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1. 发明授权

US08609404B2 Vaccines containing canine parvovirus genetic variants 有权
标题翻译：含有犬细小病毒遗传变体的疫苗
公开(公告)号：US08609404B2
公开(公告)日：2013-12-17
申请号：US13532425
申请日：2012-06-25
申请人： Sanjay Kapil , Emily Cooper
发明人： Sanjay Kapil , Emily Cooper
IPC分类号： C12N15/00 , C07K5/00
CPC分类号： A61K39/23 , A61K39/12 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2750/14022 , C12N2750/14032 , C12N2750/14034 , C12N2750/14043 , C12N2750/14051 , C12N2750/14071 , C12N2750/14334 , C12Q1/701 , G01N33/56983 , G01N2333/015
摘要： Canine parvovirus vaccines and diagnostics and methods for their use are provided. The vaccines are effective against emerging canine parvovirus variants.
摘要翻译：提供犬细小病毒疫苗及其使用的诊断和方法。疫苗对新出现的犬细小病毒变体有效。

2. 发明申请

US20120263756A1 VACCINES CONTAINING CANINE PARVOVIRUS GENETIC VARIANTS 有权
标题翻译：含有犬类病毒遗传变异体的疫苗
公开(公告)号：US20120263756A1
公开(公告)日：2012-10-18
申请号：US13532425
申请日：2012-06-25
申请人： Sanjay Kapil , Emily Cooper
发明人： Sanjay Kapil , Emily Cooper
IPC分类号： A61K39/23 , C12N15/63 , C12N7/00 , A61P31/20
CPC分类号： A61K39/23 , A61K39/12 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2750/14022 , C12N2750/14032 , C12N2750/14034 , C12N2750/14043 , C12N2750/14051 , C12N2750/14071 , C12N2750/14334 , C12Q1/701 , G01N33/56983 , G01N2333/015
摘要： Canine parvovirus vaccines and diagnostics and methods for their use are provided. The vaccines are effective against emerging canine parvovirus variants.
摘要翻译：提供犬细小病毒疫苗及其使用的诊断和方法。疫苗对新出现的犬细小病毒变体有效。

3. 发明申请

US20090098152A1 Vaccines Containing Canine Parvovirus Genetic Variants 有权
标题翻译：含有犬细小病毒基因变异的疫苗
公开(公告)号：US20090098152A1
公开(公告)日：2009-04-16
申请号：US12211174
申请日：2008-09-16
申请人： Sanjay Kapil , Emily Cooper
发明人： Sanjay Kapil , Emily Cooper
IPC分类号： A61K39/00 , C12Q1/70 , C12N7/00
CPC分类号： A61K39/23 , A61K39/12 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2750/14022 , C12N2750/14032 , C12N2750/14034 , C12N2750/14043 , C12N2750/14051 , C12N2750/14071 , C12N2750/14334 , C12Q1/701 , G01N33/56983 , G01N2333/015
摘要： Canine parvovirus vaccines and diagnostics and methods for their use are provided.
摘要翻译：提供犬细小病毒疫苗及其使用的诊断和方法。

4. 发明授权

US08258274B2 Vaccines containing canine parvovirus genetic variants 有权
标题翻译：含有犬细小病毒遗传变体的疫苗
公开(公告)号：US08258274B2
公开(公告)日：2012-09-04
申请号：US12138085
申请日：2008-06-12
申请人： Sanjay Kapil , Emily Cooper
发明人： Sanjay Kapil , Emily Cooper
IPC分类号： C07H230/00
CPC分类号： A61K39/23 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/14022 , C12N2750/14032 , C12N2750/14043 , C12N2750/14051 , C12N2750/14071 , G01N33/56983 , G01N2333/015
摘要： Canine parvovirus vaccines and diagnostics and methods for their use are provided.
摘要翻译：提供犬细小病毒疫苗及其使用的诊断和方法。

5. 发明授权

US08227583B2 Vaccines containing canine parvovirus genetic variants 有权
公开(公告)号：US08227583B2
公开(公告)日：2012-07-24
申请号：US12211174
申请日：2008-09-16
申请人： Sanjay Kapil , Emily Cooper
发明人： Sanjay Kapil , Emily Cooper
IPC分类号： C07H23/00
CPC分类号： A61K39/23 , A61K39/12 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2750/14022 , C12N2750/14032 , C12N2750/14034 , C12N2750/14043 , C12N2750/14051 , C12N2750/14071 , C12N2750/14334 , C12Q1/701 , G01N33/56983 , G01N2333/015
摘要： Canine parvovirus vaccines and diagnostics and methods for their use are provided.

6. 发明申请

US20090010955A1 Vaccines Containing Canine Parvovirus Genetic Variants 有权
标题翻译：含有犬细小病毒基因变异的疫苗
公开(公告)号：US20090010955A1
公开(公告)日：2009-01-08
申请号：US12138085
申请日：2008-06-12
申请人： Sanjay Kapil , Emily Cooper
发明人： Sanjay Kapil , Emily Cooper
IPC分类号： A61K39/00 , C12Q1/70 , C12N7/00 , A61P31/00
CPC分类号： A61K39/23 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/14022 , C12N2750/14032 , C12N2750/14043 , C12N2750/14051 , C12N2750/14071 , G01N33/56983 , G01N2333/015
摘要： Canine parvovirus vaccines and diagnostics and methods for their use are provided. The vaccines are effective against emerging dominant canine parvovirus variants.
摘要翻译：提供犬细小病毒疫苗及其使用的诊断和方法。疫苗对新出现的主要犬细小病毒变体有效。

7. 发明申请

US20100137159A1 Simple Tests for Rapid Detection of Canine Parvovirus Antigen and Antibodies 审中-公开
标题翻译：用于快速检测犬细小病毒抗原和抗体的简单测试
公开(公告)号：US20100137159A1
公开(公告)日：2010-06-03
申请号：US12606451
申请日：2009-10-27
申请人： Sanjay Kapil , Shashidhara Marulappa
发明人： Sanjay Kapil , Shashidhara Marulappa
IPC分类号： C12Q1/70 , C40B30/04
CPC分类号： G01N33/56983 , C12N2750/14311 , G01N2333/015 , G01N2469/20
摘要： Slide agglutination tests (SATs) and slide inhibition tests (SITs) provide rapid detection, quantitation and strain identification of red blood cell (RBC) agglutinating viruses such as canine parvovirus (CPV) in biological samples. The tests are rapid, low-cost, and easy to use. These tests do not require any expensive equipment and can thus be used to monitor infections and antibody titers under field conditions. The tests can be modified to detect results using fluorescence (FSAT). FSAT is useful for rapid high-throughput screening (HTS) of libraries of small molecules and/or chemical compounds to identify antiviral compounds useful for the treatment of diseases caused by emerging hemaglutinating viruses that infect animals and humans.
摘要翻译：幻灯片凝集试验（SAT）和幻灯片抑制试验（SITs）可提供生物样品中红细胞（RBC）凝集病毒如犬细小病毒（CPV）的快速检测，定量和毒株鉴定。测试速度快，成本低，易于使用。这些测试不需要任何昂贵的设备，因此可用于监测现场条件下的感染和抗体滴度。可以修改测试以使用荧光（FSAT）检测结果。 FSAT可用于小分子和/或化学化合物文库的快速高通量筛选（HTS），以鉴定可用于治疗由感染动物和人类的新出现的血液流感病毒引起的疾病的抗病毒化合物。

8. 发明授权

US06740490B2 Identification and applications of porcine reproductive and respiratory syndrome virus host susceptibility factor(s) for improved swine breeding 失效
标题翻译：鉴定和应用猪繁殖与呼吸综合征病毒宿主易感因子，改善猪繁殖
公开(公告)号：US06740490B2
公开(公告)日：2004-05-25
申请号：US09772044
申请日：2001-01-29
申请人： Sanjay Kapil , Kumar Shanmukhappa
发明人： Sanjay Kapil , Kumar Shanmukhappa
IPC分类号： C12Q168
CPC分类号： C12N7/00 , A01K2217/05 , A01K2227/108 , A01K2267/02 , A61K39/00 , C07K14/70596 , C12N2770/38011 , C12N2770/38022 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/56983 , G01N33/6872 , G01N2333/70596
摘要： Porcine reproductive and respiratory syndrome virus (PRRSV) causes serious economic losses in swine. The present invention determined that CD 151 is a susceptibility factor for PRRSV infection by transfecting a cell line which is not susceptible to PRRSV infection (BHK-21) with CD 151, which rendered the cell line susceptible. Because CD 151 can be accessed in cellular material including blood platelets and germplasm, the present invention provides a non-invasive method of screening different swine for susceptibility to PRRSV, thereby improving breeding plans. In the case of a valuable animal, results from such screening can indicate any offspring's susceptibility to PPRSV. Additionally, the viral RNA-CD 151 interaction possesses high affinity and can be used as a tool to detect anti-viral compounds which can be further improved by using combinatorial chemistry. Accordingly, anti-viral compounds that can block the viral RNA-CD 151 interaction can be developed. Advantageously, transfection of CD 151 into non-simian cell lines can confer susceptibility to PRRSV and these recombinant cell lines can be used for preparation of biologics that will avoid simian cell lines which could be a source of primate viruses in xenotransplanted organs from pigs. Finally, the present invention describes the basic mechanism by which the virus RNA enters a target cell. This novel class of proteins is termed viral RNA entry proteins and a novel class of compounds named anti-RNA Entry Proteins can be used to block the entry of viral RNA, thereby preventing viral infections.
摘要翻译：猪繁殖与呼吸综合征病毒（PRRSV）导致猪严重经济损失。本发明通过用CD151转染对PRRSV感染（BHK-21）不敏感的细胞系（其使细胞系易感）确定CD151是PRRSV感染的易感因子。由于CD 151可以在包括血小板和种质的细胞材料中进行，所以本发明提供了对PRRSV易感性的不同猪筛选的非侵入性方法，从而改善育种计划。在有价值的动物的情况下，这种筛选的结果可以指示任何后代对PPRSV的易感性。此外，病毒RNA-CD 151相互作用具有高亲和力，可用作检测抗病毒化合物的工具，可通过组合化学进一步改善。因此，可以开发可以阻断病毒RNA-CD 151相互作用的抗病毒化合物。有利地，将CD 151转染到非猿猴细胞系中可以赋予PRRSV的易感性，并且这些重组细胞系可用于制备生物制剂，其将避免可能是来自猪的异种移植器官中的灵长类动物病毒源的猿猴细胞系。最后，本发明描述了病毒RNA进入靶细胞的基本机制。这种新型的蛋白质类型被称为病毒RNA进入蛋白质，一类名为抗RNA进入蛋白质的化合物可用于阻断病毒RNA的进入，从而防止病毒感染。

9. 发明授权

US08734808B2 Isolation of a virus related to canine parvovirus-2 from a raccoon 有权
标题翻译：从浣熊中分离与犬细小病毒-2相关的病毒
公开(公告)号：US08734808B2
公开(公告)日：2014-05-27
申请号：US13501895
申请日：2010-10-14
申请人： Sanjay Kapil
发明人： Sanjay Kapil
IPC分类号： A61K39/12 , A61K39/23 , C07K14/015
CPC分类号： C12N7/00 , C12N2750/14321 , C12N2750/14322 , C12N2750/14332 , C12N2750/14334
摘要： Vaccines preparations against canine parvovirus are provided. The vaccines include a novel canine parvovirus-2 isolated from a raccoon, and related nucleic acids and proteins.
摘要翻译：提供针对犬细小病毒的疫苗制剂。疫苗包括从浣熊分离的新型犬细小病毒-2以及相关的核酸和蛋白质。

10. 发明授权

US07175984B2 Identification and applications of porcine reproductive and respiratory syndrome virus host susceptibility factor(s) for improved swine breeding and development of a non-simian recombinant cell line for propagation of the virus and a target for a novel class of antiviral compounds 失效
标题翻译：识别和应用猪繁殖与呼吸综合征病毒宿主易感性因子，用于改善猪繁殖和开发用于病毒繁殖的非猿类重组细胞系和新型抗病毒化合物的靶标
公开(公告)号：US07175984B2
公开(公告)日：2007-02-13
申请号：US10058597
申请日：2002-01-28
申请人： Sanjay Kapil , Kumar Shanmukhappa
发明人： Sanjay Kapil , Kumar Shanmukhappa
IPC分类号： C12Q1/68 , C12N1/20 , C12N5/00 , C07H19/00
CPC分类号： C12N7/00 , A01K2217/05 , A01K2227/108 , A01K2267/02 , A61K39/00 , C07K14/70596 , C12N2770/38011 , C12N2770/38022 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/56983 , G01N33/6872 , G01N2333/70596
摘要： Porcine reproductive and respiratory syndrome virus (PRRSV) causes serious economic losses in swine. The present invention determined that CD 151 is a susceptibility factor for PRRSV infection by transfecting a cell line which is not susceptible to PRRSV infection (BHK-21) with CD 151, which rendered the cell line susceptible. Because CD 151 can be accessed in cellular material including blood platelets and germplasm, the present invention provides a non-invasive method of screening different swine for susceptibility to PRRSV, thereby improving breeding plans. In the case of a valuable animal, results from such screening can indicate any offspring's susceptibility to PPRSV. Additionally, the viral RNA-CD 151 interaction possesses high affinity and can be used as a tool to detect anti-viral compounds which can be further improved by using combinatorial chemistry. Accordingly, anti-viral compounds that can block the viral RNA-CD 151 interaction can be developed. Advantageously, transfection of CD 151 into non-simian cell lines can confer susceptibility to PRRSV and these recombinant cell lines can be used for preparation of biologics that will avoid simian cell lines which could be a source of primate viruses in xenotransplanted organs from pigs. Finally, the present invention describes the basic mechanism by which the virus RNA enters a target cell. This novel class of proteins is termed viral RNA entry proteins and a novel class of compounds named anti-RNA Entry Proteins can be used to block the entry of viral RNA, thereby preventing viral infections.
摘要翻译：猪繁殖与呼吸综合征病毒（PRRSV）导致猪严重经济损失。本发明通过用CD151转染对PRRSV感染（BHK-21）不敏感的细胞系（其使细胞系易感）确定CD151是PRRSV感染的易感因子。由于CD 151可以在包括血小板和种质的细胞材料中进行，所以本发明提供了对PRRSV易感性的不同猪筛选的非侵入性方法，从而改善育种计划。在有价值的动物的情况下，这种筛选的结果可以指示任何后代对PPRSV的易感性。此外，病毒RNA-CD 151相互作用具有高亲和力，可用作检测抗病毒化合物的工具，可通过组合化学进一步改善。因此，可以开发可以阻断病毒RNA-CD 151相互作用的抗病毒化合物。有利地，将CD 151转染到非猿猴细胞系中可以赋予PRRSV的易感性，并且这些重组细胞系可用于制备生物制剂，其将避免可能是来自猪的异种移植器官中的灵长类动物病毒源的猿猴细胞系。最后，本发明描述了病毒RNA进入靶细胞的基本机制。这种新型的蛋白质类型被称为病毒RNA进入蛋白质，一类名为抗RNA进入蛋白质的化合物可用于阻断病毒RNA的进入，从而防止病毒感染。

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