447
CPC分类号： G01N27/44747
摘要： The present invention relates to a method and apparatus for the separation of analytes based on their molecular weight, by application of an electric field across a low-friction matrix that includes with a charged separation agent. The matrix comprises charged regions ordered in a monotonous sequence distributed throughout the matrix so as to generate a charge density gradient. When an external electric field is applied, the complex will move through the different charged regions and focusing of different analytes in different charge regions will occur. These systems are suitable for planar, capillary in-tube electrophoresis, as well as multi-channel arrays of capillaries filled with charge gradient gels, serial arrays of discrete compartments with charge density gradient, arrays in a chip format, pre-designed mass focusing arrays for specific protein masses in application for protein and DNA marker diagnostics, and multi compartment trapping devices for specific mass ranges.
摘要翻译：本发明涉及通过在包含带电分离剂的低摩擦基质上施加电场来分离基于其分子量的分析物的方法和装置。矩阵包括以分布在整个矩阵中的单调序列排列的带电区域，以产生电荷密度梯度。当施加外部电场时，复合体将移动穿过不同的充电区域，并且将发生不同分析物在不同电荷区域中的聚焦。这些系统适用于平面，毛细管内电泳，以及填充有电荷梯度凝胶的多通道阵列的毛细管阵列，具有电荷密度梯度的离散隔室的串行阵列，芯片格式的阵列，预先设计的质量聚焦阵列用于蛋白质和DNA标记诊断的特定蛋白质质量，以及用于特定质量范围的多隔室捕获装置。

3. 发明授权

US08697102B2 Compositions and methods for cell killing 失效
标题翻译：细胞杀伤的组合物和方法
公开(公告)号：US08697102B2
公开(公告)日：2014-04-15
申请号：US12823354
申请日：2010-06-25
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A01N25/34 , A61K31/74
CPC分类号： A61L31/16 , A01N25/10 , A01N27/00 , A01N41/08 , A61K31/745 , A61K31/795 , A61L2/232 , A61L15/24 , A61L15/44 , A61L17/005 , A61L17/145 , A61L31/10 , A61L2202/26 , A61L2300/404 , A61L2300/606 , A61L2420/00 , Y02A50/471 , A01N33/12 , A01N37/18 , A01N41/04
摘要： A solid buffer including one or more ion exchange materials, wherein said solid buffer has a volumetric buffering capacity greater than about 20 mM H+/(L.pH unit) and further wherein, when said material is in an environment capable of transporting H+ ions, said solid buffer is adapted to cause the death of at least one target cell within or in contact with said environment. A selectively permeable barrier layer may be provided covering the solid buffer.
摘要翻译：一种包含一种或多种离子交换材料的固体缓冲液，其中所述固体缓冲液具有大于约20mM H + /（L.pH单位）的体积缓冲能力，此外，当所述材料处于能够输送H +离子的环境中时，所述固体缓冲液适于引起至少一个目标细胞在所述环境中或与所述环境接触中的死亡。可以提供覆盖固体缓冲液的选择性可渗透阻挡层。

4. 发明申请

US20100136077A1 BIOCIDIC HOUSEHOLD CLEANSING MATERIALS 审中-公开
标题翻译：生物化学家用清洁材料
公开(公告)号：US20100136077A1
公开(公告)日：2010-06-03
申请号：US12598428
申请日：2008-04-03
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A01N61/00 , A01N25/00 , C08F112/08
CPC分类号： A01N61/00 , A61L2/22 , C11D3/48 , C11D17/049 , Y10T442/10 , Y10T442/60
摘要： The present invention discloses household cleaning materials comprising at least one insoluble proton sink or source (PSS) and to method for utilizing the PSS as a biocidic agent. The household cleaning materials are provided useful for killing living target cells (LTCs) or otherwise inhibiting LTCs growth, disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The household cleaning materials consisting of at least one PSS, comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of said LTC and/or disrupting vital intercellular interactions of said LTCs while efficiently preserving the pH of said LTCs' environment.
摘要翻译：本发明公开了包含至少一种不溶性质子沉或源（PSS）的家用清洁材料以及将PSS用作生物杀伤剂的方法。家用清洁材料可用于杀死活细胞（LTC）或以其他方式抑制LTC的生长，破坏LTC在接触时的重要细胞内过程和/或细胞间相互作用。由至少一个PSS组成的家用清洁材料尤其包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS有效地破坏所述LTC的限定体积内的pH稳态和/或电平衡和/或破坏所述LTC的重要细胞间相互作用，同时有效地保持所述LTC的环境的pH。

5. 发明申请

US20100087769A1 BIOCIDIC MEDICAL DEVICES, IMPLANTS AND WOUND DRESSINGS 审中-公开
标题翻译：生物医疗器械，植入物和创新衣服
公开(公告)号：US20100087769A1
公开(公告)日：2010-04-08
申请号：US12598429
申请日：2008-04-03
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A61F13/00 , A61L27/50 , A61L15/42 , A61L2/00
CPC分类号： A61L27/54 , A61L15/44 , A61L29/16 , A61L31/16 , A61L2300/20 , A61L2300/404
摘要： The present invention discloses a medical device selected from a group consisting of medical devices, implants wound dressings, comprises at least one insoluble proton sink or source (PSS). The medical device is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment.
摘要翻译：本发明公开了一种从包括医疗装置，植入物伤口敷料组成的组中选择的医疗装置，其包括至少一个不溶性质子沉或源（PSS）。提供的医疗装置可用于杀死活细胞（LTC），或以其他方式破坏LTC在接触时的重要的细胞内过程和/或细胞间相互作用。 PSS尤其包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS正在有效地破坏LTC的限制体积内的pH稳态和/或电气平衡和/或破坏LTC的重要的细胞间相互作用，同时有效地保持LTC的环境的pH。

6. 发明申请

US20130040026A1 EXTENDED SHELF-LIFE LIQUIDS AND METHOD THEREOF 审中-公开
标题翻译：延长寿命的液体及其方法
公开(公告)号：US20130040026A1
公开(公告)日：2013-02-14
申请号：US13512969
申请日：2010-12-02
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A23L2/44 , A01N41/04 , A01P1/00 , A01N61/00
CPC分类号： A01N25/10 , A01N33/12 , A01N41/04 , A23L2/44 , A23L3/3463 , A23L3/3526 , A23L3/3535
摘要： A method of producing a liquid substantially free of beverage spoiling microorganisms, characterized in that said method comprises steps of: (a) obtaining a liquid; (b) obtaining a bioactive material that does not affect a predetermined set of organoleptic parameters of said liquid upon contact with said concentrate for a predetermined length of time; and, (c) treating said liquid with said bioactive material until the concentration of beverage-spoiling microorganism falls below a predetermined threshold.
摘要翻译：一种生产基本上不含饮料破坏微生物的液体的方法，其特征在于所述方法包括以下步骤：（a）获得液体; （b）获得生物活性材料，所述生物活性材料在与所述浓缩物接触预定长度的时间后不影响所述液体的预定组感官参数; 和（c）用所述生物活性材料处理所述液体，直到饮料破坏微生物的浓度降到预定阈值以下。

7. 发明申请

US20110112050A1 SEPARATION OF POLYSACCHARIDES BY CHARGE DENSITY GRADIENT 审中-公开
标题翻译：通过电荷密度梯度分离多糖
公开(公告)号：US20110112050A1
公开(公告)日：2011-05-12
申请号：US12993236
申请日：2009-05-20
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A61K31/727 , C08B37/10 , A61P1/00 , A61P25/28 , A61P7/00 , A61P3/00 , B01D57/02 , B01D61/42
CPC分类号： C08B37/0075 , A61K31/727 , Y02A50/411
摘要： Methods and apparatus for the separation of polysaccharides, particular heparin products, and glycosylated molecules are provided. The separation is based on the molecular weight and charge, by application of an electric field across a low-friction matrix, modified with a charged separation agent comprising charged regions ordered in a monotonous sequence distributed throughout the matrix, to generate a charge density gradient formed when an external electric field is applied. Saccharides of different charges migrate differently across the porous matrix and immobilized by charge neutralization in different charge regions of the matrix.
摘要翻译：提供了分离多糖，特定肝素产物和糖基化分子的方法和装置。分离基于分子量和电荷，通过施加电穿过低摩擦基质的电场，用包含分布在整个基体上的单调序列中排列的带电区域的带电分离剂修饰，以产生形成的电荷密度梯度当施加外部电场时。不同电荷的糖在多孔基质中迁移不同，并通过在基质的不同电荷区域中的电荷中和来固定。

8. 发明申请

US20100316697A1 METHODS AND COMPOSITIONS FOR DRUG TARGETING 审中-公开
标题翻译：用于药物治疗的方法和组合物
公开(公告)号：US20100316697A1
公开(公告)日：2010-12-16
申请号：US12599667
申请日：2008-05-07
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A61K38/02 , C12N5/071 , A61K9/127 , A61K38/43 , A61K39/395 , A61K31/7088 , A61K31/713 , C40B30/06 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00
CPC分类号： A61K41/0004 , A61K47/62
摘要： The present invention provides methods and compositions for targeting a drug to a specific desired location, such as an intracellular location in a mammalian cell, by causing said drug to migrate along a pH gradient to the specific location, where the drug preferentially accumulates at a pH range of the specific location. Accordingly, the invention described herein is based on providing a drug which is “pH matched” with that of a particular location, such that the drug preferentially migrates to and accumulates at the pH or pH range at that location. The location may be a type of tissue, a type of cell, a sub-cellular location or an intracellular location, such as an organelle. Without being bound to any theory, the drug migrates along or across a pH gradient, and stops migrating and accumulates at a location of specific pH or range of pH at which the drug is energetically neutral, or where its diffusion potential is at a minimum.
摘要翻译：本发明提供了通过使所述药物沿着pH梯度迁移到特定位置而将药物靶向特定所需位置（例如哺乳动物细胞中的细胞内位置）的方法和组合物，其中药物优选在pH 范围的具体位置。因此，本文所述的本发明基于提供与特定位置的“pH匹配”的药物，使得药物优选迁移到该位置处的pH或pH范围并积累。该位置可以是组织的类型，细胞类型，亚细胞位置或细胞内位置，例如细胞器。不受任何理论束缚，药物沿着或跨越pH梯度迁移，并停止迁移并积聚在特定pH或pH范围内的位置，在该位置处药物处于能量中性，或其扩散电位处于最小值的位置。

9. 发明申请

US20100136074A1 BIOCIDIC TEXTILES AND FABRICS 审中-公开
标题翻译：生物纺织品和织物
公开(公告)号：US20100136074A1
公开(公告)日：2010-06-03
申请号：US12598430
申请日：2008-04-03
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A01N25/34 , B05D5/12 , A01P1/00
CPC分类号： D06M16/00
摘要： It is in the scope of the invention to disclose a biocidic textiles and fabrics, comprising at least one insoluble proton sink or source (PSS). The textiles and fabrics is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact; the PSS comprising (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential; wherein the PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment.
摘要翻译：公开了包含至少一种不溶性质子阱或源（PSS）的生物活性织物和织物的本发明的范围。提供的纺织品和织物可用于杀死活细胞（LTC），或以其他方式破坏接触时LTC的细胞内过程和/或细胞间相互作用; PSS包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电位的装置; 其中PSS有效地破坏LTC的有限体积内的pH稳态和/或电气平衡和/或破坏LTC的重要细胞间相互作用，同时有效地保持LTC的环境的pH。

10. 发明申请

US20090055131A1 AUTOMATIC RECORDING VOLUME MEASUREMENT APPARATUS 审中-公开
标题翻译：自动记录音量测量装置
公开(公告)号：US20090055131A1
公开(公告)日：2009-02-26
申请号：US11912022
申请日：2006-04-20
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： G06F17/40
CPC分类号： B01L3/02 , B01L3/0227 , B01L2200/143 , B01L2300/023 , B01L2300/0663 , G01N35/00871
摘要： Data acquisition apparatus for use with a fluid dispensing device and providing an electronic record of the precise volumes of fluid dispensed from the fluid dispensing device. The fluid dispensing device may be laboratory or clinical apparatus such as an automatic or manual pipette. The apparatus generally includes a fluid volume sensor for detecting the volume of fluid released from the fluid dispensing device and producing electrical signals determined by the volume of fluid released from the device, a data transmission device configured to receive the electrical signals, and a data storage device for storing them.
摘要翻译：用于流体分配装置并提供从流体分配装置分配的精确体积的流体的电子记录的数据采集装置。流体分配装置可以是实验室或临床装置，例如自动或手动移液器。该装置通常包括用于检测从流体分配装置释放的流体的体积的流体体积传感器，并且产生由从装置释放的流体的体积确定的电信号，被配置为接收电信号的数据传输装置和数据存储用于存储它们的设备。

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