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1. 发明授权

US6117343A Filler-packing apparatus, filler-packing method, and filler-packed column assembly 失效
标题翻译：填料包装设备，填料填充方法和填料填充柱组件
公开(公告)号：US6117343A
公开(公告)日：2000-09-12
申请号：US91890
申请日：1998-06-26
申请人： Shinji Nagamatsu , Koichi Murazumi
发明人： Shinji Nagamatsu , Koichi Murazumi
IPC分类号： B01D15/02 , B01J8/02 , B65B3/00 , G01N30/56 , B01D24/38
CPC分类号： G01N30/56 , G01N2030/565
摘要： A filler-packing apparatus comprises a bundled filler-receiving space assembly, a movable bottom stopper assembly having bottom stoppers which are insertable into bottom openings of the filler-receiving spaces of said assembly, and top stoppers which are respectively insertable into top openings of the filler-receiving spaces and enabling packing filler in a plurality of columns in a short period of time. A filler-packing method uses this apparatus and thereby enables packing of the filler into the filler-receiving spaces in short period of time uniformly. An assembly of columns is uniformly packed with a filler and assembled by using the filler-packing apparatus and the filler-packing method.
摘要翻译： PCT No.PCT / JP96 / 03708 Sec。 371日期：1998年6月26日 102（e）日期1998年6月26日PCT 1996年12月19日PCT PCT。出版物WO97 / 24612 PCT 日期1997年7月10日一种填料包装设备包括一个捆扎的填料容纳空间组件，一个可移动的底部止动器组件，其具有可以插入到所述组件的填料容纳空间的底部开口中的底部止动器，以及分别可插入的顶部止动件在填充物接收空间的顶部开口中，并且能够在短时间内使多个列中的包装填料成为可能。填料填充方法使用该装置，从而能够在短时间内将填料填充到填料接收空间中。柱的组装均匀地填充填料并通过使用填料填充装置和填料填充方法组装。

2. 发明授权

US06217774B1 Simulated moving bed separation apparatus 失效
标题翻译：模拟移动床分离装置
公开(公告)号：US06217774B1
公开(公告)日：2001-04-17
申请号：US09476354
申请日：2000-01-03
申请人： Shinji Nagamatsu , Koichi Murazumi
发明人： Shinji Nagamatsu , Koichi Murazumi
IPC分类号： B01D1508
CPC分类号： B01D15/1828 , B01D15/1842 , B01D2215/023
摘要： This invention is intended to provide a simulated moving bed separation apparatus which is able to monitor concentration distribution of components in the fluid circulation passage or a simulated moving bed separation apparatus which is able to automatically control the operation conditions to optimum and provides a simulated moving bed apparatus provided with concentration detectors installed in the fluid circulation passage and means for measuring concentrations installed at outlets of the fluid circulation passage.
摘要翻译：本发明旨在提供一种模拟移动床分离装置，其能够监测流体循环通道中的部件的浓度分布或模拟移动床分离装置，其能够自动控制操作条件以最佳化并提供模拟移动床设置有安装在流体循环通道中的浓度检测器的装置和用于测量安装在流体循环通道的出口处的浓度的装置。

3. 发明申请

US20060016756A1 Process for producing packing for resolving optical isomers 失效
标题翻译：用于生产用于分解光学异构体的填料的方法
公开(公告)号：US20060016756A1
公开(公告)日：2006-01-26
申请号：US10529698
申请日：2003-10-09
申请人： Hirokazu Ikeda , Atsushi Onishi , Koichi Murazumi
发明人： Hirokazu Ikeda , Atsushi Onishi , Koichi Murazumi
IPC分类号： B01D15/08
CPC分类号： B01J20/3272 , B01D15/1821 , B01J20/26 , B01J20/262 , B01J20/265 , B01J20/28004 , B01J20/28078 , B01J20/286 , B01J20/29 , B01J20/3204 , B01J20/3274 , B01J20/328 , B01J2220/54 , B01J2220/56 , B01J2220/58
摘要： The present invention provides a production method with which a porous carrier can be allowed to evenly carry a polysaccharide derivative. That is, the present invention provides a method of producing an enantiomeric isomer-separating filler, including bringing a porous carrier and a solution of a polysaccharide derivative into contact with each other through a stirring operation in a stirring device, to allow the porous carrier to carry an optically active polymer compound, in which: a two-axis vertical stirring device is used as the stirring device; and the porous carrier is allowed to carry the polysaccharide derivative in a carrying amount of 23 mass % or more.
摘要翻译：本发明提供可以使多孔载体均匀地携带多糖衍生物的制备方法。也就是说，本发明提供一种制备对映体异构体分离填料的方法，包括使多糖载体和多糖衍生物的溶液通过搅拌装置中的搅拌操作彼此接触，以使多孔载体携带光学活性高分子化合物，其中使用两轴垂直搅拌装置作为搅拌装置; 允许多孔载体携带23质量％以上的载体量的多糖衍生物。

4. 发明申请

US20060079708A1 Method of separating optically active dihydroxy-heptenoic acid esters 失效
标题翻译：分离光学活性二羟基庚烯酸酯的方法
公开(公告)号：US20060079708A1
公开(公告)日：2006-04-13
申请号：US11254856
申请日：2005-10-21
申请人： Keiko Kudo , Kozo Tachibana , Koichi Murazumi
发明人： Keiko Kudo , Kozo Tachibana , Koichi Murazumi
IPC分类号： C07C69/76 , C08B37/00
CPC分类号： C07D209/24 , B01D15/1821 , B01D15/3833 , B01J20/285 , B01J20/286 , B01J20/3272 , B01J20/328 , C07B2200/07 , C07D209/12
摘要： An optically active dihydroxyheptenoic acid ester having an aromatic group is separated from a solution containing a mixture of optical isomers of digydroxyheptenoic acid ester by liquid chromatography with a packing material constituted of a carrier and a polysaccharide derivative carried on the carrier. The polysaccharide derivative is a polysaccharide in which the hydrogen atoms constituting the hydroxyl and amino groups are partially or all replaced by one or more kinds of groups selected from among carbamoyl groups monosubstituted with aromatic groups having specific alkyl groups and benzoyl groups having specific alkyl groups. According to the invention, optically active dihydroxyheptenoic acid esters can be separated more distinctly.
摘要翻译：具有芳族基团的光学活性二羟基庚烯酸酯通过液相色谱与含有载体的载体和载体上的多糖衍生物的包装材料从含有二羟基庚酸的旋光异构体的混合物的溶液中分离出来。多糖衍生物是其中构成羟基和氨基的氢原子部分或全部被选自由具有特定烷基的芳族基团和具有特定烷基的苯甲酰基单取代的氨基甲酰基中的一种或多种基团取代的多糖。根据本发明，可以更明确地分离光学活性的二羟基庚烯酸酯。

5. 发明授权

US07306734B2 Method for separation of enantiomeric isomers by simulated moving bed chromatography 失效
标题翻译：通过模拟移动床层析分离对映体异构体的方法
公开(公告)号：US07306734B2
公开(公告)日：2007-12-11
申请号：US10943436
申请日：2004-09-17
申请人： Atsushi Ohnishi , Koichi Murazumi
发明人： Atsushi Ohnishi , Koichi Murazumi
IPC分类号： B01D15/08
CPC分类号： B01J20/3272 , B01D15/1821 , B01D15/206 , B01D15/22 , B01D15/3833 , B01J20/286 , B01J20/29 , B01J20/328 , B01J2220/54 , G01N2030/565
摘要： The present invention provides a method having a high productivity for preparative separation by simulated moving bed chromatography. That is, in a filler for enantiomeric isomer separation by simulated moving bed chromatography, which has a porous carrier carrying a polysaccharide derivative thereon and has a TS coefficient in a range of 0.55 to 1.20, the TS coefficient being defined by the below-shown formula (I), and obtained by using an enantiomeric isomer separation column for simulated moving bed chromatography in which the filler is filled in a column tube by a slurry filling method: TS coefficient=[Vc−[t(TS)−t(blank)]×FR]/[t(TS)−t(blank)]×FR, (I) wherein Vc (cm3): a column volume; FR (ml/min.): a flow velocity; t(TS) (min.): an elution time for tetrakis(trimethylsilyl)silane (=TS); and t(blank) (min.): an elution time for TS in the state where the column is not connected.
摘要翻译：本发明提供了一种通过模拟移动床色谱法制备分离的高生产率的方法。也就是说，在通过模拟移动床层析法的对映体异构体分离的填料中，其具有在其上载有多糖衍生物的多孔载体并且TS系数在0.55至1.20的范围内，TS系数由下表所示的式（I），并通过使用用于模拟移动床层析的对映体异构体分离柱，其中通过浆料填充方法将填料填充在柱管中获得：<？在线公式描述=“在线配方”末端 =“lead”？> TS系数= [Vc- [t（TS）-t（空白）] xFR] / [t（TS）-t（空白）] xFR，（I） =“直线公式”end =“tail”？>其中Vc（cm 3）：柱体积; FR（ml / min）：流速; t（TS）（分钟）：四（三甲基甲硅烷基）硅烷（= TS）的洗脱时间; 和t（空白）（分钟）：在未连接色谱柱的状态下TS的洗脱时间。

6. 发明授权

US06946557B2 Process for producing optically active ethyl (3R, 5S, 6E)-7-[2-cycloproply-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate 失效
标题翻译：制备旋光性（3R，5S，6E）-7- [2-环丙基-4-（4-氟苯基）喹啉-3-基] -3,5-二羟基-6-庚烯酸乙酯的方法
公开(公告)号：US06946557B2
公开(公告)日：2005-09-20
申请号：US10398915
申请日：2001-10-12
申请人： Atsushi Onishi , Koichi Murazumi , Kozo Tachibana
发明人： Atsushi Onishi , Koichi Murazumi , Kozo Tachibana
IPC分类号： A61K31/47 , B01D15/08 , B01D15/18 , B01D15/38 , B01J20/26 , B01J20/281 , B01J20/29 , B01J20/32 , C07B57/00 , C07D215/04 , C07D215/14
CPC分类号： B01J20/328 , B01D15/185 , B01D15/3833 , B01J20/262 , B01J20/265 , B01J20/286 , B01J20/29 , B01J20/3204 , B01J20/3272 , B01J2220/54 , C07B2200/07 , C07D215/14
摘要： The objective of this invention is to provide a process for producing an optically active isomer of ethyl 7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate by optically resolving an optical isomer mixture of the compound at a high productivity. The process is characterized by employing a filler comprising a carrier and a specific amount of cellulose tris (4-chlorophenyl carbamate) supported the carrier and carrying out chromatographic separation under the condition that the capacity factors have specific values.
摘要翻译：本发明的目的是提供通过光学制备7- [2-环丙基-4-（4-氟苯基）喹啉-3-基] -3,5-二羟基-6-庚烯酸乙酯的旋光异构体的方法以高生产率分解化合物的旋光异构体混合物。该方法的特征在于使用包含载体和特定量的纤维素三（4-氯苯基氨基甲酸酯）的填料负载载体并在容量因子具有特定值的条件下进行色谱分离。

7. 发明授权

US07399409B2 Packing material for separation of optical isomer and method of separating optical isomer with the same 有权
标题翻译：用于分离光学异构体的包装材料和与其分离光学异构体的方法
公开(公告)号：US07399409B2
公开(公告)日：2008-07-15
申请号：US10398937
申请日：2001-10-12
申请人： Atsushi Onishi , Koichi Murazumi , Kozo Tachibana
发明人： Atsushi Onishi , Koichi Murazumi , Kozo Tachibana
IPC分类号： B01D15/08
CPC分类号： B01J20/29 , B01D15/1821 , B01D15/185 , B01D15/3833 , B01D2215/023 , B01J20/286 , B01J20/327 , B01J20/3274 , B01J20/328 , C07B57/00
摘要： The objectives of this invention are to provide a filler for separating optical isomers, capable of efficiently carrying out optical resolution of optical isomer mixtures, and to provide a process for separating optical isomers by a simulated moving bed chromatography utilizing the filler. This invention provides a filler made of a carrier supporting a specific amount of an optically active high molecular weight compound. Separation by the simulated moving bed chromatography using the filler is carried out under the condition that the capacity factors have specific values.
摘要翻译：本发明的目的是提供一种用于分离光学异构体的填料，其能够有效地进行光学异构体混合物的光学拆分，并提供通过使用填料的模拟移动床色谱分离光学异构体的方法。本发明提供了由支持特定量的光学活性高分子量化合物的载体制成的填料。在容量因子具有特定值的条件下，通过使用填料的模拟移动床层析法进行分离。

8. 发明授权

US07258794B2 Process for producing packing for resolving optical isomers 失效
标题翻译：用于生产用于分解光学异构体的填料的方法
公开(公告)号：US07258794B2
公开(公告)日：2007-08-21
申请号：US10529698
申请日：2003-10-09
申请人： Hirokazu Ikeda , Atsushi Onishi , Koichi Murazumi
发明人： Hirokazu Ikeda , Atsushi Onishi , Koichi Murazumi
IPC分类号： B01D15/08
CPC分类号： B01J20/3272 , B01D15/1821 , B01J20/26 , B01J20/262 , B01J20/265 , B01J20/28004 , B01J20/28078 , B01J20/286 , B01J20/29 , B01J20/3204 , B01J20/3274 , B01J20/328 , B01J2220/54 , B01J2220/56 , B01J2220/58
摘要： The present invention provides a production method with which a porous carrier can be allowed to evenly carry a polysaccharide derivative. That is, the present invention provides a method of producing an enantiomeric isomer-separating filler, including bringing a porous carrier and a solution of a polysaccharide derivative into contact with each other through a stirring operation in a stirring device, to allow the porous carrier to carry an optically active polymer compound, in which: a two-axis vertical stirring device is used as the stirring device; and the porous carrier is allowed to carry the polysaccharide derivative in a carrying amount of 23 mass % or more.
摘要翻译：本发明提供可以使多孔载体均匀地携带多糖衍生物的制备方法。也就是说，本发明提供一种制备对映体异构体分离填料的方法，包括使多糖载体和多糖衍生物的溶液通过搅拌装置中的搅拌操作彼此接触，以使多孔载体携带光学活性高分子化合物，其中使用两轴垂直搅拌装置作为搅拌装置; 允许多孔载体携带23质量％以上的载体量的多糖衍生物。

9. 发明授权

US06991729B2 Optical isomer separating filler, production method therefor and application method therefor 失效
标题翻译：光学异构体分离填料及其制备方法及其应用方法
公开(公告)号：US06991729B2
公开(公告)日：2006-01-31
申请号：US10474438
申请日：2002-04-12
申请人： Hirokazu Ikeda , Atsushi Onishi , Koichi Murazumi
发明人： Hirokazu Ikeda , Atsushi Onishi , Koichi Murazumi
IPC分类号： B01D15/08
CPC分类号： B01D15/3833 , B01D15/1821 , B01J20/103 , B01J20/28004 , B01J20/28078 , B01J20/286 , B01J20/29 , B01J20/3204 , B01J20/3219 , B01J20/3257 , B01J20/3274 , B01J20/328 , B01J2220/54 , B01J2220/56 , B01J2220/58
摘要： The objectives of this invention are to provide a filler for separating optical isomers, capable of efficiently carrying out optical resolution of optical isomer mixtures, a process for producing the filler, and a method for using the filler.The present invention provides a process for producing a filler for separating optical isomers which process comprises stirring a carrier and a solution including an optically active polymer compound with a double spindle vertical mixer. The present invention further provides a filler produced by the process and a method for using the filler in liquid chromatographic separation methods and simulated moving bed chromatographic separation methods.
摘要翻译：本发明的目的是提供一种能够有效地进行光学异构体混合物的光学拆分的光学异构体的分离装置，填料的制造方法和使用该填料的方法。本发明提供了一种用于分离光学异构体的填料的制备方法，该方法包括用双轴立式混合器搅拌载体和包含光学活性聚合物化合物的溶液。本发明还提供了一种通过该方法制备的填料，以及在液相色谱分离方法和模拟移动床色谱分离方法中使用填料的方法。

10. 发明授权

US07749389B2 Filler used for separating optical isomers and process for separating optical isomers with the filler 有权
标题翻译：用于分离光学异构体的填料和用填料分离光学异构体的方法
公开(公告)号：US07749389B2
公开(公告)日：2010-07-06
申请号：US11637157
申请日：2006-12-12
申请人： Atsushi Onishi , Koichi Murazumi , Kozo Tachibana
发明人： Atsushi Onishi , Koichi Murazumi , Kozo Tachibana
IPC分类号： B01D15/08
CPC分类号： B01J20/29 , B01D15/1821 , B01D15/185 , B01D15/3833 , B01D2215/023 , B01J20/286 , B01J20/327 , B01J20/3274 , B01J20/328 , C07B57/00
摘要： The objectives of this invention are to provide a filler for separating optical isomers, capable of efficiently carrying out optical resolution of optical isomer mixtures, and to provide a process for separating optical isomers by a simulated moving bed chromatography utilizing the filler. This invention provides a filler made of a carrier supporting a specific amount of an optically active high molecular weight compound. Separation by the simulated moving bed chromatography using the filler is carried out under the condition that the capacity factors have specific values.
摘要翻译：本发明的目的是提供一种用于分离光学异构体的填料，其能够有效地进行光学异构体混合物的光学拆分，并提供通过使用填料的模拟移动床色谱分离光学异构体的方法。本发明提供了由支持特定量的光学活性高分子量化合物的载体制成的填料。在容量因子具有特定值的条件下，通过使用填料的模拟移动床层析法进行分离。

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