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1. 发明申请

US20080039710A1 SYSTEMS AND METHODS USING NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY TO EVALUATE PAIN AND DEGENERATIVE PROPERTIES OF TISSUE 有权
标题翻译：使用核磁共振（NMR）光谱评估组织的疼痛和变性特性的系统和方法
公开(公告)号：US20080039710A1
公开(公告)日：2008-02-14
申请号：US11829847
申请日：2007-07-27
申请人： Sharmila Majumdar , John Kurhanewicz , Jeffrey Lotz , David Bradford , Kayvan Keshari
发明人： Sharmila Majumdar , John Kurhanewicz , Jeffrey Lotz , David Bradford , Kayvan Keshari
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , A61B5/4824 , G01N24/08 , G01R33/465 , G01R33/483 , G01R33/485
摘要： NMR spectroscopy is performed on intervertebral disc tissue. Extent of degeneration is determined based on the NMR spectroscopy. Correlation between NMR spectral regions and at least one of tissue degeneration and pain are made. Accordingly, NMR spectroscopy is used to determine location and/or extent of at least one of degeneration or pain associated with a region of tissue, such as for example in particular disc degeneration, or discogenic pain. NMR spectral peak ratios, such as between N-Acetyl/cho and cho/carb, are readily acquired and analyzed to predict degree of tissue degeneration and/or pain for: tissue samples using HR-MAS spectroscopy; and larger portions of anatomy such as joint segments such as a spine, using clinical 3 T MRI systems with surface head or knee coils; and tissue regions such as discs within spines of living patients using 3 T MRI systems with a surface spine coil, thus providing a completely non-invasive diagnostic toolset and method to image and localize degeneration and/or pain.
摘要翻译：对椎间盘组织进行NMR光谱。基于NMR光谱测定退化程度。 NMR光谱区域与组织变性和疼痛中的至少一种之间的相关性。因此，使用NMR光谱来确定与组织区域相关的变性或疼痛中的至少一种的位置和/或程度，例如特别是椎间盘变性或椎间盘性疼痛。核磁共振光谱峰比例，如N-乙酰基/ cho和cho / carb之间，容易获得和分析，以预测组织变性和/或疼痛程度：组织样本使用HR-MAS光谱; 和较大部分的解剖结构，如关节节段如脊柱，使用具有表面头部或膝部线圈的临床3 T MRI系统; 和组织区域，例如使用具有表面脊髓线圈的3T MRI系统的活体患者脊柱内的椎间盘，从而提供完全无创的诊断工具和方法来成像和定位变性和/或疼痛。

2. 发明申请

US20060293751A1 Biodegradable/bioactive nucleus pulposus implant and method for treating degenerated intervertebral discs 失效
公开(公告)号：US20060293751A1
公开(公告)日：2006-12-28
申请号：US11505783
申请日：2006-08-16
申请人： Jeffrey Lotz , Olivier Colliou , David Bradford
发明人： Jeffrey Lotz , Olivier Colliou , David Bradford
IPC分类号： A61F2/44
CPC分类号： B29C41/14 , A61F2/30965 , A61F2/441 , A61F2/442 , A61F2/4611 , A61F2002/30062 , A61F2002/30069 , A61F2002/30133 , A61F2002/30957 , A61F2002/444 , A61F2002/4627 , A61F2002/4629 , A61F2002/4635 , A61F2210/0004 , A61F2230/0015 , A61F2310/00365 , A61F2310/0097 , A61L27/18 , A61L27/58 , A61L2430/38 , B29C41/42 , C08L75/04 , C08L71/02
摘要： A bioactive/biodegradable nucleus implant for repairing degenerated intervertebral discs that is inflated inside the nucleus space after the degenerated nucleus has been removed to re-pressurize the nuclear space within the intervertebral disc. The implant is inflated with a high molecular weight fluid, gel or combination of fluid and elastomer, preferably an under-hydrated HA hydrogel/growth factor mixture with or without host cells. The implant includes an internal, integral, self-sealing valve that allows one-way filling of the implant after it is placed within the disc, and is made from a material that allows fibrous in growth thereby stabilizing the implant. A variety of substances can be incorporated into the implant to promote healing, prevent infection, or arrest pain.

3. 发明申请

US20060241576A1 System and method providing directional ultrasound therapy to skeletal joints 审中-公开
标题翻译：向骨骼关节提供定向超声治疗的系统和方法
公开(公告)号：US20060241576A1
公开(公告)日：2006-10-26
申请号：US11364357
申请日：2006-02-27
申请人： Chris Diederich , Jeffrey Lotz , Will Nau , David Bradford
发明人： Chris Diederich , Jeffrey Lotz , Will Nau , David Bradford
IPC分类号： A61B18/04 , A61F7/00 , A61F7/12
CPC分类号： A61N7/02 , A61B18/04 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2090/374 , A61N7/022 , A61N2007/0021 , A61N2007/003 , A61N2007/0056 , A61N2007/0078
摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.
摘要翻译：提供超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，该范围受到诸如体内椎间盘之类的预应力组织的显着影响。特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现其他响应而没有明显的重塑。

4. 发明申请

US20060149380A1 Systems, devices and methods for treatment of intervertebral disorders 审中-公开
标题翻译：用于治疗椎间疾病的系统，装置和方法
公开(公告)号：US20060149380A1
公开(公告)日：2006-07-06
申请号：US11292335
申请日：2005-12-01
申请人： Jeffrey Lotz , David Bradford
发明人： Jeffrey Lotz , David Bradford
IPC分类号： A61F2/44
CPC分类号： A61F2/30907 , A61B17/0401 , A61B2017/044 , A61F2/30771 , A61F2/3094 , A61F2/30965 , A61F2/441 , A61F2/442 , A61F2/4611 , A61F2002/009 , A61F2002/30014 , A61F2002/30023 , A61F2002/30062 , A61F2002/30075 , A61F2002/30092 , A61F2002/302 , A61F2002/30324 , A61F2002/30565 , A61F2002/30578 , A61F2002/30579 , A61F2002/30586 , A61F2002/30601 , A61F2002/30677 , A61F2002/3092 , A61F2002/30932 , A61F2002/30971 , A61F2002/4435 , A61F2002/444 , A61F2002/4627 , A61F2002/4629 , A61F2210/0004 , A61F2210/0014 , A61F2210/0061 , A61F2230/0065 , A61F2250/0018 , A61F2250/0034 , A61F2250/0036 , A61F2310/00976
摘要： A bioactive/biodegradable nucleus implant for repairing degenerated intervertebral discs that is inflated inside the nucleus space after the degenerated nucleus has been removed to re-pressurize the nuclear space within the intervertebral disc. The implant is inflated with a high molecular weight fluid, gel or combination of fluid and elastomer, preferably an under-hydrated HA hydrogel/growth factor mixture with or without host cells. The implant includes an internal, integral, self-sealing valve that allows one-way filling of the implant after it is placed within the disc, and is made from a material that allows fibrous in growth thereby stabilizing the implant. A variety of substances can be incorporated into the implant to promote healing, prevent infection, or arrest pain.
摘要翻译：用于修复退化椎间盘的生物活性/可生物降解的核植入物，其在退化的细胞核被去除之后在细胞核空间内充气以对椎间盘内的核空间重新加压。植入物用高分子量流体，凝胶或流体和弹性体的组合充气，优选含有或不含宿主细胞的水合不足的HA水凝胶/生长因子混合物。植入物包括内部的，一体式的自密封阀，其允许植入物在盘被放置在盘中之后进行单向填充，并且由允许纤维生长从而稳定植入物的材料制成。植入物中可以掺入各种物质以促进愈合，预防感染或阻止疼痛。

5. 发明申请

US20050144114A1 System and method for providing global information on risks and related hedging strategies 审中-公开
公开(公告)号：US20050144114A1
公开(公告)日：2005-06-30
申请号：US10949112
申请日：2004-09-24
申请人： Thomas Ruggieri , David Bradford , Edward Forer
发明人： Thomas Ruggieri , David Bradford , Edward Forer
IPC分类号： G06Q40/00 , G06F17/60
CPC分类号： G06Q40/08 , G06Q40/025 , G06Q40/04
摘要： The present invention provides a system and method for information and data aggregation and analysis which provides risk managers, benefits managers, brokers, insurers and other insurance professional to have access to information resources, knowledge management tools, and powerful analytical models needed to increase their value and productivity. In accordance with one embodiment of the invention, the system and method provided is designed for information and data aggregation that allows for the compilation of data for mining and categorization by a knowledge management system, which stores all retrieved information in accordance with categories provided by a categorization engine referred to as a Taxonomy module. A contextualization module is configured to retrieve relevant information, based on various factors, including the user's profile, and the user's particular task. The system dynamically provides relevant information as the user interacts and conducts various tasks. The stored information is analyzed by a concept clustering module, so that various concepts relating to a particular topic can be uncovered and stored. In accordance with another embodiment of the invention, the system provides for various analytical tools that allow users to carry on with highly complex analysis of insurance related topics. The range of available analytical tool dynamically varies based on the user's needs and research topics. In accordance with yet another embodiment of the invention, the system provides for a unique interactive workspace that combines the features explained above in a logical manner. To this end, the system interface provides for various job templates, so as to enable the user's to carry various projects by a template driven task assignments. As the user navigates through the workspace, the range of available information to the user changes, based on the user's profile and navigation pattern.

6. 发明授权

US08713118B2 End to end email monitor 有权
标题翻译：端到端电子邮件监控
公开(公告)号：US08713118B2
公开(公告)日：2014-04-29
申请号：US13548850
申请日：2012-07-13
申请人： Larry Katz , Ramana Juvvadi , David Bradford
发明人： Larry Katz , Ramana Juvvadi , David Bradford
IPC分类号： G06F15/16
CPC分类号： H04L51/24 , H04L43/50 , H04L51/00
摘要： An example method to monitor an email system involves sending a test email to an email server. The email server is to automatically forward the test email to a plurality of email accounts of corresponding domains different from one another and different from the email system. When the test email does not arrive at the plurality of email accounts within a time period, a notification identifying the email server is generated. Other test emails are distinguished from the test email based on checksum values in subject fields of the test email and the other test emails. The other test emails correspond to different ones of a plurality of other email systems being tested for operability. Each checksum uniquely identifies a respective one of the test emails and a respective one of the email systems.
摘要翻译：监控电子邮件系统的示例方法包括将测试电子邮件发送到电子邮件服务器。电子邮件服务器将自动将测试电子邮件转发到彼此不同的不同于电子邮件系统的相应域的多个电子邮件帐户。当测试电子邮件在一段时间内没有到达多个电子邮件帐户时，生成标识该电子邮件服务器的通知。其他测试电子邮件与测试电子邮件区别在于测试电子邮件和其他测试电子邮件的主题字段中的校验和值。其他测试电子邮件对应于正在测试可操作性的多个其他电子邮件系统中的不同的电子邮件。每个校验和唯一地标识相应的测试电子邮件和相应的一个电子邮件系统。

7. 发明申请

US20070250245A1 METHOD AND APPARATUS FOR OPERATING A GAS TURBINE ENGINE 有权
标题翻译：用于运行气体涡轮发动机的方法和装置
公开(公告)号：US20070250245A1
公开(公告)日：2007-10-25
申请号：US11379669
申请日：2006-04-21
申请人： Gert van der Merwe , David Bradford
发明人： Gert van der Merwe , David Bradford
IPC分类号： G06F19/00
CPC分类号： F04D27/001 , F01D21/003 , F01D21/045 , F05D2260/96 , G01H1/006 , Y02T50/672
摘要： A method for operating a gas turbine engine includes coupling at least one sensor within the gas turbine engine to transmit a signal indicative of a vibration level of a rotor assembly within the gas turbine engine, detecting the vibration level of the rotor assembly based on the signal transmitted from the at least one sensor, comparing the detected vibration level to a predetermined vibration threshold, and generating an output if the detected vibration amplitude exceeds the threshold amplitude for a predetermined duration to facilitate identifying a gas turbine engine impulse event.
摘要翻译：一种用于操作燃气涡轮发动机的方法包括联接燃气涡轮发动机内的至少一个传感器以传送指示燃气涡轮发动机内的转子组件的振动水平的信号，基于该信号检测转子组件的振动水平从所述至少一个传感器发射，将检测到的振动水平与预定的振动阈值进行比较，以及如果检测到的振动振幅超过阈值振幅达预定持续时间，则产生输出，以便于识别燃气涡轮发动机冲击事件。

8. 发明授权

US08224903B1 End to end email monitor 有权
标题翻译：端到端电子邮件监控
公开(公告)号：US08224903B1
公开(公告)日：2012-07-17
申请号：US11505593
申请日：2006-08-17
申请人： Larry Katz , Ramana Juvvadi , David Bradford
发明人： Larry Katz , Ramana Juvvadi , David Bradford
IPC分类号： G06F15/16
CPC分类号： H04L51/24 , H04L43/50 , H04L51/00
摘要： An end to end email monitoring system which monitors and verifies the ability of a client mail system to send and receive email messages to and from local and remote networks. The monitor tests inbound email flow, internal email services, database availability, and outbound email flow. It uses checksums for precise identification and allows emails from multiple client environments to arrive in a single, shared Internet test account. The use of multiple targets for email verification eliminates false positives due to a single email destination being unavailable. Moreover, SNMP alerting is used in addition to email alerting to provide an out of band notification method. The SNMP alerting has been enhanced to send the identification of the tested email server as the source. The monitor stores historical information for 45 days and can produce detailed reports summarizing outage events and delay occurrences in addition to providing real-time alerts.
摘要翻译：端到端电子邮件监控系统，用于监视和验证客户邮件系统向本地和远程网络发送和接收电子邮件的能力。监视器测试入站电子邮件流，内部电子邮件服务，数据库可用性和出站电子邮件流。它使用校验和进行精确识别，并允许来自多个客户端环境的电子邮件到达一个共享的互联网测试帐户。使用多个目标进行电子邮件验证可以消除由于单个电子邮件目的地不可用造成的误报。此外，除了电子邮件警报以外还提供SNMP警报以提供带外通知方法。已经增强了SNMP警报，以发送测试的电子邮件服务器的标识作为源。监视器存储45天的历史信息，并可以生成详细的报告，总结中断事件和延迟事件以及提供实时警报。

9. 发明申请

US20060057498A1 Substituted benzene developing solvent for photopolymerizable printing plates 失效
标题翻译：用于光聚合印版的取代苯显影溶剂
公开(公告)号：US20060057498A1
公开(公告)日：2006-03-16
申请号：US10937386
申请日：2004-09-10
申请人： Constance Hendrickson , David Bradford
发明人： Constance Hendrickson , David Bradford
IPC分类号： G03F7/00
CPC分类号： B01D21/283 , B01D21/0012 , B01D21/26 , B01D21/262 , G03F7/3092
摘要： Flexographic printing plates are produced by exposing the photopolymer plates to a light source and washing out (developing) the masked out, non-exposed areas with a solvent. The invention provides substituted benzene solvents suitable for use in the development of photopolymer printing plates. The solvents, which include substituted benzene alone or mixed with co-solvents and/or non-solvents, are effective in developing a large number of different photopolymer printing plates and can produce images superior to those obtained with commercially available solvents currently used in such applications.
摘要翻译：柔版印刷版通过将光聚合物板暴露于光源并用溶剂洗涤（显影）被掩蔽的未曝光区域来制备。本发明提供了适用于开发光聚合物印版的取代苯溶剂。单独使用取代苯或与共溶剂和/或非溶剂混合的溶剂可有效开发大量不同的光聚合物印版，并能产生比目前用于这些应用的市售溶剂获得的图像更好的图像。

10. 发明申请

US20050100823A1 TERPENE ETHER DEVELOPING SOLVENT FOR PHOTOPOLYMERIZABLE PRINTING PLATES 有权
标题翻译：用于光致变色印刷板的TERPENE ETHER开发溶剂
公开(公告)号：US20050100823A1
公开(公告)日：2005-05-12
申请号：US10701662
申请日：2003-11-06
申请人： Constance Hendrickson , David Bradford
发明人： Constance Hendrickson , David Bradford
IPC分类号： B41N3/00 , G03F7/00 , G03F7/26 , G03F7/30 , G03F7/32
CPC分类号： B41N3/006 , G03F7/325
摘要： Flexographic printing plates are produced by exposing the photopolymer plates to a light source and washing out (developing) the masked out, non-exposed areas with a solvent. The invention provides terpene ether solvents suitable for use in the development of photopolymer printing plates. The solvents, which include terpene ethers alone or mixed with co-solvents and/or non-solvents, are effective in developing a large number of different photopolymer printing plates and can produce images superior to those obtained with commercially available solvents currently used in such applications.
摘要翻译：柔版印刷版通过将光聚合物板暴露于光源并用溶剂洗涤（显影）被掩蔽的未曝光区域来制备。本发明提供适用于开发光聚合物印版的萜醚溶剂。单独使用萜烯醚或与共溶剂和/或非溶剂混合的溶剂可有效开发大量不同的光聚合物印版，并且可以产生优于目前在这些应用中使用的市售溶剂获得的图像的图像。

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