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1. 发明申请

US20080261829A1 ANTIBODY-BASED ARRAYS FOR DETECTING MULTIPLE SIGNAL TRANSDUCERS IN RARE CIRCULATING CELLS 有权
标题翻译：用于检测罕见循环细胞中多个信号转导体的基于抗体的阵列
公开(公告)号：US20080261829A1
公开(公告)日：2008-10-23
申请号：US12046381
申请日：2008-03-11
申请人： Jeanne Harvey , Sharat Singh , Phillip Kim , Xinjun Liu , Robert Barham , Limin Liu
发明人： Jeanne Harvey , Sharat Singh , Phillip Kim , Xinjun Liu , Robert Barham , Limin Liu
IPC分类号： C40B40/00 , G01N33/53
CPC分类号： G01N33/574 , C40B30/08 , C40B40/10 , G01N33/542 , G01N33/57415 , G01N33/582 , G01N33/6845 , G01N33/6854 , G01N2333/902 , G01N2333/908
摘要： The present invention provides antibody-based arrays for detecting the activation state and/or total amount of a plurality of signal transduction molecules in rare circulating cells and methods of use thereof for facilitating cancer prognosis and diagnosis and the design of personalized, targeted therapies.
摘要翻译：本发明提供用于检测稀有循环细胞中多个信号转导分子的活化状态和/或总量的基于抗体的阵列及其用于促进癌症预后和诊断以及个性化靶向治疗的设计的方法。

2. 发明授权

US08609349B2 Drug selection for breast cancer therapy using antibody-based arrays 有权
标题翻译：使用基于抗体的阵列进行乳腺癌治疗的药物选择
公开(公告)号：US08609349B2
公开(公告)日：2013-12-17
申请号：US13439737
申请日：2012-04-04
申请人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
发明人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
IPC分类号： G01N33/50 , G01N33/548 , C12Q1/26 , C12Q1/28
CPC分类号： G01N33/57415 , G01N33/5011 , G01N2800/52 , G01N2800/60
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞中信号转导途径的组分的激活状态的组合物和方法。关于使用本发明的信号转导途径的组分的激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。

3. 发明授权

US08658388B2 Antibody-based arrays for detecting multiple signal transducers in rate circulating cells 有权
标题翻译：用于在稀有循环细胞中检测多个信号传感器的基于抗体的阵列
公开(公告)号：US08658388B2
公开(公告)日：2014-02-25
申请号：US12046381
申请日：2008-03-11
申请人： Jeanne Harvey , Sharat Singh , Phillip Kim , Xinjun Liu , Robert Barham , Limin Liu
发明人： Jeanne Harvey , Sharat Singh , Phillip Kim , Xinjun Liu , Robert Barham , Limin Liu
IPC分类号： G01N33/573 , C07H21/04
CPC分类号： G01N33/574 , C40B30/08 , C40B40/10 , G01N33/542 , G01N33/57415 , G01N33/582 , G01N33/6845 , G01N33/6854 , G01N2333/902 , G01N2333/908
摘要： The present invention provides antibody-based arrays for detecting the activation state and/or total amount of a plurality of signal transduction molecules in rare circulating cells and methods of use thereof for facilitating cancer prognosis and diagnosis and the design of personalized, targeted therapies.
摘要翻译：本发明提供用于检测稀有循环细胞中多个信号转导分子的活化状态和/或总量的基于抗体的阵列及其用于促进癌症预后和诊断以及个性化靶向治疗的设计的方法。

4. 发明申请

US20090035792A1 DRUG SELECTION FOR LUNG CANCER THERAPY USING ANTIBODY-BASED ARRAYS 有权
标题翻译：使用基于抗体的阵列进行肺癌治疗的药物选择
公开(公告)号：US20090035792A1
公开(公告)日：2009-02-05
申请号：US12172100
申请日：2008-07-11
申请人： Sharat Singh , Jeanne Harvey
发明人： Sharat Singh , Jeanne Harvey
IPC分类号： G01N33/574 , C12M1/34
CPC分类号： G01N33/57423 , G01N33/5041 , G01N33/5044 , G01N33/5082 , G01N2500/10 , G01N2800/52
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞中信号转导途径的组分的激活状态的组合物和方法。关于使用本发明的信号转导途径的组分的激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。

5. 发明申请

US20070254295A1 METHODS OF PREDICTING AND MONITORING TYROSINE KINASE INHIBITOR THERAPY 有权
标题翻译：预测和监测酪氨酸激酶抑制剂治疗方法
公开(公告)号：US20070254295A1
公开(公告)日：2007-11-01
申请号：US11687254
申请日：2007-03-16
申请人： Jeanne Harvey , Bruce Neri , Sharat Singh
发明人： Jeanne Harvey , Bruce Neri , Sharat Singh
IPC分类号： G01N33/53 , A61P35/00 , C12Q1/68
CPC分类号： G06F19/18 , C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , G01N33/57484 , G01N2333/91215 , G01N2500/04 , G01N2800/52 , G06F19/24
摘要： The present invention provides methods for analyzing a combination of biomarkers to individualize tyrosine kinase inhibitor therapy in patients who have been diagnosed with cancer. In particular, the assay methods of the present invention are useful for predicting, identifying, or monitoring the response of a tumor, tumor cell, or patient to treatment with a tyrosine kinase inhibitor using an algorithm based upon biomarker profiling. The assay methods of the present invention are also useful for predicting whether a patient has a risk of developing toxicity or resistance to treatment with a tyrosine kinase inhibitor. In addition, the assay methods of the present invention are useful for monitoring tyrosine kinase inhibitor therapy in a patient receiving the drug to evaluate whether the patient will develop resistance to the drug. Furthermore, the assay methods of the present invention are useful for optimizing the dose of a tyrosine kinase inhibitor in a patient receiving the drug to achieve therapeutic efficacy and/or reduce toxic side-effects.
摘要翻译：本发明提供了用于分析已经被诊断患有癌症的患者中的酪氨酸激酶抑制剂治疗的生物标志物的组合的方法。特别地，本发明的测定方法可用于使用基于生物标志物分析的算法预测，鉴定或监测肿瘤，肿瘤细胞或患者用酪氨酸激酶抑制剂治疗的应答。本发明的测定方法也可用于预测患者是否具有产生毒性或抗酪氨酸激酶抑制剂治疗的风险。此外，本发明的测定方法可用于监测接受药物的患者中的酪氨酸激酶抑制剂治疗，以评估患者是否会产生对药物的抗药性。此外，本发明的测定方法可用于优化接受该药物的患者中的酪氨酸激酶抑制剂的剂量以达到治疗功效和/或减少毒副作用。

6. 发明申请

US20130045880A1 DRUG SELECTION FOR BREAST CANCER THERAPY USING ANTIBODY-BASED ARRAYS 有权
标题翻译：使用基于抗体的阵列进行乳腺癌治疗的药物选择
公开(公告)号：US20130045880A1
公开(公告)日：2013-02-21
申请号：US13439737
申请日：2012-04-04
申请人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
发明人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
IPC分类号： C40B30/04
CPC分类号： G01N33/57415 , G01N33/5011 , G01N2800/52 , G01N2800/60
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞中信号转导途径的组分的激活状态的组合物和方法。关于使用本发明的信号转导途径的组分的激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。

7. 发明授权

US07908091B2 Methods of predicting and monitoring tyrosine kinase inhibitor therapy 有权
标题翻译：预测和监测酪氨酸激酶抑制剂治疗方法
公开(公告)号：US07908091B2
公开(公告)日：2011-03-15
申请号：US11687254
申请日：2007-03-16
申请人： Jeanne Harvey , Bruce Neri , Sharat Singh
发明人： Jeanne Harvey , Bruce Neri , Sharat Singh
IPC分类号： G06F7/00
CPC分类号： G06F19/18 , C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , G01N33/57484 , G01N2333/91215 , G01N2500/04 , G01N2800/52 , G06F19/24
摘要： The present invention provides methods for analyzing a combination of biomarkers to individualize tyrosine kinase inhibitor therapy in patients who have been diagnosed with cancer. In particular, the assay methods of the present invention are useful for predicting, identifying, or monitoring the response of a tumor, tumor cell, or patient to treatment with a tyrosine kinase inhibitor using an algorithm based upon biomarker profiling. The assay methods of the present invention are also useful for predicting whether a patient has a risk of developing toxicity or resistance to treatment with a tyrosine kinase inhibitor. In addition, the assay methods of the present invention are useful for monitoring tyrosine kinase inhibitor therapy in a patient receiving the drug to evaluate whether the patient will develop resistance to the drug. Furthermore, the assay methods of the present invention are useful for optimizing the dose of a tyrosine kinase inhibitor in a patient receiving the drug to achieve therapeutic efficacy and/or reduce toxic side-effects.
摘要翻译：本发明提供了用于分析已经被诊断患有癌症的患者中的酪氨酸激酶抑制剂治疗的生物标志物的组合的方法。特别地，本发明的测定方法可用于使用基于生物标志物分析的算法预测，鉴定或监测肿瘤，肿瘤细胞或患者用酪氨酸激酶抑制剂治疗的应答。本发明的测定方法也可用于预测患者是否具有产生毒性或抗酪氨酸激酶抑制剂治疗的风险。此外，本发明的测定方法可用于监测接受药物的患者中的酪氨酸激酶抑制剂治疗，以评估患者是否会产生对药物的抗药性。此外，本发明的测定方法可用于优化接受该药物的患者中的酪氨酸激酶抑制剂的剂量以达到治疗功效和/或减少毒副作用。

8. 发明授权

US09250243B2 Drug selection for lung cancer therapy using antibody-based arrays 有权
标题翻译：使用基于抗体的阵列进行肺癌治疗的药物选择
公开(公告)号：US09250243B2
公开(公告)日：2016-02-02
申请号：US12172100
申请日：2008-07-11
申请人： Sharat Singh , Jeanne Harvey
发明人： Sharat Singh , Jeanne Harvey
IPC分类号： G01N33/574 , G01N33/50 , G01N33/53
CPC分类号： G01N33/57423 , G01N33/5041 , G01N33/5044 , G01N33/5082 , G01N2500/10 , G01N2800/52
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞中信号转导途径的组分的激活状态的组合物和方法。关于使用本发明的信号转导途径的组分的激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。

9. 发明授权

US08163499B2 Drug selection for breast cancer therapy using antibody-based arrays 有权
标题翻译：使用基于抗体的阵列进行乳腺癌治疗的药物选择
公开(公告)号：US08163499B2
公开(公告)日：2012-04-24
申请号：US12511017
申请日：2009-07-28
申请人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
发明人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
IPC分类号： G01N33/53 , G01N33/58 , G01N33/68 , G01N33/545 , G01N33/574
CPC分类号： G01N33/57415 , G01N33/5011 , G01N2800/52 , G01N2800/60
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞中信号转导途径的组分的激活状态的组合物和方法。关于使用本发明的信号转导途径的组分的激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。

10. 发明申请

US20110275097A9 DRUG SELECTION FOR LUNG CANCER THERAPY USING ANTIBODY-BASED ARRAYS 有权
标题翻译：使用基于抗体的阵列进行肺癌治疗的药物选择
公开(公告)号：US20110275097A9
公开(公告)日：2011-11-10
申请号：US12172100
申请日：2008-07-11
申请人： Sharat Singh , Jeanne Harvey
发明人： Sharat Singh , Jeanne Harvey
IPC分类号： G01N33/574 , C12M1/34
CPC分类号： G01N33/57423 , G01N33/5041 , G01N33/5044 , G01N33/5082 , G01N2500/10 , G01N2800/52
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞中信号转导途径的组分的激活状态的组合物和方法。关于使用本发明的信号转导途径的组分的激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。

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